Medicine and Health Sciences Commons^™

Integrating Galectin-3 Into A Computational Model Of Cardiac Fibrosis Progression, Adam Pieratt

Chemical Engineering Undergraduate Honors Theses

Cardiac fibrosis, a large contributor to heart failure, is the excessive accumulation of extracellular matrix in response to stress or injury. There are no approved treatments for cardiac fibrosis, and targeting specific species involved creates complex problems for drug development, so a computational model of the cardiac fibroblast signaling network can be used to observe the interactions involved in the progression of cardiac fibrosis. In this paper, a new protein called galectin-3 is integrated into this existing model, and connections are established to expand the coverage of the network. The additions are described, simulated using Netflux biological system simulation software, …

Modeling Sex-Specific Changes In Myocardial Fibrosis, Grace Martin

Chemical Engineering Undergraduate Honors Theses

Heart disease the leading cause of death for both men and women in the United States. Cardiac fibrosis, or accumulation of extracellular matrix proteins in the heart, can occur after a heart attack and increase the risk for further complications. Current treatments for heart disease do not include extracellular matrix regulators, partly due to the complicated signaling network responsible for the production of these proteins. By using a computational model of the signaling network in cardia fibroblasts, the relationship between particular molecules and downstream extracellular matrix production can be examined.

Biological sex is an important factor for cardiac health and …

Functional Stereotyping Of Women’S Self-Objectification As A Function Of Life History And Body Fat, Vienne Howay

Psychological Science Undergraduate Honors Theses

Individuals prioritize different goals as a function of stability in their environment, oftentimes leading people to prioritize reproduction in hostile ecologies. From this shift in priorities, perceivers could develop heuristics about how women may attempt to attract mates. Previous research suggests that higher levels of body fat are more attractive to men with a fast life history. With this awareness of men’s preferences in body fat, high-fat women from hostile ecologies could be expected to engage in more self-objectifying behavior in the service of mate attraction or attempting present themselves as objects of affection to men. This study tasked participants …

Effect Of Progesterone On Cognition Among College Aged Women, Katelyn Helberg

Biological Sciences Undergraduate Honors Theses

Women who have a reoccurring menstrual cycle and do not take hormonal birth control naturally experience changes in the amount of sex hormones that their body produces. These sex hormones help promote sexual development, fertility, and mood regulation, but can be hard to study due to their conflicting effects on each other. One such hormone, progesterone, is produced in different concentrations throughout the menstrual cycle to prepare the uterus for a potential pregnancy. However, it also may have secondhand effects on how well women can complete everyday tasks involving memory, attention, processing speed, and more which is what we measured …

Effects Of Nonpharmacological And Pharmacological Interventions On The Management Of Polycystic Ovarian Syndrome, Ellington Fagg

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: Polycystic ovarian syndrome, commonly known as PCOS, is a metabolic endocrine disorder that affects many women of childbearing age. Although PCOS is a rather common disease, there is a general lack of knowledge on how to approach treatment for different types of women.

Purpose: The purpose of this literature review is to investigate both nonpharmacological and pharmacological treatment interventions that can be used to manage both the symptoms and underlying conditions associated with PCOS.

Methodology: Twenty articles that contained a mix of clinical trials and randomized control trials were reviewed for the evidence that is included in this literature …

The Effect Of Hormonal Contraceptive Use On Dominance And Prestige Tactics, Carson Chappell

Biological Sciences Undergraduate Honors Theses

This study was designed to investigate the relationship between hormonal contraceptives and prestige and dominance status-seeking tactics. Existing literature has examined how the hormones estrogen and progesterone, especially in relation to the fertile window of the menstrual cycle, are associated with prestige and dominance but has yet to look in depth at how hormonal contraceptives might alter this impact. The current study asked participants to complete a 22- item questionnaire assessing dominance and prestige. I hypothesized that women on hormonal contraceptives would have lower scores for prestige and dominance compared to women who are naturally cycling. The results did not …

Examining Young Adult E-Cigarette Users By Device Type: A Latent Class Analysis, Mufazzela Tabassum

Health, Human Performance and Recreation Undergraduate Honors Theses

Examining Young Adult E-Cigarette Users by Device Type: A Latent Class Analysis

Purpose. This study examined which factors influence the type(s) of e-cigarette devices someone uses and if there are heterogeneous groups of young adult e-cigarette users.

