Medicine and Health Sciences Commons^™

Distinguishing Leukemic Cells Using Fractal Chromatin Patterns And Machine Learning, Abigail Gordhamer, Paul Young, Ryan Cordner

Annual Research Symposium

One of the most important tests in the clinical laboratory is the Complete Blood Count, which involves identifying the white blood cells in a patient’s blood. The respective counts of the different white blood cell types correlate with various states of health and disease, and are critical to diagnosing diseases such as leukemia. Leukemic cells are considered especially difficult to distinguish, and it is of the upmost importance that these cells are identified correctly. To aid in the process of leukemic cell identification, we quantified fractal patterns in the chromatin of white blood cells and used the data to identify …

Alginate Dressings- Revisiting The Past, Oshine Jha, Oshine Jha

Annual Research Symposium

Wound healing in simple terms is the healing of skin which involves various mechanisms. It is not dressings themselves that heal wounds, but the careful selection of appropriate dressings that provide the optimal wound-healing environment for the individual wound. Wound dressings are prepared from biopolymers, synthetic polymers and biomaterials.

Pathogenic Implications Of Candidal Species In Both Oral Cancer And Oral Potentially Malignant Disorders - A Review, Dr Dominic Augustine, Sowmya Sv, Kuntala Mondal

Annual Research Symposium

Oral squamous cell carcinoma (OSCC) is the 6th most common cancer in worldwide. Cigarette smoking, alcohol consumption, and betel quid chewing are its major risk factors other factors that can lead to OSCC include excessive sun exposure, viral or fungal infection, poor nutrition, and poor oral hygiene. The carcinogenesis of OSCC occurs gradually and oral epithelial dysplasia is considered a potential histologic precursor of OSCC. Most OSCC cases are preceded by clinically evident oral potentially malignant disorders (OPMDs). The aim of this review is to correlate the association between Candida species and oral potentially malignant disorders and its possible mechanisms …

Immunohistochemical Expression Of Cyclin D1 In Dentigerous Cyst, Odontogenic Keratocyst And Unicystic Ameloblastoma- An In-Vitro Study, Kuntala Mondal, Sv Sowmya, Dominic Augustine

Annual Research Symposium

Cyclin D1, a G1 cyclin member, regulates the transition of the cell cycle from the G1 phase to the S phase. The uncontrolled and elevated expression of cyclin D1 has been associated with rapid growth, heightened proliferative activity and increased histologic aggressiveness. Unicystic ameloblastoma pertains to cystic lesions that present clinical, radiographic, or gross features akin to jaw cysts. Nevertheless, upon histological scrutiny, these lesions display a distinctive ameloblastomatous epithelium lining the cystic cavity, with or without luminal or mural proliferation. This cystic variant of tumor bears substantial resemblances to dentigerous cysts, and occasionally, both entities can become indistinguishable upon …

An Immunohistochemical Panel For The Accurate Differentiation Between Mucoepidermoid Carcinoma And Pleomorphic Adenoma, Kuntala Mondal, Sv Sowmya, Dominic Augustine

Annual Research Symposium

Salivary Gland Tumors (SGTs) are a diverse group of neoplasms, with a wide range of histological subtypes, some of which can exhibit overlapping features. Amongst this group of tumors, Pleomorphic Adenoma (PA) and Mucoepidermoid Carcinoma (MEC) stand out as prevalent entities originating from the salivary glands. The accurate differentiation between these two entities is crucial for treatment planning, as it influences decisions regarding the extent of surgical resection. Because of the overlapping histopathological features, it is difficult to differentiate these two lesions with the help of conventional Hematoxylin & Eosin (H& E). The evaluation of Immunohistochemical (IHC) markers holds pivotal …

Cheiloscopic Characteristics Detection And Pattern Classification By Machine Learning Technique, Dr Dominic Augustine, Sowmya Sv

Annual Research Symposium

Machine Learning (ML) is a field enhancing the rapid growth of technology. Though use of digital softwares for cheiloscopic investigations have been attempted with limited success, the use of ML based techniques are scarce and seldom have been employed in forensic odontology. The present study aimed to identify cheiloscopic patterns through machine learning based methods and to correlate the segmented patterns with age and gender of individuals.

Association Between Abo Blood Grouping And Odontometry: An Unexplored Evidence In Forensics, Dr Dominic Augustine, Sowmya Sv

Annual Research Symposium

Recent research has exhibited a strong association between ABO blood groups and susceptibility to diseases. Extraoral and intraoral hard tissue landmarks provide a stable and reliable record for odontological and anthropological analysis, forensic investigations and identification. The association between anthropometric indices and ABO blood grouping have been reported in the past, however, the association between ABO blood groups and odontometric indices is yet to be comprehensively explored. This study aimed to establish the correlation of ABO blood groups with odontometric indices and extraoral hard tissue landmarks for personnel identification.

