Medicine and Health Sciences Commons^™

Jefferson Digital Commons Quarterly Report: January-March 2022, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

In this Issue:

• Articles
• Thesis/Dissertations
• Grand Rounds and Lectures
• Capstone Presentations
• Journals and Newsletters
• Posters
• Miscellaneous
• What People are Saying About the Jefferson Digital Commons

Jefferson Digital Commons Quarterly Report: July-September 2021, Kelsey Duinkerken, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Data Sets
• Dissertations
• Grand Rounds and Lectures
• JCPH Capstone Presentations
• Jefferson Research Newsletter
• Journals and Newsletters
• Posters
• What People are Saying About the Jefferson Digital Commons

Jefferson Digital Commons Quarterly Report: April-June 2021, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• CREATE Day Capstone Projects
• Department of Surgery Resident Research Day
• Dissertations
• Grand Rounds and Lectures
• House Staff Quality Improvement and Patient Safety Conference
• JCPH Capstone Presentations
• Journals and Newsletters
• Know Diabetes by Heart Meetings
• MPH Course Projects
• Occupational Therapy Doctorate Capstones
• Posters and Conference Presentations:
• Promotional Video
• Scholarly Inquiry Abstracts
• What People are Saying About the Jefferson Digital Commons

Jefferson Digital Commons Quarterly Report: January-March 2021, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Dissertations
• Grand Rounds and Lectures
• JCPH Capstone Presentations
• Journals and Newsletters
• Know Diabetes by Heart Meetings
• Library Resources
• MPH COVID-19 Infographics
• Posters
• Scholarly Inquiry Graphics
• The Big in Big Data Symposium
• What People are Saying About the Jefferson Digital Commons

Jefferson Digital Commons Quarterly Report: October-December 2020, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Departmental Reports
• Dissertations
• Doctorate of Occupational Therapy (OTD) Capstones
• Educational Materials
• Grand Rounds and Lectures
• JCPH Capstone Presentations
• Journals and Newsletters
• Library Presentations
• Posters
• The Big in Big Data Symposium
• What People are Saying About the Jefferson Digital Commons

Law Library Blog (December 2020): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.

Jefferson Digital Commons Quarterly Report: July-September 2020, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

Included in this Report

• Abington Health Articles
• Articles
• Collaborative Healthcare: Interprofessional Practice, Education, and Evaluation (JCIPE)
• Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)
• Covid 19-: Spread the Science, Not the Virus
• Department of Family and Community Medicine Presentations and Grand Rounds
• Master of Population Health Program Thesis and Capstone Presentations
• Master of Public Health Thesis and Capstone Presentations
• Jefferson Surgical Solutions
• The Medicine Forum
• Sex and Gender Health Education Summit 2020
• Student Papers and Posters
• Misc. Uploads
• What people are saying about the Jefferson Digital Repository

Jefferson Digital Commons Quarterly Report: April-June 2020, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• New Collection: COVID-19 Papers, Posters, and Presentations
• Articles
• Collaborative Research and Evidence Among Therapists and Educators (CREATE) Day Presentations
• COVID-19 Working Papers
• Dissertations
• Doctorate of Occupational Therapy (OTD) Capstones
• Educational Materials
• From the Archives
• Grand Rounds and Lectures
• House Staff Quality Improvement and Patient Safety Posters
• JeffMD Scholarly Inquiry Abstracts
• Journals and Newsletters
• Master of Public Health Capstone Presentations
• Posters
• Spread the Science, NOT the Virus Seminar Series
• What People are Saying About the Jefferson the Digital Commons

Jefferson Digital Commons Quarterly Report: January-March 2020, Kelsey Duinkerken, Msi, James Copeland, Libt, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• New Look for the Jefferson Digital Commons
• Articles
• COVID-19 Working Papers
• Educational Materials
• From the Archives
• Grand Rounds and Lectures
• JeffMD Scholarly Inquiry Abstracts
• Journals and Newsletters
• Master of Public Health Capstones
• Oral Histories
• Posters and Conference Presentations
• What People are Saying About the Jefferson the Digital Commons

Jefferson Digital Commons Quarterly Report: October-December 2019, Kelsey Duinkerken, Msi, James Copeland, Libt, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Dean's Research Development Lunch Conference
• Dissertations
• Educational Materials
• From the Archives
• Grand Rounds and Lectures
• Journals and Newsletters
• Population Health Presentation Materials
• Posters
• Reports
• Symposiums
• What People are Saying About the Jefferson Digital Commons

