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Impact Of 4r Management On Crop Production And Nitrate-Nitrogen Loss In Tile Drainage, Matthew Helmers, John Sawyer, Josh Sievers 2017 Iowa State University

Impact Of 4r Management On Crop Production And Nitrate-Nitrogen Loss In Tile Drainage, Matthew Helmers, John Sawyer, Josh Sievers

Matthew J. Helmers

Corn Belt corn and soybean producers are increasingly challenged to maximize crop production while addressing the contributions farm practices make to Gulf hypoxia. Based on the need for nitrate-N reductions to meet water quality goals, new management practices are needed to reduce nitrate-N losses at minimal cost and maximum economic benefits. This three-year field research and demonstration project is evaluating various promising N management methods and technologies by documenting the nitrate-N export and crop yield from various systems.


Diversity Oriented Synthesis, Characterization And Anti-Cancer Activity Of Killer Peptide Nucleolipid Bioconjugates, Niki K. Rana 2017 Seton Hall University

Diversity Oriented Synthesis, Characterization And Anti-Cancer Activity Of Killer Peptide Nucleolipid Bioconjugates, Niki K. Rana

Seton Hall University Dissertations and Theses (ETDs)

The killer peptide sequence D-(KLAKLAK)2 has been originally designed and developed as an antibacterial agent. Despite having excellent cytotoxicity towards bacteria, this sequence maintains low cell cytotoxity in malignant mammalian cell types such as cancer. The chemical basis for its selectivity has been attributed to its poly(cationic) amphiphilic nature, which facilitates cell permeability across the negatively charged bacterial membrane, but with limited permeability across the zwitterionic membrane of mammalian cells. The positively charged D-(KLAKLAK)2 sequence has been found to accumulate on the surface of the mitochondria causing dissipation of the negatively charged mitochondrial membrane potential ...


Connecting Energy Metabolism And Neurodegeneration: Pyruvate Kinase And Oxidative Stress, Julia P. Zuercher 2017 College of William and Mary

Connecting Energy Metabolism And Neurodegeneration: Pyruvate Kinase And Oxidative Stress, Julia P. Zuercher

Undergraduate Honors Theses

Pyruvate kinase (PK), an important glycolytic enzyme that catalyzes the final step of glycolysis through an irreversible mechanism to produce energy for the cell, contains nine cysteines, some of which are highly reactive and critical for function. This research sought to develop a protocol to measure quantitatively the functionality of PK under different experimental conditions. Using a three stage, consistent procedure, it was possible to analyze the effects of thiol modification by Ellman’s Reagent (DTNB) and oxidation by hypochlorous acid (HOCl) on PK activity. Results showed that both DTNB and HOCl inhibited activity at high concentrations, which illustrates that ...


Circumventing Cisplatin Resistance In Ovarian Cancers Through Reactivation Of P53 By Non-Cross-Resistant Platinum Analogs, Michelle Martinez-Rivera 2016 The University of Texas Graduate School of Biomedical Sciences at Houston

Circumventing Cisplatin Resistance In Ovarian Cancers Through Reactivation Of P53 By Non-Cross-Resistant Platinum Analogs, Michelle Martinez-Rivera

UT GSBS Dissertations and Theses (Open Access)

Abstract

CIRCUMVENTING CISPLATIN RESISTANCE IN OVARIAN CANCERS THROUGH REACTIVATION OF P53 BY NON-CROSS-RESISTANT PLATINUM ANALOGS

Michelle Martinez-Rivera, B.S.

Advisory Professor: Zahid H. Siddik, Ph.D.

Cisplatin (cis-Pt), an anticancer platinum (Pt) drug, is used widely in the treatment of several malignancies, such as ovarian cancer. This Pt compound induces DNA damage, which results in p53 activation through post-translational modifications, mainly phosphorylation, culminating in execution of programmed cell-death. However, despite initial therapeutic response to cis-Pt, clinical resistance to this drug emerges leading to disease progression. Pt-resistance phenotypes have been associated with dysfunction in the p53 signaling pathway. Therefore, an effort ...


