Medicine and Health Sciences Commons^™

Asylum Architecture: The Brick-By-Brick Development Of Patient Treatment, Kris D. Sass

The Purdue Historian

The following research and analysis will investigate the intersection of architecture and treatment in asylums with a specific interest on the time period of the late 19^th century to mid-20^th century in the United States. Not only were specific environmental demands key to some treatment methodologies, such as rural environments to moral therapy, but the architecture of mental hospitals were integral parts of patient’s experiences. Here three specific hospital designs will be analyzed: the Kirkbride Plan, the Cottage Plan, and Kiyoshi Izumi’s Socio-Petal. The following analysis will be built on a series of blueprints, building notes, secondary histories, …

Animal-Assisted Services And Occupational Therapy Within An Australian Context: A Survey Study, Jessica Hill, Carlie Driscoll, Kelly Pearse

People and Animals: The International Journal of Research and Practice

Introduction: The incorporation of animal-assisted services is an emerging field of occupational therapy. There remains varying levels of involvement and knowledge of what is involved in animal-assisted services among Australian occupational therapists. The profession of occupational therapy acknowledges that competence as a clinician requires appropriate education and knowledge guiding clinical decision making.

Research Question: This study aimed to explore the understanding and role of Australian occupational therapists including animal-assisted services in their practice, as well as the changes required to support future service delivery.

Methods: A cross sectional survey was conducted online. Participants were recruited through a digital mailing list, …

Characterization Of Biological Particles Using An Integrated Hyperspectral Imaging And Machine Learning, Kaeul Lim, Arezoo Ardekani

Graduate Industrial Research Symposium

Hyperspectral imaging (HSI) is a promising modality in medicine with many potential applications. This study focuses on developing a label-free lipid nanoparticle characterization method using a convolutional neural network (CNN) analysis of HSI images. The HSI data, hypercube, consists of a series of images acquired at different wavelengths for the same field of view, providing continuous spectra information for each pixel. Three distinct liposome samples were collected for analysis. Advanced image preprocessing and classification methods for HSI data were developed to differentiate liposomes based on their material compositions. Our machine learning-based classification method was able to distinguish different liposome types …

Sepsis Treatment: Reinforced Sequential Decision-Making For Saving Lives, Dipesh Tamboli, Jiayu Chen, Kiran Pranesh Jotheeswaran, Denny Yu, Vaneet Aggarwal

Graduate Industrial Research Symposium

Sepsis, a life-threatening condition triggered by the body's exaggerated response to infection, demands urgent intervention to prevent severe complications. Existing machine learning methods for managing sepsis struggle in offline scenarios, exhibiting suboptimal performance with survival rates below 50%. Our project introduces the "PosNegDM: Reinforcement Learning with Positive and Negative Demonstrations for Sequential Decision-Making" framework utilizing an innovative transformer-based model and a feedback reinforcer to replicate expert actions while considering individual patient characteristics. A mortality classifier with 96.7% accuracy guides treatment decisions towards positive outcomes. The PosNegDM framework significantly improves patient survival, saving 97.39% of patients and outperforming established machine learning …

Measurement And Imaging Of Intra Matrix Igg Diffusion, Riya Debbarma, Antonio C. F. Dos Santos, Diana Milena Ramiez Gutierrez, Fernanda M. Da Cunha, Michael Ladisch

Graduate Industrial Research Symposium

Bovine IgG diffusion measurement by tracking the movement of the protein over time in an in-vitro matrix is motivated by the large number of protein/peptide therapeutics currently under various stages of development in the pharmaceutical industry. Many of these therapeutics are monoclonal antibodies (IgG type proteins) that are candidates for subcutaneous, intra-vitreous and intra-articular administration depending on the target of the therapeutic. Hyaluronic acid (HA) is a major constituent and determines the key attributes of the subcutaneous environment, vitreous humor of the eye and synovial fluid of the knee joint. HA exhibits varying molecular weight at these anatomic locations thereby …

Impact Of Equine Interaction During Psychotherapy On Anxiety And Depression For Residential Treatment Program Patients Experiencing Substance Withdrawal, Molly M. Friend, Molly C. Nicodemus, Clay Cavinder, Caleb Lemley, Pauline Prince, Katherine A. Cagle-Holtcamp, Rebecca M. Swanson

People and Animals: The International Journal of Research and Practice

As incidences of substance use disorders (SUD) increase in the wake of the COVID-19 pandemic, there is a need for more effective treatment approaches. Further, treatment approaches currently available struggle to retain patients during the period of substance withdrawal in early treatment due to patients’ withdrawal symptoms including increased feelings of anxiety and depression. Withdrawal symptoms have been linked to dysregulated cortisol concentrations present in this period. Psychotherapy incorporating equine interaction (PIE) has emerged in other populations as a treatment that decreases cortisol concentrations and improves treatment retention. The present study investigated the impact of 4 weeks of PIE on …

