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Nephrology

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Disruption Of Apol1-Mir193a Axis Induces Disorganization Of Podocyte Actin Cytoskeleton, V. Kumar, N. Paliwal, K. Ayasolla, H. Vashistha, A. Jha, N. Chandel, S. Chowdhary, M. A. Saleem, A. Malhotra, P. C. Singhal, +2 Additional Authors Jan 2019

Disruption Of Apol1-Mir193a Axis Induces Disorganization Of Podocyte Actin Cytoskeleton, V. Kumar, N. Paliwal, K. Ayasolla, H. Vashistha, A. Jha, N. Chandel, S. Chowdhary, M. A. Saleem, A. Malhotra, P. C. Singhal, +2 Additional Authors

Journal Articles

No abstract provided.


Fibrillary Glomerulonephritis: An Update, J. L. Rosenstock, G. S. Markowitz Jan 2019

Fibrillary Glomerulonephritis: An Update, J. L. Rosenstock, G. S. Markowitz

Journal Articles

© 2019 International Society of Nephrology Fibrillary glomerulonephritis (FGN) is a rare proliferative form of glomerular disease characterized by randomly oriented fibrillar deposits with a mean diameter of 20 nm. By immunofluorescence (IF), the deposits stain for IgG, C3, and κ and λ light chains, suggesting that the fibrils may be composed of antigen-antibody immune complexes. A recent major advance in our understanding of the pathogenesis of FGN resulted from the discovery that a major component of the fibrils is DNA-J heat-shock protein family member B9 (DNAJB9), and immunohistochemical staining for DNAJB9 now makes it possible to diagnose FGN in the ...


A 30-Year-Old Carrier Of Gaucher Disease With Multiple Myeloma., J. Chadha, T. Sahai, J. Schwimmer, D. Shani Jan 2019

A 30-Year-Old Carrier Of Gaucher Disease With Multiple Myeloma., J. Chadha, T. Sahai, J. Schwimmer, D. Shani

Journal Articles

We are reporting a case of a 30-year-old male with no past medical history who presented with new onset of renal failure, anemia, and splenomegaly and was diagnosed with multiple myeloma. Given the splenomegaly and the patient's Jewish heritage, blood tests were done and the patient was found to be a Gaucher disease carrier. The association of Gaucher disease and multiple myeloma has previously been reported; however, we want to describe the case of a young Gaucher disease carrier who developed multiple myeloma and provide a review of the literature.


Randomized Controlled Trial Of Subcutaneous Epoetin Alfa-Epbx Versus Epoetin Alfa In End-Stage Kidney Disease, S. Fishbane, B. S. Spinowitz, W. A. Wisemandle, N. E. Martin Jan 2019

Randomized Controlled Trial Of Subcutaneous Epoetin Alfa-Epbx Versus Epoetin Alfa In End-Stage Kidney Disease, S. Fishbane, B. S. Spinowitz, W. A. Wisemandle, N. E. Martin

Journal Articles

© 2019 Introduction: This double-blind, randomized controlled trial compared the safety and efficacy of subcutaneous epoetin alfa-epbx, an epoetin alfa biosimilar, with the reference product, epoetin alfa, in hemodialysis patients with end-stage kidney disease (ESKD) and anemia who were receiving epoetin alfa maintenance treatment. Methods: Eligible patients (n = 320) were randomized (1:1) to subcutaneous epoetin alfa-epbx or epoetin alfa in a titration phase; patients who demonstrated stable subcutaneous dosing (n = 246) were re-randomized to receive subcutaneous epoetin alfa-epbx or epoetin alfa 1 to 3 times per week in a 16-week maintenance phase. Co-primary endpoints were least-squares mean difference between treatments ...


