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Is Aprepitant Effective In Preventing Postoperative Nausea And Vomiting?, Rebeccah M. Gomberg
Is Aprepitant Effective In Preventing Postoperative Nausea And Vomiting?, Rebeccah M. Gomberg
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not aprepitant is effective in preventing postoperative nausea and vomiting.
STUDY DESIGN: Review of three English language primary randomized controlled trials from 2012-2014.
DATA SOURCES: Three double-blind, randomized controlled trials comparing oral aprepitant with placebo. All articles were found using PubMed.
OUTCOMES MEASURED: The three studies measured nausea severity using a verbal rating system and number of episodes of nausea and vomiting recorded by a blinded study investigator.
RESULTS: Vallejo et al found that 29.7% of the patients in the placebo group vomited compared to 9.3% of …