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Articles 1 - 2 of 2
Full-Text Articles in Medical Molecular Biology
Factors Regulating Features Of Metabolic Syndrome, Sonja S. Pijut
Factors Regulating Features Of Metabolic Syndrome, Sonja S. Pijut
Theses and Dissertations--Pharmacy
The collective presence of central obesity, low HDL-cholesterol, and elevated triglycerides, blood pressure, and fasting blood glucose constitutes Metabolic Syndrome (MetS), a disease state that increases the risk of cardiovascular disease (CVD) and Type 2 Diabetes Mellitus (T2DM). Nonalcoholic fatty liver disease (NAFLD), present in up to 90% of obese adults, is also linked to MetS. As in CVD, disruptions in cholesterol metabolism play a contributing role in the development of T2DM and NAFLD. Genes involved in cholesterol synthesis, secretion, and catabolism are diurnally regulated in the liver and adipose. Disruptions in the sleep-wake cycle are thought to potentiate metabolic …
The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, Robert N. Helsley
The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, Robert N. Helsley
Theses and Dissertations--Pharmacology and Nutritional Sciences
Cardiovascular disease (CVD) is the leading cause of death worldwide and is partially attributed to perturbations in lipid metabolism. Xenobiotics, such as pharmaceutical drugs and environmental chemicals, have been associated with increased risk of CVD in multiple large-scale human population studies, but the underlying mechanisms remain poorly defined. We and others have identified several xenobiotics as potent agonists for the pregnane X receptor (PXR), a nuclear receptor that can be activated by numerous drugs as well as environmental and dietary chemicals. However, the role of PXR in mediating the pathophysiological effects of xenobiotic exposure in humans and animals remains elusive. …