Open Access. Powered by Scholars. Published by Universities.®

Hormones, Hormone Substitutes, and Hormone Antagonists Commons

Open Access. Powered by Scholars. Published by Universities.®

227 Full-Text Articles 770 Authors 109,598 Downloads 63 Institutions

All Articles in Hormones, Hormone Substitutes, and Hormone Antagonists

Faceted Search

227 full-text articles. Page 1 of 10.

Sex Differences In Locomotor Activity And Behavioral Sensitization In Rats Administered Fentanyl, Jessica J. Lee, Nareen Sadik, Cameron Davidson PhD, Majd Yahya, Josie Zdun, Shane Perrine PhD 2022 Wayne State University

Sex Differences In Locomotor Activity And Behavioral Sensitization In Rats Administered Fentanyl, Jessica J. Lee, Nareen Sadik, Cameron Davidson Phd, Majd Yahya, Josie Zdun, Shane Perrine Phd

Medical Student Research Symposium

Opioid overdoses have continued to increase, and women have experienced a greater rate of increase than males. Preclinical studies demonstrate marked sex differences in addiction-related behaviors, with females being more vulnerable due to a potential role of estradiol. We sought to understand how the estrous cycle, as a proxy measure of estradiol, influences sex differences in the sensitizing effects of fentanyl. In this ongoing study, we used male and female rats to investigate potential sex effects of fentanyl (20µg/kg subcutaneously) administration for 14 days and a forced abstinence period of 13 days on behavioral sensitization via locomotor activity (LMA ...


Risk Of Cardiovascular Disease And Events In Transgender Patients Undergoing Hormone Therapy, Adrian T. Rainer 2022 St. Cloud State University

Risk Of Cardiovascular Disease And Events In Transgender Patients Undergoing Hormone Therapy, Adrian T. Rainer

SCSU Journal of Student Scholarship

The number of transgender individuals currently being prescribed cross-sex hormone replacement therapy (CSHRT) is currently at an all-time high, but the short- and long-term effects that those medications have upon the cardiovascular system remains largely unknown. To examine the effect that CSHRT has on the cardiovascular system, this review synthesizes the results of five different studies on CSHRT and cardiovascular outcomes in transgender individuals. The report also examines differences in cardiovascular outcomes associated with different dosages and preparations of CSHRT. This review notes that transgender women are at highest risk of adverse cardiovascular events, with those taking high-dose oral estrogen ...


Use Of Steroids In Covid-19 Patients: What Is Known?, Syed Muhammad Mustahsan, Marzia Tahir, Emaduddin Siddiqui 2022 South City Hospital, Karachi

Use Of Steroids In Covid-19 Patients: What Is Known?, Syed Muhammad Mustahsan, Marzia Tahir, Emaduddin Siddiqui

Department of Emergency Medicine

COVID-19 pandemic has exaggerated the role of steroids in the standard of care despite minimum direct evidence of their efficacy in COVID-19 patients and their well-known adverse effects. The literature abounds on the side effects of steroids affecting different organ systems of the body. COVID-19 patients, who are on long-term steroids, are more susceptible to their adverse effects. We, herein, briefly review the potential uses and the adverse effects of steroids on different organ systems of the body. Key Words: Steroids, COVID-19, Adverse effects.


Management Of Adult Growth Hormone Deficiency Related To Hypopituitarism, Kellie Jamin 2022 Arcadia University

Management Of Adult Growth Hormone Deficiency Related To Hypopituitarism, Kellie Jamin

Capstone Showcase

The treatment of growth hormone deficiency (GHD) is well-established in childhood but less understood in adults, given the more complex role that growth hormone (GH) assumes in this population. Decreased functionality of the pituitary gland, otherwise known as hypopituitarism, can present with an isolated GHD in adulthood, which may result from a number of factors including neoplasm, ischemia, infection, traumatic injury, or systemic disease. Adult GHD may be definitively diagnosed with a stimulation test, the insulin tolerance test (ITT) being the study of choice. With a positive ITT, the disorder can be treated with growth hormone replacement therapy (GHRT), which ...