Risk Factors Associated With Post-Kidney Transplant Malignancies: An Article From The Cancer-Kidney International Network, B. Sprangers, V. Nair, V. Launay-Vacher, L. V. Riella, K. D. Jhaveri Jan 2018

Risk Factors Associated With Post-Kidney Transplant Malignancies: An Article From The Cancer-Kidney International Network, B. Sprangers, V. Nair, V. Launay-Vacher, L. V. Riella, K. D. Jhaveri

Journal Articles

© The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA.. In kidney transplant recipients, cancer is one of the leading causes of death with a functioning graft beyond the first year of kidney transplantation, and malignancies account for 8-10% of all deaths in the USA (2.6 deaths/1000 patient-years) and exceed 30% of deaths in Australia (5/1000 patient-years) in kidney transplant recipients. Patient-, transplant- and medication-related factors contribute to the increased cancer risk following kidney transplantation. While it is well established that the overall immunosuppressive dose is associated with an increased risk for cancer following transplantation ...


Chimeric Antigen Receptor T Cell Therapy And The Kidney What The Nephrologist Needs To Know, K. D. Jhaveri, M. H. Rosner Jan 2018

Chimeric Antigen Receptor T Cell Therapy And The Kidney What The Nephrologist Needs To Know, K. D. Jhaveri, M. H. Rosner

Journal Articles

No abstract provided.


Modulation Of Apolipoprotein L1-Microrna-193a Axis Prevents Podocyte Dedifferentiation In High-Glucose Milieu, A. Mishra, K. Ayasolla, V. Kumar, X. Lan, H. Vashistha, R. Aslam, A. Hussain, S. Chowdhary, A. Malhotra, P. C. Singhal, +6 Additional Authors Jan 2018

Modulation Of Apolipoprotein L1-Microrna-193a Axis Prevents Podocyte Dedifferentiation In High-Glucose Milieu, A. Mishra, K. Ayasolla, V. Kumar, X. Lan, H. Vashistha, R. Aslam, A. Hussain, S. Chowdhary, A. Malhotra, P. C. Singhal, +6 Additional Authors

Journal Articles

No abstract provided.


Medication Discrepancies In Late-Stage Chronic Kidney Disease., J. Ibrahim, A. D. Hazzan, A. T. Mathew, V. Sakhiya, M. Zhang, C. Halinski, S. Fishbane Jan 2018

Medication Discrepancies In Late-Stage Chronic Kidney Disease., J. Ibrahim, A. D. Hazzan, A. T. Mathew, V. Sakhiya, M. Zhang, C. Halinski, S. Fishbane

Journal Articles

Background: Late-stage chronic kidney disease (LS-CKD) can be defined by glomerular filtration rate (GFR) 0-30 mL/min. It is a period of risk for medication discrepancies because of frequent hospitalizations, fragmented medical care, inadequate communication and polypharmacy. In this study, we sought to characterize medication discrepancies in LS-CKD.

Methods: We analyzed all patients enrolled in Northwell Health's Healthy Transitions in LS-CKD program. All patients had estimated GFR 0-30 mL/min, not on dialysis. Medications were reviewed by a nurse at a home visit. Patients' medication usage and practice were compared with nephrologists' medication lists, and discrepancies were characterized. Patients ...


Barriers To Peritoneal Dialysis In Aboriginal Patients, A. T. Mathew, J. Park, M. Sachdeva, M. M. Sood, K. Yeates Jan 2018

Barriers To Peritoneal Dialysis In Aboriginal Patients, A. T. Mathew, J. Park, M. Sachdeva, M. M. Sood, K. Yeates

Journal Articles

© The Author(s) 2018. Background: Aboriginal people in Canada have an unduly high burden of end-stage kidney disease (ESKD) and many live in rural settings. Peritoneal dialysis (PD) is a home-based dialysis modality that may provide a valuable alternative to in-center hemodialysis which is relatively underutilized by the Aboriginal population. Objective: We aim to assess the barriers to PD utilization in Aboriginal patients with ESKD. Design: This article is a prospective observational cohort study. Setting: The setting involves 3 predialysis clinics in Winnipeg, Kingston, and Moose Factory. Patients: The patients were 99 individuals (67 non-Aboriginal and 32 Aboriginal) who were ...


