Medical Sciences Commons^™

Evaluation Of Transconjunctival Approach Mixed With Lower Lateral Tarsal Incision For Zygomatico-Maxillary Complex Fracture, Mahmoud Ahmed Amin, Sherif Hamdeno Youssif, Ahmed Moustafa Omran, Ahmed Mohammed Mekawy

Al-Azhar International Medical Journal

Background: Orbital fractures are typical in modern society due to various accidents affecting the craniofacial region. Transconjunctival incisions have the main benefit of causing minimum scar formation compared to other orbital access procedures.

Aim: To assess the value of the Transconjunctival Approach with Lower Lateral Tarsal Incision for accessing ZMC fractures.

Subject and Method: In this prospective clinical study, we recruited 20 patients with unilateral Orbito-Zygomatic-Maxillary complex fracture operated at the Plastic and Reconstruction Department, Al-Azhar University Hospital, Damietta.

Results: All participants were male, with a mean age of 35.4±11.3 years. We found the mean time needed for the incision …

Ultrasound-Guided Caudal Block Versus Pudendal Nerve Block For Post-Operative Analgesia In Anal Surgery, Ismael Abd-Ellatif Shabayek, Alaa-Aldine Mahmoud Said Ahmed, Ahmed Mohamed Abd-Allah Marzook

Al-Azhar International Medical Journal

Background; Anal fissure is a frequent disorder that is regarded as a prevalent surgical condition that frequently arises in the anorectal area. The administration of a caudal block can offer an extended duration of pain relief following anorectal surgery.

Aim and objectives: To compare Ultrasound (US)-Guided caudal Block group and US -Guided Pudendal Nerve Block.

Subjects and methods: this prospective, randomized clinical trial included (116) cases divided into two groups. It was conducted in Al-Azhar University Hospitals for Boys in Cairo.

Results: There were insignificant differences among the studied groups concerning the baseline characteristics (Age, height, sex, weight, BMI, and …

Do Hourly Neuro Exams Lead To Sleep Deprivation And Icu Delirium: A Research Review, Toni Gafford

Covenant Nurses Week 2024

No abstract provided.

Impact Of Rehab Among Stroke Patients Affecting Anxiety And Depression; Faith 4 Neurosurgical Icu, Stephanie Pigg, Stephan R Smith

Covenant Nurses Week 2024

No abstract provided.

Resting State Electroencephalographic Brain Activity In Neonates Can Predict Age And Is Indicative Of Neurodevelopmental Outcome, Amir Ansari, Kirubin Pillay, Emad Arasteh, Anneleen Dereymaeker, Gabriela Schmidt Mellado, Katrien Jansen, Anderson M. Winkler, Gunnar Naulaers, Aomesh Bhatt, Sabine Van Huffel

School of Medicine Publications and Presentations

Objective: Electroencephalography (EEG) can be used to estimate neonates' biological brain age. Discrepancies between postmenstrual age and brain age, termed the brain age gap, can potentially quantify maturational deviation. Existing brain age EEG models are not well suited to clinical cot-side use for estimating neonates' brain age gap due to their dependency on relatively large data and pre-processing requirements.

Methods: We trained a deep learning model on resting state EEG data from preterm neonates with normal neurodevelopmental Bayley Scale of Infant and Toddler Development (BSID) outcomes, using substantially reduced data requirements. We subsequently tested this model in two independent datasets …

Admixture Mapping Of Cognitive Function In Diverse Hispanic And Latino Adults: Results From The Hispanic Community Health Study/Study Of Latinos, Rui Xia, Xueqiu Jian, Amanda L. Rodrigue, Jan Bressler, Eric Boerwinkle, Biqi Cui, Martha L. Daviglus, Charles Decarli, Linda C. Gallo, John Blangero

School of Medicine Publications and Presentations

Introduction: We conducted admixture mapping and fine-mapping analyses to identify ancestry-of-origin loci influencing cognitive abilities.

Methods: We estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years). We prioritized genetic variants in associated loci and tested them for replication in four independent cohorts.

Results: We identified nine local ancestry-associated regions for the five neurocognitive measures. There was strong biological support for the observed associations to cognitive function at all loci and there was statistical evidence of independent replication at 4q12, 9p22.1, and 13q12.13.