In-Season N Fertilization Strategies Using Active Sensors, Daniel Barker, John Sawyer 2016 Iowa State University

In-Season N Fertilization Strategies Using Active Sensors, Daniel Barker, John Sawyer

John E. Sawyer

The objectives of this project were to measure corn yield response to applied nitrogen (N) fertilizer based on active canopy sensing during the mid-vegetative corn growth stage (V10) and compare yield and N use efficiency between pre-plant N (PP-N), pre-plant + sensor N (PP+S-N), split N strategy (SNS), and rescue N strategy (RNS).


In-Season N Fertilization Strategies Using Active Sensors, Daniel Barker, John Sawyer 2016 Iowa State University

In-Season N Fertilization Strategies Using Active Sensors, Daniel Barker, John Sawyer

John E. Sawyer

The objectives of this project were to measure corn yield response to applied nitrogen (N) fertilizer based on active canopy sensing during the mid-vegetative corn growth stage (V10) and compare yield and N use efficiency between pre-plant N (PP-N), pre-plant + sensor N (PP+S-N), split N strategy (SNS), and rescue N strategy (RNS).


In-Season N Fertilization Strategies Using Active Sensors, Daniel Barker, John Sawyer 2016 Iowa State University

In-Season N Fertilization Strategies Using Active Sensors, Daniel Barker, John Sawyer

John E. Sawyer

The objectives of this project were to measure corn yield response to applied nitrogen (N) fertilizer based on active canopy sensing during the mid-vegetative corn growth stage (V10) and compare yield and N use efficiency between pre-plant N (PP-N), pre-plant + sensor N (PP+S-N), split N strategy (SNS), and rescue N strategy (RNS).


Impact Of 4r Management On Crop Production And Nitrate-Nitrogen Loss In Tile Drainage, Matthew Helmers, John Sawyer, Josh Sievers 2016 Iowa State University

Impact Of 4r Management On Crop Production And Nitrate-Nitrogen Loss In Tile Drainage, Matthew Helmers, John Sawyer, Josh Sievers

John E. Sawyer

Corn Belt corn and soybean producers are increasingly challenged to maximize crop production while addressing the contributions farm practices make to Gulf hypoxia. Based on the need for nitrate-N reductions to meet water quality goals, new management practices are needed to reduce nitrate-N losses at minimal cost and maximum economic benefits. This three-year field research and demonstration project is evaluating various promising N management methods and technologies by documenting the nitrate-N export and crop yield from various systems.


Impacts Of Cover Crops On Phosphorus And Nitrogen Loss With Surface Runoff, Antonio Mallarino, Richard Cruse, Dan Jaynes, John Sawyer, Pablo Barbieri 2016 Iowa State University

Impacts Of Cover Crops On Phosphorus And Nitrogen Loss With Surface Runoff, Antonio Mallarino, Richard Cruse, Dan Jaynes, John Sawyer, Pablo Barbieri

John E. Sawyer

Iowa research has demonstrated that cover crops can improve soil productivity and water quality by increasing soil organic matter and reducing nitrate nitrogen (N) leaching. Other research has investigated and is investigating the agronomic and economic viability of using cereal rye cover crops in continuous corn or corn-soybean rotations. However, no Iowa research has evaluated under natural rainfall the impact of cover crops on phosphorus (P) and N loss with surface runoff interacting with other management practices. The need for this type of research was indicated in the Iowa Nutrient Reduction Strategy documents. This effort assessed what would be needed ...


Zn(Ii), Cu(Ii), Sn(Ii), And Ni(Ii) And Other Metal Cations Do Not Prevent The Aggregation Of Hiapp, Charles Hoying 2016 Loyola Marymount University and Loyola Law School

Zn(Ii), Cu(Ii), Sn(Ii), And Ni(Ii) And Other Metal Cations Do Not Prevent The Aggregation Of Hiapp, Charles Hoying

Honors Thesis

The Zn(II) metal ion has been shown to interact with Islet Amyloid Polypeptide (IAPP), a protein implicated in the progression of Type II Diabetes Mellitus, in such a way as to prevent the protein from aggregating into toxic fibers. We set out to find whether other metal ions might similarly prevent IAPP aggregation. Using Thioflavin T (ThT) spectroscopic assays, which measure fluorescence of ThT upon binding to aggregated IAPP, we observed a decrease in aggregation when incubated with Zn(II), Cu(II), Ni(II), and Sn(II). Atomic Force Microscopy (AFM), which can visualize fibril formation, revealed that the ...


