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Articles 1 - 30 of 110
Full-Text Articles in Medicine and Health Sciences
The Journey Through Doctoral Education, Nila Reimer
The Journey Through Doctoral Education, Nila Reimer
Nila Reimer
Students who gain new knowledge by integrating scholarliness and stewardship for the nursing profession possess key ambitions for succeeding in nursing doctoral education. In this narrative inquiry, a student reflects on themes of scholarly integration, intellectual community, and stewardship that are embedded in the values and attitudes evidenced in the culture of a Doctor of Philosophy in nursing program. The doctoral student’s personal reflection demonstrates professional growth during the experience of nursing doctoral education. This inquiry provides guidance for other students as they embark on their journey toward scholarly development and stewardship during their doctoral education experience.
The Statistics Of Sensitivity Analyses, Alexander R. Luedtke, Ivan Diaz, Mark J. Van Der Laan
The Statistics Of Sensitivity Analyses, Alexander R. Luedtke, Ivan Diaz, Mark J. Van Der Laan
Alex Luedtke
Suppose one wishes to estimate a causal parameter given a sample of observations. This requires making unidentifiable assumptions about an underlying causal mechanism. Sensitivity analyses help investigators understand what impact violations of these assumptions could have on the causal conclusions drawn from a study, though themselves rely on untestable (but hopefully more interpretable) assumptions. Díaz and van der Laan (2013) advocate the use of a sequence (or continuum) of interpretable untestable assumptions of increasing plausibility for the sensitivity analysis so that experts can have informed opinions about which are true. In this work, we argue that using appropriate statistical procedures …
Haematopoietic Stem Cells In Spleen Have Distinct Differentiative Potential For Antigen Presenting Cells., Jonathan Tan, Helen O'Neill
Haematopoietic Stem Cells In Spleen Have Distinct Differentiative Potential For Antigen Presenting Cells., Jonathan Tan, Helen O'Neill
Jonathan Tan
Dendritic cells (DC) are known to develop from macrophage dendritic progenitors (MDP) in bone marrow (BM), which give rise to conventional (c)DC and monocytes, both dominant antigen presenting cell (APC) subsets in spleen. This laboratory has however defined a distinct dendritic-like cell subset in spleen (L-DC), which can also be derived in long-term cultures of spleen. In line with the restricted in vitro development of only L-DC in these stromal cultures, we questioned whether self-renewing HSC or progenitors exist in spleen with restricted differentiative capacity for only L-DC. Neonatal spleen and BM were compared for their ability to reconstitute mice …
Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill
Spleen As A Distinct Site For Dendritic Cell Haematopoiesis, Jonathan Tan, Helen O'Neill
Jonathan Tan
No abstract provided.
Synthesis And Preliminary Investigations Into Novel 1,2,3-Triazole-Derived Androgen Receptor Antagonists Inspired By Bicalutamide, Jarrad Altimari, Birunthi Niranjan, Gail Risbridger, Stephanie Schweiker, Anna Lohning, Luke Henderson
Synthesis And Preliminary Investigations Into Novel 1,2,3-Triazole-Derived Androgen Receptor Antagonists Inspired By Bicalutamide, Jarrad Altimari, Birunthi Niranjan, Gail Risbridger, Stephanie Schweiker, Anna Lohning, Luke Henderson
Anna Lohning
A versatile and high yielding synthesis of novel androgen receptor (AR) antagonists is presented. Using this methodology, six 1,4-substituted-1,2,3-triazole derived bicalutamide mimics were synthesised in five steps and in isolated overall yields from 41% to 85%. Evaluation of these compounds for their anti-proliferative properties against androgen dependent (LNCaP) and independent (PC-3) cells showed promising IC50 values of 34-45 μM and 29-151 μM, respectively. The data suggest that the latter compounds may be an excellent starting point for the development of prostate cancer therapeutics for both androgen dependent and independent forms of this disease. Docking of these compounds (each enantiomer) in …
Preliminary Investigations Into Triazole Derived Androgen Receptor Antagonists, Jarrad Altimari, Birunthi Niranjan, Gail Risbridger, Stephanie Schweiker, Anna Lohning, Luke Henderson
Preliminary Investigations Into Triazole Derived Androgen Receptor Antagonists, Jarrad Altimari, Birunthi Niranjan, Gail Risbridger, Stephanie Schweiker, Anna Lohning, Luke Henderson
Anna Lohning
A range of 1,4-substituted-1,2,3-N-phenyltriazoles were synthesized and evaluated as non-steroidal androgen receptor (AR) antagonists. The motivation for this study was to replace the N-phenyl amide portion of small molecule antiandrogens with a 1,2,3-triazole and determine effects, if any, on biological activity. The synthetic methodology presented herein is robust, high yielding and extremely rapid. Using this methodology a series of 17 N-aryl triazoles were synthesized from commercially available starting materials in less than 3 h. After preliminary biological screening at 20 and 40 lM, the most promising three compounds were found to display IC50 values of 40–50 lM against androgen dependent …
Association Between Applications Scores And Positive Onsite Interviews Of Pharmacy Residency Applicants, Sarah Nisly, Meredith L. Howard, Alex N. Issacs, Tate Trujillo
Association Between Applications Scores And Positive Onsite Interviews Of Pharmacy Residency Applicants, Sarah Nisly, Meredith L. Howard, Alex N. Issacs, Tate Trujillo
Sarah A. Nisly
Application to pharmacy residency programs has become increasingly competitive over the past several years. Although successful candidates must excel in the various stages of the application process, preparing written applications and securing onsite interviews are early and arguably the most difficult steps. Residency programs vary in the criteria used for offering onsite interviews. The majority of insight into this topic comes from surveys of residency program directors, but corresponding analyses of interview offers have been minimal...
