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Full-Text Articles in Medical Molecular Biology
Investigating Trail Sensitivity In Platinum-Resistant Ovarian Cancer, Nicholas Pathoulas
Investigating Trail Sensitivity In Platinum-Resistant Ovarian Cancer, Nicholas Pathoulas
All College Thesis Program, 2016-2019
Ovarian cancer is the deadliest gynecologic malignancy in the United States. While these tumors may have a promising initial response to platinum-based chemotherapies, the patient’s prognosis is commonly hindered by the development of platinum resistant cancer. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been implicated as a potential treatment for many cancers based on its tumor selective nature. Combination therapies with TRAIL and platinum drugs have been shown to increase apoptosis and have been used in a variety of clinical trials, which have thus far failed to pass phase II.1 Researchers have not yet elucidated the complex mechanism(s) of TRAIL …