Methods. This study first quantitatively explored if there are heterogeneous groups of e-cigarette users by utilizing data from an online cross-sectional survey. E-cigarette users (n = 595) were able to participate in the survey if they were 18-29 years of age, used an e-cigarette for 1-5 days in the past 30 days, own their own e-cigarette, and live in the United States. Participants …

Social Influences On Quitting E-Cigarette Use: A Mixed Method Analysis, Olivia Peterson, Page Dobbs

Health, Human Performance and Recreation Undergraduate Honors Theses

Social Influences on Quitting E-Cigarette Use: A Mixed Method Analysis

Page Dobbs, Olivia Peterson, Erin Arthur, Jessica Seymore, Jenn Veilleux, Robert Davis, Mance Buttram, Mufazzela Tabassum

Words: 250/250

Introduction. Young adult e-cigarette users report peers as a reason for using these products; however, it is unclear how social influences are associated with attempting to quit e-cigarettes. The purpose of this mixed-methods study was to examine the relationship between social factors and quitting e-cigarettes.

Methods. E-cigarette users from a large southern university were recruited to take part in an explanatory, sequential mixed-methods study. First, participants (n=423) completed a cross-sectional survey about …

Utilizing Biomimicry To Design Sustainable Architecture, Virginia Hammond

Architecture Undergraduate Honors Theses

Nature has an integral relationship with architecture and serves as a sustainable role model and inspiration for designers. The process of biomimicry in architecture has the potential to produce more sustainable design solutions and foster a connection between humans and nature. Existing biomimetic design projects have varying strengths and weaknesses as examples of the process. Utilizing guidelines and references from key leaders in biomimetic design consultancy (Biomimicry 3.8), selected case studies are assessed for their ability to demonstrate the benefits of this design strategy. Using these evaluations, the case studies are diagrammed and critiqued to determine how new projects could …

Respiratory Illnesses In Women And Children From Ghana: Problem Identification And Intervention, Stephanie Dale

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Rural communities in the upper east region of Ghana currently cook with traditional coal pots that produce increased levels of smoke resulting in rapid fuel consumption, increased air pollution, and high levels of respiratory illness in the women and children who use them. New stoves have been developed that remain similar to the traditional ones in use but are designed to provide a variety of benefits such as lowering the cost of fuel, reducing air pollution, and decreasing rates of respiratory illness in women and children. The purpose of this research study was to identify why women have not begun …

How Engaged Are Infants And Toddlers While Picture Book Reading?, Zoe Lawless

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Introduction: Literacy is a very important skill that begins to be acquired at birth. Most children start to develop pre-literacy skills by being read to by their parents or other adults around them. Being read aloud to can occur at many different ages and can start as early as infancy. As children grow, they interact and engage with books in different ways. This thesis aims to investigate the read-aloud behaviors of two different groups of young children, to reveal differences in engagement interactions among infants and young toddlers when being read picture books by their teacher.

Methods: The …

A Meta-Analysis For Laboratory Diagnostics For Coccidioidomycosis, Mary C. Cowen

Biological Sciences Undergraduate Honors Theses

Coccidioidomycosis, commonly referred to as Valley Fever, is a fungal infection found in arid regions of the southwestern United States and Mexico. Infection occurs through inhalation of airborne spores from Coccidioides species, Coccidioides immitis and/or Coccidioides posadasii, and proceeds in both pulmonary and disseminated fashions. Approximately 60% of patients with coccidioidomycosis remain asymptomatic, while 40% will experience symptoms. Within the literature, there are no papers that summarize sensitivity and specificity values between different tests; therefore, this paper presents sensitivity and specificity results across different tests and companies (Meridian, IMMY, and MiraVista).

