Medicine and Health Sciences Commons^™

Brachytherapy Seed And Applicator Localization Via Iterative Forward Projection Matching Algorithm Using Digital X-Ray Projections, Damodar Pokhrel

Theses and Dissertations

Interstitial and intracavitary brachytherapy plays an essential role in management of several malignancies. However, the achievable accuracy of brachytherapy treatment for prostate and cervical cancer is limited due to the lack of intraoperative planning and adaptive replanning. A major problem in implementing TRUS-based intraoperative planning is an inability of TRUS to accurately localize individual seed poses (positions and orientations) relative to the prostate volume during or after the implantation. For the locally advanced cervical cancer patient, manual drawing of the source positions on orthogonal films can not localize the full 3D intracavitary brachytherapy (ICB) applicator geometry. A new iterative forward …

Time Series Analysis As Input For Predictive Modeling: Predicting Cardiac Arrest In A Pediatric Intensive Care Unit, Curtis Kennedy

Dissertations & Theses (Open Access)

The first manuscript, entitled "Time-Series Analysis as Input for Clinical Predictive Modeling: Modeling Cardiac Arrest in a Pediatric ICU" lays out the theoretical background for the project. There are several core concepts presented in this paper. First, traditional multivariate models (where each variable is represented by only one value) provide single point-in-time snapshots of patient status: they are incapable of characterizing deterioration. Since deterioration is consistently identified as a precursor to cardiac arrests, we maintain that the traditional multivariate paradigm is insufficient for predicting arrests. We identify time series analysis as a method capable of characterizing deterioration in an objective, …

Exploring Oncology Nurses Attitudes Towards Suicide In Cancer Patients, Bonnie L. Hoover

Nursing Masters

Oncology nurses are recognized experts in the care of patients with cancer. As such, oncology nurses excel at the management of symptoms related to both the disease itself, as well as treatment, affecting the lives of patients experiencing cancer. These symptoms include physical, social, and psychological components.

Using Photoactive Vitamin Nanoparticles As Photodynamic Antimicrobial Chemotherapeutic (Pact) Agents To Treat Chronic Wounds, Rahul A. Khanke

All Capstone Projects

The objective of the proposed study is to develop new materials and methods to manage microbial growth in chronic wounds using phototherapy. Chronic wounds are considered as a worldwide health problem. The most common chronic wounds can be classified into three categories: venous ulcers, diabetic ulcers, and pressure ulcers. Venous ulcers, which usually occur in the legs, account for about 70% to 90% of chronic wounds and can become infected easily. Venous ulcers are sores that develop after veins in the legs have been damaged. These ulcers can penetrate deeply into the skin. Occasionally, if a venous ulcer persists for …

Synthesis And Analytical Evaluation Of Folate Conjugates For Use In Cancer Cell Detection, Sneha Reddy Kuthuru

All Capstone Projects

Recent clinical studies have shown the importance of folate receptor in drug delivery system as they increase the potency and reduce toxicity of many cancer therapies. The folate receptor alpha ( FR-a) binds with high affinity for folic acid and serves for receptor mediated transport of folate into cells. Folate is necessary for DNA metabolism and thus it is speculated that rapidly dividing cancer cells have an increased requirement for folic acid. It is known that FR-a levels are elevated in specific malignant diseases (solid tumors, leukemia) and thus the FR receptor serves as useful targeting moiety for the diagnosis …

Total Protein Determination Using Micro Plate Assay, Julie Ruffatti

All Capstone Projects

One of the largest challenges that food manufactures are facing today is the management of food allergens. Allergenic protein in trace amounts, part per million concentrations, will trigger a reaction in some individuals. Food manufacturers need to prevent allergen cross-contamination by performing adequate sanitation after production of an allergenic containing food. Allergen detection kits are used to determine if sufficient protein was removed from the equipment surfaces during sanitation. One kit on the market is the 3M™ Clean- Trace™ Surface Protein (Allergen) swab tests. The test qualitatively detects the presence of protein based on the biuret reaction and will yield …

Ruthenium Complexes As Dna Photonucleases In Treatment Of Malignant Skin Carcinoma, Devi Kalyan Karumanchi

All Capstone Projects

A variety of Ruthenium complexes possessing terpyridine complexes as ligands in their coordination sphere have been investigated extensively as DNA photo nucleases in vitro. This work has led to the realization that compounds of Ruthenium bind to DNA purines and that the interactions are of an unprecedented bridging variety. Owing to the molar absorptivity of these complexes in the visible region, direct cleavage of duplex DNA by these complexes requires irradiation in the range of 400-500 nm.