Canagliflozin, A New Sodium-Glucose Co-Transporter 2 Inhibitor, In The Treatment Of Diabetes, Sarah A. Nisly, Denise M. Kolanczyk, Alison M. Walton
Canagliflozin, A New Sodium-Glucose Co-Transporter 2 Inhibitor, In The Treatment Of Diabetes, Sarah A. Nisly, Denise M. Kolanczyk, Alison M. Walton
Alison M. Walton
Purpose. The published evidence on the pharmacology, pharmacodynamics, pharmacokinetics, safety, and efficacy of a promising investigational agent for managing type 2 diabetes is evaluated. Summary. Canagliflozin belongs to a class of agents—the sodium–glucose cotransporter 2 (SGLT2) inhibitors—whose novel mechanism of action offers potential advantages over other antihyperglycemic agents, including a relatively low hypoglycemia risk and weight loss-promoting effects. Canagliflozin has dose-dependent pharmacokinetics, and research in laboratory animals demonstrated high oral bioavailability (85%) and rapid effects in lowering glycosylated hemoglobin (HbA1c) values. In four early-stage clinical trials involving a total of over 500 patients, the use of canagliflozin for varying periods …
Teratogen Use In Women Of Childbearing Potential: An Intervention Study, Karie Morical-Kline, Alison Walton, Tracey Guildenbecher
Teratogen Use In Women Of Childbearing Potential: An Intervention Study, Karie Morical-Kline, Alison Walton, Tracey Guildenbecher
Alison M. Walton
Purpose: The purpose of this study was to quantify the number of women of childbearing potential who are prescribed angiotensin-converting enzyme inhibitor (ACE inhibitor), angiotensin receptor blocker (ARB), or HMG-coenzyme A reductase inhibitor (statin) and to determine the number of documented teratogenic risk discussions (risk documentation) before and after educational interventions. Methods: The institutional review board–approved retrospective chart review included female patients ages 15 to 45 years who were prescribed an ACE inhibitor, ARB, or statin between January 1, 2007, and March 1, 2009. Exclusion criteria were tubal ligation and hysterectomy. A survey determined physician knowledge of teratogenic risks and …
Patient Perceptions Of Pharmacist-Managed Clinics: A Qualitative Analysis, Jasmine Gonsalvo, Darin Ramsey, Ashley Vincent, Alison Walton, Zachary Weber, Jessica Wilhoite
Patient Perceptions Of Pharmacist-Managed Clinics: A Qualitative Analysis, Jasmine Gonsalvo, Darin Ramsey, Ashley Vincent, Alison Walton, Zachary Weber, Jessica Wilhoite
Alison M. Walton
Background: Pharmacist-managed clinics have consistently demonstrated improvement in patient outcomes. Quantitative research offers the benefit of objective outcomes to track progress toward therapeutic goals at pharmacist-managed clinics. While quantitative studies are readily available in the literature, there is a paucity of qualitative studies to capture the patients' perspectives of pharmacy services. Objective: To assess through the use of qualitative research methods patient perceptions of pharmacist-managed services within ambulatory care clinics that operate under a collaborative practice agreement. Methods: A semi-structured interview questionnaire was developed, pilot tested, and revised using a focus group of clinical pharmacists. The questionnaire was used to …
Redesign Of A Statewide Teaching Certificate Program For Pharmacy Residents, Jasmine Gonsalvo, Darin Ramsey, Amy Sheehan, Tracy Sprunger
Redesign Of A Statewide Teaching Certificate Program For Pharmacy Residents, Jasmine Gonsalvo, Darin Ramsey, Amy Sheehan, Tracy Sprunger
Tracy L. Sprunger
Objectives. To identify and assess changes made to the Indiana Pharmacy Resident Teaching Certificate program over 10 years to adapt to the growing number and changing needs of pharmacy educators in the next generation. Design. In 2011, all resident program participants and directors were sent an electronic survey instrument designed to assess the perceived value of each program component. Assessment. Since 2003, the number of program participants has tripled, and the program has expanded to include additional core requirements and continuing education. Participants generally agreed that the speakers, seminar topics, seminar video recordings, and seminar offerings during the fall semester …