Safety, Efficacy, And Reversibility Of Novel Male Contraceptives For Improved Pregnancy Prevention, Danielle Anton 2022 Arcadia University

Safety, Efficacy, And Reversibility Of Novel Male Contraceptives For Improved Pregnancy Prevention, Danielle Anton

Capstone Showcase

Unintended pregnancy is a global issue that can result from contraceptive failure or from a lack of contraceptive use. A literature search was conducted to explore novel methods of male contraceptives being developed for improved pregnancy prevention. Seven articles were selected, reporting on either oral contraceptive pills, transdermal gel, injectable hormonal, or bilateral intravas deferens polymer injection. The most common adverse events reported across all studies include changes in libido, mood, weight gain, acne, and headache. After reaching hormone and sperm concentration levels sufficient for pregnancy prevention, authors reported complete reversibility of contraceptive effects. Four studies described changes in various ...


Effects Of Hormone Replacement Therapy (Hrt) On Gene Expression In The Amyloid Processing Pathway Of Ovariectomized Rhesus Macaque Females Under An Obesogenic Diet, Megan Ball 2021 Portland State University

Effects Of Hormone Replacement Therapy (Hrt) On Gene Expression In The Amyloid Processing Pathway Of Ovariectomized Rhesus Macaque Females Under An Obesogenic Diet, Megan Ball

University Honors Theses

Estrogens rapidly decline at the onset of menopause, putting women at higher risk of osteoporosis, obesity, and neurodegenerative diseases, including Alzheimer’s disease (AD). Estradiol hormone therapies (HT) have been suggested to limit these negative effects on women, with controversial findings as to their effectiveness. A study at OHSU recently found differentially expressed genes (DEGs) using RNAseq between ovariectomized/hysterectomized (OvH) old (range = 19.4–23.2 years) female rhesus macaques on HT and those on a placebo on chronic western style diet (WSD). The DEGs identified in the amyloid processing pathway of the amygdala were selected for validation using ...


A Therapeutic Convection-Enhanced Macroencapsulation Device For Enhancing Beta Cell Viability And Insulin Secretion, Kisuk Yang, Dale L. Greiner, Jeffrey M. Karp 2021 Massachusetts Institute of Technology

A Therapeutic Convection-Enhanced Macroencapsulation Device For Enhancing Beta Cell Viability And Insulin Secretion, Kisuk Yang, Dale L. Greiner, Jeffrey M. Karp

Open Access Publications by UMass Chan Authors

Islet transplantation for type 1 diabetes treatment has been limited by the need for lifelong immunosuppression regimens. This challenge has prompted the development of macroencapsulation devices (MEDs) to immunoprotect the transplanted islets. While promising, conventional MEDs are faced with insufficient transport of oxygen, glucose, and insulin because of the reliance on passive diffusion. Hence, these devices are constrained to two-dimensional, wafer-like geometries with limited loading capacity to maintain cells within a distance of passive diffusion. We hypothesized that convective nutrient transport could extend the loading capacity while also promoting cell viability, rapid glucose equilibration, and the physiological levels of insulin ...


The Onset Of Exercise-Associated Hyponatremia And Individual Differences In Inappropriate Arginine Vasopressin Excretion: A Review Of Proposed Mechanisms, Michelle Stehman, Stephen A. Maris 2021 Springfield College

The Onset Of Exercise-Associated Hyponatremia And Individual Differences In Inappropriate Arginine Vasopressin Excretion: A Review Of Proposed Mechanisms, Michelle Stehman, Stephen A. Maris

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 2: Issue 1, Article 10, 2021. Exercise-associated hyponatremia (EAH) has been reported to develop during endurance events such as triathlons and marathons. As these events become more popular, the incidence of developing EAH also increases. The development of EAH is commonly associated with the overconsumption of hypotonic fluids such as water and tends to be more prevalent in females. There is also evidence to suggest the inappropriate secretion of arginine vasopressin (AVP) leading to water retention may predispose an individual for developing EAH, especially when coupled with the overconsumption of fluids. Recent research ...