Although the observation of DNA photo cleavage in vitro makes these systems good candidates for further investigation, it does not provide any information …

Spirituality, Religiosity, And Weight Management In Black Women, Shené L. Bowie

Loma Linda University Electronic Theses, Dissertations & Projects

Background

Obesity is a major concern in the United States and Black Americans are among those with the highest rates of overweight, obesity, and related co- morbidities. While weight loss among Black women has been studied within the context of a faith-based setting, there is little information about the relationship between spirituality, or relationship with the transcendent, and self-efficacy in the achievement and maintenance of a healthy weight.

Purpose

The purpose of this study was to analyze the relationships among spirituality, self-efficacy for physical activity and healthy eating, and body composition measures among Black women over the period of participation …

Ice Hockey Injuries: Weber Type C Fibular Fracture In A Collegiate Hockey Player: A Case Report, Stefanie K. Arndt

Culminating Projects in Kinesiology

No abstract provided.

More Than S.K.I.N. Deep: Decreasing Pressure Ulcer Development In The Pediatric Intensive Care Unit, Christine A. Schindler

Dissertations (1934 -)

Pressure ulcers are defined as localized areas of tissue destruction that develop when soft tissue is compressed between a bony prominence and an external surface for a prolonged period of time. Although any hospitalized child is at risk for the development of a pressure ulcer, the critically ill child is at increased risk. The critical care environment poses special challenges to preventing the development of pressure ulcers secondary to the high acuity of patients and the highly invasive nature of interventions and therapies those patients receive. The incidence of pediatric pressure ulcer development in the critical care population has been …

The Association Of Spirituality, Religiosity, Depression, Anxiety, And Drug Use Among Persons Undergoing Methadone Maintenance Therapy, Linda B. Piacentine

Dissertations (1934 -)

The Substance Abuse and Mental Health Services Administration estimated 22.2 million (9.1 %) of Americans ages 12 and older abused or were dependent on an illicit substance or alcohol in 2005. Substance abuse often leads to addiction, and is damaging to the health of persons, families, and society.

Using Neuman's System Model as the conceptual framework, it was proposed that addiction weakens person's defenses with resultant loss of health. The person with addiction often also suffers from anxiety, depression, or both, increasing the risk for continued substance abuse and its concomitant negative consequences, such as loss of employment, poor finances, …

Utilization Patterns And Economic Impact Of Iv Iron And Erythropoiesis Stimulating Agents In Chronic Kidney Disease Patients: A Multi-Hospital Study, Avani Joshi

Theses and Dissertations

Background: Chronic kidney disease (CKD) affects approximately 20 million Americans and is the cause of significant morbidity and mortality. Anemia, common in CKD, develops early in the disease process. It contributes to increased risk of cardiovascular disease, hospitalization, mortality, and diminishes health-related quality of life. Intravenous iron and Erythropoiesis Stimulating Agents (ESAs) are recommended for anemia management in CKD. The utilization patterns of IV iron and ESA, and their impact on hospital costs and length of stay merits investigation. Objectives: There were five general objectives of this investigation. The rate and extent of utilization of IV iron in anemic CKD …

Preventive Care Utilization Among Black Women : Perceived Beliefs, Benefits And Barriers To Mammography Screening, Rowandalla Y. Dunbar

Loma Linda University Electronic Theses, Dissertations & Projects

Blacks, in comparison to other racial or ethnic groups, suffer higher rates of illness and death from many preventable or treatable diseases. Despite the significantly higher rates of mortality and disease, Blacks are least likely to utilize clinical preventive care services. Black women, who are more likely to have advanced breast cancer at time of diagnosis (Chu, Lamar, & Freeman, 2003) are least likely to seek mammography screening (National Health Interview Study, 2000). Allen, Bastani, Bazargan and Leonard (2002) examined predictors of mammography screening among women 40 years old and older residing in the South Central area of Los Angeles, …

An After School Program To Reduce Teen Violence, Recidivism, And Prepare Teens For The Workplace In Douglas County, Georgia, Christina E. Crane

