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Articles 1 - 13 of 13
Full-Text Articles in Medicine and Health Sciences
Genome Of Mycoplasma Haemofelis, Unraveling Its Strategies For Survival And Persistence, Andrea P. Santos, Ana Ms Guimaraes, Naila C. Do Nascimento, Phillip J. Sanmiguel, Samuel W. Martin, Joanne Messick
Genome Of Mycoplasma Haemofelis, Unraveling Its Strategies For Survival And Persistence, Andrea P. Santos, Ana Ms Guimaraes, Naila C. Do Nascimento, Phillip J. Sanmiguel, Samuel W. Martin, Joanne Messick
Department of Comparative Pathobiology Faculty Publications
Mycoplasma haemofelis is a mycoplasmal pathogen (hemoplasma) that attaches to the host’s erythrocytes. Distributed worldwide, it has a significant impact on the health of cats causing acute disease and, despite treatment, establishing chronic infection. It might also have a role as a zoonotic agent, especially in immunocompromised patients. Whole genome sequencing and analyses of M. haemofelis strain Ohio2 was undertaken as a step toward understanding its survival and persistence. Metabolic pathways are reduced, relying on the host to supply many of the nutrients and metabolites needed for survival. M. haemofelis must import glucose for ATP generation and ribose derivates for …
Comparison Of Genomic And Proteomic Data In Recurrent Airway Obstruction Affected Horses Using Ingenuity Pathway Analysis, Julien Racine, Vinzenz Gerber, Marybeth Miskovic Feutz, C Paige Riley, Jiri Adamec, June E. Swinburne, Laurent Couetil
Comparison Of Genomic And Proteomic Data In Recurrent Airway Obstruction Affected Horses Using Ingenuity Pathway Analysis, Julien Racine, Vinzenz Gerber, Marybeth Miskovic Feutz, C Paige Riley, Jiri Adamec, June E. Swinburne, Laurent Couetil
Department of Comparative Pathobiology Faculty Publications
Background: Recurrent airway obstruction (RAO) is a severe chronic respiratory disease affecting horses worldwide, though mostly in the Northern hemisphere. Environmental as well as genetic factors strongly influence the course and prognosis of the disease. Research has been focused on characterization of immunologic factors contributing to inflammatory responses, on genetic linkage analysis, and, more recently, on proteomic analysis of airway secretions from affected horses. The goal of this study was to investigate the interactions between eight candidate genes previously identified in a genetic linkage study and proteins expressed in bronchoalveolar lavage fluid (BALF) collected from healthy and RAO-affected horses. The …
Transcriptome Sequencing Of The Blind Subterranean Mole Rat, Spalax Galili: Utility And Potential For The Discovery Of Novel Evolutionary Patterns, Assaf Malik, Abraham Korol, Sariel Hubner, Aaron Avivi, Alvaro Hernandez, Jyothi Thimmapuram, Shahjahan Ali, Mark Bond, Fabian Glaser, Arnon Paz
Transcriptome Sequencing Of The Blind Subterranean Mole Rat, Spalax Galili: Utility And Potential For The Discovery Of Novel Evolutionary Patterns, Assaf Malik, Abraham Korol, Sariel Hubner, Aaron Avivi, Alvaro Hernandez, Jyothi Thimmapuram, Shahjahan Ali, Mark Bond, Fabian Glaser, Arnon Paz
Cyber Center Publications
The blind subterranean mole rat (Spalax ehrenbergi superspecies) is a model animal for survival under extreme environments due to its ability to live in underground habitats under severe hypoxic stress and darkness. Here we report the transcriptome sequencing of Spalax galili, a chromosomal type of S. ehrenbergi. cDNA pools from muscle and brain tissues isolated from animals exposed to hypoxic and normoxic conditions were sequenced using Sanger, GS FLX, and GS FLX Titanium technologies. Assembly of the sequences yielded over 51,000 isotigs with homology to ~12,000 mouse, rat or human genes. Based on these results, it was …
Complete Genome Sequence Of Mycoplasma Suis And Insights Into Its Biology And Adaption To An Erythrocyte Niche, Ana Ms Guimaraes, Andrea P. Santos, Phillip Sanmiguel, Thomas Walter, Jorge Timenetsky, Joanne Messick
Complete Genome Sequence Of Mycoplasma Suis And Insights Into Its Biology And Adaption To An Erythrocyte Niche, Ana Ms Guimaraes, Andrea P. Santos, Phillip Sanmiguel, Thomas Walter, Jorge Timenetsky, Joanne Messick
Department of Comparative Pathobiology Faculty Publications
