Other Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons^™

Functional 3-D Cellulose & Nitrocellulose Paper-Based, Multiplex Diagnostic Platforms Without Coupling Agents, Mackenzie Elizabeth Tageson

Master's Theses

The purpose of this thesis was to demonstrate device functionality of 3-D paper-based, multiplex platforms, µPADs, without the use of coupling agents between layers. Previously, these platforms were fabricated with double-sided tape and cellulose powder to try to augment proper fluid routing, but difficulties with this method occurred. An acrylic housing unit with strategically placed pressure tabs was designed to aid horizontal and vertical fluid routing through the platform, thus eliminating the inconsistencies associated with coupling agents. Channel characterization studies, a COMSOL^TM simulation, and development time studies were performed to aid device design and demonstrate device functionality.

The implementation …

A Multidisciplinary Approach To The Prevention Of Infant Torticollis And Plagiocephaly, Anne H. Zachry, S. K. Slaughter

Faculty Presentations

Research suggests that parents are more likely to carry out positioning recommendations from a health care professional than any other source. Occupational therapy practitioners can play an important role in educating parents, caregivers, and healthcare providers about the importance of providing tummy time and limiting infant time spent in baby gear.

Short Term Sensory And Vascular Responses To Physical Agent Modalities And Exercise In Healthy Volunteers And Patients With Distal Radius Fracture., Shaguftha Shaik

Electronic Thesis and Dissertation Repository

Currently, there is weak evidence on the effectiveness of different rehabilitation regimens following distal radius fracture (DRF). This thesis evaluated sensory and vascular effects of exercise, thermal and ultrasound interventions that can be used in the mobilization phase (cast removal) after DRF.

Methods

• This thesis includes 3 studies. The first study compared responses to Immersion in Cold water Evaluation (ICE) in the DRF and uninjured hands. Skin blood flow (Sbf), skin temperature (temp.) and sensory perception thresholds (sPT) at 2000Hz for A –beta fibres and at 5 Hz for C fibres were obtained before, immediately after ICE and 10 min …

Sex Differences In White Matter Development During Adolescence: A Dti Study, Yingying Wang, Chris Adamson, Weihong Yuan, Mekibib Altaye, Anna W. Byars, Scott K. Holland

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

Adolescence is a complex transitional period in human development, composing physical maturation, cognitive and social behavioral changes. The objective of this study is to investigate sex differences in white matter development and the associations between intelligence and white matter microstructure in the adolescent brain using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). In a cohort of 16 typically-developing adolescents aged 13 to 17 years, longitudinal DTI data were recorded from each subject at two time points that were one year apart. We used TBSS to analyze the diffusion indices including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity …

Combined Erp/Fmri Evidence For Early Word Recognition Effects In The Posterior Inferior Temporal Gyrus, Joseph Dien, Eric S. Brian, Dennis L. Molfese, Brian T. Gold

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

Two brain regions with established roles in reading are the posterior middle temporal gyrus and the posterior fusiform gyrus. Lesion studies have also suggested that the region located between them, the posterior inferior temporal gyrus (pITG), plays a central role in word recognition. However, these lesion results could reflect disconnection effects since neuroimaging studies have not reported consistent lexicality effects in pITG. Here we tested whether these reported pITG lesion effects are due to disconnection effects or not using parallel ERP/fMRI studies. We predicted that the Recognition Potential (RP), a left-lateralized ERP negativity that peaks at about 200–250 ms, might …

Near-Unity Nuclear Polarization With An Open-Source 129xe Hyperpolarizer For Nmr And Mri, Panayiotis Nikolaou, Aaron M. Coffey, Laura L. Walkup, Brogan M. Gust, Nicholas Whiting, Hayley Newton, Scott Barcus, Iga Muradyan, Mikayel Dabaghyan, Gregory D. Moroz, Matthew S. Rosen, Samuel Patz, Michael J. Barlow, Eduard Y. Chekmenev, Boyd M. Goodson

Nicholas Whiting

Rapid Quantitative Pharmacodynamic Imaging By A Novel Method: Theory, Simulation Testing And Proof Of Principle, Kevin J. Black, Jonathan M. Koller, Brad D. Miller

Kevin J. Black, MD

Pharmacological challenge imaging has mapped, but rarely quantified, the sensitivity of a biological system to a given drug. We describe a novel method called rapid quantitative pharmacodynamic imaging. This method combines pharmacokinetic-pharmacodynamic modeling, repeated small doses of a challenge drug over a short time scale, and functional imaging to rapidly provide quantitative estimates of drug sensitivity including EC50 (the concentration of drug that produces half the maximum possible effect). We first test the method with simulated data, assuming a typical sigmoidal dose-response curve and assuming imperfect imaging that includes artifactual baseline signal drift and random error. With these few assumptions, …