Worldwide Inequality In Access To Full Text Scientific Articles: The Example Of Ophthalmology., Christophe Boudry, Patricio Alvarez-Muñoz, Ricardo Arencibia-Jorge, Didier Ayena, Niels J Brouwer, Zia Chaudhuri, Brenda Chawner, Emilienne Epee, Khalil Erraïs, Akbar Fotouhi, Almutez M Gharaibeh, Dina H Hassanein, Martina C Herwig-Carl, Katherine Howard, Dieudonne Kaimbo Wa Kaimbo, Patricia-Ann Laughrea, Fernando A Lopez, Juan D Machin-Mastromatteo, Fernando K Malerbi, Papa Amadou Ndiaye, Nina A Noor, Josmel Pacheco-Mendoza, Vasilios P Papastefanou, Mufarriq Shah, Carol L Shields, Ya Xing Wang, Vasily Yartsev, Frederic Mouriaux

Wills Eye Hospital Papers

Background: The problem of access to medical information, particularly in low-income countries, has been under discussion for many years. Although a number of developments have occurred in the last decade (e.g., the open access (OA) movement and the website Sci-Hub), everyone agrees that these difficulties still persist very widely, mainly due to the fact that paywalls still limit access to approximately 75% of scholarly documents. In this study, we compare the accessibility of recent full text articles in the field of ophthalmology in 27 established institutions located worldwide.

Methods: A total of 200 references from articles were retrieved using the …

Jefferson Digital Commons Quarterly Report: July-September 2019, Kelsey Duinkerken, Msi, James Copeland, Libt, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Conferences
• From the Archives
• Grand Rounds and Lectures
• Journals and Newsletters
• Master of Population Health Capstone Presentations
• Master of Public Health Capstone Presentations
• Posters
• What People are Saying About the Jefferson Digital Commons

Jefferson Digital Commons Quarterly Report: April-June 2019, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• CREATE Day Presentations
• Dissertations
• From the Archives
• Grand Rounds and Lectures
• House Staff Quality Improvement and Patient Safety Posters
• JCIPE Student Hotspotting Posters
• Journals and Newsletters
• MPH Capstone Presentations
• Posters
• Sigma Xi Research Day
• What People are Saying About the Jefferson Digital Commons

Jefferson Digital Commons Quarterly Report: January-March 2019, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

This quarterly report includes:

• Arlen Specter Center Research Fellowship
  
• Papers
  
• Articles
  
• Dissertations
  
• From the Archives
  
• Grand Rounds and Lectures
  
• Handouts
  
• JeffMD Scholarly Inquiry Abstracts
  
• Journals and Newsletters
  
• Posters
  
• What People are Saying About the Jefferson Digital Commons

Jefferson Digital Commons Quarterly Report: October-December 2018, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Dissertations
• From the Archives
• Grand Rounds and Lectures
• Industrial Design Capstones
• Journals and Newsletters
• LabArchives Launch
• Masters of Public Health Capstones
• Posters
• Reports
• Videos
• What People are Saying About the Jefferson Digital Commons

Jefferson Digital Commons Quarterly Report: January-March 2018, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Conference materials
• From the Archives - Yearbooks
• Grand Rounds
• Journals
• MPH Capstones
• Newsletters
• Podcasts
• Posters
• Reports
• Symposiums
• What People are Saying About the Jefferson Digital Commons

The Journey Through Doctoral Education, Nila Reimer

Nila Reimer

Students who gain new knowledge by integrating scholarliness and stewardship for the nursing profession possess key ambitions for succeeding in nursing doctoral education. In this narrative inquiry, a student reflects on themes of scholarly integration, intellectual community, and stewardship that are embedded in the values and attitudes evidenced in the culture of a Doctor of Philosophy in nursing program. The doctoral student’s personal reflection demonstrates professional growth during the experience of nursing doctoral education. This inquiry provides guidance for other students as they embark on their journey toward scholarly development and stewardship during their doctoral education experience.