Hemoglobin Response To Ferric Citrate In Patients With Nondialysis-Dependent Chronic Kidney Disease And Iron Deficiency Anemia, P. E. Pergola, S. Fishbane, R. D. Lewinter, J. F. Neylan, K. Uhlig, G. A. Block, G. M. Chertow Jan 2018

Hemoglobin Response To Ferric Citrate In Patients With Nondialysis-Dependent Chronic Kidney Disease And Iron Deficiency Anemia, P. E. Pergola, S. Fishbane, R. D. Lewinter, J. F. Neylan, K. Uhlig, G. A. Block, G. M. Chertow

Journal Articles

No abstract provided.


Nephropathology Education During Nephrology Fellowship Training In The United States, V. Mechery, T. Hernandez, A. T. Mathew, R. Wanchoo, S. V. Seshan, K. D. Jhaveri, H. H. Shah Jan 2018

Nephropathology Education During Nephrology Fellowship Training In The United States, V. Mechery, T. Hernandez, A. T. Mathew, R. Wanchoo, S. V. Seshan, K. D. Jhaveri, H. H. Shah

Journal Articles

No abstract provided.


Prevalence Of Proteinuria And Albuminuria In An Obese Population And Associated Risk Factors., J. L. Rosenstock, M. Pommier, G. Stoffels, S. Patel, M. F. Michelis Jan 2018

Prevalence Of Proteinuria And Albuminuria In An Obese Population And Associated Risk Factors., J. L. Rosenstock, M. Pommier, G. Stoffels, S. Patel, M. F. Michelis

Journal Articles

Obesity has been increasingly recognized as a risk factor for kidney disease and both proteinuria and microalbuminuria have been associated with obesity. The actual prevalence of microalbuminuria and proteinuria in obese patients in the United States (US) has not been clearly described in the literature. Furthermore, obesity is associated with risk factors of kidney disease, such as diabetes and hypertension (HTN), and the prevalence of proteinuria and albuminuria excluding these risk factors is uncertain. In this study, we collected urine albumin/creatinine and urine protein/creatinine ratios on obese patients undergoing bariatric surgery to determine the prevalence of albuminuria and ...


Prevalence Of Proteinuria And Albuminuria In An Obese Population And Associated Risk Factors, J. L. Rosenstock, M. Pommier, G. Stoffels, S. Patel, M. F. Michelis Jan 2018

Prevalence Of Proteinuria And Albuminuria In An Obese Population And Associated Risk Factors, J. L. Rosenstock, M. Pommier, G. Stoffels, S. Patel, M. F. Michelis

Journal Articles

©2018 Rosenstock, Pommier, Stoffels, Patel and Michelis. Obesity has been increasingly recognized as a risk factor for kidney disease and both proteinuria and microalbuminuria have been associated with obesity. The actual prevalence of microalbuminuria and proteinuria in obese patients in the United States (US) has not been clearly described in the literature. Furthermore, obesity is associated with risk factors of kidney disease, such as diabetes and hypertension (HTN), and the prevalence of proteinuria and albuminuria excluding these risk factors is uncertain. In this study, we collected urine albumin/creatinine and urine protein/creatinine ratios on obese patients undergoing bariatric surgery ...


Practice Patterns In Transitioning Patients From Chronic Kidney Disease To Dialysis: A Survey Of United States Nephrologists, M. C. Mallappallil, S. Fishbane, R. Wanchoo, E. Lerma, A. Roche-Recinos, M. Salifu Jan 2018

Practice Patterns In Transitioning Patients From Chronic Kidney Disease To Dialysis: A Survey Of United States Nephrologists, M. C. Mallappallil, S. Fishbane, R. Wanchoo, E. Lerma, A. Roche-Recinos, M. Salifu

Journal Articles

No abstract provided.