Mycoplasma suis, the causative agent of porcine infectious anemia, has never been cultured in vitro and mechanisms by which it causes disease are poorly understood. Thus, the objective herein was to use whole genome sequencing and analysis of M. suis to define pathogenicity mechanisms and biochemical pathways. M. suis was harvested from the blood of an experimentally infected pig. Following DNA extraction and construction of a paired end library, whole-genome sequencing was performed using GS-FLX (454) and Titanium chemistry. Reads on paired-end constructs were assembled using GS De Novo Assembler and gaps closed by primer walking; assembly was validated by …
Orchardgrass (Dactylis Glomerata L.) Est And Ssr Marker Development, Annotation, And Transferability., B.S. Bushman, S.R. Larson, M Tuna, M.S. West, A.G. Hernandez, D Vullaganti, G Gong, J.G. Robbins, K. B. Jensen, Jyothi Thimmapuram
Orchardgrass (Dactylis Glomerata L.) Est And Ssr Marker Development, Annotation, And Transferability., B.S. Bushman, S.R. Larson, M Tuna, M.S. West, A.G. Hernandez, D Vullaganti, G Gong, J.G. Robbins, K. B. Jensen, Jyothi Thimmapuram
Cyber Center Publications
Orchardgrass, or cocksfoot [Dactylis glomerata (L.)], has been naturalized on nearly every continent and is a commonly used species for forage and hay production. All major cultivated varieties of orchardgrass are autotetraploid, and few tools or information are available for functional and comparative genetic analyses and improvement of the species. To improve the genetic resources for orchardgrass, we have developed an EST library and SSR markers from salt, drought, and cold stressed tissues. The ESTs were bi-directionally sequenced from clones and combined into 17,373 unigenes. Unigenes were annotated based on putative orthology to genes from rice, Triticeae grasses, other Poaceae, …
Information-Seeking Behaviors Of First-Semester Veterinary Students: A Preliminary Report, Sharon A. Weiner, Gretchen Stephens, Abdelfattah Y.M. Nour
Information-Seeking Behaviors Of First-Semester Veterinary Students: A Preliminary Report, Sharon A. Weiner, Gretchen Stephens, Abdelfattah Y.M. Nour
Libraries Faculty and Staff Scholarship and Research
Although emphasis in veterinary education is increasingly being placed on the ability to find, use, and communicate information, studies on the information behaviors of veterinary students or professionals are few. Improved knowledge in this area will provide valuable information for course and curriculum planning and the design of information resources. This article describes a survey of the information-seeking behaviors of first-semester veterinary students at Purdue University. A survey was administered as the first phase of a progressive semester-long assignment for a first semester DVM course in systemic mammalian physiology. The survey probed for understanding of the scientific literature and its …
The P53 Inhibitor Mdm2 Facilitates Sonic Hedgehog- Mediated Tumorigenesis And Influences Cerebellar Foliation, Reem Malek, Jennifer Matta, Natalie Taylor, Mary Ellen Perry, Susan Mendrysa
The P53 Inhibitor Mdm2 Facilitates Sonic Hedgehog- Mediated Tumorigenesis And Influences Cerebellar Foliation, Reem Malek, Jennifer Matta, Natalie Taylor, Mary Ellen Perry, Susan Mendrysa
Department of Basic Medical Sciences Faculty Publications
Disruption of cerebellar granular neuronal precursor (GNP) maturation can result in defects in motor coordination and learning, or in medulloblastoma, the most common childhood brain tumor. The Sonic Hedgehog (Shh) pathway is important for GNP proliferation; however, the factors regulating the extent and timing of GNP proliferation, as well as GNP differentiation and migration are poorly understood. The p53 tumor suppressor has been shown to negatively regulate the activity of the Shh effector, Gli1, in neural stem cells; however, the contribution of p53 to the regulation of Shh signaling in GNPs during cerebellar development has not been determined. Here, we …
Effects Of Alcohol On The Acquisition And Expression Of Fear Potentiated Startle In Mouse Lines Selectively Bred For High And Low Alcohol Preference, Gustavo D. Barrenha, Laran E. Coon, Julia Chester
Effects Of Alcohol On The Acquisition And Expression Of Fear Potentiated Startle In Mouse Lines Selectively Bred For High And Low Alcohol Preference, Gustavo D. Barrenha, Laran E. Coon, Julia Chester
Department of Psychological Sciences Faculty Publications