Investigating Metal Cations As Potential Inhibitors Of Iapp Aggregation: Kcl, Cacl2, And Cucl2, Megan Burke 2016 Loyola Marymount University

Investigating Metal Cations As Potential Inhibitors Of Iapp Aggregation: Kcl, Cacl2, And Cucl2, Megan Burke

Honors Thesis

IAPP is an amyloid protein that misfolds, causing toxic aggregation in the pancreas of Type II Diabetes patients. In this study, three metal cations (KCl, CaCl2, and CuCl2) are tested in Thioflavin T assays and atomic force microscopy (AFM) to see if they inhibit the aggregation of IAPP.


Can A Metallated Cyclen Species Be Used To Prepare New Odorants?, Jalynn Taylor-Farmer 2016 Virginia Commonwealth University

Can A Metallated Cyclen Species Be Used To Prepare New Odorants?, Jalynn Taylor-Farmer

Undergraduate Research Posters

Scientists in the fragrance industry are constantly searching for new odors to create as well as new, more efficient processes to create them. Scientists mainly look for new ways to synthesize fragrances that will reduce the impact on the environment, produce them at lower costs, produce higher yields, and sometimes to produce a more potent odor [4]. In this research, we investigated the use of metallic macrocycles and/or metal-dioxygen chemistry to prepare new fragrances.

Cyclen (1,4,7,10-tetraazacyclododecane) has significant uses in many pharmaceutical and medicinal research developments such as advances in targeted cancer and Alzheimer’s agents ...


On-Farm Sulfur Fertilization Of Corn And Soybean Trials, Jim Fawcett, John Sawyer, Lance Miller, Jim Rogers, Wayne Roush 2015 Iowa State University

On-Farm Sulfur Fertilization Of Corn And Soybean Trials, Jim Fawcett, John Sawyer, Lance Miller, Jim Rogers, Wayne Roush

Iowa State Research Farm Progress Reports

In the past several years, sulfur (S) deficiency has been showing up more frequently in Iowa fields. This has been especially true in corn and alfalfa fields of northeast Iowa. This is thought to be partially due to Iowa receiving less S in the rainfall due to more stringent air pollution regulations, less S fertilizer applications, and less widespread use of manure. Sulfur fertilizer applications can offer yield increases when S deficiencies are present. The objective of these trials was to evaluate potential for S deficiency and grain yield response in corn and soybean to S applications.


Evaluation Of Foliar Fungicides And Insecticides On Soybeans In Central Iowa, Daren Mueller, Stith Wiggs, Warren Pierson 2015 Iowa State University

Evaluation Of Foliar Fungicides And Insecticides On Soybeans In Central Iowa, Daren Mueller, Stith Wiggs, Warren Pierson

Iowa State Research Farm Progress Reports

Researchers at Iowa State University assessed fungicide and insecticide applications to soybeans at seven locations across Iowa including the Northwest Farm (Sutherland), Northern Farm (Kanawha), Northeast Farm (Nashua), Agronomy Farm (Boone), Armstrong Farm (Lewis), McNay Farm (Chariton), and Southeast Farm (Crawfordsville) (Figure 1).


On-Farm Soybean Fertilizer Trials, Jim Fawcett, Antonio Mallarino, Josh Sievers, Micah Smidt, Matt Schnabel, Lance Miller 2015 Iowa State University

On-Farm Soybean Fertilizer Trials, Jim Fawcett, Antonio Mallarino, Josh Sievers, Micah Smidt, Matt Schnabel, Lance Miller

Iowa State Research Farm Progress Reports

All cropping systems require fertilizer inputs in order to maintain crop yields. Farmers continue to search for ways to increase soybean yields, such as applying micronutrients and using foliar applications of fertilizer. Although micronutrients are just as essential to plant growth as macronutrients, past research has indicated most Iowa soils can supply the micronutrient needs of soybeans.