Mortality And Hospitalizations In Intensive Dialysis: A Systematic Review And Meta-Analysis, A. Mathew, J. A. Mcleggon, N. Mehta, S. Leung, V. Barta, T. Mcginn, G. Nesrallah Jan 2018

Mortality And Hospitalizations In Intensive Dialysis: A Systematic Review And Meta-Analysis, A. Mathew, J. A. Mcleggon, N. Mehta, S. Leung, V. Barta, T. Mcginn, G. Nesrallah

Journal Articles

© The Author(s) 2018. Background: Survival and hospitalization are critically important outcomes considered when choosing between intensive hemodialysis (HD), conventional HD, and peritoneal dialysis (PD). However, the comparative effectiveness of these modalities is unclear. Objective: We had the following aims: (1) to compare the association of mortality and hospitalization in patients undergoing intensive HD, compared with conventional HD or PD and (2) to appraise the methodological quality of the supporting evidence. Data Sources: MEDLINE, Embase, ISI Web of Science, CENTRAL, and nephrology conference abstracts. Study Eligibility, Participants, and Interventions: We included cohort studies with comparator arm, and randomized controlled trials ...


Intravenous Epoetin Alfa-Epbx Versus Epoetin Alfa For Treatment Of Anemia In End-Stage Kidney Disease, S. Fishbane, B. Singh, S. Kumbhat, W. A. Wisemandle, N. E. Martin Jan 2018

Intravenous Epoetin Alfa-Epbx Versus Epoetin Alfa For Treatment Of Anemia In End-Stage Kidney Disease, S. Fishbane, B. Singh, S. Kumbhat, W. A. Wisemandle, N. E. Martin

Journal Articles

© 2018 by the American Society of Nephrology. Background and objectives This study was conducted to compare the safety and efficacy of intravenous epoetin alfa-epbx, an epoetin alfa biosimilar, to epoetin alfa in patients on hemodialysis with ESKD and anemia. Design, setting, participants, & measurements In this 24-week, multicenter, double-blind comparative efficacy and safety study, 612 patients on hemodialysis with ESKD and anemia who had stable hemoglobin and were receiving stable doses of intravenous epoetin alfa were randomized (1:1) to intravenous epoetin alfa or epoetin alfa-epbx. Dosing was adjusted according to the epoetin alfa prescribing information. The coprimary efficacy endpoints were ...


Opportunities For Increasing The Rate Of Preemptive Kidney Transplantation, S. Fishbane, V. Nair Jan 2018

Opportunities For Increasing The Rate Of Preemptive Kidney Transplantation, S. Fishbane, V. Nair

Journal Articles

No abstract provided.


Strongyloides Stercoralis−Associated Tip Variant Focal Segmental Glomerulosclerosis, M. Merzkani, N. N. Uppal, D. W. Ross, P. Gautam-Goyal, P. Malhotra, H. H. Shah, K. D. Jhaveri, V. D. D'Agati Jan 2018

Strongyloides Stercoralis−Associated Tip Variant Focal Segmental Glomerulosclerosis, M. Merzkani, N. N. Uppal, D. W. Ross, P. Gautam-Goyal, P. Malhotra, H. H. Shah, K. D. Jhaveri, V. D. D'Agati

Journal Articles

No abstract provided.


Apol1 Risk Variants Cause Podocytes Injury Through Enhancing Endoplasmic Reticulum Stress, H. Wen, V. Kumar, X. Lan, S. S. Shoshtari, J. M. Eng, X. Zhou, F. Wang, H. Wang, A. Malhotra, P. C. Singhal, +4 Additional Authors Jan 2018

Apol1 Risk Variants Cause Podocytes Injury Through Enhancing Endoplasmic Reticulum Stress, H. Wen, V. Kumar, X. Lan, S. S. Shoshtari, J. M. Eng, X. Zhou, F. Wang, H. Wang, A. Malhotra, P. C. Singhal, +4 Additional Authors

Journal Articles

c 2018 The Author(s). Two coding sequence variants (G1 and G2) of Apolipoprotein L1 (APOL1) gene have been implicated as a higher risk factor for chronic kidney diseases (CKD) in African Americans when compared with European Americans. Previous studies have suggested that the APOL1 G1 and G2 variant proteins are more toxic to kidney cells than the wild-type APOL1 G0, but the underlying mechanisms are poorly understood. To determine whether endoplasmic reticulum (ER) stress contributes to podocyte toxicity, we generated human podocytes (HPs) that stably overexpressed APOL1 G0, G1, or G2 (Vec/HPs, G0/HPs, G1/HPs, and G2 ...