Rationale: Anxiety disorders and alcohol-use disorders frequently co-occur in humans perhaps because alcohol relieves anxiety. Studies in humans and rats indicate that alcohol may have greater anxiolytic effects in organisms with increased genetic propensity for high alcohol consumption. Objectives and Methods: The purpose of this study was to investigate the effects of moderate doses of alcohol (0.5, 1.0, 1.5 g/kg) on the acquisition and expression of anxiety-related behavior using a fear-potentiated startle (FPS) procedure. Experiments were conducted in two replicate pairs of mouse lines selectively bred for high- (HAP1 and HAP2) and low- (LAP1 and LAP2) alcohol preference; these lines …
The Role Of Nursing Students At Two Rural Nurse-Managed Health Clinics, Elizabeth Richards, Elizabeth O'Neil, Carmen Jones, Lynn Davis, Loretta Krebs
The Role Of Nursing Students At Two Rural Nurse-Managed Health Clinics, Elizabeth Richards, Elizabeth O'Neil, Carmen Jones, Lynn Davis, Loretta Krebs
School of Nursing Faculty Publications
With stiff competition for clinical sites, one Midwestern university partners nursing students with faculty who provide primary healthcare to clients in two rural nurse-managed clinics. Some students are also assigned to follow select clients during weekly home visit rotations for their public health clinical course. The result has been a successful faculty practice and preceptor model that benefits rural communities, a clinical setting which provides opportunities for students to experience client care needs of the underinsured or uninsured in small communities, and student exposure to the financial burdens and challenges of today’s healthcare environment in the United States.
Stop The Silence Of Elder Abuse, Elizabeth Richards
Stop The Silence Of Elder Abuse, Elizabeth Richards
School of Nursing Faculty Publications
No abstract provided.
Identification And Analysis Of Common Bean (Phaseolus Vulgaris L.) Transcriptomes By Massively Parallel Pyrosequencing, Venu Kalavacharla, Zhanji Liu, Blake C. Meyers, Jyothi Thimmapuram, Kalpalatha Melmaiee
Identification And Analysis Of Common Bean (Phaseolus Vulgaris L.) Transcriptomes By Massively Parallel Pyrosequencing, Venu Kalavacharla, Zhanji Liu, Blake C. Meyers, Jyothi Thimmapuram, Kalpalatha Melmaiee
Cyber Center Publications
Common bean (Phaseolus vulgaris) is the most important food legume in the world. Although this crop is very important to both the developed and developing world as a means of dietary protein supply, resources available in common bean are limited. Global transcriptome analysis is important to better understand gene expression, genetic variation, and gene structure annotation in addition to other important features. However, the number and description of common bean sequences are very limited, which greatly inhibits genome and transcriptome research. Here we used 454 pyrosequencing to obtain a substantial transcriptome dataset for common bean.
Privacy-Preserving Assessment Of Location Data Trustworthiness, Chenyun Dai, Fang-Yu Rao, Gabriel Ghinita, Elisa Bertino
Privacy-Preserving Assessment Of Location Data Trustworthiness, Chenyun Dai, Fang-Yu Rao, Gabriel Ghinita, Elisa Bertino
Cyber Center Publications
Assessing the trustworthiness of location data corresponding to individuals is essential in several applications, such as forensic science and epidemic control. To obtain accurate and trustworthy location data, analysts must often gather and correlate information from several independent sources, e.g., physical observation, witness testimony, surveillance footage, etc. However, such information may be fraudulent, its accuracy may be low, and its vol-
ume may be insufficient to ensure highly trustworthy data. On the other hand, recent advancements in mobile computing and positioning systems, e.g., GPS-enabled cell phones, highway sensors, etc., bring new and effective technological means to track the location of …
Prox-Rbac: A Proximity-Based Spatially Aware Rbac, Michael Kirkpatrick, Maria Luisa Damiani, Elisa Bertino
Prox-Rbac: A Proximity-Based Spatially Aware Rbac, Michael Kirkpatrick, Maria Luisa Damiani, Elisa Bertino
Cyber Center Publications
As mobile computing devices are becoming increasingly dominant in enterprise and government organizations, the need for fine-grained access control in these environments continues to grow. Specifically, advanced forms of access control can be deployed to ensure authorized users can access sensitive resources only when in trusted locations. One technique that has been proposed is to augment role-based access control (RBAC) with spatial constraints. In such a system, an authorized user must be in a designated location in order to exercise the privileges associated with a role. In this work, we extend spatially aware RBAC systems by defining the notion of …