Public Health Theses

Violence is a leading cause of death and injury for juveniles and is projected to increase in the state of Georgia. Many if not most of these violent acts occur while teens are unsupervised between after school and when guardians return from work. After school programs have been proven effective in improving academic preparation and social skills while also providing adequate supervision. An additional and important component in reducing violence and other high-risk opportunities is related to workplace readiness. However, a review of existing programs concludes that there are currently no programs that contain all three components of academic preparation, …

Comparative Study Of Intravenous Insulin Protocols: Paper-Based Versus Computer-Based, Arleen B. Miller

Nursing Masters

Background: Scientific evidence exists to demonstrate that glycemic control produces a positive outcome for critically ill patients by decreasing mortality and morbidity. Results of published research have revealed a reduction of mortality in critically ill patients when serum blood glucose levels are maintained at a level of less than 150mg/dL. Recommendations from the Surviving Sepsis Campaign for treatment of patients in septic shock include use of intravenous insulin therapy to control hyperglycemia via the use of a validated protocol for insulin dose adjustment. Purpose: The purpose of this study was to determine whether glycemic control (less than 150mg/dL) was attained …

Perceptions And Evaluation Of An Urban Environment For Pedestrian Friendliness: A Case Study, Elizabeth H. Lee

Master's Theses

Public health is an increasingly important issue addressed from both environmental and public health sectors for the future development of urban environments. From a planning perspective, one possible solution is to increase walkability throughout the cities. Many assessment methods are being developed and administered to evaluate the quality of existing urban environments to promote walkable cities/communities. The results from using these methods provide policymakers and stakeholders with valuable information regarding the existing physical conditions of the environment. Although several US cities started to develop and refocus plans toward pedestrian-oriented policies approaches, results from this particular study determined that the quality …

The Transition From Hospital To Home In Parents Of Pediatric Solid Organ Transplant Recipients, Stacee M. Lerret

Dissertations (1934 -)

Readiness for hospital discharge is an under-investigated topic in pediatric solid organ transplant. The immediate post-operative period and first few weeks after transplant are a critical time period where patients are at high risk for transplant-related complications.

A correlation design framed by Meleis' Transitions Theory were used to determine; (1) the influences of discharge teaching and care coordination on parent readiness for hospital discharge among parents of children who have experienced solid organ transplantation; and (2) the relationship of parent readiness for hospital discharge with coping, adherence difficulty, utilization of healthcare resources, and family impact in the first three weeks …

The Lived Experience Of Hispanic New Graduate Nurses In The United States, Esther Morales

Dissertations (1934 -)

There has been a significant increase in the Hispanic population in the United States that is not mirrored by representation of Hispanic registered nurses in the United States . Hispanic new graduate nurses enter nursing practice with few Hispanic role models and their story is not found in nursing literature. A qualitative study with a phenomenological philosophy and methodology was conducted to investigate the lived experience of seven Mexican American new graduate nurses, a subgroup of Hispanic nurses. Findings of this study were the seven themes: (a) being an employee; (b) an orientation with or without preceptors; (c) a transition; …

The Human In 3d: Advanced Morphometric Analysis Of High-Resolution Anatomically Accurate Computed Models, Summer J. Decker

USF Tampa Graduate Theses and Dissertations

Computed virtual models of anatomical structures are proving to be of increasing value in clinical medicine, education and research. With a variety of fields focused on craniofacial and pelvic anatomy there is a need for accurate anatomical models. Recent technological advancements in computer and medical imaging technologies have provided the tools necessary to develop three-dimensional (3D) functional models of human anatomy for use in medicine (surgical planning and education), forensics and engineering (computer-aided design (CAD) and finite element analysis).

Traditionally caliper methodologies are used in the quantitative analysis of human anatomy. In order for experts in anatomy and morphometrics to …

Dispersion Of Cytotoxic Properties Of Multi-Walled Carbon Nanotubes Suspended In Biological Solutions With Tween 80: Their Role In Enhancing Killing Effects Of Nanosecond Pulse Electric Fields On Tumor Cell Lines, Bhargava S. Kalluri

