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Full-Text Articles in Amino Acids, Peptides, and Proteins
The Effect Of Ethanol Treatment On The Protein Content Of Difi Exosomes, Kenzie Rushing
The Effect Of Ethanol Treatment On The Protein Content Of Difi Exosomes, Kenzie Rushing
Belmont University Research Symposium (BURS)
Colorectal cancer (CRC) is the second most common cause of cancer death in the United States in both men and women combined, second only to lung cancer.1 CRC metastasis is the primary cause of mortality largely due to therapy resistant cancer cells.2 Therefore, detection before metastasis is of great importance and could potentially lead to earlier detection and decreased mortality. Extracellular vesicles (EVs), including exosomes, are lipid bound vesicles secreted by cells3 that are involved in cell-cell communication and have been found to promote CRC progression and metastasis.4 The proteome of exosomes is thought to reflect that of the originating …
Synthesis Of Selenotryptophan For Protein Elucidation, James P. Reiselman
Synthesis Of Selenotryptophan For Protein Elucidation, James P. Reiselman
Belmont University Research Symposium (BURS)
Through complex intermolecular and intramolecular forces, proteins conformationally change to form complex 3-d geometry that carries out biochemical processes and mapping their structures is becoming a field of interest in the biological community. Techniques for modeling protein’s structure typically follow the path of X-ray crystallography, which has an intrinsic phase problem that can make reading the electron density map they produce very difficult. This can be mitigated by appending a heavy-atom containing amino acid analogue into a crystal sample of the protein being studied. A selenium containing tryptophan analogue will be synthesized to be appended into proteins as a chemical …