Impact Of 4r Management On Crop Production And Nitrate-Nitrogen Loss In Tile Drainage, Matthew Helmers, John Sawyer, Josh Sievers 2015 Iowa State University

Impact Of 4r Management On Crop Production And Nitrate-Nitrogen Loss In Tile Drainage, Matthew Helmers, John Sawyer, Josh Sievers

Iowa State Research Farm Progress Reports

Corn Belt corn and soybean producers are increasingly challenged to maximize crop production while addressing the contributions farm practices make to Gulf hypoxia. Based on the need for nitrate-N reductions to meet water quality goals, new management practices are needed to reduce nitrate-N losses at minimal cost and maximum economic benefits. This three-year field research and demonstration project is evaluating various promising N management methods and technologies by documenting the nitrate-N export and crop yield from various systems.


On-Farm Soybean Fertilizer Trials, Jim Fawcett, Antonio Mallarino, Josh Sievers, Micah Smidt, Matt Schnabel, Lance Miller 2015 Iowa State University

On-Farm Soybean Fertilizer Trials, Jim Fawcett, Antonio Mallarino, Josh Sievers, Micah Smidt, Matt Schnabel, Lance Miller

Iowa State Research Farm Progress Reports

All cropping systems require fertilizer inputs in order to maintain crop yields. Farmers continue to search for ways to increase soybean yields, such as applying micronutrients and using foliar applications of fertilizer. Although micronutrients are just as essential to plant growth as macronutrients, past research has indicated most Iowa soils can supply the micronutrient needs of soybeans.


On-Farm Sulfur Fertilization Of Corn And Soybean Trials, Jim Fawcett, John Sawyer, Lance Miller, Jim Rogers, Wayne Roush 2015 Iowa State University

On-Farm Sulfur Fertilization Of Corn And Soybean Trials, Jim Fawcett, John Sawyer, Lance Miller, Jim Rogers, Wayne Roush

Iowa State Research Farm Progress Reports

In the past several years, sulfur (S) deficiency has been showing up more frequently in Iowa fields. This has been especially true in corn and alfalfa fields of northeast Iowa. This is thought to be partially due to Iowa receiving less S in the rainfall due to more stringent air pollution regulations, less S fertilizer applications, and less widespread use of manure. Sulfur fertilizer applications can offer yield increases when S deficiencies are present. The objective of these trials was to evaluate potential for S deficiency and grain yield response in corn and soybean to S applications.


On-Farm Soybean Fertilizer Trials, Jim Fawcett, Antonio Mallarino, Josh Sievers, Micah Smidt, Matt Schnabel, Lance Miller 2015 Iowa State University

On-Farm Soybean Fertilizer Trials, Jim Fawcett, Antonio Mallarino, Josh Sievers, Micah Smidt, Matt Schnabel, Lance Miller

Iowa State Research Farm Progress Reports

All cropping systems require fertilizer inputs in order to maintain crop yields. Farmers continue to search for ways to increase soybean yields, such as applying micronutrients and using foliar applications of fertilizer. Although micronutrients are just as essential to plant growth as macronutrients, past research has indicated most Iowa soils can supply the micronutrient needs of soybeans.


In-Season N Fertilization Strategies Using Active Sensors, Daniel Barker, John Sawyer 2015 Iowa State University

In-Season N Fertilization Strategies Using Active Sensors, Daniel Barker, John Sawyer

Iowa State Research Farm Progress Reports

The objectives of this project were to measure corn yield response to applied nitrogen (N) fertilizer based on active canopy sensing during the mid-vegetative corn growth stage (V10) and compare yield and N use efficiency between pre-plant N (PP-N), pre-plant + sensor N (PP+S-N), split N strategy (SNS), and rescue N strategy (RNS).


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