Discussion: Our …

Long-Term Weight Loss Effects Of Semaglutide In Obesity Without Diabetes In The Select Trial, Donna H Ryan, Ildiko Lingvay, John Deanfield, Steven E Kahn, Eric Barros, Bartolome Burguera, Helen M Colhoun, Cintia Cercato, Dror Dicker, Deborah B Horn, G Kees Hovingh, Ole Kleist Jeppesen, Alexander Kokkinos, A Michael Lincoff, Sebastian M Meyhöfer, Tugce Kalayci Oral, Jorge Plutzky, André P Van Beek, John P H Wilding, Robert F Kushner

Student and Faculty Publications

In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes. Here in this prespecified analysis, we examined effects of semaglutide on weight and anthropometric outcomes, safety and tolerability by baseline body mass index (BMI). In patients treated with semaglutide, weight loss continued over 65 weeks and was sustained for up to 4 years. At 208 weeks, semaglutide was associated with mean reduction in weight (-10.2%), waist circumference (-7.7 cm) and waist-to-height ratio (-6.9%) versus placebo (-1.5%, -1.3 cm and -1.0%, respectively; P < 0.0001 for all comparisons versus placebo). Clinically meaningful weight loss occurred in both sexes and all races, body sizes and regions. Semaglutide was associated with fewer serious adverse events. For each BMI category (

The Impact Of Intraoperative Glucagon On The Diagnostic Accuracy Of Intraoperative Cholangiogram For The Diagnosis Of Choledocholithiasis: Experience From A Large Tertiary Care Center, Nitish Mittal, Faisal S Ali, Antonio Pizuorno Machado, Sean Ngo, Malek Shatila, Tomas Davee, Nirav Thosani, Vaibhav Wadhwa

Student and Faculty Publications

A proportion of patients who undergo intraoperative cholangiogram (IOC) do not have bile duct stones at the time of endoscopic retrograde cholangiopancreatography (ERCP), either due to the spontaneous passage of stones or a false-positive IOC. Glucagon has been utilized as an inexpensive tool to allow the passage of micro-choledocholithiasis to the duodenum and resolve filling defects caused by stones or air bubbles. The purpose of our study is to understand the change in diagnostic accuracy of IOC to detect choledocholithiasis with intraoperative glucagon. We conducted a retrospective study at a tertiary care center on adult patients who underwent laparoscopic cholecystectomy …

Expanded-Access Use Of Elamipretide In A Patient With Membrane Protein-Associated Neurodegeneration, Jorge Patino, Anna Haertling Clearman, Lindsey Miller, Mary Kay Koenig

Student and Faculty Publications

This case report presents a progressively declining 17-year-old patient with membrane protein-associated neurodegeneration who demonstrated symptomatic improvements in her dysarthria, dysphagia, and gait, and objective improvements in her 6-minute walk test and 5 times sit-to-stand test during elamipretide treatment.

Identification Of Immune-Associated Biomarkers Of Diabetes Nephropathy Tubulointerstitial Injury Based On Machine Learning: A Bioinformatics Multi-Chip Integrated Analysis, Lin Wang, Jiaming Su, Zhongjie Liu, Shaowei Ding, Yaotan Li, Baoluo Hou, Yuxin Hu, Zhaoxi Dong, Jingyi Tang, Hongfang Liu, Weijing Liu

Student and Faculty Publications

BACKGROUND: Diabetic nephropathy (DN) is a major microvascular complication of diabetes and has become the leading cause of end-stage renal disease worldwide. A considerable number of DN patients have experienced irreversible end-stage renal disease progression due to the inability to diagnose the disease early. Therefore, reliable biomarkers that are helpful for early diagnosis and treatment are identified. The migration of immune cells to the kidney is considered to be a key step in the progression of DN-related vascular injury. Therefore, finding markers in this process may be more helpful for the early diagnosis and progression prediction of DN.