Preterm Birth And The Controversy Over Universal Cervical Length Screenings, Elizabeth Mearns, Laura Pizzi Pharmd, Mph, Jason K. Baxter Md, Mscp, Vincenzo Berghella Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Biomedical Photoacoustic Imaging Using Gas-Coupled Laser Acoustic Detection, Jami Johnson

Student Research Initiative

Several detection methods have been explored for photoacoustic and ultrasound imaging of biological tissues. Piezoelectric transducers are commonly used, which require contact with the sample to be imaged and have limiting bandwidth characteristics. Interferometry detection exhibits improved bandwidth characteristics and resolution, yet generally require complicated optics and the incorporation of a contacting reflective medium. In this paper, we report the use of a noncontact photoacoustic imaging system that does not require the use of a reflective layer. A simple, robust technique known as gas-coupled laser acoustic detection is used, which has previously been applied to evaluation of composite materials. This …

Automated Home Apnea System, Collin G. Howser, Trevor Grieco

Chancellor’s Honors Program Projects

No abstract provided.

A Knowledge-Based Clinical Toxicology Consultant For Diagnosing Multiple Exposures, Joel D. Schipper, Douglas D. Dankel Ii, A. Antonio Arroyo, Jay L. Schauben

Publications

Objective: This paper presents continued research toward the development of a knowledge-based system for the diagnosis of human toxic exposures. In particular, this research focuses on the challenging task of diagnosing exposures to multiple toxins. Although only 10% of toxic exposures in the United States involve multiple toxins, multiple exposures account for more than half of all toxin-related fatalities. Using simple medical mathematics, we seek to produce a practical decision support system capable of supplying useful information to aid in the diagnosis of complex cases involving multiple unknown substances.

Methods: The system is automatically trained using data mining …

Bone Properties Of Recombinant Inbred Line - Bxd Mouse, Yueying Angela Zhang

Theses and Dissertations (ETD)

Osteoporosis is identified by reduced bone mass, decreased bone quality and altered bone micro-architecture. These traits are quantitative and also highly regulated by genetic and environmental factors. As a powerful tool for collaborative analysis of quantitative traits and gene function, BXD recombinant inbred (RI) lines mice have been used to identify genetic effects for bone density.

For the first time, we investigated the bone properties of BXD RI mice by analyzing femur and tibia and compared their phenotypes of different compartments. In this study, microcomputed tomography (µCT) provided an accurate measurement on characterizing bone quality and bone architecture ex-vivo; three-point …

Using Optimal Control Theory To Optimize The Use Of Oxygen Therapy In Chronic Wound Healing, Donna Lynn Daulton

Masters Theses & Specialist Projects

Approximately 2 to 3 million people in the United States suffer from chronic wounds, which are defined as wounds that do not heal in 30 days time; an estimated $25 billion per year is spent on their treatment in the United States. In our work, we focused on treating chronic wounds with bacterial infections using hyperbaric and topical oxygen therapies.

We used a mathematical model describing the interaction between bacteria, neutrophils and oxygen. Optimal control theory was then employed to study oxygen treatment strategies with the mathematical model. Existence of a solution was shown for both therapies. Uniqueness was also …

Design, Synthesis And Development Of Transporter Targeting Agents For Image-Guided Therapy And Drug Delivery, Ning Tsao

Dissertations & Theses (Open Access)

The purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents, N4-guanine (N4amG) and glycopeptide (GP) were synthesized for tumor cell proliferation assessment and cancer theranostic platform, respectively. N4amG and GP were synthesized and radiolabeled with ^99mTc and ⁶⁸Ga. The chemical and radiochemical purities as well as radiochemical stabilities of radiolabeled N4amG and GP were tested. In vitro stability assessment showed both ^99mTc-N4amG and ^99mTc-GP were stable up to 6 hours, whereas ⁶⁸Ga-GP was stable up to 2 hours. Cell culture studies …

The Effects Of Nursing Care On The Patient Experiencing A Stillborn Birth, Katherine Totten

Senior Honors Theses

Childbirth has the potential of being one of the most joyous and fulfilling experiences a woman goes through in her entire life. Being a mom, driving the kids to soccer practice, and sitting around the Christmas tree with the family can easily be seen as an ideal life. Conversely, the negative experiences with childbirth are rarely discussed. There is an overlooked category: moms who conceive but lose the baby in the womb. Not only are these women overlooked, but also the hospital care they receive proves inconsistent with the latest research. Nurses and doctors should be aware of the latest …

Flash4 Dark Reference Images, George Mcnamara

George McNamara

Hamamatsu FLASH4.0 dark reference images, acquired with 10 second exposure times, no light to camera. Camera offset (set by Hamamatsu( is ~100 (the average intensity of the first image is always ~1 intensity level higher - an odd feature, but trivial in practice for a 16-bit camera).