Awareness Of The 20-20-20 Rule Amongst Students, Faculty, And Staff, Joseph Bachman, Jonathon Reynolds, Elizabeth Turner, Tipsuda Junsanto-Bahri Md

Annual Research Symposium

In the past several years, medical schools have increased utilization of recorded lectures and electronic devices: computers, smartphones, and tablets. Increased screen exposure hours where students, faculty, and staff may acquire eye strain. Many are not aware of the 20-20-20 rule: for every 20 minutes of screen time, it is recommended to look at something 20 feet away for 20 seconds; a reminder to take frequent breaks to help prevent eye strain. We want to share reports from our institution regarding student, faculty and staff digital device usage and awareness of the 20-20-20 rule.

Assessing The Prevalence Of Computer Vision Syndrome At An Osteopathic Medical School With An Electronic Content Delivery Model, Jonathon Reynolds, Joseph Bachman, Elizabeth Turner, Tipsuda Junsanto-Bahri Md

Annual Research Symposium

To determine the overall prevalence of computer vision syndrome (CVS) among students, faculty, and staff while promoting awareness. CVS is caused by extended screen exposure that can lead to eye discomfort and vision changes which can affect quality of life and educational performance. Our institution is a new Osteopathic medical school that aims to create an innovative approach to medical education delivery via employment of modern technology that is already prevalent. Implementation of pre-recorded lecture materials in the curriculum requires 4-6 additional electronic screen exposure hours. Members of our institution are potentially at increased risk for CVS stemming from the …

Advanced Techniques For Tooth Pulp Rna Extraction In Forensic Investigations-A Systematic Review, Kuntala Mondal, Sv Sowmya, Dominic Augustine

Annual Research Symposium

Teeth are fundamental structures in a forensic context due to their high strength and specificity. It is challenging to obtain high quality RNA from pulpal tissues. It has been described that pulp RNA degradation could be an indicator of post-mortem interval. Researchers have been in the quest to develop optimal techniques for tooth RNA extraction. The systematic review aimed to determine the most reliable method of RNA extraction from dental tooth pulp for forensic investigations.

Assessment Of Micrometastasis In Lymph Nodes Of Oral Squamous Cell Carcinoma –Attaining Excellence Through Immunohistochemistry, Dr Dominic Augustine, Sowmya Sv, Kuntala Mondal

Annual Research Symposium

Cervical lymph node metastasis is the most important prognostic factor in Squamous Cell Carcinoma of Head and Neck (SCCHN). Lymph node prognostic determinants hold immense significance in influencing both patient’s survival outcomes and the propensity for recurrence. The current study aimed to evaluate the diagnostic accuracy of Cyclin D1 and Pan-CK for the detection of lymph node micrometastasis in oral squamous cell carcinoma tissue sections and re-evaluate the tumor staging.

Harm Reduction Measures In Substance Use Disorder (Sud), Kent Wood

Annual Research Symposium

This literature review aims to comprehensively analyze harm reduction strategies employed in addressing Substance Use Disorder (SUD). Focusing on key interventions such as fentanyl testing strips, naloxone distribution, syringe exchange programs, and methadone/buprenorphine clinics, the study seeks to evaluate the effectiveness of these approaches in reducing the associated harms of substance misuse.

Substance Use Disorder –The Role Of The Pharmacist, Mackenzie Cruzan

Annual Research Symposium

The study illuminates the pivotal role of community pharmacists as accessible healthcare providers, offering medication management, patient education, and preventive care services. Simultaneously, it explores the intricate responsibilities of inpatient pharmacists, emphasizing their involvement in therapeutic monitoring and collaboration with healthcare teams.

Once Upon A Lime: A Tale Of Pediatric Phytophotodermatitis, Kyanna Orr

Annual Research Symposium

Phytophotodermatitis is a blistering skin condition caused by photoactivation of furocoumarins in certain plants including limes, carrots, and parsnips. High clinical suspicion based on the presentation and distribution of a patient’s findings, followed by thorough history-taking and identification of an exposure, were enough to diagnose this condition in an otherwise healthy child.

Clinical, Radiographic And Biochemical Evaluation Of One-Piece Vs Two-Piece Single Implants After 5 Years Of Functional Loading, Ippolito Caputo

Annual Research Symposium

The aim of this study was to compare the clinical and radiographic conditions and the expression of proinflammatory cytokines in peri-implant crevicular fluid (PICF) of two-piece/bone level (TP/BL) versus one-piece/tissue level (OP/TL) single implants with a laser-microgrooved collar after at least 5 years of functional loading.

