Medicine and Health Sciences Commons^™

Public Health Importance Of Preventive Measures For Salmonella Tennessee And Salmonella Typhimurium Strain Lt2 Biofilms, Simen Asefaw, Sadiye Aras, Md Niamul Kabir, Sabrina Wadood, Shahid Chowdhury, Aliyar Cyrus Fouladkhah

Biology Faculty Research

Various serovars of Salmonella had been the subject of research for over 150 years; nonetheless, the bacterium has remained an important pathogen of public health concern to date. The tremendous ability of Salmonella to form biofilms on biotic and abiotic surfaces is an important underlying reason for the prevalence of this opportunistic pathogen in healthcare, manufacturing, and the food chain. The current study illustrates that using very common industrial antimicrobial treatments at the highest concentrations suggested by the manufacturers is only efficacious against planktonic and one-day mature biofilms of the pathogen while exhibiting a lack of efficacy for complete removal …

Using Community-Based Participatory Research To Assess The Needs Of Hiv-Related Services For Infected Individuals In Rural Communities, Elizabeth Brown, Charles Brown, Owen Johnson, Wendelyn Inman, Revlon Briggs, Wanda Burrell, Rosemary Theriot, Elizabeth Williams, Alexis Heaston

Public Health, Health Administration, and Health Sciences Faculty Research

HIV/AIDS remains a significant health concern in rural communities, which may also experience many disparate issues including reduced access to health services (Department of Health and Human Services, 2015). Community efforts should be increased to improve services to people living with HIV/AIDS (PLWHA), especially in rural communities. In the state of Tennessee, using a community-based participatory research (CBPR) approach, a needs assessment was conducted to identify gaps, barriers, and strategies for improving HIV-related comprehensive care services for people diagnosed with HIV/AIDS in 26 rural counties. The paper describes the CBPR partnership and the needs assessment project that was conducted and …

The Black Church And Public Health: A Key Partnership For Theory Driven Covid-19 Recovery Efforts, Natasha R. Brown, Candice L. Alick, Alexis G. Heaston, Shanada Monestime, Nicolette Powe

Public Health, Health Administration, and Health Sciences Faculty Research

The COVID-19 epidemic has negatively impacted the Black community in the United States. Despite current disease mitigation efforts, work is still needed to ensure that Black individuals living in the United States understand their risks regarding COVID-19 infection whether vaccinated or unvaccinated. Thus, the current article posits that the Black church, in concert with public health practitioners, is a venue through which theoretically based health messages should be designed and disseminated regarding COVID-19 recovery efforts. The Health Belief Model and the Harm Reduction approach are posed as theoretical frameworks to facilitate the design of such messages.

Jordan's Public Policy Response To Covid-19 Pandemic: Insight And Policy Analysis, Wa’Ed Alshoubaki, Michael Harris

Public Administration Faculty Research

The aim of this study was to gain an understanding of how the Jordanian government has responded and continues to respond to the COVID-19 pandemic. It utilizes the interpretive policy analysis approach through document analysis. The analysis showed that Jordan created social protection policies to assist people who lost their jobs or whose work was suspended due to the coronavirus. The economic policies build solidarity and facilitate the private sector’s recovery. The health care measures firmly applied included lockdown, wearing masks, and restrictions on gatherings and public events. Jordan uses hard power and imposes sanctions on any violation that threatens …

The Threat Of Antibiotic Resistance In Changing Climate, Aliyar Cyrus Fouladkhah, Brian Thompson, Janey Smith Camp

Agricultural and Environmental Sciences Faculty Research

As the earliest form of life, microorganisms have elaborate mechanisms for adapting to changes in environmental conditions.

Fate And Biofilm Formation Of Wild-Type And Pressure-Stressed Pathogens Of Public Health Concern In Surface Water And On Abiotic Surfaces, Md Niamul Kabir, Sadiye Aras, Sabrina Wadood, Shahid Chowdhury, Aliyar Cyrus Fouladkhah

Agricultural and Environmental Sciences Faculty Research

Since the historic outbreak near Broad Street in London, which serves as cornerstone of modern epidemiology, infectious diseases spread in surface and sub-surface water has been a persisting public health challenge. The current study investigated persistence of wild-type and pressure-stressed Listeria monocytogenes, Escherichia coli O157:H7, and non-typhoidal Salmonella enterica serovars in surface water stored aerobically for up to 28 days at 5, 25, and 37 °C. Additionally, biofilm formation of wild-type and pressure-stressed non-typhoidal Salmonella serovars were monitored on surface of stainless steel and rubber coupons for 28 days at 25 and 37 °C. While L. monocytogenes exhibited a lower …