Educational Attainment Of Same-Sex And Opposite-Sex Dizygotic Twins: An Individual-Level Pooled Study Of 19 Twin Cohorts, Keith E. Whitfield, Numerous Authors, See Full List Below 2021 University of Nevada, Las Vegas

Educational Attainment Of Same-Sex And Opposite-Sex Dizygotic Twins: An Individual-Level Pooled Study Of 19 Twin Cohorts, Keith E. Whitfield, Numerous Authors, See Full List Below

Office of the President Faculty Publications

Comparing twins from same- and opposite-sex pairs can provide information on potential sex differences in a variety of outcomes, including socioeconomic-related outcomes such as educational attainment. It has been suggested that this design can be applied to examine the putative role of intrauterine exposure to testosterone for educational attainment, but the evidence is still disputed. Thus, we established an international database of twin data from 11 countries with 88,290 individual dizygotic twins born over 100 years and tested for differences between twins from same- and opposite-sex dizygotic pairs in educational attainment. Effect sizes with 95% confidence intervals (CI) were ...


Maternal 3,3'-Diiodothyronine Sulfate Formation From Guinea Pig Placenta Perfused With 3,3',5-Triodothyronine, Sing-Yung Wu, Charles H. Emerson, Edward Tjioe, Dong-Bao Chen 2021 University of California Irvine Medical Center

Maternal 3,3'-Diiodothyronine Sulfate Formation From Guinea Pig Placenta Perfused With 3,3',5-Triodothyronine, Sing-Yung Wu, Charles H. Emerson, Edward Tjioe, Dong-Bao Chen

Open Access Publications by UMass Chan Authors

OBJECTIVE: Serum 3, 3',5-triiodothyronine (T3) remains low in near-term fetus to prevent the growing fetus from undue exposure to its active catabolic effect in mammals. The present study was undertaken to gain insight in the role of placenta in T3 metabolism, fetal to maternal transfer of T3, and its metabolites by in situ placenta perfusion with outer-ring labeled [(125)I]-T3 in pregnant guinea pig, a species showing increased sulfated 3, 3'-diiodothyronine (T2S) levels in maternal serum in late pregnancy (term = 65 days), similarly to humans in pregnancy.

MATERIALS AND METHODS: One-pass placenta perfusions performed on pregnant guinea ...


Insulin Sensitivity Is Retained In Mice With Endothelial Loss Of Carcinoembryonic Antigen Cell Adhesion Molecule 1, Harrison T. Muturi, Saja S. Khuder, Hilda E. Ghadieh, Emily L. Esakov, Hye Lim Noh, Heejoon Kang, Marcia F. McInerney, Jason K. Kim, Abraham D. Lee, Sonia M. Najjar 2021 Ohio University

Insulin Sensitivity Is Retained In Mice With Endothelial Loss Of Carcinoembryonic Antigen Cell Adhesion Molecule 1, Harrison T. Muturi, Saja S. Khuder, Hilda E. Ghadieh, Emily L. Esakov, Hye Lim Noh, Heejoon Kang, Marcia F. Mcinerney, Jason K. Kim, Abraham D. Lee, Sonia M. Najjar

Open Access Publications by UMass Chan Authors

CEACAM1 regulates endothelial barrier integrity. Because insulin signaling in extrahepatic target tissues is regulated by insulin transport through the endothelium, we aimed at investigating the metabolic role of endothelial CEACAM1. To this end, we generated endothelial cell-specific Ceacam1 null mice (VECadCre+Cc1(fl/fl)) and carried out their metabolic phenotyping and mechanistic analysis by comparison to littermate controls. Hyperinsulinemic-euglycemic clamp analysis showed intact insulin sensitivity in VECadCre+Cc1(fl/fl) mice. This was associated with the absence of visceral obesity and lipolysis and normal levels of circulating non-esterified fatty acids, leptin, and adiponectin. Whereas the loss of endothelial Ceacam1 did ...