Anti-Erosion Potential Of Fluoride Solutions Associated With Aminomethacrylate Copolymer: In Situ Randomized Crossover Study, Taiana Paola Prado, Karine Carvalho Dos Santos, Carlos Rocha Gomes Torres, Tais Scaramucci, Idalina Vieira Aoki, Alessandra Buhler Borges

Annual Research Symposium

The anti-erosion potential of fluoride solutions associated with aminomethacrylate (AMC) was evaluated in the presence of acquired pellicle on enamel and dentin. It is concluded that AMC was able to increase the anti-erosion potential of fluoride solutions in the presence of acquired pellicle.

Influence Of Intraradicular Restoration Technique On The Biomechanical Behavior Of Upper Canines, Ana Paula Gomes

Annual Research Symposium

This study assessed the stress distribution in endodontically treated upper canines subjected to the cementation of two types of intraradicular retainers.

Detection Of Cervical Lymph Node Micrometastasis - A Machine Learning Based Approach, Dr. Sowmya Sv, Dominic Augustine, Kuntala Mondal

Annual Research Symposium

No abstract provided.

Influence Of Abutments Surface (Machined Vs. Laser-Microgrooved) In Soft-Tissue Response During One Year Of Function: Clinical And Biochemical Outcomes Of A Rct With Split-Mouth Design, Elisa Maccari

Annual Research Symposium

To evaluate peri-implant soft tissue behaviour around machined vs laser-microgrooved implants/healing/prosthetic abutments during 1 year of function by assessing IL-6, IL-1b and MMP-8 levels in peri-implant crevicular fluid (PICF).

Clinical Success Of Restorations With Bioactive And Non-Bioactive Materials: Systematic Review And Network Meta-Analysis, Juliana Benace Fernandes, Sheila Mondragón Contreras, Eduardo Bresciani, Taciana Marco Ferraz Caneppele

Annual Research Symposium

The oral cavity is a complex and dynamic environment with frequent pH and temperature changes that can affect the longevity of dental restorations. Consequently, bioactive restorative materials, capable of advantageous interactions with the oral environment and dental tissues, are promising alternatives. However, there is limited scientific evidence of their clinical performance. Therefore, we conducted this systematic review and network meta-analysis of clinical studies to address the research question: Does the clinical evaluation of restorations on permanent teeth with bioactive materials show greater success rates than those with non-bioactive materials?

Matlab Based Phenotypic Evaluation And Gene Expression Of Cd44 And Cd133 Biomarkers In The Prediction Of Oral Squamous Cell Carcinoma Metastasis, Dr. Sowmya Sv

Annual Research Symposium

Oral cancer accounts to 20–30% of all cancers in India. The major difficulty in managing carcinomas is due to failure in the control and detection of metastases (>90% deaths). Cancer stem cells (CSCs) are tumor-initiating cells that survive even after extensive radiotherapy and chemotherapy. Recently, the use of computer-assisted quantification methods employing image processing is drawing attention wherein information can be automatically extracted from the immunostained digitized images. The aim of the study was to assess the metastatic risk of Oral Squamous Cell Carcinoma (OSCC) by the phenotypic evaluation and gene expression of CD44 and CD133 biomarkers with clinical …

Determination Of The Correlation Between Age And Gender With Canine Index, Intermolar Width And Palatal Rugae Patterns, Dr. Sowmya Sv, Dominic Augustine

Annual Research Symposium

Dental records are of paramount importance in human identification considering the distinct traits of every individual. Although DNA and finger print analysis are techniques employed for faster and secure identification, in mass disasters, odontometric analysis can play a vital role in identification. Studies in the past have used parameters like arch perimeters, lip prints and palatal rugae pattern to determine age and gender of an individual. However, these studies correlated one parameter at a time and concluded that there was no significant correlation of the parameters to age and gender. The present study aimed to assess the canine index, intermolar …

Efficacy Of Bone Marrow Aspirates In Bone Regeneration Compared To Conventional Bone Grafts- A Systematic Review, Hannah Kadic, Shilpa Bhandi, Kamran H. Awan, Frank Licari, Shankargouda Patil

Annual Research Symposium

The search for a superior bone graft substitute compared to the gold standard of harvesting autogenous bone grafts has plagued dentists for decades. With the advent of tissue engineering, the search has been aimed at bone graft substitutes with osteogenic potential, in addition to the osteoinductive and osteoconductive properties. Bone Marrow Aspirates (BMAs) has evolved as a potential adjunct to conventional bone grafts that can substantially enhance the bone regeneration potential of these materials. The present systematic review aims to explore and assess the literature on the efficacy of bone marrow aspirates in new bone formation.