Pets In Practice: A Practical Guide To The Introduction Of Dogs To Mental Health Work Settings Derived From The Direct Experiences Of Staff, Tatiana (Tia) Urgasova, Donna Sloss, Mary Lavelle

People and Animals: The International Journal of Research and Practice

The aim of this study was to evaluate the introduction of dogs in mental health workplace settings: specifically, exploring staff perspectives on the acceptability of dogs in mental health teams; the impact of the dogs on themselves directly, their patients, and their team; and the challenges of implementing dogs in mental health settings. This qualitative study design used semi-structured interviews. Twelve participants were interviewed; six from a Crisis Assessment and Treatment team, five from a Recovery College team, and one from the Inpatient and Outreach Psychiatric Service. Interviews were transcribed and six key themes were identified: facilitating staff well-being, improving …

Proposal Of A Private Caretaker-Completed Questionnaire To Assess The Suitability Of Domestic Cats For Animal-Assisted Interventions, Alina Simona Rusu, Iulia Francesca Pop, Christine Olsen, Magdalena Nawarecka-Piątek, Michal Plewczynski, Eivind Øverli Holm, Dennis C. Turner

People and Animals: The International Journal of Research and Practice

The objective of this study was to develop a caretaker-completed questionnaire entitled “Cats’ Behavioral Suitability for Animal-Assisted Interventions” (CatSAAI), covering two categories of items associated with seven feline personality factors. These feline personality factors were previously identified and validated by Mikkola et al. (2021) on a large sample of domestic cat guardians. The aim of the CatSAAI questionnaire is to facilitate the interpretation of the behavioral suitability or unsuitability of each individual cat for inclusion in feline-assisted interventions, while considering the prevention of stress and risks in AAI settings for both people and animals. The tool was proposed by an …

Promises And Risks Of Applying Ai Medical Imaging To Early Detection Of Cancers, And Regulation For Ai Medical Imaging, Yiyao Zhang

The Journal of Purdue Undergraduate Research

No abstract provided.

The Cross-Linguistic And Cross-Situational Association Between Accentedness And Its Impact As Rated By Speakers, Makaila Groves

The Journal of Purdue Undergraduate Research

No abstract provided.

Examining The Examiner: An Amicus Brief On Conflicts Between Forensic Technology And Indigenous Religious Freedoms In Favor Of Virtual Autopsies, Peyton James

The Journal of Purdue Undergraduate Research

No abstract provided.

Formulation Of Preservation Solutions For Model Generation With In Vivo Tissue Morphology, Holly Pickett

The Journal of Purdue Undergraduate Research

No abstract provided.

Analyzing Health Care Delivery Costs From 2011 To 2020 In The Emergency Departments And Overall Hospital Costs, Jacob A. Corey

The Journal of Purdue Undergraduate Research

No abstract provided.

Active Herbicide Ingredients In Roundup Ready Xtend Products, Glyphosate And Dicamba, Results In Hypoactivity In Zebrafish Larvae When Exposed During Development, Ryker Bond

The Journal of Purdue Undergraduate Research

No abstract provided.

Is Northwest Indiana Prepared To Be A “Climate Haven”?, Luke Carl Jorgensen

The Journal of Purdue Undergraduate Research

No abstract provided.

The Role Of Vocal Development Patterns: Predicting Neurogenetic Risk In Infancy Using Early Vocal Development And Sex, Alyssa Cregg, Rachel Siela, Olivia Battaglia, Kaylee Bobay, Madison Chin, Athena Fordwor, Conghao Gao, Deeksha Handa, Erin Lee, Tiernan Mcdivitt, Grace Strabala, Victoria Tuell, Laurel Williams

The Journal of Purdue Undergraduate Research

Extant literature documents a higher rate of language/speech disorders in males; however, despite sex being a potential moderator of outcomes, we do not know what role it plays in early vocal behavior of infants at high risk for such disorders. The purpose of this study was to ask: (1) Do high-risk infants demonstrate atypical vocal development patterns? (2) Is the quality and quantity of early babble distinct for male and female infants, and does this pattern vary across risk? To answer these questions, we examined the canonical babbling ratio (CBR; the ratio of canonical syllables, those with a consonant and …

Genome-Wide Mutagenesis To Investigate The N-Terminal Methylome: The Protective Effects Of Hsp31 And Other Methylated Proteins In Yeast, James Rooney, Jacob Lindsey