The Statistics Of Sensitivity Analyses, Alexander R. Luedtke, Ivan Diaz, Mark J. Van Der Laan

Alex Luedtke

Suppose one wishes to estimate a causal parameter given a sample of observations. This requires making unidentifiable assumptions about an underlying causal mechanism. Sensitivity analyses help investigators understand what impact violations of these assumptions could have on the causal conclusions drawn from a study, though themselves rely on untestable (but hopefully more interpretable) assumptions. Díaz and van der Laan (2013) advocate the use of a sequence (or continuum) of interpretable untestable assumptions of increasing plausibility for the sensitivity analysis so that experts can have informed opinions about which are true. In this work, we argue that using appropriate statistical procedures …

Haematopoietic Stem Cells In Spleen Have Distinct Differentiative Potential For Antigen Presenting Cells., Jonathan Tan, Helen O'Neill

Jonathan Tan

Dendritic cells (DC) are known to develop from macrophage dendritic progenitors (MDP) in bone marrow (BM), which give rise to conventional (c)DC and monocytes, both dominant antigen presenting cell (APC) subsets in spleen. This laboratory has however defined a distinct dendritic-like cell subset in spleen (L-DC), which can also be derived in long-term cultures of spleen. In line with the restricted in vitro development of only L-DC in these stromal cultures, we questioned whether self-renewing HSC or progenitors exist in spleen with restricted differentiative capacity for only L-DC. Neonatal spleen and BM were compared for their ability to reconstitute mice …

Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill

Jonathan Tan

No abstract provided.

Synthesis And Preliminary Investigations Into Novel 1,2,3-Triazole-Derived Androgen Receptor Antagonists Inspired By Bicalutamide, Jarrad Altimari, Birunthi Niranjan, Gail Risbridger, Stephanie Schweiker, Anna Lohning, Luke Henderson

Anna Lohning

A versatile and high yielding synthesis of novel androgen receptor (AR) antagonists is presented. Using this methodology, six 1,4-substituted-1,2,3-triazole derived bicalutamide mimics were synthesised in five steps and in isolated overall yields from 41% to 85%. Evaluation of these compounds for their anti-proliferative properties against androgen dependent (LNCaP) and independent (PC-3) cells showed promising IC50 values of 34-45 μM and 29-151 μM, respectively. The data suggest that the latter compounds may be an excellent starting point for the development of prostate cancer therapeutics for both androgen dependent and independent forms of this disease. Docking of these compounds (each enantiomer) in …

Preliminary Investigations Into Triazole Derived Androgen Receptor Antagonists, Jarrad Altimari, Birunthi Niranjan, Gail Risbridger, Stephanie Schweiker, Anna Lohning, Luke Henderson

Anna Lohning

A range of 1,4-substituted-1,2,3-N-phenyltriazoles were synthesized and evaluated as non-steroidal androgen receptor (AR) antagonists. The motivation for this study was to replace the N-phenyl amide portion of small molecule antiandrogens with a 1,2,3-triazole and determine effects, if any, on biological activity. The synthetic methodology presented herein is robust, high yielding and extremely rapid. Using this methodology a series of 17 N-aryl triazoles were synthesized from commercially available starting materials in less than 3 h. After preliminary biological screening at 20 and 40 lM, the most promising three compounds were found to display IC50 values of 40–50 lM against androgen dependent …

Association Between Applications Scores And Positive Onsite Interviews Of Pharmacy Residency Applicants, Sarah Nisly, Meredith L. Howard, Alex N. Issacs, Tate Trujillo

Sarah A. Nisly

Application to pharmacy residency programs has become increasingly competitive over the past several years. Although successful candidates must excel in the various stages of the application process, preparing written applications and securing onsite interviews are early and arguably the most difficult steps. Residency programs vary in the criteria used for offering onsite interviews. The majority of insight into this topic comes from surveys of residency program directors, but corresponding analyses of interview offers have been minimal...

Canagliflozin, A New Sodium-Glucose Co-Transporter 2 Inhibitor, In The Treatment Of Diabetes, Sarah A. Nisly, Denise M. Kolanczyk, Alison M. Walton

Alison M. Walton

Purpose. The published evidence on the pharmacology, pharmacodynamics, pharmacokinetics, safety, and efficacy of a promising investigational agent for managing type 2 diabetes is evaluated. Summary. Canagliflozin belongs to a class of agents—the sodium–glucose cotransporter 2 (SGLT2) inhibitors—whose novel mechanism of action offers potential advantages over other antihyperglycemic agents, including a relatively low hypoglycemia risk and weight loss-promoting effects. Canagliflozin has dose-dependent pharmacokinetics, and research in laboratory animals demonstrated high oral bioavailability (85%) and rapid effects in lowering glycosylated hemoglobin (HbA1c) values. In four early-stage clinical trials involving a total of over 500 patients, the use of canagliflozin for varying periods …

Teratogen Use In Women Of Childbearing Potential: An Intervention Study, Karie Morical-Kline, Alison Walton, Tracey Guildenbecher