Androgen Activity Is Associated With Pd-L1 Downregulation In Thyroid Cancer, Timmy J. O'Connell, Sina Dadafarin, Melanie Jones, Tomás Rodríguez, Anvita Gupta, Edward Shin, Augustine Moscatello, Codrin Iacob, Humayun Islam, Raj K. Tiwari, Jan Geliebter 2021 New York Medical College

Androgen Activity Is Associated With Pd-L1 Downregulation In Thyroid Cancer, Timmy J. O'Connell, Sina Dadafarin, Melanie Jones, Tomás Rodríguez, Anvita Gupta, Edward Shin, Augustine Moscatello, Codrin Iacob, Humayun Islam, Raj K. Tiwari, Jan Geliebter

Open Access Publications by UMass Chan Authors

Thyroid cancer is the most prevalent endocrine malignancy in the United States with greater than 53,000 new cases in 2020. There is a significant gender disparity in disease incidence as well, with women developing thyroid cancer three times more often than men; however, the underlying cause of this disparity is poorly understood. Using RNA-sequencing, we profiled the immune landscape of papillary thyroid cancer (PTC) and identified a significant inverse correlation between androgen receptor (AR) levels and the immune checkpoint molecule PD-L1. The expression of PD-L1 was then measured in an androgen responsive-thyroid cancer cell line. Dihydrotestosterone (DHT) treatment resulted ...


Distinct Changes In Gut Microbiota Are Associated With Estradiol-Mediated Protection From Diet-Induced Obesity In Female Mice, Kalpana D. Acharya, Hye Lim Noh, Madeline E. Graham, Sujin Suk, Randall H. Friedline, Cesiah C. Gomez, Abigail E.R. Parakoyi, Jun Chen, Jason K. Kim, Marc J. Tetel 2021 Wellesley College

Distinct Changes In Gut Microbiota Are Associated With Estradiol-Mediated Protection From Diet-Induced Obesity In Female Mice, Kalpana D. Acharya, Hye Lim Noh, Madeline E. Graham, Sujin Suk, Randall H. Friedline, Cesiah C. Gomez, Abigail E.R. Parakoyi, Jun Chen, Jason K. Kim, Marc J. Tetel

Open Access Publications by UMass Chan Authors

A decrease in ovarian estrogens in postmenopausal women increases the risk of weight gain, cardiovascular disease, type 2 diabetes, and chronic inflammation. While it is known that gut microbiota regulates energy homeostasis, it is unclear if gut microbiota is associated with estradiol regulation of metabolism. In this study, we tested if estradiol-mediated protection from high-fat diet (HFD)-induced obesity and metabolic changes are associated with longitudinal alterations in gut microbiota in female mice. Ovariectomized adult mice with vehicle or estradiol (E2) implants were fed chow for two weeks and HFD for four weeks. As reported previously, E2 increased energy expenditure ...


Associations Of Hdl Metrics With Coronary Artery Calcium Score And Density Among Women Traversing Menopause, Samar R. El Khoudary, Alexis Nasr, Karen A. Matthews, Trevor J. Orchard, Maria M. Brooks, Jeffrey Billheimer, Dan McConnell, Imke Janssen, Susan A. Everson-Rose, Sybil L. Crawford, Daniel J. Rader 2021 University of Pittsburgh

Associations Of Hdl Metrics With Coronary Artery Calcium Score And Density Among Women Traversing Menopause, Samar R. El Khoudary, Alexis Nasr, Karen A. Matthews, Trevor J. Orchard, Maria M. Brooks, Jeffrey Billheimer, Dan Mcconnell, Imke Janssen, Susan A. Everson-Rose, Sybil L. Crawford, Daniel J. Rader