George McNamara, Ph.D.

Single Cells Analyst at L.J.N. Cooper Lab

University of Texas M.D. Anderson Cancer Center

Concordance Of Meg And Fmri Patterns In Adolescents During Verb Generation, Yingying Wang, Scott K. Holland, Jennifer Vannest

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

In this study we focused on direct comparison between the spatial distributions of activation detected by functional magnetic resonance imaging (fMRI) and localization of sources detected by magnetoencephalography (MEG) during identical language tasks. We examined the spatial concordance between MEG and fMRI results in 16 adolescents performing a three-phase verb generation task that involves repeating the auditorily presented concrete noun and generating verbs either overtly or covertly in response to the auditorily presented noun. MEG analysis was completed using a synthetic aperture magnetometry (SAM) technique, while the fMRI data were analyzed using the general linear model approach with random-effects. To …

Just Beautiful Portrays Of The Mind? The Relevance Of Aesthetic Strategies On Knowledge Creation In Neuroscience, Valerie Kummer

The STEAM Journal

We live in the age of big data. All types of data are being generated at an increasing rate but theories about the strategies and methods to visualize them is lagging. One of the main challenges we face today in research is to keep up with the massive amounts of data we produce (Allen, Elena A. et.al, 2012). Especially in the field of neuroscience and its use of imaging technologies, the vast array of data has risen to such a high number that it is impossible to grasp the inherent information without additional software tools and intelligent interfaces. Only through …

Video Codec Performance (Excel Spreadsheet), George Mcnamara

George McNamara

Video codec performance (Excel spreadsheet). Movie was made in 2005-2006 when I worked at City of Hope National Medical Center. VTLF refers to Video Timelapse Light Facility. Videos were outputted from MetaMorph as AVI files. Personally, I always recommend uncompressed video files fro scientific uses. I also encourage posting the original scientific data format (ex. .lsm, .zvi, .lif, .stk).

Pubspectra Tattletales, George Mcnamara

George McNamara

Tattletales for Multiplex Fluorescent Reporters in Single Cells for Metabolomics

George McNamara

As of April 2013: L.J.N. Cooper & D.A. Lee Cellular Immunotherapy Lab, University of Texas M.D. Anderson Cancer Center, Houston, TX

Email: gtmcnamara@mdanderson.org, geomcnamara@earthlink.net

Tattletales is my concept for spatial multiplexing many fluorescent protein (FP) biosensors in the same live cell. For example, there are excellent FP biosensors to Ca++ ions, pH, glucose, ribose, glutamine, glutamate, ATP, redox, ROS, pyruvate, cAMP, cGMP, IP3, PI(3,4,5)P3, cell cycle indicators (Fucci2), PKA, PKC, photsphatases, caspase(s) [1, 2]. However, these are typically used one biosensor per experiment, due in part to flooding …

Anti-Cancer Drug Screening Of Dual Tubulin And Hsp27 Inhibitors With 2d And 3d Lung Cancer Cell Assays, Janine Maria Naim, Rati Lama

Rati Lama

Cancer is the leading cause of death worldwide. The current treatment options available for lung cancer are limited and have drawbacks such as poor bioavailability, numerous side effects, poor efficacy and drug resistance. 3D model serve as a novel approach for drug screening purposes and the evaluation of compounds in the platform can help identify potent compounds for further in vivo xenograft studies.

Relación Entre Signos Y Síntomas Para Valorar La Función Lagrimal Y La Superficie Ocular En Sujetos Colombianos Y Españoles Sin Patología Ocular Aparente, Matilde Mora-Valencia, Antonio López-Alemany, Francisco Pertusa Grau

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo: encontrar una relación entre los síntomas y signos hallados al valorar la función lagrimal y la superficie ocular con pruebas diagnósticas de ojo seco, en un grupo de sujetos colombianos y españoles aparentemente sanos. Método: un total de cien sujetos sanos, cincuenta de población colombiana y cincuenta de población española sin historia previa de lentes de contacto se reclutaron y evaluaron. Los sujetos contestaron el cuestionario para ojo seco de McMonnies y se les realizó tiempo de ruptura lagrimal no invasivo (NIBUT), tiempo de ruptura de la película lagrimal (TFBUT), tinción con fluoresceína y tinción con lisamina y citología …

Development Of A Patient Specific Image Planning System For Radiation Therapy, Bishnu Bahadur Thapa

Theses and Dissertations--Physics and Astronomy

A patient specific image planning system (IPS) was developed that can be used to assist in kV imaging technique selection during localization for radiotherapy. The IPS algorithm performs a divergent ray-trace through a three dimensional computed tomography (CT) data set. Energy-specific attenuation through each voxel of the CT data set is calculated and imaging detector response is integrated into the algorithm to determine the absolute values of pixel intensity and image contrast. Phantom testing demonstrated that image contrast resulting from under exposure, over exposure as well as a contrast plateau can be predicted by use of a prospective image planning …

Editorial, Edgar Hernán Leguizamón Salamanca

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.