Alison M. Walton

Purpose: The purpose of this study was to quantify the number of women of childbearing potential who are prescribed angiotensin-converting enzyme inhibitor (ACE inhibitor), angiotensin receptor blocker (ARB), or HMG-coenzyme A reductase inhibitor (statin) and to determine the number of documented teratogenic risk discussions (risk documentation) before and after educational interventions. Methods: The institutional review board–approved retrospective chart review included female patients ages 15 to 45 years who were prescribed an ACE inhibitor, ARB, or statin between January 1, 2007, and March 1, 2009. Exclusion criteria were tubal ligation and hysterectomy. A survey determined physician knowledge of teratogenic risks and …

Patient Perceptions Of Pharmacist-Managed Clinics: A Qualitative Analysis, Jasmine Gonsalvo, Darin Ramsey, Ashley Vincent, Alison Walton, Zachary Weber, Jessica Wilhoite

Alison M. Walton

Background: Pharmacist-managed clinics have consistently demonstrated improvement in patient outcomes. Quantitative research offers the benefit of objective outcomes to track progress toward therapeutic goals at pharmacist-managed clinics. While quantitative studies are readily available in the literature, there is a paucity of qualitative studies to capture the patients' perspectives of pharmacy services. Objective: To assess through the use of qualitative research methods patient perceptions of pharmacist-managed services within ambulatory care clinics that operate under a collaborative practice agreement. Methods: A semi-structured interview questionnaire was developed, pilot tested, and revised using a focus group of clinical pharmacists. The questionnaire was used to …

Redesign Of A Statewide Teaching Certificate Program For Pharmacy Residents, Jasmine Gonsalvo, Darin Ramsey, Amy Sheehan, Tracy Sprunger

Tracy L. Sprunger

Objectives. To identify and assess changes made to the Indiana Pharmacy Resident Teaching Certificate program over 10 years to adapt to the growing number and changing needs of pharmacy educators in the next generation. Design. In 2011, all resident program participants and directors were sent an electronic survey instrument designed to assess the perceived value of each program component. Assessment. Since 2003, the number of program participants has tripled, and the program has expanded to include additional core requirements and continuing education. Participants generally agreed that the speakers, seminar topics, seminar video recordings, and seminar offerings during the fall semester …

Association Of Antipsychotic Use With Hospital Events And Mortality Among Medicare Beneficiaries Residing In Long-Term Care Facilities, Linda Simoni-Wastila, Priscilla T. Ryder, Jingjing Qian, Ilene H. Zuckermann, Thomas Shaffer, Lirong Zhao

Priscilla T. Ryder

Objective—Antipsychotic (AP) utilization has grown significantly in long-term care (LTC) settings. Although a growing literature associates AP use with higher mortality in elderly with dementia, the association of APs with hospital events is unclear. The authors examine prevalence and trends in AP use by Medicare beneficiaries residing in LTC and the association of APs and other drug use variables with hospital events and mortality. Design—Retrospective analysis using sequential multivariate Cox proportional hazards models. Setting—Medicare Current Beneficiary Survey linked to Institutional Drug Administration and Minimum Data Set files. Participants—A total of 2,363 LTC Medicare beneficiaries, 1999–2002. Measurements—Trends in LTC AP use …

Herbal Product Use Among Anticoagulation Patients, Ilene H. Zuckerman, Eileen K. Steinberger, Priscilla T. Ryder, Stuart Haines

Priscilla T. Ryder

Warfarin interacts with many conventional drug products and herbal products,1-3 Given the incompleteness of information on drug-herbal product interactions and the potential for health care practitioners to be unaware of their patients' utilization of herbal products, we surveyed the use of such products among patients receiving warfarin through an anticoagulation clinic. Patients at the University of Maryland Medical System Anticoagulation Clinic were asked to complete an anonymous written questionnaire during their regularly scheduled appointments over one month.

Administrators’ Perceptions Of Medication Management In Assisted Living Facilities: Results From Focus Groups, Priscilla T. Ryder, Melanie Joseph, Marnie Zuckermann, Ilene H. Zuckermann

Priscilla T. Ryder

Objective: Assisted living (AL) residents are vulnerable to adverse events as a result of using numerous medications and frequently need assistance in administering medications. Very little is known, however, about the ways in which medications are managed within this level of care. Design: AL administrators from the metropolitan Baltimore, Maryland area were invited to participate in focus groups to explore issues involved in medication management. Setting and Participants: Four administrators from smaller (15 beds or fewer) and six larger (more than 15 beds) certified AL facilities serving primarily older residents participated. Administrators must have served in their position at least …