Open Access Publications by UMass Chan Authors

The cardioprotective association of high-density lipoprotein cholesterol (HDL-C) may vary by menopause stage or estradiol level. We tested whether associations of comprehensive HDL metrics (HDL subclasses, phospholipid and triglyceride content, and HDL cholesterol efflux capacity [HDL-CEC]) with coronary artery calcium (CAC) score and density vary by menopause stage or estradiol level in women transitioning through menopause. Participants (N = 294; mean age [SD]: 51.3 [2.9]) had data on HDL metrics and CAC measures at one or two time points during the menopause transition. Generalized estimating equations were used for analyses. Effect modifications by menopause stage or estradiol level were ...


Progesterone Stimulates Histone Citrullination To Increase Igfbp1 Expression In Uterine Cells, Coleman H. Young, Bryce Snow, Stanley B. DeVore, Adithya Mohandass, Venkatesh V. Nemmara, Paul R. Thompson, Baskaran Thyagarajan, Amy M. Navratil, Brian D. Cherrington 2021 University of Wyoming

Progesterone Stimulates Histone Citrullination To Increase Igfbp1 Expression In Uterine Cells, Coleman H. Young, Bryce Snow, Stanley B. Devore, Adithya Mohandass, Venkatesh V. Nemmara, Paul R. Thompson, Baskaran Thyagarajan, Amy M. Navratil, Brian D. Cherrington

Open Access Publications by UMass Chan Authors

Peptidylarginine deiminases (PAD) enzymes were initially characterized in uteri, but since then little research has examined their function in this tissue. PADs post-translationally convert arginine residues in target proteins to citrulline and are highly expressed in ovine caruncle epithelia and ovine uterine luminal epithelial (OLE)-derived cell line. Progesterone (P4) not only maintains the uterine epithelia but also regulates the expression of endometrial genes that code for proteins that comprise the histotroph and are critical during early pregnancy. Given this, we tested whether P4 stimulates PAD-catalyzed histone citrullination to epigenetically regulate expression of the histotroph gene insulin-like growth factor binding ...


Cardiometabolic Responses In Individuals With/Without Family History Of Type 2 Diabetes, Christopher J. Cavazos 2021 The University of Texas Rio Grande Valley

Cardiometabolic Responses In Individuals With/Without Family History Of Type 2 Diabetes, Christopher J. Cavazos

MEDI 8127 Scholarly Activities Pre-Clerkship

Intro: Type 2 diabetes (T2D) has become a national epidemic and is a disease that greatly affects the Rio Grande Valley. Many individuals in the United States, especially in the Rio Grande Valley, have a family history of T2D. Previous evidence has shown that those with a family history of T2D are metabolically inflexible, have a decreased ability to clear circulating glucose, and poor postprandial microvascular recruitment in skeletal muscle tissue. The aforementioned occurs in otherwise healthy individuals with a family history of T2D to nearly the same extent as those who have T2D. Previous studies have not shown where ...


The Effects Of Progesterone Induced Blocking Factor And 17-Hydroxyprogesterone Caproate On The Pathophysiology Of Preeclampsia, Kyleigh M. Comley 2021 University of Mississippi

The Effects Of Progesterone Induced Blocking Factor And 17-Hydroxyprogesterone Caproate On The Pathophysiology Of Preeclampsia, Kyleigh M. Comley

Honors Theses

Preeclampsia (PE) is responsible for about 20% of the 13 million preterm births each year worldwide, including 100,000 cases annually in the United States. Despite being a leading cause of maternal and perinatal morbidity, the mechanisms of pathogenesis are still largely unknown. PE is progesterone deficient state characterized by hypertension, chronic immune activation, endothelial dysfunction and severe forms can lead to seizures. Treatment of seizures includes the administration of magnesium sulfate (MgSO4) though not all PE patients are responsive, and it does not decrease PE-associated hypertension. To resolve these conditions, PE patients are delivered early thereby making PE the ...