Fiabilidad De La Técnica De Retinoscopia Dinámica Monocular De Merchán En La Cuantificación Del Defecto Refractivo En Adultos Jóvenes, Alejandro León Álvarez, Jorge Mario Estrada Álvarez, Andrés Ladino Giraldo

Ciencia y Tecnología para la Salud Visual y Ocular

La cuantificación de una ametropía se hace por medio de técnicas de refracción. Objetivo: determinar la fiabilidad de la retinoscopia dinámica monocular (RDM) de Merchán en la medición de los defectos refractivos. Métodos: en un estudio descriptivo de concordancia se evaluaron 110 sujetos (220 ojos) entre los dieciocho y los treinta años de edad con la RDM, la retinoscopia estática (RE), el cilindro cruzado de Jackson (JCC) y el neto de la RDM obtenido compensando el LAG de la retinoscopia de Nott (RDMc), con medición independiente por parte de dos evaluadores en dos sesiones diferentes. En el análisis estadístico de …

Piggyback: Una Alternativa De Corrección Para Córneas Irregulares, Ana Lucía Rosales, Diana Correa, Lina Agudelo, Vanessa Garzón, Myriam Teresa Mayorga C.

Ciencia y Tecnología para la Salud Visual y Ocular

El sistema de lentes de contacto denominado Piggyback consiste en una combinación de un lente rígido gaspermeable sobrepuesto a un lente blando. Esta combinación pretende disminuir el inconfort que genera el uso de lentes rígidos, especialmente en los pacientes con ectasias e irregularidades corneales, para los cuales es un hecho que la adaptación de un lente rígido es ideal y les proporcionará la mejor imagen óptica posible e incluso mejor que la que proporciona un lente blando, pero que en la mayoría de los casos las molestias, principalmente al momento de parpadear, frenan el proceso de adaptación de estos pacientes. …

Uso De Exámenes Especiales Para Diagnósticos Más Precisos De Ectasias Corneales. Reporte De Caso, Rosario Vidal Olarte

Ciencia y Tecnología para la Salud Visual y Ocular

En la actualidad, los profesionales de la salud visual y ocular, nos vemos enfrentados a casos típicos de ectasias corneales primarias o secundarias, y aunque los más frecuentes son los queratoconos, no siempre es así. De allí la importancia de una buena correlación clínica, además de la solicitud de exámenes especiales que ayuden a concluir un mejor diagnóstico. Es fundamental recordar que estos son procesos binoculares, en la mayoría de los casos asimétricos, de tal manera que si un ojo lo presenta más avanzado, se debe monitorear el ojo contralateral, porque muy posiblemente la condición puede progresar más adelante. Se …

Resistencia A Los Impactos: Una Mirada Óptica, Jimmy Fernando Reyes Domínguez

Ciencia y Tecnología para la Salud Visual y Ocular

El objetivo de este artículo de revisión de tema es aportar información acerca de un aspecto que pocas veces se tiene en cuenta (principalmente por la falta de material documentado, escrito o publicado) en el momento de realizar una prescripción a una persona que requiera una ayuda óptica. Se analizará, desde diferentes puntos de vista, el aporte de un lente oftálmico a la seguridad y salud del paciente, con independencia del material en que se fabrique. La resistencia a los impactos de un sistema óptico depende de muchos aspectos, entre ellos: el espesor del lente, el índice de refracción del …

Los Editores De Revistas De La Salle Respecto Al Modelo De Medición De Revistas De Publindex, Esther Juliana Vargas A.

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.

Valores Normales De Amplitud De Acomodación Mediante Una Técnica Objetiva En Personas Emétropes De 35 A 40 Años De Edad De La Clínica De Optometría De La Universidad De La Salle, Johanna M. González Bermúdez, Luz Ángela Rozo Castillo, Sandra M. Medrano Muñoz, Alejandro León Álvarez

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo: determinar los valores de referencia de amplitud de acomodación mediante la medición objetiva dinámica de la amplitud de acomodación (MODAA) en personas preprésbitas emétropes de 35 a 40 años de edad, examinadas en la Clínica de Optometría de la Universidad de La Salle. Metodología: se incluyeron cincuenta pacientes emétropes, agudeza visual de lejos y de cerca con cada ojo igual o mejor a 20/30, binocularidad normal. Se excluyeron defectos de más de 1,50 Dpt en su esfera o más de 1,00 Dpt en el cilindro, alteraciones acomodativas o vergenciales, estrabismos, ambliopía, anisometropía (≥ 1,00 Dpt en la esfera o …