Association Of Antipsychotic Use With Hospital Events And Mortality Among Medicare Beneficiaries Residing In Long-Term Care Facilities, Linda Simoni-Wastila, Priscilla T. Ryder, Jingjing Qian, Ilene H. Zuckermann, Thomas Shaffer, Lirong Zhao
Association Of Antipsychotic Use With Hospital Events And Mortality Among Medicare Beneficiaries Residing In Long-Term Care Facilities, Linda Simoni-Wastila, Priscilla T. Ryder, Jingjing Qian, Ilene H. Zuckermann, Thomas Shaffer, Lirong Zhao
Priscilla T. Ryder
Objective—Antipsychotic (AP) utilization has grown significantly in long-term care (LTC) settings. Although a growing literature associates AP use with higher mortality in elderly with dementia, the association of APs with hospital events is unclear. The authors examine prevalence and trends in AP use by Medicare beneficiaries residing in LTC and the association of APs and other drug use variables with hospital events and mortality. Design—Retrospective analysis using sequential multivariate Cox proportional hazards models. Setting—Medicare Current Beneficiary Survey linked to Institutional Drug Administration and Minimum Data Set files. Participants—A total of 2,363 LTC Medicare beneficiaries, 1999–2002. Measurements—Trends in LTC AP use …
Herbal Product Use Among Anticoagulation Patients, Ilene H. Zuckerman, Eileen K. Steinberger, Priscilla T. Ryder, Stuart Haines
Herbal Product Use Among Anticoagulation Patients, Ilene H. Zuckerman, Eileen K. Steinberger, Priscilla T. Ryder, Stuart Haines
Priscilla T. Ryder
Warfarin interacts with many conventional drug products and herbal products,1-3 Given the incompleteness of information on drug-herbal product interactions and the potential for health care practitioners to be unaware of their patients' utilization of herbal products, we surveyed the use of such products among patients receiving warfarin through an anticoagulation clinic. Patients at the University of Maryland Medical System Anticoagulation Clinic were asked to complete an anonymous written questionnaire during their regularly scheduled appointments over one month.
Administrators’ Perceptions Of Medication Management In Assisted Living Facilities: Results From Focus Groups, Priscilla T. Ryder, Melanie Joseph, Marnie Zuckermann, Ilene H. Zuckermann
Administrators’ Perceptions Of Medication Management In Assisted Living Facilities: Results From Focus Groups, Priscilla T. Ryder, Melanie Joseph, Marnie Zuckermann, Ilene H. Zuckermann
Priscilla T. Ryder
Objective: Assisted living (AL) residents are vulnerable to adverse events as a result of using numerous medications and frequently need assistance in administering medications. Very little is known, however, about the ways in which medications are managed within this level of care. Design: AL administrators from the metropolitan Baltimore, Maryland area were invited to participate in focus groups to explore issues involved in medication management. Setting and Participants: Four administrators from smaller (15 beds or fewer) and six larger (more than 15 beds) certified AL facilities serving primarily older residents participated. Administrators must have served in their position at least …
Racial And Ethnic Disparities In Treatment Of Dementia Among Medicare Beneficiaries, Ilene H. Zuckerman, Priscilla T. Ryder, Linda Simoni-Wastila, Thomas Shaffer, Masayo Sato, Lirong Zhao, Bruce Stuart
Racial And Ethnic Disparities In Treatment Of Dementia Among Medicare Beneficiaries, Ilene H. Zuckerman, Priscilla T. Ryder, Linda Simoni-Wastila, Thomas Shaffer, Masayo Sato, Lirong Zhao, Bruce Stuart
Priscilla T. Ryder
Objectives—Numerous studies have documented disparities in health care utilization between non-Hispanic White and minority elders. We investigated differences in anti-dementia medication use between non-Hispanic White and minority community-dwelling Medicare beneficiaries with dementia. Methods—Using multivariate analysis with generalized estimating equations, we estimated prevalence ratios (PRs) for anti-dementia medication use by race/ethnicity for 1,120 beneficiaries with dementia from years 2001 through 2003 of the Medicare Current Beneficiary Survey. Results—After adjusting for demographics, socioeconomics, health care access and utilization, comorbidities, and service year, we found that anti-dementia medication use was approximately 30% higher among non-Hispanic Whites compared to other racial/ethnic groups (PR = …