Clinical Assessment Of Erosive Tooth Wear Objective Outcome Measures, Elizabeth Wewers

Biological Sciences Undergraduate Honors Theses

The purpose of this study was to determine whether enamel surface texture can be used as objective and quantitative measurements to detect and monitor erosive tooth wear (ETW) as an adjunct to the subjective Basic Erosive Wear Evaluation (BEWE) that is commonly used today. This longitudinal observational clinical study enrolled 32 subjects with a sample of n = 584 teeth. Conventional dental microwear surface texture parameters (surface complexity, roughness, and anisotropy - Asfc, Sa, Str, respectively) (were generated using white-light scanning confocal profilometry) from the buccal surfaces of each tooth accepted to the study. I personally scanned and analyzed n …

Examining The Effects Of Menstrual Cycle Phase And Hormonal Contraceptive Use On Women's Sleep, Charles Ethan Coombs

Psychological Science Undergraduate Honors Theses

Women overrepresent men for sub-optimal sleep, a consequence of hormone fluctuation in the menstrual cycle affecting sleep regulatory pathways. While research has examined the prevalence of sub-optimal sleep through cycle phases, little research has examined how hormonal contraceptives (HC’s) could similarly affect women’s sleep, while also neglecting to utilize subjective sleep measures. In this study, we examine subjective sleep quality among naturally cycling (NC) women, women using different HC types, and between active and inactive phase pill users by subjecting 463 women to a subjective sleep battery. We hypothesized that HC users would report more sub-optimal sleep than NC women. …

Establishing An Objective, Quantifiable Method For Detecting Erosive Tooth Wear, Camille Kita

Biological Sciences Undergraduate Honors Theses

This study aims to monitor and evaluate erosive tooth wear (ETW) by measurement of enamel surface thickness and texture in a clinical setting. The objective approach is fundamentally different from the standard subjective visual assessment that professionals in the dental field using the Basic Erosive Wear Evaluation (BEWE) method.

Twenty-nine hyposalivation and three control subjects were used in this longitudinal study, for a total of 597 samples (only 577 teeth were eligible for surface texture analysis) evaluated in a longitudinal study including both baseline and 12 month follow up surfaces. Each participant’s buccal surface of the tooth was first analyzed …

Human-Bat Interactions In A Disease Emergence Hotspot: Implications For Human Health And Bat Conservation, Reilly Tempest Jackson

Graduate Theses and Dissertations

Bats are an ecologically important taxon that can host zoonotic pathogens. Globally, many bat species are synanthropic and live closely with humans, often roosting in man-made structures. The spatial overlap between humans and bats creates opportunities for human-bat contact, which can lead to human exposure to bat-borne pathogens and conflicts that cause bat mortality. Despite this risk, little is known about the drivers and characteristics of these human-bat interactions in buildings and work is needed to understand this aspect of the wildlife-urban interface. In Chapter I, I present a literature review that identifies the geographic and taxonomic trends in reported …

Postpartum Visitation Policies, Jenna B. Holderman, Morgan E. Matthews

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: Continual support for the birthing person during labor improves delivery outcomes and overall childbirth experiences. How many support people are present and their relation to the birthing person varies based on individual preference, family dynamics, and sociocultural expectations. During the Covid-19 pandemic, many hospitals implemented a one-visitor policy for deliveries. With these new guidelines in place, the length of hospital stays significantly decreased, and there were a variety of opinions towards these restrictions.

Purpose: The purpose of this study was to explore birthing persons’ overall sentiment towards visitors in the immediate postpartum period.

Methods: The current study analyzed …

Lactation Benefits, Experiences, And Education In Bereaved Mothers: A Literature Review, Grace Davis

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Abstract

Background: Parents who lose an infant through miscarriage, elective termination, or stillbirth experience perinatal bereavement (Centers for Disease Control and Prevention, 2022). A bereaved mother’s grief could be influenced by lactation as most will still experience lactation regardless of their loss. Generally, these women are solely taught to suppress their milk production, oftentimes resulting in discomfort, leakage, clogged ducts, and even mastitis (Carroll et al., 2020). To prevent adverse effects, bereaved mothers need a comprehensive list of options and education regarding lactation including donation, expression, and suppression. Bereaved mothers' lactation experiences, education, and benefits are vital areas to be …

