Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
- Publication
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Medical Pathology
Copy Number Alterations Of Aggressive Pituitary Neuroendocrine Tumors, Grace Zhang
Copy Number Alterations Of Aggressive Pituitary Neuroendocrine Tumors, Grace Zhang
Scripps Senior Theses
Pituitary neuroendocrine tumors (PitNETs) are tumors of the pituitary gland. Although most are benign, they can cause severe morbidity if compression of surrounding tissue and/or endocrinopathies occur.
Aggressive PitNETs are notably detrimental and difficult to predict, and their effects are further exacerbated by challenges in treatment. Although histological studies can detect certain markers of tumor aggressiveness, they are insufficient at wholly predicting PitNET aggressiveness, making the clinical behavior of PitNETs challenging to determine. Since treatment of aggressive tumors also remains suboptimal, this further results in negative impacts on health and quality of life.
Genetic markers, such as copy number variations …
Specimens, Sara Kapadia