We Can Do More Than Just Sell The Test: Pharmacist Perspectives About Over-The-Counter Rapid Hiv Tests, Beth Meyerson, Priscilla T. Ryder, Christiana Van Hippel, Kelsey Coy
We Can Do More Than Just Sell The Test: Pharmacist Perspectives About Over-The-Counter Rapid Hiv Tests, Beth Meyerson, Priscilla T. Ryder, Christiana Van Hippel, Kelsey Coy
Priscilla T. Ryder
Pharmacist attitudes about the over-the-counter (OTC) sale of HIV rapid tests in pharmacies were explored through interviews conducted among 17 licensed community pharmacists in a Midwestern, moderate HIV incidence state between May and September 2012. Participants recognized that OTC rapid HIV tests would increase the number of people aware of their HIV status. Concerns included linkage to care and results consultation for those who test HIV-positive. Point of sale was identified as an opportunity for consultation about the test and to establish a relationship for future discussion about results and linkage to care. Pharmacists could provide initial test consultation or …
Achieving Pharmacy Based Public Health: Call For Public Health Engagement, Beth Meyerson, Priscilla Ryder, Cariann Richey-Smith
Achieving Pharmacy Based Public Health: Call For Public Health Engagement, Beth Meyerson, Priscilla Ryder, Cariann Richey-Smith
Priscilla T. Ryder
The evolution of pharmacy practice in the last 15 years has created expanded public health access. Community pharmacies now provide a range of public health services with promising improvements in health access and outcomes. The observed practice changes call our attention to systemic issues that remain in need of collective attention. As we strengthen our intersectoral public health system, we must focus on the pharmacy-public health partnership and establish collaborative policy and research agendas to guide this system change for maximum public health impact. Our collective effort to assure the health of communities depends upon our seeing opportunities across systems …
Complementary And Alternative Medicine Use Among Older Urban African Americans: Individual And Neighborhood Associations, Priscilla Ryder, Beverly Wolpert, Denise Orwig, Olivia Carter-Pokras, Sandra Black
Complementary And Alternative Medicine Use Among Older Urban African Americans: Individual And Neighborhood Associations, Priscilla Ryder, Beverly Wolpert, Denise Orwig, Olivia Carter-Pokras, Sandra Black
Priscilla T. Ryder
Purpose: Older African Americans may be vulnerable to risks due to impaired healthcare access and understudied complementary and alternative medicine (CAM) use and other traditions. We describe C AM use among older African Americans in Baltimore, MD, examining associations among CAM and sociodemographic, health status, healthcare utilization and neighborhood factors. Methods: Cross sectional telephone survey of 95 African Americans ages ≥60 on use of CAM modalities (herb/home remedies, prayer, group spiritual practices, meditation/visualization, massage, chiropractic, acupuncture, relaxation/ biofeedback) in prior year. Results: A large majority (88.4%) reported CAM use in the previous year; 50.5% reported CAM use excluding individual prayer. …
Timely Follow-Up Among Multicultural Women With Abnormal Mammograms, Pamela Arnsberger, Patrick Fox, Priscilla Ryder, Brenda Nussey, Xiulan Zhang, Regina Otero-Sabogal
Timely Follow-Up Among Multicultural Women With Abnormal Mammograms, Pamela Arnsberger, Patrick Fox, Priscilla Ryder, Brenda Nussey, Xiulan Zhang, Regina Otero-Sabogal
Priscilla T. Ryder
Objective: To examine factors influencing time from screening to final diagnosis among multicultural women with abnormal mammograms using the precede-proceed model. Methods: Staff of 58 clinics and a sample of 436 women served by these clinics were interviewed and their medical records examined. Results: Longer duration from screening to diagnosis was associated with speaking Spanish and having clinic staff make appointments. Ease of access to health care, provision of early morning screening services and higher levels of patient anxiety shortened the time to diagnosis. Conclusion: The precede-proceed model is useful in delineating personal and structural factors that affect timely diagnosis.