METHODS: The …

Ghcu, A Molecular Chaperone, Regulates Leaf Curling By Modulating The Distribution Of Kngh1 In Cotton, Yihao Zang, Chenyu Xu, Lishan Yu, Longen Ma, Lisha Xuan, Sunyi Yan, Yayao Zhang, Yiwen Cao, Xiaoran Li, Zhanfeng Si, Jieqiong Deng, Tianzhen Zhang, Yan Hu

Student and Faculty Publications

Leaf shape is considered to be one of the most significant agronomic traits in crop breeding. However, the molecular basis underlying leaf morphogenesis in cotton is still largely unknown. In this study, through genetic mapping and molecular investigation using a natural cotton mutant cu with leaves curling upward, the causal gene GHCU is successfully identified as the key regulator of leaf flattening. Knockout of GHCU or its homolog in cotton and tobacco using CRISPR results in abnormal leaf shape. It is further discovered that GHCU facilitates the transport of the HD protein KNOTTED1-like (KNGH1) from the adaxial to the abaxial …

Genetic Analysis Of Seven Patients With Inherited Ichthyosis And Nagashima-Type Palmoplantar Keratoderma, Jing Zhang, Yue Yao, Ya Tan, Hua-Ying Hu, Lin-Xi Zeng, Guo-Qiang Zhang

Student and Faculty Publications

Inherited ichthyosis comprises a series of heterogeneous dermal conditions; it mainly manifests as widespread hyperkeratosis, xerosis and scaling of the skin. At times, overlapping symptoms require differential diagnosis between ichthyosis and several other similar disorders. The present study reports seven patients with confirmed or suspected to be associated with ichthyosis by conducting a thorough clinical and genetic investigation. Genetic testing was conducted using whole-exome sequencing, with Sanger sequencing as the validation method. The MEGA7 program was used to analyze the conservation of amino acid residues affected by the detected missense variants. The enrolled patients exhibited ichthyosis-like but distinct clinical manifestations. …

The Relationship Between Diet, Depression, And Alzheimer's Disease: A Narrative Review, Hilal Salim Said Al Shamsi, Stephanie R. Rainey-Smith, Samantha L. Gardener, Hamid R. Sohrabi, Rodrigo Canovas, Ralph N. Martins, Warnakulasuriya Mary Ann Dipika Binosha Fernando

Research outputs 2022 to 2026

Purpose of Review: This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings: AD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, …

Uses Of Herbal Extracts In Endodontology: A Literature Review, Reem Chamseddine, Roula S. Abiad

BAU Journal - Science and Technology

The use of natural herbal extracts in the field of dentistry, and specifically in endodontology had gained a high popularity in the past few years. The main objective of endodontic treatment is to prevent and eliminate the infection from the root canal, seize the invasion of microorganisms to periradicular tissues and preserve the natural dentition. Studies had shown that some herbs are better alternatives to traditional chemical irrigants or medicaments used in root canal treatment, based on their potential antimicrobial effect, smear layer removal capabilities, tissue dissolution effect, antioxidant, anti-inflammatory and regenerative properties. Aim: The purpose of this literature review …

Hubungan Antara Partisipasi Dalam Pengambilan Keputusan Kesehatan Perempuan Dengan Kehamilan Yang Tidak Diinginkan, Maria Anastasia Audrey, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Prevalensi Kehamilan Tidak Diinginkan (KTD) di Indonesia mencapai 10,7% pada tahun 2021. Pada wanita yang sudah menikah, keputusan kesehatan mencakup keputusan tentang kontrasepsi, yang idealnya melibatkan partisipasi perempuan bersama suaminya agar dapat dilakukan secara konsisten sehingga dapat mencegah KTD. Namun, data tahun 2017 menunjukkan proporsi pengambilan keputusan kesehatan perempuan yang dilakukan perempuan bersama suami hanya sebesar 43,7%. Penelitian ini bertujuan untuk mengetahui hubungan antara partisipasi bersama antara istri dan suami dalam pengambilan keputusan kesehatan perempuan dengan terjadinya KTD. Penelitian ini menggunakan desain studi crosssectional dengan menganalisis data Survei Demografi dan Kesehatan Indonesia tahun 2017. Kriteria inklusi sampel adalah perempuan yang …

A Comprehensive Scoping Review Of Snoezelen Room In Occupatioanal Therapy Best Practices, Muhammad Hidayat Sahid, Andriani Pratiwi, Mohamad Ghazali Masuri, Akehsan Dahlan

