Open Access. Powered by Scholars. Published by Universities.®
APOL1 risk variants;; kidney disease;; podocyte;; necrosis;; lysosomal;; membrane permeability;; HIV-ASSOCIATED NEPHROPATHY;; TRYPANOSOME LYTIC FACTOR;; CHRONIC;; KIDNEY-DISEASE;; LIPID-BINDING PROTEIN;; AUTOPHAGIC CELL-DEATH;; STAGE;; RENAL-DISEASE;; AFRICAN-AMERICANS;; HUMAN SERUM;; TRYPANOLYTIC FACTOR;; APOLIPOPROTEIN-L;; Physiology;; Urology & Nephrology
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Apol1 Risk Variants Enhance Podocyte Necrosis Through Compromising Lysosomal Membrane Permeability, X. Q. Lan, A. Jhaveri, K. Cheng, H. X. Wen, M. A. Saleem, P. W. Mathieson, S. Aviram, A. Malhotra, K. Skorecki, P. C. Singhal, +1 Additional Author
Apol1 Risk Variants Enhance Podocyte Necrosis Through Compromising Lysosomal Membrane Permeability, X. Q. Lan, A. Jhaveri, K. Cheng, H. X. Wen, M. A. Saleem, P. W. Mathieson, S. Aviram, A. Malhotra, K. Skorecki, P. C. Singhal, +1 Additional Author
Journal Articles
Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To date, the cellular function and the role of APOL1 variants (Vs) in GS are still unknown. In this study, we examined the effects of overexpressing wild-type (G0) and kidney disease risk variants (G1 and G2) of APOL1 in human podocytes using a lentivirus expression system. Interestingly, G0 inflicted podocyte injury only at a higher concentration; however, G1 and G2 promoted moderate podocyte injury at lower and higher concentrations. APOL1Vs expressing podocytes displayed diffuse …