Potentially Avoidable Readmissions In United States Hemodialysis Patients, A. T. Mathew, L. Rosen, R. Pekmezaris, A. Kozikowski, D. W. Ross, T. Mcginn, K. Kalantar-Zadeh, S. Fishbane Jan 2018

Potentially Avoidable Readmissions In United States Hemodialysis Patients, A. T. Mathew, L. Rosen, R. Pekmezaris, A. Kozikowski, D. W. Ross, T. Mcginn, K. Kalantar-Zadeh, S. Fishbane

Journal Articles

© 2017 International Society of Nephrology Introduction: Patients with end-stage kidney disease have a high risk of 30-day readmission to hospital. These readmissions are financially costly to health care systems and are associated with poor health-related quality of life. The objective of this study was to describe and analyze the frequency, causes, and predictors of 30-day potentially avoidable readmission to hospital in patients on hemodialysis. Methods: We conducted a retrospective cohort study using the US Renal Data System data from January 1, 2008, to December 31, 2008. A total of 107,940 prevalent United States hemodialysis patients with 248,680 index ...


Relevance Of B-Lines On Lung Ultrasound In Volume Overload And Pulmonary Congestion: Clinical Correlations And Outcomes In Patients On Hemodialysis., Marc M Saad, Jeanne Kamal, E. Moussaly, B. Karam, W. Mansour, Emad Gobran, Saqib Hussen Abbasi, Ahmed Mahgoub, Puja Singh, Ross Hardy, D. Das, C. Brown, M. Kapoor, S. Demissie, M. J. Kleiner, E. El Charabaty, S. E. El Sayegh Jan 2018

Relevance Of B-Lines On Lung Ultrasound In Volume Overload And Pulmonary Congestion: Clinical Correlations And Outcomes In Patients On Hemodialysis., Marc M Saad, Jeanne Kamal, E. Moussaly, B. Karam, W. Mansour, Emad Gobran, Saqib Hussen Abbasi, Ahmed Mahgoub, Puja Singh, Ross Hardy, D. Das, C. Brown, M. Kapoor, S. Demissie, M. J. Kleiner, E. El Charabaty, S. E. El Sayegh

Journal Articles

BACKGROUND: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes.

METHODS: End-stage renal disease patients on HD at the Island Rehab Center being older than 18 years were screened. Patients achieving their dry weight (DW) had a lung ultrasound in a supine position. Scores were classified as mild (0-14), moderate (15-30), and severe (>30) for pulmonary congestion. Patients with more than 60 were further classified as very severe. Patients were followed ...


The Social Media Revolution In Nephrology Education, G. B. Colbert, J. Topf, K. D. Jhaveri, T. Oates, M. N. Rheault, S. Shah, S. Hiremath, M. A. Sparks Jan 2018

The Social Media Revolution In Nephrology Education, G. B. Colbert, J. Topf, K. D. Jhaveri, T. Oates, M. N. Rheault, S. Shah, S. Hiremath, M. A. Sparks

Journal Articles

© 2018 International Society of Nephrology The past decade has been marked by the increasing use of social media platforms, often on mobile devices. In the nephrology community, this has resulted in the organic and continued growth of individuals interested in using these platforms for education and professional development. Here, we review several social media educational resources used in nephrology education and tools including Twitter, videos, blogs, and visual abstracts. We will also review how these tools are used together in the form of games (NephMadness), online journal clubs (NephJC), interactive learning (GlomCon), and digital mentorship (Nephrology Social Media Collective [NSMC ...