The Journal of Purdue Undergraduate Research

The purpose of this study was to understand the role of methylation in regulating the cellular stress response of Hsp31 in Saccharomyces cerevisiae yeast cells. Hsp31 is known to be methylated by the N-terminal methyltransferase Tae1. Changing the methylation site can affect the methylation status of Hsp31, which may play a role in the protective activity of Hsp31 against cellular stress. GLO1 is a gene in yeast involved in catalyzing the detoxification of methylglyoxal (MGO), which is a by-product of glycolysis. We established that S. cerevisiae in the glo1Δ and background is sensitive to cellular stress by MGO. Mutant strains …

Getting Off On The Right Foot: Addressing Severe Lymphedema Through A Novel Shoe Design, Carl R. Russell Iii, Anjollie M. Ramakrishna, Christopher H. Johns Iii, Alana V. Van Wijnen

Purdue Journal of Service-Learning and International Engagement

Engineering Projects in Community Service (EPICS) is a service-learning design program run by the College of Engineering at Purdue University. EPICS teaches students design skills by providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. Biomedical Engineering is a team within EPICS that strives to serve community partners through biomedical applications. HR is a patient who suffers from severe lymphedema. This condition results in her foot swelling three times its original size and requires her to utilize weekly leg compression therapy. Prescription shoes are slightly adequate. However, they lead to sores and pain …

Service Dogs: A Scoping Review Of Interdisciplinary Research, K. Lynn Pierce, Nancy A. Dreschel

People and Animals: The International Journal of Research and Practice

Despite a long history of service dogs (SDs) being paired with human partners as a systematic intervention and increasing numbers of and roles for SDs, there remains a lack of empirical knowledge and professional guidance regarding the implementation of SDs into treatment plans for individuals with disabilities. The purpose of this scoping review was to review the peer-reviewed literature specific to SDs and their handlers, to identify successful search term strategies, and to determine in what disciplines research is being conducted. Terminology used in referring to service dogs continues to be a challenge. Through a series of preliminary searches, search …

Impact Of Covid-19 On Service Dog Organizations, Danny Benbassat, Abigail Konopasky, Michael Fox

People and Animals: The International Journal of Research and Practice

The 2019 coronavirus pandemic led to federal, state, and local measures that paralyzed businesses across the nation. Among them were behavioral and mental health nonprofit organizations. The purpose of this study was to understand the impact of the pandemic on nonprofit programs that train and place service dogs with veterans/service members. Six service dog managers completed eight reflection probe questionnaires and participated in three focus groups. This study found that facility shutdown, businesses shutdown, and social distancing resulted in a training bottleneck for both canines and humans. These primary challenges created secondary and tertiary challenges that mirror and lend support …

Using Behavior Sequence Analysis To Study Teams During Long- Duration Isolation And Confinement, Andres Käosaar, Dr. Nathan Smith, Dr. David A. Keatley, Pranav Ambhorkar, Dr. Moritz Von Looz, Konstantinos Konstantinidis

Journal of Human Performance in Extreme Environments

With a renewed impetus and appetite for human space exploration, both government-funded agencies and private companies are focusing on longer and farther crewed missions into the solar system. Such space missions rely on highly interdependent teams living and working together in isolated, confined, and extreme (ICE) environments. Understanding the behavioral patterns of teams in ICE environments is, thus, paramount for the future success of such missions. Due to the complexity of studying ICE teams, several researchers have called for methodological innovations to advance knowledge in this area. In the current research, a proof-of-concept methodological approach is introduced that provides a …

Dog Guardians’ Subjective Well-Being During Times Of Stress And Crisis: A Diary Study Of Affect During Covid-19, Lori S. Hoy, Brigitte Stangl, Nigel Morgan

People and Animals: The International Journal of Research and Practice

The impacts of companion animals on human well-being have been receiving increased media and research attention, especially in relation to the COVID-19 pandemic. Previously, there have been calls for research to consider the major components of subjective well-being separately and for research designs to include assessments over time. In line with this suggestion, the purpose of this study was to gain a more comprehensive understanding of how being a dog guardian can impact affect and contribute to the overall assessment of subjective well-being. This study used a seven-day diary design to capture 31 dog guardians’ day-to- day feelings and thoughts …

Comprehensive Analysis Of The Retinal Cell Contributions To The Human Erg, Christopher W. Tyler

MODVIS Workshop

Purpose. Standard electroretinogram (ERG) protocols are largely designed to isolate the responses of the rod and cone retinal pathways, including the use of adapting backgrounds to suppress unwanted off-pathway responses. Here, we record spectral ERGs in the low-to-high mesopic sensitivity range in the absence of any adapting background in order to assess interactions between the pathways.

