Medical Sciences Commons^™

Detection Of Point Mutations In The Dystrophin Gene, John Pedretti

Theses : Honours

The dystrophin gene has been localised to Xp 21.1. Mutations of this gene can lead to the clinical manifestations of Duchenne and Becker muscular dystrophies (DMD/BMD). In the majority of DMD and BMD patients the disease-causing mutation is a deletion detectable by southern analysis or multiplex PCR, however in 30% of patients no deletion is observed using these conventional tests. Using PCR amplification of cDNA it was possible to detect a deletion in the product of the dystrophin gene of one such individual affected with BMD. It was then necessary to characterise the mutation in order to determine whether this …

Bone Density And Muscle Development Problems In Female Lightweight Rowers Trying To Make-Weight, Carmel A. Shipway

Theses : Honours

The purpose of this study was to determine whether high intensity exercise, combined with restriction of diet, is counter-productive to the normal health and development of the competitor. The study investigated the effects of high intensity exercise on body composition (fat, muscle and bone); bone density; and physical performance (aerobic capacity, rowing performance, quadricep strength, power and fatiguability) in twelve lightweight female rowers (age range 17- 25yrs), training for the State and National lightweight championships. Six of the rowers completed the testing, which consisted of test1 (pre-training) and test2 (post-training) after a 12 weeks training regime.

Skinfold measurements were lower …