Jurnal Epidemiologi Kesehatan Indonesia

Penelitian ini merupakan analisis komprehensif terhadap literatur, penelitian, dan sumber daya yang terkait dengan ruang Snoezelen, dengan tujuan menyajikan gambaran mengenai manfaat, praktik terbaik, dan potensi aplikasi dari lingkungan multi-sensorik ini. Tinjauan ini mensintesis dan menganalisis secara kritis informasi yang tersedia untuk berkontribusi pada pemahaman dan implementasi ruang Snoezelen bagi individu dengan kebutuhan beragam. Pencarian sistematis basis data elektronik, termasuk PubMed, PsycINFO, dan CINAHL, bersama dengan pencarian manual pada daftar referensi, mengidentifikasi 27 artikel relevan yang memenuhi kriteria inklusi. Proses seleksi yang ketat memastikan inklusi sumber yang berkualitas tinggi dan relevan. Metode ekstraksi dan sintesis data digunakan untuk mengidentifikasi tema …

Determinan Kegagalan Pengobatan Pada Pasien Tuberkulosis Sensitif Obat Dewasa Di Provinsi Jawa Tengah Tahun 2022, Elizabeth Wulandari, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Tuberkulosis (TB) adalah salah satu penyakit menular penyebab kematian tertinggi di dunia. Pada populasi pasien TB, terdapat banyak faktor yang dapat meningkatkan risiko kejadian yang tidak diharapkan dari pengobatan. Tujuan dari penelitian ini adalah untuk mengidentifikasi faktor-faktor yang berhubungan dengan kegagalan pengobatan pada pasien TB dewasa di Provinsi Jawa Tengah pada tahun 2022. Studi cross-sectional ini menganalisis data sekunder dari Sistem Informasi TB (SITB), menggunakan 14.542 sampel yang memenuhi kriteria inklusi dan eksklusi. Pasien TB berusia >15 tahun dan terdapat hasil pengobatan merupakan kriteria inklusi dalam penelitian ini. Kegagalan pengobatan merupakan variabel dependen dan variabel independennya adalah usia, jenis kelamin, …

Hubungan Campak Dengan Berat Badan Kurang Pada Anak Usia 24-59 Bulan Di Indonesia (Analisis Data Survei Status Gizi Indonesia 2021), Wiandhari Esa Gautami, Mondastri Korib Sudaryo

Jurnal Epidemiologi Kesehatan Indonesia

Berat badan kurang atau underweight merupakan masalah gizi kurang yang diukur dengan perbandingan berat badan dan umur. Berat badan kurang pada balita akan mempengaruhi pertumbuhan fisik, kemampuan kognitif, meningkatkan risiko kematian dan penularan infeksi penyakit, salah satu penyakit infeksi yang umum terjadi pada balita adalah campak. Tujuan penelitian ini adalah mengetahui hubungan infeksi campak dengan berat badan kurang pada balita usia 24-59 bulan di Indonesia, dengan mengontrol variabel kovariat diantaranya jenis kelamin, usia, pendidikan ibu BBLR, riwayat TB paru, riwayat diare, riwayat ISPA, riwayat imunisasi campak dan pola makan. Studi ini menggunakan data Survei Status Gizi Indonesia (SSGI) di 34 …

Severe Febrile Neutropenia And Pancytopenia In A Patient With Advanced Hepatocellular Carcinoma Treated With Atezolizumab And Bevacizumab: A Case Report, Shadi Chamseddine, Michael Lapelusa, Kristen Carter, Van Nguyen, Yehia I Mohamed, Yara Sakr, Cristhiam M Rojas-Hernandez, Rikita I Hatia, Manal Hassan, John A Goss, Khaled M Elsayes, Asif Rashid, Ryan Sun, Hop Sanderson Tran Cao, Hesham M Amin, Ahmed O Kaseb

Student and Faculty Publications

BACKGROUND: Immune checkpoint inhibitors (ICIs), agents that stimulate T-cell function, have become the standard first-line treatment for unresectable hepatocellular carcinoma (HCC). However, they may also cause immune-related adverse events (irAEs), which are rare and have not been extensively reported. Here, we describe a case of severe febrile neutropenia and pancytopenia after atezolizumab plus bevacizumab (atezo/bev) therapy and its treatment course.

