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Full-Text Articles in Medicine and Health Sciences
Disruption Of Apol1-Mir193a Axis Induces Disorganization Of Podocyte Actin Cytoskeleton, V. Kumar, N. Paliwal, K. Ayasolla, H. Vashistha, A. Jha, N. Chandel, S. Chowdhary, M. A. Saleem, A. Malhotra, P. C. Singhal, +2 Additional Authors
Disruption Of Apol1-Mir193a Axis Induces Disorganization Of Podocyte Actin Cytoskeleton, V. Kumar, N. Paliwal, K. Ayasolla, H. Vashistha, A. Jha, N. Chandel, S. Chowdhary, M. A. Saleem, A. Malhotra, P. C. Singhal, +2 Additional Authors
Journal Articles
No abstract provided.
A 30-Year-Old Carrier Of Gaucher Disease With Multiple Myeloma., J. Chadha, T. Sahai, J. Schwimmer, D. Shani
A 30-Year-Old Carrier Of Gaucher Disease With Multiple Myeloma., J. Chadha, T. Sahai, J. Schwimmer, D. Shani
Journal Articles
We are reporting a case of a 30-year-old male with no past medical history who presented with new onset of renal failure, anemia, and splenomegaly and was diagnosed with multiple myeloma. Given the splenomegaly and the patient's Jewish heritage, blood tests were done and the patient was found to be a Gaucher disease carrier. The association of Gaucher disease and multiple myeloma has previously been reported; however, we want to describe the case of a young Gaucher disease carrier who developed multiple myeloma and provide a review of the literature.
Fibrillary Glomerulonephritis: An Update, J. L. Rosenstock, G. S. Markowitz
Fibrillary Glomerulonephritis: An Update, J. L. Rosenstock, G. S. Markowitz
Journal Articles
© 2019 International Society of Nephrology Fibrillary glomerulonephritis (FGN) is a rare proliferative form of glomerular disease characterized by randomly oriented fibrillar deposits with a mean diameter of 20 nm. By immunofluorescence (IF), the deposits stain for IgG, C3, and κ and λ light chains, suggesting that the fibrils may be composed of antigen-antibody immune complexes. A recent major advance in our understanding of the pathogenesis of FGN resulted from the discovery that a major component of the fibrils is DNA-J heat-shock protein family member B9 (DNAJB9), and immunohistochemical staining for DNAJB9 now makes it possible to diagnose FGN in …
Randomized Controlled Trial Of Subcutaneous Epoetin Alfa-Epbx Versus Epoetin Alfa In End-Stage Kidney Disease, S. Fishbane, B. S. Spinowitz, W. A. Wisemandle, N. E. Martin
Randomized Controlled Trial Of Subcutaneous Epoetin Alfa-Epbx Versus Epoetin Alfa In End-Stage Kidney Disease, S. Fishbane, B. S. Spinowitz, W. A. Wisemandle, N. E. Martin
Journal Articles
© 2019 Introduction: This double-blind, randomized controlled trial compared the safety and efficacy of subcutaneous epoetin alfa-epbx, an epoetin alfa biosimilar, with the reference product, epoetin alfa, in hemodialysis patients with end-stage kidney disease (ESKD) and anemia who were receiving epoetin alfa maintenance treatment. Methods: Eligible patients (n = 320) were randomized (1:1) to subcutaneous epoetin alfa-epbx or epoetin alfa in a titration phase; patients who demonstrated stable subcutaneous dosing (n = 246) were re-randomized to receive subcutaneous epoetin alfa-epbx or epoetin alfa 1 to 3 times per week in a 16-week maintenance phase. Co-primary endpoints were least-squares mean difference …