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Evaluation Of Nitric Oxide In Respiratory Distress Syndrome, Kimberly S. Myruski
Evaluation Of Nitric Oxide In Respiratory Distress Syndrome, Kimberly S. Myruski
Loma Linda University Electronic Theses, Dissertations & Projects
Little is known of the effects of low concentrations of inhaled nitric oxide (NO) on pulmonary mechanics and lung volumes in premature newborn infants with lung disease. Cardiopulmonary function tests including blood gas analyses were obtained from eleven premature lamb models with respiratory distress syndrome to determine if compliance, airways resistance, tidal volume, functional residual capacity, and gas exchange were affected. The effect of inhaled NO on the direction of shunting through the ductus arteriosus was determined using echocardiography.
Twin lambs were cannulated with arterial and venous catheters and intubated with an endotracheal tube before delivery on gestational day 126-130 …