Biological Sciences Theses & Dissertations

The objective of this study was to determine whether multi-walled carbon nanotubes (MWCNTs) suspended in the surfactant Tween 80 give an additive killing effect on tumor cells when exposed to nsPEFs. In this study, MWCNTs were suspended in DMEM and RPMI with or without T80 (surfactant). The size distribution of MWCNTs suspended in these solutions was evaluated with a Delsa™ Nano Zeta potential and sub micro particle Size Analyzer and confirmed with microscopy. The cytotoxicity of MWCNTs dispersed in different concentrations of T80 was evaluated in PANC1 (Human pancreatic cancer cell line) and Jurkat cell lines (Human T-cell lymphoblast cell …

The Biogeochemistry Of Submerged Coastal Karst Features In West Central Florida, Keith Michael Garman

USF Tampa Graduate Theses and Dissertations

West Central Florida is a complex karst environment with numerous sinkholes, springs, and submerged cave systems. Many of these karst features are anchialine, located within the subterranean estuary where freshwater and saltwater mix. Water quality data and/or fauna data were obtained from twenty-one karst features and their associated cave systems. The anchialine karst environment of the study area has a wide range of habitats with measured salinities ranging from freshwater at <0.2 ppt to sulfidic, hypersaline water at 38.5 ppt and measured pH readings ranging from 6.39 in water impacted by sulfur oxidizing bacteria to 10.3 in an isolated room of a cave. Stygobitic crustaceans were identified in conduits extending beneath the Gulf of Mexico supporting the hypotheses that freshwater crustaceans could survive higher sea levels in freshwater conduits beneath saltwater. The fauna associated with the anchialine cave systems included Sabellidae and Polychaeta worms, hydroids, cnidarians and hydrobiid snails. Jewfish Sink, like other anaerobic marine basins that were submarine springs, has four zones: oxic zone, transition zone, upper anoxic zone and anoxic bottom water. The upper zones have seasonal water quality variations from winter cooling and sinking of surface water and changes in the microbial communities. Activity of sulfate reducing bacteria is carbon limited in the anoxic zones, where sulfate reduction is the major metabolic process, and primary production is phosphate limited in the oxic zones. Organic input from the Gulf of Mexico drives the bacterial anaerobic ecosystem, resulting in a “sulfide pump”, in which sulfide percolates upward removing oxygen from the overlying sediment.

Assessing Plasticity : The Populations Responsible For The Epithelial Engraftment On Marrow-Derived Cells, Justin Brent Cohen

Yale Medicine Thesis Digital Library

Bone marrow-derived cells (BMDCs) have significant plasticity allowing them to give rise to various non-hematopoietic cell types including epithelial cells of the lung, liver, gut, and skin. These findings offer tremendous possibilities for the use of cell therapy to treat tissue injury and disease. However, the specific populations of cells responsible for this phenomenon are still unclear with considerable controversy over the mechanism of this transformation. In this study, we sought to compare the epithelial engraftment ability of two populations enriched for hematopoietic stem cells (HSCs), specifically the fractionated, lineage-depleted, and homed subset (FLH) and the lineage-Sca-1+c-Kit+ sorted population (LSK), …

B Cell Adam10 Activity Is Increased By Kainate Receptor Activation: Potential Role Of This Pathway In Th2 Immunity And Cancer, Jamie Sturgill

Theses and Dissertations

CD23 has long been appreciated to be a natural, negative regulator of IgE synthesis. This understanding is due in part to animal models in which CD23 deficient or CD23 transgenic animals display exacerbated or reduced IgE levels respectively. Interestingly, CD23 is susceptible to proteolytic cleavage from the cell surface. When this occurs, CD23 loses its regulatory capability and the solubilized form can lead to pro-inflammatory events through its cytokinergic activity on macrophages. Thus, targeting this specific cleavage would be beneficial to the control of allergic disease by stabilizing CD23 at the cell surface. Inhibitor studies performed by our group as …

Antifolate Modulators Of Amp-Activated Protein Kinase Signaling As Cancer Therapeutics, Scott Rothbart

Theses and Dissertations

Since its discovery, it was appreciated that the antifolate pemetrexed had multiple targets within folate metabolism. This laboratory was instrumental in showing that pemetrexed elicited its primary action as a thymidylate synthase inhibitor. Unusual for an antifolate, pemetrexed showed significant clinical activity against malignant pleural mesothelioma and non-small cell lung cancer. Accordingly, the FDA recently issued first-line approvals for pemetrexed in these diseases, leading us to question whether the effects of pemetrexed on other folate-dependent targets could explain this atypical clinical activity of the drug. Studies in this dissertation showed that in addition to thymidylate synthase inhibition, pemetrexed was also …