CASE DESCRIPTION: The combination of atezo/bev was initiated as the first-line treatment for a man in his early 50s, who was diagnosed with unresectable HCC. The first treatment cycle was administered in the outpatient setting, and the patient developed a …

Analisis Faktor Risiko Kejadian Malaria Di Kabupaten Batu Bara Tahun 2022, Fitri Wahyuni, Tri Yunis Miko Wahyono

Jurnal Epidemiologi Kesehatan Indonesia

Malaria adalah masalah kesehatan yang serius dan dapat berakibat fatal, terutama pada kelompok risiko tinggi seperti bayi, anak kecil, dan ibu hamil. Selain itu, malaria juga menyebabkan anemia dan menurunkan produktivitas tenaga kerja. Pada tahun 2010, sekitar 65% kabupaten di Indonesia merupakan daerah endemis malaria, dan sekitar 45% penduduk di daerah endemis berisiko tertular malaria. Di Kabupaten Batu Bara, kasus malaria meningkat dari tahun ke tahun. Penelitian ini bertujuan untuk mengetahui faktor-faktor risiko kejadian malaria. Penelitian ini menggunakan kasus-kontrol dan dilakukan pada Juni 2022 di Kabupaten Batu Bara dengan melibatkan responden berusia 12 tahun ke atas sebanyak 170 sampel. Indiividu …

Hubungan Komorbiditas Terhadap Kondisi Akhir Pasien Covid-19 Di Rsud Siti Fatimah Provinsi Sumatera Selatan, Dewie Suranti

Jurnal Epidemiologi Kesehatan Indonesia

Pada tahun 2021, Indonesia menempati peringkat pertama dengan kasus COVID-19 terbanyak di ASEAN. Angka kematian COVID-19 di Indonesia sebesar 3,4% dan peringkat ke-5 ditempati oleh Provinsi Sumatera Selatan. Penelitian terdahulu menunjukkan komorbiditas berkontribusi terhadap kematian pasien COVID-19 disertai usia dan jenis kelamin. Penelitian ini bertujuan untuk menganalisis peran usia, jenis kelamin, dan komorbiditas terhadap kondisi akhir pasien COVID-19 di RSUD Siti Fatimah. Metode penelitian menggunakan desain cohort retrospective dengan analisis cox regression pendekatan model proportional hazard. Penelitian ini menggunakan data sekunder yaitu rekam medik pasien terkonfirmasi COVID-19 di RSUD Siti Fatimah dari Januari-Desember 2021 berjumlah 928 pasien yang diambil dengan …

Agapanthus Allergic Contact Dermatitis: A Case Report, Yasuhiro Horiuchi

Journal of General - Procedural Dermatology & Venereology Indonesia

Background: Agapanthus (Lily of the Nile) is a genus in the flowering plant family Amaryllidaceae. Contact dermatitis caused by flowering plants is common, but there are no reports of contact dermatitis caused by this plant, Agapanthus.

Case Illustration: An 82-year-old Japanese man had cultivated Agapanthus in his home garden. After breaking the stem of the leaf while wearing shorts, he noticed erythematous rashes on the thighs. The patch test of the leaf stem sap “as is” showed mildly positive, with erythematous papules.

Discussion: The patch test confirmed the allergic contact dermatitis of Agapanthus with leaf stem sap. There are many …

Metabolomics Analysis Reveals Metabolite Diversity Of The Rare Cliff Plant Oresitrophe Rupifraga Unge, Hao Wang, Jinjun Cao, Sheng Chang, Caifeng Yan, Guangming Zhang

Student and Faculty Publications

No abstract provided.

Pengaruh Promosi Kesehatan Melalui Media Sosial Whatsapp Terhadap Pemahaman Ibu Tentang Menu Mpasi Bergizi Di Kabupaten Sumedang, Dini Afriani, Witri Dewi Mentari, Ziana Azahra

Jurnal Epidemiologi Kesehatan Indonesia

Masyarakat menggunakan media sosial sebagai platform untuk berbagi teks, gambar, suara, dan video satu sama lain dan juga dengan pelaku bisnis. Studi ini meneliti pengetahuan ibu tentang menu makanan tambahan yang khas dan kaya nutrisi dengan menggunakan media sosial Whatsapp dan teknik video/teks dalam kelompok. Tujuannya adalah untuk mengetahui dampak dari promosi kesehatan melalui media sosial Whatsapp terhadap pemahaman para ibu mengenai menu makanan tambahan yang khas dan kaya gizi untuk bayi baru lahir. Penelitian ini menggunakan desain One Group Pre-test Post-test untuk pengujian sebelum dan sesudahnya. Dalam penelitian ini, ibu dari anak-anak berusia 6 hingga 24 bulan digunakan. Ibu …

