Inorganic Chemicals Commons^™

The Analysis Of Diruthenium Compounds On Human Cells As Potential Chemotherapeutic Agents, Elizabeth Mcculloch

Honors Program Theses

Chemotherapy is a common method of cancer treatment, and cisplatin is a common anticancer compound used in chemotherapy. While effective, cisplatin is known to cause many side effects, and people can form resistance to it. Because of these problems, new chemotherapeutic compounds are needed. One compound that has shown anticancer properties, an ability to overcome resistance, and nontoxicity is ruthenium. Multiple mono-ruthenium compounds have been previously studied and were found to be effective. The current research project synthesized a diruthenium compound Cp₂Ru₂(bipy)₂(DMSO)₂ and exposed the compound to human liver cells (HepG2) to determine …