Methods. We have developed a comprehensive neuroanalytic model of the component structure of the ERG driven by knowledge of the underlying retinal physiology, to enhance its power as a critical diagnostic tool for a broad range of both retinal and systemic dysfunctions. The ERG …

Effects Of Equine Interaction On Mutual Autonomic Nervous System Responses And Interoception In A Learning Program For Older Adults, Ann L. Baldwin, Lisa Walters, Barbara K. Rector, Ann C. Alden

People and Animals: The International Journal of Research and Practice

Equine-assisted learning (EAL) may improve the health of older adults, but scientific data are sparse. This study investigated whether people aged 55 and older show increased heart rate variability (HRV) during EAL and awareness of bodily sensations that are overall pleasant. Subjects (n = 24) participated in mindful grooming during which they slowed their breathing and brushed a horse while noticing sensations in their body and watching the horse’s reactions. The subject’s and horse’s HRV were recorded simultaneously before, during, and after mindful grooming. For control, the same subjects performed mindful grooming with a plush simulation horse. During exit …

From In-Person To Virtual: A Case Study Of An Animal-Assisted Visiting Program In A Pediatric Setting, Whitney Romine

People and Animals: The International Journal of Research and Practice

This article focuses on the practical aspects of converting a successful in-person AAA program to a virtual program in a health care setting including human, canine, and physical resources; animal welfare considerations; training, infection control, and safety guidelines; and visit delivery procedures. In 1992, an interdisciplinary team at Akron Children’s Hospital founded the Doggie Brigade, an animal-assisted activities (AAA) program where volunteer therapy dogs and their handlers visit pediatric patients. The program has become a cornerstone of the hospital’s culture over its now 30-year tenure. In March 2020, the announcement of the COVID-19 pandemic forced health care organizations to suspend …

A Scoping Review Of Campus-Based Animal-Assisted Interactions Programs For College Student Mental Health, Tanya K. Bailey

People and Animals: The International Journal of Research and Practice

Background: People have long found support by interacting with animals, which has developed into a health care modality called animal-assisted interactions (AAI). In the past 10 years, AAI has increased as a way to support college students’ mental health; however, there is no comprehensive evidence on the effectiveness of these programs.
Method: A scoping review was conducted using the JBI and PRISMA-ScR criteria. Empirical articles were identified through Academic Search Premier (EBSCOhost), PsychINFO (Ovid), and Web of Science using three groups of keywords: AAI, college students, and mental health.
Results: Of the 1,195 publications identified, 37 met this study’s eligibility …

Birs Course: Rna Vaccine Manufacture And Assessment Of Regulatory Documents For Rna Vaccines, Stephen R. Byrn, Nathaniel Milton, Kari L. Clase

BIRS Technical Report Papers

This paper is in three segments: (A) Segment on Vaccine Manufacture; (B) Segment on Ready to Use (RTU) Fluid Path for Compounded Sterile Preparations, mRNA Vaccines, and Phage Therapy, (C) Segment on Competency Framework for Addressing Regulatory Review These segments can be used separately or in combination. Additionally, they can be presented in any order. The time devoted to each segment depends on the depth of the course coverage. These segments are interrelated and describe how to make vaccines, how to manufacture vaccines with a point-of-care system built from ready-to-use parts; and how to regulate vaccines. This is a timely …

The Association Between Inflammatory Diet And Infection-Related Cancers In Adults: A Systematic Review, Alfu Laily, Jason B. Reed, Madeline Q. Powers, Anna Giuliano, Monica Kasting

Libraries Faculty and Staff Supplemental Materials

Poster presented at the 2023 American Academy of Health Behavior conference. Presents preliminary results of a systematic review investigating the relationship between inflammatory dietary patterns and infection-related cancers in adults.

Rim-To-Rim Wearables At The Canyon For Health (R2r Watch): Physiological, Cognitive, And Biological Markers Of Performance Decline In An Extreme Environment, Kristin Divis, Robert Abbott, Cathy Branda, Glory Emmanuel-Aviña, Jon Femling, J. Gabriel Huerta, Lucie Jelinková, J. Kyle Jennings, Emily A. Pearce, Daniel Ries, Danielle Sanchez, Austin Silva

Journal of Human Performance in Extreme Environments

Success in extreme environments comes with a cost of subtle performance decrements that if not mitigated properly can lead to lifethreatening consequences. Identification and prediction of performance decline could alleviate deleterious consequences and enhance success in challenging and high-risk operations. The Rim-to-Rim Wearables at the Canyon for Health (R2R WATCH) project was designed to examine the cognitive, physiological, and biological markers of performance decline in the extreme environment of the Grand Canyon Rim-to-Rim (R2R) hike. The study utilized commercial off-the-shelf cognitive and physiological monitoring techniques, along with subjective self-assessments and hematologic measurements to determine subject performance and changes across the …

The Effect Of Fatty Acid Synthase (Fasn) Depletion In Pulmonary Metastatic Formation In Breast Cancer Murine Models, Zilin Xianyu

The Journal of Purdue Undergraduate Research

No abstract provided.