Verbal Learning And Memory Deficits Across Neurological And Neuropsychiatric Disorders: Insights From An Enigma Mega Analysis., Eamonn Kennedy, Spencer W Liebel, Hannah M Lindsey, Shashank Vadlamani, Pui-Wa Lei, Maheen M Adamson, Martin Alda, Silvia Alonso-Lana, Tim J Anderson, Celso Arango, Robert F Asarnow, Mihai Avram, Rosa Ayesa-Arriola, Talin Babikian, Nerisa Banaj, Laura J Bird, Stefan Borgwardt, Amy Brodtmann, Katharina Brosch, Karen Caeyenberghs, Vince D Calhoun, Nancy D Chiaravalloti, David X Cifu, Benedicto Crespo-Facorro, John C Dalrymple-Alford, Kristen Dams-O'Connor, Udo Dannlowski, David Darby, Nicholas Davenport, John Deluca, Covadonga M Diaz-Caneja, Seth G Disner, Ekaterina Dobryakova, Stefan Ehrlich, Carrie Esopenko, Fabio Ferrarelli, Lea E Frank, Carol E Franz, Paola Fuentes-Claramonte, Helen Genova, Christopher C Giza, Janik Goltermann, Dominik Grotegerd, Marius Gruber, Alfonso Gutierrez-Zotes, Minji Ha, Jan Haavik, Charles Hinkin, Kristen R Hoskinson, Daniela Hubl, Andrei Irimia, Andreas Jansen, Michael Kaess, Xiaojian Kang, Kimbra Kenney, Barbora Keřková, Mohamed Salah Khlif, Minah Kim, Jochen Kindler, Tilo Kircher, Karolina Knížková, Knut K Kolskår, Denise Krch, William S Kremen, Taylor Kuhn, Veena Kumari, Junsoo Kwon, Roberto Langella, Sarah Laskowitz, Jungha Lee, Jean Lengenfelder, Victoria Liou-Johnson, Sara M Lippa, Marianne Løvstad, Astri J Lundervold, Cassandra Marotta, Craig A Marquardt, Paulo Mattos, Ahmad Mayeli, Carrie R Mcdonald, Susanne Meinert, Tracy R Melzer, Jessica Merchán-Naranjo, Chantal Michel, Rajendra A Morey, Benson Mwangi, Daniel J Myall, Igor Nenadić, Mary R Newsome, Abraham Nunes, Terence O'Brien, Viola Oertel, John Ollinger, Alexander Olsen, Victor Ortiz García De La Foz, Mustafa Ozmen, Heath Pardoe, Marise Parent, Fabrizio Piras, Federica Piras, Edith Pomarol-Clotet, Jonathan Repple, Geneviève Richard, Jonathan Rodriguez, Mabel Rodriguez, Kelly Rootes-Murdy, Jared Rowland, Nicholas P Ryan, Raymond Salvador, Anne-Marthe Sanders, Andre Schmidt, Jair C Soares, Gianfranco Spalleta, Filip Španiel, Scott R Sponheim, Alena Stasenko, Frederike Stein, Benjamin Straube, April Thames, Florian Thomas-Odenthal, Sophia I Thomopoulos, Erin B Tone, Ivan Torres, Maya Troyanskaya, Jessica A Turner, Kristine M Ulrichsen, Guillermo Umpierrez, Daniela Vecchio, Elisabet Vilella, Lucy Vivash, William C Walker, Emilio Werden, Lars T Westlye, Krista Wild, Adrian Wroblewski, Mon-Ju Wu, Glenn R Wylie, Lakshmi N Yatham, Giovana B Zunta-Soares, Paul M Thompson, Mary Jo Pugh, David F Tate, Frank G Hillary, Elisabeth A Wilde, Emily L Dennis

Student and Faculty Publications

Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15–90. The effects of dementia, mild cognitive impairment, Parkinson’s disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals. Random forest …

Lifestyle Medicine For The Health Care Worker, Workplace, And Community Well-Being: A Butterfly Effect, Karina Doucet, Nicholas D'Angelo