Predictors Of Irritability Symptoms In Mildly Depressed Perimenopausal Women, Anouk E. de Wit, Erik J. Giltay, Marrit K. de Boer, Margo Nathan, Aleta Wiley, Sybil L. Crawford, Hadine Joffe 2021 Harvard Medical School

Predictors Of Irritability Symptoms In Mildly Depressed Perimenopausal Women, Anouk E. De Wit, Erik J. Giltay, Marrit K. De Boer, Margo Nathan, Aleta Wiley, Sybil L. Crawford, Hadine Joffe

Tan Chingfen Graduate School of Nursing Publications

OBJECTIVE: Irritability is a highly burdensome complaint, commonly, but not universally, linked with depressive symptoms. While increased variability in estradiol has been associated with depressive symptoms during perimenopause, more insight is needed into reproductive hormone dynamics and other factors that predispose perimenopausal women to irritable mood.

METHODS: Among 50 mildly depressed perimenopausal women (mean (SD) age 48.4 (3.9) years), severity of irritability symptoms (on Symptom Questionnaire Hostility subscale, range 0-23) was assessed weekly for eight weeks, concurrent with potential predictors. Associations between these were examined using generalized estimating equating models.

RESULTS: Most women (82.0%) reported having moderate ...


Long-Term Gh Therapy Does Not Advance Skeletal Maturation In Children And Adolescents, Benjamin U. Nwosu, Gabrielle Jasmin, Sadichchha Parajuli, Alan D. Rogol, Ellen C. Wallace, Austin F. Lee 2021 University of Massachusetts Medical School

Long-Term Gh Therapy Does Not Advance Skeletal Maturation In Children And Adolescents, Benjamin U. Nwosu, Gabrielle Jasmin, Sadichchha Parajuli, Alan D. Rogol, Ellen C. Wallace, Austin F. Lee

Open Access Publications by UMass Chan Authors

Context: There is no consensus on the effect of recombinant human GH (rhGH) therapy on skeletal maturation in children despite the current practice of annual monitoring of skeletal maturation with bone age in children on rhGH therapy.

Aims: To investigate the effects of long-term rhGH therapy on skeletal age in children and explore the accuracy of bone age-predicted adult height (BAPAH) at different ages based on 13 years of longitudinal data.

Methods: A retrospective longitudinal study of 71 subjects aged 2 to 16 years, mean 9.9 +/- 3.8 years, treated with rhGH for nonsyndromic short stature for a duration ...


Oxytocin, Cortisol, And Cognitive Control During Acute And Naturalistic Stress, Shari Young Kuchenbecker, Sarah D. Pressman, Jared Celniker, Karen M. Grewen, Ken D. Sumida, Naveen Jonathan, Brendan Everett, George M. Slavich 2021 Chapman University

Oxytocin, Cortisol, And Cognitive Control During Acute And Naturalistic Stress, Shari Young Kuchenbecker, Sarah D. Pressman, Jared Celniker, Karen M. Grewen, Ken D. Sumida, Naveen Jonathan, Brendan Everett, George M. Slavich

Health Sciences and Kinesiology Faculty Articles

Although stress is a strong risk factor for poor health, especially for women, it remains unclear how stress affects the key neurohormones cortisol and oxytocin, which influence stress-related risk and resilience. Whereas cortisol mediates energy mobilization during stress, oxytocin has anti-inflammatory, anxiolytic, and analgesic effects that support social connection and survival across the lifespan. However, how these neurohormones interrelate and are associated with cognitive control of emotional information during stress remains unclear. To address these issues, we recruited 37 college-aged women (Mage = 19.19, SD = 1.58) and randomly assigned each to a one-hour experimental session consisting of either ...


Digital Commons powered by bepress