Nicotine Enhances Mesangial Cell Proliferation And Fibronectin Production In High Glucose Milieu Via Activation Of Wnt/Beta-Catenin Pathway, X. Lan, H. Wen, R. Aslam, S. S. Shoshtari, A. Mishra, V. Kumar, H. Wang, G. Wu, A. Malhotra, P. C. Singhal, +1 Additional Author Jan 2018

Nicotine Enhances Mesangial Cell Proliferation And Fibronectin Production In High Glucose Milieu Via Activation Of Wnt/Beta-Catenin Pathway, X. Lan, H. Wen, R. Aslam, S. S. Shoshtari, A. Mishra, V. Kumar, H. Wang, G. Wu, A. Malhotra, P. C. Singhal, +1 Additional Author

Journal Articles

No abstract provided.


Lung Ultrasonography In End-Stage Renal Disease: Moving From Evidence To Practice-A Narrative Review, D. W. Ross, M. M. Abbasi, K. D. Jhaveri, M. Sachdeva, I. Miller, R. Barnett, M. Narasimhan, P. Mayo, M. Merzkani, A. T. Mathew Jan 2018

Lung Ultrasonography In End-Stage Renal Disease: Moving From Evidence To Practice-A Narrative Review, D. W. Ross, M. M. Abbasi, K. D. Jhaveri, M. Sachdeva, I. Miller, R. Barnett, M. Narasimhan, P. Mayo, M. Merzkani, A. T. Mathew

Journal Articles

© The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. Traditionally, point of care ultrasonography in nephrology has been used for renal biopsies and dialysis line placement. However, there is an emerging literature supporting the value of point of care lung ultrasonography in the assessment of volume status for dialysis patients.We conducted a review and identified 12 studies that examined the utility of lung ultrasonography in assessing volume status in patients with end-stage renal disease.We conclude that lung ultrasonography can be used to determine volume status in chronic dialysis patients by identifying lung congestion using the ...


Angiotensin Ii Down-Regulates Nephrin-Akt Signaling And Induces Podocyte Injury: Roleof C-Abl, Q. Yang, Y. Ma, Y. Liu, W. Liang, X. Chen, Z. Ren, H. Wang, P. C. Singhal, G. Ding Jan 2016

Angiotensin Ii Down-Regulates Nephrin-Akt Signaling And Induces Podocyte Injury: Roleof C-Abl, Q. Yang, Y. Ma, Y. Liu, W. Liang, X. Chen, Z. Ren, H. Wang, P. C. Singhal, G. Ding

Journal Articles

Recent studies have shown that nephrin plays a vital role in angiotensin II (Ang II)-induced podocyte injury and thus contributes to the onset of proteinuria and the progression of renal diseases, but its specific mechanism remains unclear. c-Abl is an SH2/SH3 domain-containing nonreceptor tyrosine kinase that is involved in cell survival and regulation of the cytoskeleton. Phosphorylated nephrin is able to interact with molecules containing SH2/SH3 domains, suggesting that c-Abl may be a downstream molecule of nephrin signaling. Here we report that Ang II-infused rats developed proteinuria and podocyte damage accompanied by nephrin dephosphorylation and minimal interaction ...


Quality Measurement In Wonderland: The Curious Case Of A Dialysis Readmissions Measure, S. Fishbane, J. B. Wish Jan 2016

Quality Measurement In Wonderland: The Curious Case Of A Dialysis Readmissions Measure, S. Fishbane, J. B. Wish

Journal Articles

The standardized readmission ratio is a new quality measure for dialysis facilities that will affect public reporting and payment beginning in 2017. Like all quality measures affecting public reporting and payment, the standardized readmission ratio was vetted by a process that included a technical expert panel convened by the US Centers for Medicare and Medicaid Services, and, then, the National Quality Forum. Unlike previous measures, standardized readmission ratio followed a tortuous path that exposed problems in the development and endorsement process. Although it is acknowledged that processes in the dialysis facility can be improved to decrease readmissions, multiple objections to ...