The Influence Of Language Production, Comprehension, And Pragmatic Judgment On Prosocial Behavior In Children With Language Impairment, Nicole Yvette Weber

Theses and Dissertations

The purpose of this study was to examine the relationship between language skills and prosocial behavior in 37 children with language impairment (LI) and 37 typically developing peers matched for age (ranging from 6;11 to 11;1 years). The influence of gender on this relationship was also considered. Three different subtests of the Comprehensive Assessment of Spoken Language (Carrow-Woolfolk, 1999) were used to evaluate language ability in the areas of language comprehension, language production and pragmatic judgment skills. The Teacher Behavior Rating Scale (C. H. Hart & Robinson, 1996) was used to evaluate prosocial behavior. The current study replicated previous research …

Transition To Fatherhood: A Puerto Rican Perspective, Suzanne Barenski

Open Access Dissertations

The purpose of this study was to explore the events that have promoted or hindered a first-time Puerto Rican father's transition to fatherhood. Interviews were conducted with twelve fathers who reported one child one year of age or less. Within the United States the Hispanic population is the largest and the fasting growing minority population. Early father involvement for immigrant and ethnically diverse families has not been widely studied. Analysis of the interview data revealed two main themes; "Accepting of Fatherhood" and "Adjusting to Fatherhood." Specific to these themes, three categories became apparent; "Buying-In: Initial Step to Fatherhood," "The Journey: …

What Women Want To Know: Assessing The Value, Relevance, And Efficacy Of A Self-Management Intervention For Rural Women With Coronary Heart Disease, Holly Evans Madison

Open Access Dissertations

Background: Women have experienced increased mortality from coronary heart disease over the last two decades, while men‘s rate has declined. This suggests that current treatment and prevention strategies are less effective for women. Furthermore, since most women don‘t participate in cardiac rehabilitation, alternatives to these programs must be explored. Purpose: This study sought to refine an intervention for rural women with coronary heart disease designed to promote self-management and provide pilot data evaluating the efficacy of the intervention. Design and Methods: The study design was mixed methods. Focused qualitative interviews provided data regarding the self-management program. In-depth interviews determined the …

Development Of A Lung Cancer-Specific Model For Support Group Interest, Laura Testerman

Loma Linda University Electronic Theses, Dissertations & Projects

Despite high levels of both emotional and physical distress and desire for utilization of support group services, lung cancer patients rarely participate in these supportive services. Lung cancer survivors’ interest in and use of supportive psychosocial services remains poorly understood, and Internet-based services may be of particular benefit to this population. The Behavioral Model for Vulnerable Populations, which emphasizes Predisposing (i.e., demographic as well as attitudes about support services), Enabling (i.e., accessibility of services), and Illness (i.e., need for services based on health) factors, was applied to the prediction of survivors’ behavioral intention to participate in face-to-face support groups (F2F) …

Facial Type Analysis Comparison Between Mri, Cbct, And Lateral Cephalometrics, Matthew A. Sanders

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Single Cephalometric measurements are comparable between Cone Beam Computed Tomography (CBCT), Magnetic Resonance Imaging (MRl) and Conventional Lateral Cephalometric (LC) imaging methods. This study evaluated the agreement between the three imaging methods in facial type analysis (using a composite of 5 cephalometric measures).

Methods and Materials: Twenty-two subjects participated in this study. Cranial images were generated via three modalities: LC, CBCT and MRl. Cephalometric landmarks were identified on the three images per subject and a facial type analysis performed. An equally weighted facial type calculation composed of 5 cephalometric measurements (facial axis, facial depth, mandibular plane, lower face height, …

Work Of Fracture In Ceramic Bracket Bonding Systems, Tye A. Roylance

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Work of fracture (WOE) is a method of analysis of the toughness or resilience of a bracket bonding system. It is an indication of a bracket bonding systems ability to withstand forces in the mouth below the force at which failure occurs. Work of fracture gives an indication of how much abuse the bracket/bonding system can withstand and still maintain an adequate adhesion to the tooth surface. This analysis incorporates shear bond strength and displacement and is determined in part by the elasticity and resilience of the specimen being studied.

Materials and Methods: One hundred and eighty bovine teeth …