Moral Distress In Critical Care Nursing: A Literature Review, Anna Tindell

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Moral distress is a pressing concern in the healthcare field with significant implications for all areas of nursing and patient outcomes. However, those within the specialty of critical care nursing experience moral distress more frequently than those in other specialties. It arises from the complex ethical dilemmas nurses in critical intensive care units face as they work in these high-pressure environments. The purpose of this literature review is to discuss moral distress in critical care nursing and how it affects a nurse’s ability to provide quality care. Furthermore, this review will determine factors contributing to moral distress and potential interventions …

Social Media And Mental Health: The Public Health Impact And Future Policy Directives, Renae A. Merrill

Graduate Theses and Dissertations

The relationship between social media use among young people and the increasing concerns of mental health problems in the U.S. and globally is on systemic agendas. Furthermore, research on social media use and mental health indicate reasons to suspect a causal relationship, but more work needs to be done. Therefore, this three-article dissertation seeks to explore (1) associations between social media use, personality, and depression; (2) associations between social media emotional support, anxiety, and personality; and (3) the relationship between social media use and mental health using Deborah Stone’s causal stories framework. Findings from this study provide an improved understanding …

Utilizing The 3d Environment To Facilitate Learning Of Complex Visual Neural Pathways In The Avian Brain, Parker Straight

Graduate Theses and Dissertations

Neuroanatomical pathways are difficult to study often due to the limit of methods used to visualize the anatomical and physiologic characteristics. In many studies, a neural pathway is presented using 2D representations for structural connectivity. A problem is deciding which of three planes: coronal, sagittal, or horizontal is best for visualizing the pathway’s components clearly and spatially precise for those wanting to learn and utilize that information. A 3D environment would be imperative in solving this issue. We therefore attempted to develop a means of accurately presenting detailed anatomical structures within the 3D regions they occurred. It is our hope …

Injectable Immunomodulatory Strategies To Enhance Muscle Recovery Following Injury, Tai Huu Huynh

Graduate Theses and Dissertations

Although skeletal muscle displays an astonishing regenerative capacity, injuries or diseases that resulted in bedridden or chronic muscle wasting can overwhelm this intrinsic feature of skeletal muscle and lead to functional deficit (range of motion and/or strength) and overall reduction in quality of life. Microenvironmental cues within injured skeletal muscle dictate regenerative and repair process which are tightly coordinated interplay among resident cells, cells recruitment and immune response following an assault in the muscle extracellular matrix (ECM). The successful regeneration of functional tissues requires both appropriate modulation of the inflammatory response, and activation of a variety of cell populations. Biomaterials …

Studying The Stability Of Collagen/Heparin Coatings To Be Used In Cell Therapy Applications, Gavin Mussino

Biological Sciences Undergraduate Honors Theses

This honors thesis aims to investigate the reusability and performance of cell coatings for cell therapy applications. Cell therapy, which involves the use of human cells to repair or replace damaged tissues, holds immense potential for medical advancements. However, ensuring the survival and functionality of transplanted cells remains a significant challenge. We focused on studying the effectiveness of coatings applied to cells for improved cell growth and viability. The research project involved the preparation of the coatings using a layer-by-layer method and the subsequent seeding of cells. The coated cells were then subjected to a series of experiments to assess …

Obstacle Crossing In Healthy Young And Older Individuals, Hope M. Hanson, Ashlyn M. Jendro, Abigail C. Schmitt

Health, Human Performance and Recreation Undergraduate Honors Theses

Introduction: In the United States, the average population age is rising and will continue to increase in the coming years.With an older population comes increased risk of injury associated with falls. Falls are considered a leading cause of injury and death in older individuals, and many falls are caused by body imbalance or obstacle collision due to a clearly visible stationary object (e.g., rug, chair, branch). Older adults tend to cross obstacles with increased toe clearance in order to prevent tripping, but much of what is known about obstacle crossing in older adults is limited to artificial obstacles that are …

