Open Access. Powered by Scholars. Published by Universities.®
Amino Acids, Peptides, and Proteins Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (2)
- Medical Sciences (2)
- Mental and Social Health (2)
- Molecular and Cellular Neuroscience (2)
- Neuroscience and Neurobiology (2)
-
- Substance Abuse and Addiction (2)
- Alternative and Complementary Medicine (1)
- Anatomy (1)
- Behavioral Neurobiology (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Factors (1)
- Diseases (1)
- Education (1)
- Health and Physical Education (1)
- Laboratory and Basic Science Research (1)
- Molecular Biology (1)
- Pharmacology (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Respiratory System (1)
- Respiratory Tract Diseases (1)
Articles 1 - 3 of 3
Full-Text Articles in Amino Acids, Peptides, and Proteins
In Silico Identification Of Small Molecule Agonist Binding Sites On Kcc2, Kenyon Mitchell, Alfred Amendolara, Ruth Hunter, Jaden Miner, Andrew Payne
In Silico Identification Of Small Molecule Agonist Binding Sites On Kcc2, Kenyon Mitchell, Alfred Amendolara, Ruth Hunter, Jaden Miner, Andrew Payne
Annual Research Symposium
Purpose: Potassium-Chloride Cotransporter 2 (KCC2) is a neuronal membrane protein specific to the central nervous system. It is responsible for removing Cl- ions from the intracellular space, maintaining a normal Cl- gradient essential for proper function at inhibitory synapses. Dysregulation causes an upward shift in the Cl- reversal potential resulting in a hyperexcitable state of the postsynaptic neuron. Existing literature indicates that KCC2 may be involved in the addiction pathway of a variety of drugs of abuse, including opioids and alcohol. This makes KCC2 an attractive potential drug target when treating substance use disorders. A novel direct KCC2 agonist, VU0500469, …
The Effects Of Vitamin B1 Analog, Benfotiamine, On The Prevention Of Non-Small Cell Lung Cancer, Emely Fernandez, Hannah Christensen, Kota A. Ramana
The Effects Of Vitamin B1 Analog, Benfotiamine, On The Prevention Of Non-Small Cell Lung Cancer, Emely Fernandez, Hannah Christensen, Kota A. Ramana
Annual Research Symposium
No abstract provided.
The Role Of The Kcc2 In Substance Use And Abuse: A Systematic Review [Protocol], Alfred Amendolara, Steven Salazar, Chad Thompson, Hyrum Wright, Andrew Payne
The Role Of The Kcc2 In Substance Use And Abuse: A Systematic Review [Protocol], Alfred Amendolara, Steven Salazar, Chad Thompson, Hyrum Wright, Andrew Payne
Annual Research Symposium
This poster presents the protocol for an ongoing systematic review investigating the role of potassium chloride co-transporter 2 (KCC2) in substance use, abuse, and addiction.