Open Access. Powered by Scholars. Published by Universities.®
Hormones, Hormone Substitutes, and Hormone Antagonists Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (3)
- Biochemistry (2)
- Biochemistry, Biophysics, and Structural Biology (2)
- Chemical Actions and Uses (2)
- Environmental Public Health (2)
-
- Medical Specialties (2)
- Public Health (2)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Anatomy (1)
- Behavioral Neurobiology (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Biological Psychology (1)
- Cancer Biology (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Developmental Neuroscience (1)
- Diseases (1)
- Endocrine System Diseases (1)
- Endocrinology (1)
- Endocrinology, Diabetes, and Metabolism (1)
- Heterocyclic Compounds (1)
- Immune System Diseases (1)
- Immunology and Infectious Disease (1)
- Immunopathology (1)
- Medical Pathology (1)
- Medical Sciences (1)
- Medicinal Chemistry and Pharmaceutics (1)
- Institution
- Keyword
-
- Hormones (2)
- Phthalates (2)
- Adult (1)
- Alzheimer’s disease (1)
- Antiproliferative (1)
-
- ApoE4 (1)
- Apolipoprotein E4 (1)
- Autism (1)
- Azetidinone (1)
- Bisphenol A (1)
- C-Myc (1)
- CD1 (1)
- Designed multiple ligand (1)
- Dichlorodiphenyldichloroethylene (1)
- Dichlorodiphenyltrichloroethane (1)
- ERα (1)
- Emotion (1)
- Emotions, Social Motivation and Endocrine Disruption (1)
- Endocrine disrupting chemicals (1)
- Endocrine disruptors (1)
- Estrogen receptor (1)
- Female (1)
- HOXA10 (1)
- Hormonal balance (1)
- Human (1)
- Ishikawa (1)
- Male reproductive system (1)
- Mice (1)
- PR (1)
- Placenta (1)
- Publication
- Publication Type
- File Type
Articles 1 - 7 of 7
Full-Text Articles in Hormones, Hormone Substitutes, and Hormone Antagonists
Phthalates And Phthalate Alternatives: Effects On Proliferative And Estrogenic Target Genes In Ishikawa Cells, Ranjani Sundar '15, Ping Yin, Serdar E. Bulun
Phthalates And Phthalate Alternatives: Effects On Proliferative And Estrogenic Target Genes In Ishikawa Cells, Ranjani Sundar '15, Ping Yin, Serdar E. Bulun
Student Publications & Research
Phthalates are used as plasticizers in many of the products found in medical, household, and industrial applications. Much research has not been completed on the effects of these phthalates as potential endocrine disrupting chemicals (EDCs). As these chemicals are ingested, the mechanism by which they affect the reproductive system is largely unknown. The purpose of this study was to observe how 2 phthalates, Di-n-butyl phthalate (DBP) and Diisononyl phthalate (DINP), and 2 phthalate alternatives, Dioctyl terephthalate (DOTP) and BHT (butylated hydroxytoluene)affect uterine cells in comparison to a vehicle treatment and 17β-Estradiol treatment. Changes in expression of mRNA were observed using …
Control Of Inflammation In Pancreatic Β-Cells: Role Of Arylpyrazole Compounds, Whitney Lyn Powell
Control Of Inflammation In Pancreatic Β-Cells: Role Of Arylpyrazole Compounds, Whitney Lyn Powell
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
No abstract provided.