Evaluation Of The Effect Of Enterococcus Cecorum Exposure During Late Embryogenesis On Systemic Disease And Early Performance In Broiler Chickens, Marcela Arango

Graduate Theses and Dissertations

The objective of this thesis was to investigate the effects of Enterococcus cecorum (EC) administration into the amnion at day 18 of embryogenesis on performance and septicemia development in broiler chickens. Chapter I consists of a brief overview of the thesis. Chapter II provides a literature review on EC-related disease in broiler chickens and methods to isolate, detect, and differentiate between commensal and pathogenic strains of EC. Chapter III consists of a study conducted to determine if different EC strains isolated from field cases that exhibited septicemia and high mortality impacted hatchability, livability, organ colonization, and early performance in broiler …

Effects Of Time Restricted Feeding And Whey Protein Isolate Supplementation On Dietary Intake, Mood, And Sleep In A 12-Week Randomized Controlled Trial, Sydney Boudrey

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Background: Obesity is a quickly growing epidemic that is affecting adults in the United States leading to many chronic diseases and reduced well-being. Time Restricted Feeding (TRF) is type of dietary intervention that is gaining popularity among adults for weight loss. However, current data is lacking regarding the effectiveness of TRF on facets of well-being such as sleep and mood. Moreover, to our knowledge protein supplementation in conjunction with TRF has yet to be studied. The objective of this study was to determine the effect of time restricted feeding supplemented with whey protein isolate on food intake, sleep, and mood, …

The Relationship Between Communicative Confidence And Identity In Everyday Life For People With Aphasia, Karina Escobar

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Aphasia is primarily a neurological language disorder, which can also affect cognition, attention, and executive functioning skills. In recent years, researcher has taken an interest in understanding quality of life for people with aphasia, specifically communicative confidence, social relationships, and identity. The aim of this study was to determine how communicative confidence and social relationships affect a person’s identity, as well as the importance of therapy groups. We designed and used confidence and independence survey scales pre-aphasia, post-aphasia but before attending aphasia therapy groups, and post-aphasia and after having attended aphasia therapy groups. We also asked clarifying questions based on …

The Effects Of Sound-Based Intervention On The Daily Performance Of College-Aged Students, Claire Pribble

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

A mixed-methods summary examining the effects of The Listening Program (TLP) on the daily performance of a graduate student is presented. This is a pilot study that will observe the impacts of this program and the possible improvements in focus, visual perception, time management, behavior, and emotional and social regulation. Improvements in self-control/belief and overall stress management were noted.

This case study focuses on one college-aged individual who is successfully and independently managing her graduate experience, receives no accommodations for disability, and has no previous experience with The Listening Program. Self-reports indicated high levels of intermittent stress and anxiety which …

Measuring Awareness Of Spd And Interprofessional Collaboration And Practices Among Professionals In An Elementary Public School Setting, Kyra Resende

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Sensory Processing Disorder (SPD) is a neurological condition in which the brain has trouble receiving and responding to sensory information, which can lead to sensory dysregulation (Rodden, 2023). Because everyone constantly receives sensory input, having SPD can impact a child’s life in numerous ways, such as academic and social success. Research indicates that 5% to 16% of students may have this neurological condition (Bunim, 2013), which is significant enough to expect that school professionals have appropriate awareness about SPD. Additionally, there is usually an overlap of professionals who serve students experiencing SPD, resulting in a need for interprofessional collaboration (IPC) …

A Meta-Analysis Of The Correlation Between Historical Trauma And Health Outcomes In The Native American Population, Taylen Day

Psychological Science Undergraduate Honors Theses

Native Americans experience significant health disparities such as increased rates of
cardiovascular disease, diabetes, and mental illness. Recent research has suggested that historical trauma may be a contributing factor. This meta-analysis examined the association between historical trauma and health outcomes in Native Americans in the United States and Canada. Data from 14 studies (N = 14,698, 35 effect sizes) examining the physical health, mental health, and substance use domains and using the Historical Loss Scale were collected for analysis. Possible moderating factors were also examined. Overall, a small, significant association (r =.124) was found between historical trauma and health outcomes. …