HCA Healthcare Journal of Medicine

Burnout is a prevalent and expensive problem in the US, and the National Plan For Health Workforce Well-Being included a goal to institutionalize well-being as a long-term value. Lifestyle Medicine (LM), an evidence-based practice using behavioral interventions to treat, prevent, and reverse certain chronic conditions, can achieve this goal. Implementing small changes in the workplace that support lifestyle medicine has a butterfly effect on both workplace and community well-being. Furthermore, the health of health care workers (HCWs) and patients improves, and health care costs decrease. This can be done with LM wellness programs or LM training for HCWs. LM wellness …

Aging- And Alcohol-Associated Spatial Transcriptomic Signature In Mouse Acute Pancreatitis Reveals Heterogeneity Of Inflammation And Potential Pathogenic Factors, Rachel R Tindall, Yuntao Yang, Isabella Hernandez, Amy Qin, Jiajing Li, Yinjie Zhang, Thomas H Gomez, Mamoun Younes, Qiang Shen, Jennifer M Bailey-Lundberg, Zhongming Zhao, Daniel Kraushaar, Patricia Castro, Yanna Cao, W Jim Zheng, Tien C Ko

Student and Faculty Publications

The rapidly aging population is consuming more alcohol, leading to increased alcohol-associated acute pancreatitis (AAP) with high mortality. However, the mechanisms remain undefined, and currently there are no effective therapies available. This study aims to elucidate aging- and alcohol-associated spatial transcriptomic signature by establishing an aging AAP mouse model and applying Visium spatial transcriptomics for understanding of the mechanisms in the context of the pancreatic tissue. Upon alcohol diet feeding and caerulein treatment, aging mice (18 months) developed significantly more severe AAP with 5.0-fold increase of injury score and 2.4-fold increase of amylase compared to young mice (3 months). Via …

Assessing The Effects Of Repetitive Mild Traumatic Brain Injury On Risk/Reward Decision Making And Catecholamine Associated Proteins, Christopher Knapp

Theses and Dissertations

Mild traumatic brain injury (mTBI) disrupts cognitive processes that influence risk taking behavior; however, the effects of repetitive mild injury (rmTBI) or whether these outcomes are sex specific are unknown. Risk/reward decision making is mediated by the prefrontal cortex (PFC), which is densely innervated by catecholaminergic fibers. Aberrant PFC catecholamine activity has been documented following TBI and may underlie TBI-induced risky behavior. Here, we exposed rats to sham (no injury), single, or three closed-head controlled cortical impact (CH-CCI) injuries to characterize the effects of rmTBI on 1) risk/reward decision making behavior using a probabilistic discounting task (PDT) and 2) levels …

Aging- And Alcohol-Associated Spatial Transcriptomic Signature In Mouse Acute Pancreatitis Reveals Heterogeneity Of Inflammation And Potential Pathogenic Factors, Rachel R. Tindall, Yuntao Yang, Isabella Hernandez, Amy Qin, Jiajing Li, Yinjie Zhang, Thomas H. Gomez, Mamoun Younes, Qiang Shen, Jennifer M. Bailey-Lundberg, Zhongming Zhao, Daniel Kraushaar, Patricia Castro, Yanna Cao, W. Jim Zheng, Tien C. Ko

School of Medicine Faculty Publications

Abstract: The rapidly aging population is consuming more alcohol, leading to increased alcohol-associated acute pancreatitis (AAP) with high mortality. However, the mechanisms remain undefined, and currently there are no effective therapies available. This study aims to elucidate aging- and alcohol-associated spatial transcriptomic signature by establishing an aging AAP mouse model and applying Visium spatial transcriptomics for understanding of the mechanisms in the context of the pancreatic tissue. Upon alcohol diet feeding and caerulein treatment, aging mice (18 months) developed significantly more severe AAP with 5.0-fold increase of injury score and 2.4-fold increase of amylase compared to young mice (3 months). …

عدوى المستشفيات, Afaf Taha

Al Jinan الجنان

Despite the progress in the medical fields and technologies used, and the use of a number of antibiotics to eliminate microorganisms that attack the human body, bacterial infections still a major cause of patient deaths. The irony is that hospitals patients turn to for hospitalization are the source of infection caused by microorganisms resistant to a number of antibiotics. The researcher discusses this problem and tells us that the hospital is an ideal place for transmitting pathogens because patients with similar diseases placed in closed groups and are in contact with health workers so that both become a hotbed for …