Preferences Of Gay And Bisexual Men For Pharmacy-Based Hiv Testing And Over-The-Counter Hiv Tests, Beth Meyerson, Roberta Emetu, Stephanie Sanders, Marlon Bailey, Priscilla Ryder, James Armstrong
Preferences Of Gay And Bisexual Men For Pharmacy-Based Hiv Testing And Over-The-Counter Hiv Tests, Beth Meyerson, Roberta Emetu, Stephanie Sanders, Marlon Bailey, Priscilla Ryder, James Armstrong
Priscilla T. Ryder
A 2013 study among 169 Indiana men aged 18–45 who have sex with men assessed the acceptability of and preferences for pharmacy-based and over-the-counter (OTC) HIV testing. Rural men in general and men who did not know their HIV status were more likely to purchase an OTC HIV test. Men who did not know their HIV status also preferred an OTC HIV test to pharmacy-based testing. Pharmacies should enhance information around the sale of OTC HIV tests, particularly in rural areas. Information should include test results, opportunities for consultation, and linkage to care.
A Creative Application Of The Neuman Systems Model: Twas The Night Before Sickness, Sarah Beckman, O Freiburger, C Bangert, N Johnson
A Creative Application Of The Neuman Systems Model: Twas The Night Before Sickness, Sarah Beckman, O Freiburger, C Bangert, N Johnson
Sarah J. Beckman
No abstract provided.
Academe’S Response: Graduating A Workforce With Beginning Clinical Decision Making Skills Emphasizing A Nursing Theory Base, Sarah Beckman, C Bruick-Sorge
Academe’S Response: Graduating A Workforce With Beginning Clinical Decision Making Skills Emphasizing A Nursing Theory Base, Sarah Beckman, C Bruick-Sorge
Sarah J. Beckman
No abstract provided.
A Creative Interpretation And Application Of Leininger's Theory, T Watson, Sarah Beckman
A Creative Interpretation And Application Of Leininger's Theory, T Watson, Sarah Beckman
Sarah J. Beckman
No abstract provided.
Teaching Strategies That Explore The Concept Of Spirituality And Growing As A Nurse: A Full Spectrum Of Learning, Sarah Beckman, C Bruick-Sorge, Becky Salmon
Teaching Strategies That Explore The Concept Of Spirituality And Growing As A Nurse: A Full Spectrum Of Learning, Sarah Beckman, C Bruick-Sorge, Becky Salmon
Sarah J. Beckman
No abstract provided.
Teaching Strategies That Explore The Concept Of Spirituality, Sarah Beckman, S Boxley-Harges, C Bruick-Sorge, Becky Salmon
Teaching Strategies That Explore The Concept Of Spirituality, Sarah Beckman, S Boxley-Harges, C Bruick-Sorge, Becky Salmon
Sarah J. Beckman
No abstract provided.
Experience Informs: Spanning Three Decades With The Nsm, Sarah Beckman, S. Boxley-Harges, Beth Kaskel
Experience Informs: Spanning Three Decades With The Nsm, Sarah Beckman, S. Boxley-Harges, Beth Kaskel
Sarah J. Beckman
The efficacy of the Neuman systems model as a guiding framework for curriculum development of a baccalaureate program is examined. Insights from lessons learned provide directions for nursing theory-based curriculum change and program development. Challenges and opportunities during curriculum development are explored. Recommendations and strategies that contribute to consensus building are reported.
Teaching Teachers To Use And Integrate Technology Into Teaching Plans And The Curriculum, Sarah Beckman, B Ross
Teaching Teachers To Use And Integrate Technology Into Teaching Plans And The Curriculum, Sarah Beckman, B Ross
Sarah J. Beckman
No abstract provided.
Teaching Subject Matter Via Computer Technology: Professional Communication Course For Nurses, Sarah Beckman, B Ross
Teaching Subject Matter Via Computer Technology: Professional Communication Course For Nurses, Sarah Beckman, B Ross
Sarah J. Beckman
No abstract provided.
Inspirations In Education, Sarah Beckman
Diversity Matters: Engaging Students, Sarah Beckman, S. Boxley-Harges
Diversity Matters: Engaging Students, Sarah Beckman, S. Boxley-Harges
Sarah J. Beckman
No abstract provided.