Regional-Specific Effects Of Ovarian Hormone Loss On Synaptic Plasticity In Adult Human Apoe Targeted Replacement Mice, Rebecca C. Klein, Shyla Saini, Mary-Louise Risher, Shawn K. Acheson, Rebekah L. Fleming, Hannah G. Sexton, H. Scott Swartzwelder, Scott D. Moore
Regional-Specific Effects Of Ovarian Hormone Loss On Synaptic Plasticity In Adult Human Apoe Targeted Replacement Mice, Rebecca C. Klein, Shyla Saini, Mary-Louise Risher, Shawn K. Acheson, Rebekah L. Fleming, Hannah G. Sexton, H. Scott Swartzwelder, Scott D. Moore
Biomedical Sciences
The human apolipoprotein ε4 allele (APOE4) has been implicated as one of the strongest genetic risk factors associated with Alzheimer’s disease (AD) and in influencing normal cognitive functioning. Previous studies have demonstrated that mice expressing human apoE4 display deficits in behavioral and neurophysiological outcomes compared to those with apoE3. Ovarian hormones have also been shown to be important in modulating synaptic processes underlying cognitive function, yet little is known about how their effects are influenced by apoE. In the current study, female adult human APOE targeted replacement (TR) mice were utilized to examine the effects of human APOE …
The Hormones Of The Placenta, Shaya Oratz
The Hormones Of The Placenta, Shaya Oratz
The Science Journal of the Lander College of Arts and Sciences
The human pregnancy begins with fertilization and implantation. As the embryo evolves and develops within the uterus of the mother, the placenta is formed. The placenta is a transient organ that develops to meet and accommodate specific needs during pregnancy. Its two major functions are the exchange of nutrients and gases between the mother and fetus and its role as an endocrine unit. Through the production and release of many hormones the placenta works to regulate the many necessary physiological changes in the mother in order to maintain the pregnancy, meet the needs of the developing fetus and prepare the …
Exposure To Endocrine Disrupting Chemicals And Male Reproductive Health, Hueiwang Anna Jeng
Exposure To Endocrine Disrupting Chemicals And Male Reproductive Health, Hueiwang Anna Jeng
Community & Environmental Health Faculty Publications
Endocrine disrupting chemicals (EDCs) can interfere with normal hormonal balance and may exert adverse consequences on humans. The male reproductive system may be susceptible to the effects of such environmental toxicants. This review discusses the recent progress in scientific data mainly from epidemiology studies on the associations between EDCs and male reproductive health and our understanding of possible mechanisms associated with the effects of EDCs on male reproductive health. Finally, the review provides recommendations on future research to enhance our understanding of EDCs and male reproductive health. The review highlights the need for (1) well-defined longitudinal epidemiology studies, with appropriately …
Β-Lactam Estrogen Receptor Antagonists And A Dual-Targeting Estrogen Receptor/Tubulin Ligand, Niamh O'Boyle, Jade K. Pollock, Miriam Carr, Andrew Js Knox, Seema M. Nathwani, Shu Wang, Laura Caboni, Daniela M. Zisterer, Mary Meegan
Β-Lactam Estrogen Receptor Antagonists And A Dual-Targeting Estrogen Receptor/Tubulin Ligand, Niamh O'Boyle, Jade K. Pollock, Miriam Carr, Andrew Js Knox, Seema M. Nathwani, Shu Wang, Laura Caboni, Daniela M. Zisterer, Mary Meegan
Articles
Twelve novel β-lactams were synthesised and their antiproliferative effects and binding affinity for the predominant isoforms of the estrogen receptor (ER), ERα and ERβ, were determined. β-Lactams 23 and 26 had the strongest binding affinities for ERα (IC50 values: 40 and 8 nM respectively) and ERβ (IC50 values: 19 and 15 nM). β-Lactam 26 was the most potent in antiproliferative assays using MCF-7 breast cancer cells, and further biochemical analysis showed that it caused accumulation of cells in G2/M phase (mitotic blockade) and depolymerisation of tubulin in MCF-7 cells. Compound 26 also induced apoptosis and downregulation …
Effects Of Polychlorinated Biphenyl (Pcb) On Response Perseveration And Ultrasonic Vocalization Emission In Rat During Development, Howard Cromwell
Effects Of Polychlorinated Biphenyl (Pcb) On Response Perseveration And Ultrasonic Vocalization Emission In Rat During Development, Howard Cromwell
Howard Casey Cromwell
The 3 major symptoms of autistic spectrum disorders include 1) social behavioral alterations, 2) problems in communication and 3) higher-order motoric deficits of perseveration and stereotyped movements. Previous work has shown that early developmental exposure to polychlorinated biphenyls (PCBs) alters rat pup social motivation and juvenile rat social recognition/investigation. The present work extends this previous research by examining how perinatal PCB exposure alters motoric functions and communication abilities at different stages of development. Action perseveration was examined using performance measures from a T-maze environment. Communication abilities were evaluated by monitoring ultrasound emission in rat pups during a brief isolation from …