Silver Nano Particle Or Sodium Hypochlorite A Better Denture Cleanser, Dr.Tessa Kuriachan, Dr.Rahul Senan, Dr. Parvathy B, Dr. Keerthi Pt

Annual Research Symposium

Denture hygiene is compromised both due to the limitations of the denture base material as well as the lack of manual dexterity of denture wearers. Moreover, the rough tissue surface of the dentures affect the initial formation of candidal biofilms probably because it provides a greater surface area and protected sites for colonization. Among the various methods available to disinfect dentures, chemical method using Sodium hypochlorite seems to be the most effective one. Even though sodium hypochlorite is an effective denture cleanser,it has many disadvantages like the increased roughness of the denture surface and decreased colour stability. So a better …

Association Of Sleep Quality With Academic Performance Among Undergraduate Dental Students, Kamyar Bagheri, Shilpa Bhandi, Kamran Awan, Frank Licari, Shankargouda Patil

Annual Research Symposium

This systematic review aimed to assess the association between sleep quality and academic performance among undergraduate dental students.

Methods: Electronic databases of Scopus, Embase, Medline, and Web of Science were searched for relevant papers published in the English language in May 2023.Study selection, data extraction and quality assessment were performed in duplicate with JBI Institute’s Critical Appraisal Checklist used to quality assessment. GRADEwas used to assess certainty of evidence.

Mechanical Behavior Of Premolars With Incomplete Rhizogenesis After Apexification And Revascularization A Finite Element Study, Camila Barbosa, Fernando Faria-Júnior, Gustavo Guerrero, Ana Carolina Silva, Alexandre Borges, Marcia Valera

Annual Research Symposium

The aim of this study was to evaluate the mechanical resistance of premolars with incomplete rhizogenesis using the FEA methodology, comparing apexification methods and regenerative endodontic procedures.

Confidence Of Clark County Medical Students In Identifying Dermatologic Conditions On Different Fitzpatrick Skin Types, Ramaditya Srinivasmurthy

Annual Research Symposium

Racial health disparities are apparent in the field of dermatology across the United States. Certain dermatologic conditions are more likely to go undiagnosed in people with skin of color (SOC), leading to increased morbidity/mortality. Underrepresentation of darker skin tones in medical education may be a contributing factor. This study explores the ability and confidence of TUNCOM students to recognize dermatological conditions on various skin tones.

A 23 question survey was given to 173 second year students to examine their ability and confidence in identifying dermatologic conditions on non-SOC (Fitzpatrick I-III) and SOC (Fitzpatrick IV-VI). Images of common skin disorders on …

Convolutional Neural Network Based Analysis - An Aid To Diagnose Bacterial And Fungal Osteomyelitis, Saiprasad Alva, Dominic Augustine, Sowmya Sv, Mukul Saini, Sanjana Shetty

Annual Research Symposium

Osteomyelitis may be classified as Bacterial (Actinomycotic), Fungal (Mucormycotic), or combined based on the etiological agent. During histopathological examination, there is a high chance that bacterial colonies or fungal hyphae may be missed by the human eye, especially when there is a paucity of organisms. This may lead to a faulty diagnosis of the type of osteomyelitis which along with an improper treatment plan would cause further progression of the disease and various other complications. Therefore, the diagnosis of the exact etiological variant of osteomyelitis is of prime importance to design an appropriate treatment plan. In the present study, bone …

Influence Of Sleep Pattern And Oral Hydration On Academic Performance Among Undergraduate Dental Students-A Pilot Study, Bassam Alibrahim

Annual Research Symposium

Sound sleep is important for preserving good physical, mental, and emotional health. An association with learning skills, critical decision making and thinking is also observed [1]. Poor hydration is associated with several health outcomes including poor oral health and academic performance. Timely assessment of oral hydration of students holds a potential to improve their oral health and academic performance [1, 2]. This study is designed to investigate the influence of oral hydration status and sleep deprivation on academic achievements of dental college undergraduates

Development Of A Portable And Rapid Decalcification Device For Oral Hard Tissue Specimens, Upasana Das, Vijayalakshmi Bhat, Taniya Feroz, Sowmya Sv, Dominic Augustine

Annual Research Symposium

Decalcification is a routinely carried out procedure by oral pathologists, as the lesions involving the pulp can only be seen and identified through decalcified sections. The present methods involve usage of chemical agents, either with inorganic acids which dissolves the calcium to form soluble calcium salts or with chelating agents. Even though the chelating agents preserve the tissue morphology and show excellent microscopic picture, it has less diagnostic efficacy, as the time taken for it to decalcify the specimens is considerably high. It becomes important for us to develop a decalcification technique which will be faster and will maintain the …