Nephrologists As Educators: Clarifying Roles, Seizing Opportunities, K. D. Jhaveri, M. A. Perazella Jan 2016

Nephrologists As Educators: Clarifying Roles, Seizing Opportunities, K. D. Jhaveri, M. A. Perazella

Journal Articles

Nephrologists play an important role in providing medical education in a variety of settings, including the medical school classroom, nephrology consult service, outpatient clinic, and dialysis unit. Therefore, nephrologists interact with a variety of learners. In this article the current state of published literature in medical education in nephrology is reviewed. Eight attending roles are identified of the nephrologist as a medical educator in the academic settings: inpatient internal medicine service, nephrology inpatient consult service, inpatient ESRD service, outpatient nephrology clinic, kidney transplantation, dialysis unit, classroom teacher, and research mentor. Defining each of these distinct settings could help to promote ...


Fungal Infections In Renal Transplant Patients, A. Khan, E. El-Charabaty, S. El-Sayegh Jan 2015

Fungal Infections In Renal Transplant Patients, A. Khan, E. El-Charabaty, S. El-Sayegh

Journal Articles

Organ transplantation has always been considered to be the standard therapeutic interventions in patients with end-stage organ failure. In 2008, more than 29,000 organ transplants were performed in US. Survival rates among transplant recipients have greatly improved due to better understanding of transplant biology and more effective immunosuppressive agents. After transplant, the extent of the immune response is influenced by the amount of interleukin 2 (IL-2) being produced by the T-helper cells. Transplant immunosuppressive therapy primarily targets T cell-mediated graft rejection. Calcineurin inhibitor, which includes cyclosporine, pimecrolimus and tacrolimus, impairs calcineurin-induced up-regulation of IL-2 expression, resulting in increased susceptibility ...


Iga-Dominant Post-Infectious Glomerulonephritis Presenting As A Fatal Pulmonary-Renal Syndrome, M. Saad, M. Daoud, P. Nasr, R. Syed, S. El-Sayegh Jan 2015

Iga-Dominant Post-Infectious Glomerulonephritis Presenting As A Fatal Pulmonary-Renal Syndrome, M. Saad, M. Daoud, P. Nasr, R. Syed, S. El-Sayegh

Journal Articles

Over the last decades, post-infectious glomerulonephritis underwent major changes in its epidemiology, pathophysiology, and outcomes. We are reporting a case of IgA-dominant post-infectious glomerulonephritis (IgA-PIGN) presenting as a fatal pulmonary-renal syndrome. An 86-year-old Filipino man presented with worsening dyspnea, hemoptysis, and decreased urine output over 2 weeks. Past medical history is significant for hypertension, chronic kidney disease stage III, and pneumonia 3 weeks prior treated with intravenous cefazolin for methicillin-sensitive Staphylococcus aureus bacteremia. Physical examination was remarkable for heart rate of 109/min and respiratory rate of 25/min saturating 99% on 3 liters via nasal cannula. There were bibasilar ...


Iqgap1 Regulates Actin Cytoskeleton Organization In Podocytes Through Interaction With Nephrin, Y. P. Liu, W. Liang, Y. J. Yang, Y. B. Pan, Q. Yang, X. H. Chen, P. C. Singhal, G. H. Ding Jan 2015

Iqgap1 Regulates Actin Cytoskeleton Organization In Podocytes Through Interaction With Nephrin, Y. P. Liu, W. Liang, Y. J. Yang, Y. B. Pan, Q. Yang, X. H. Chen, P. C. Singhal, G. H. Ding

Journal Articles

Increasing data has shown that the cytoskeletal reorganization of podocytes is involved in the onset of proteinuria and the progression of glomerular disease. Nephrin behaves as a signal sensor of the slit diaphragm to transmit cytoskeletal signals to maintain the unique structure of podocytes. However, the nephrin signaling cascade deserves further study. IQGAP1 is a scaffolding protein with the ability to regulate cytoskeletal organization. It is hypothesized that IQGAP1 contributes to actin reorganization in podocytes through interaction with nephrin. IQGAP1 expression and IQGAP1-nephrin colocalization in glomeruli were progressively decreased and then gradually recovered in line with the development of foot ...