Improving Community Advisory Board Engagement In Precision Medicine Research To Reduce Health Disparities, Erin Connors, Rebecca Selove, Juan Canedo, Maureen Sanderson, Pamela Hull, Marilyn Adams, Ila Mcdermott, Calvin Barlow, Denice Johns-Porter, Caree Mcafee, Karen Gilliam, Oscar Miller, Nora Cox, Mary Kay Fadden, Stephen King, Hilary Tindle

Sociology Faculty Research

Community Advisory Boards (CABs) are used in efforts to reduce health disparities; however, there is little documentation in the literature regarding their use in precision medicine research. In this case study, an academic-CAB partnership developed a questionnaire and patient educational materials for two precision smoking cessation interventions that involved use of genetic information. The community-engaged research (CEnR) literature provided a framework for enhancing benefits to CAB members involved in developing research documents for use with a low-income, ethnically diverse population of smokers. The academic partners integrated three CEnR strategies: 1) in-meeting statements acknowledging their desire to learn from community partners, …

Augmenting The Pressure-Based Pasteurization Of Listeria Monocytogenes By Synergism With Nisin And Mild Heat, Sadiye Aras, Md Niamul Kabir, Shahid Chowdhury, Aliyar Cyrus Fouladkhah

Agricultural and Environmental Sciences Faculty Research

The current study investigated Listeria monocytogenes inactivation using mild heat with elevated hydrostatic pressure and nisin under buffered condition. A four-strain pathogen mixture was exposed to 0 (control) and up to 9 min of (1) 4 °C elevated pressure; (2) 4 °C elevated pressure and nisin; (3) 4 °C nisin; (4) heat at 40 °C; (5) 40 °C elevated pressure; (6) 40 °C elevated pressure and nisin; and (7) 40 °C nisin. Elevated hydrostatic pressure at 400 MPa (Hub880 Explorer, Pressure BioScience Inc., Easton, MA, USA) and nisin concentration of 5000 IU/mL were used in the trials. Analyses of variance …

Interactions Of Carvacrol, Caprylic Acid, Habituation, And Mild Heat For Pressure-Based Inactivation Of O157 And Non-O157 Serogroups Of Shiga Toxin-Producing Escherichia Coli In Acidic Environment, Md Niamul Kabir, Sadiye Aras, Abimbola Allison, Jayashan Adhikari, Shahid Chowdhury, Aliyar Fouladkhah

Agricultural and Environmental Sciences Faculty Research

The current study investigated synergism of elevated hydrostatic pressure, habituation, mild heat, and antimicrobials for inactivation of O157 and non-O157 serogroups of Shiga toxin-producing Escherichia coli. Various times at a pressure intensity level of 450 MPa were investigated at 4 and 45 °C with and without carvacrol, and caprylic acid before and after three-day aerobic habituation in blueberry juice. Experiments were conducted in three biologically independent repetitions each consist of two replications and were statistically analyzed as a randomized complete block design study using ANOVA followed by Tukey- and Dunnett’s-adjusted mean separations. Under the condition of this experiment, habituation of …

Using An Implementation Research Framework To Identify Potential Facilitators And Barriers Of An Intervention To Increase Hpv Vaccine Uptake, Rebecca Selove, Maya Foster, Raquel Mack, Maureen Sanderson, Pamela C. Hull

Center for Prevention Research Publications

Background:

Although the incidence of cervical cancer has been decreasing in the United States over the last decade, Hispanic and African American women have substantially higher rates than Caucasian women. The human papillomavirus (HPV) is a necessary, although insufficient, cause of cervical cancer. In the United States in 2013, only 37.6% of girls 13 to 17 years of age received the recommended 3 doses of a vaccine that is almost 100% efficacious for preventing infection with viruses that are responsible for 70% of cervical cancers. Implementation research has been underutilized in interventions for increasing vaccine uptake. The Consolidated Framework for …

Adoptable Interventions, Human Health, And Food Safety Considerations For Reducing Sodium Content Of Processed Food Products, Abimbola Allison, Aliyar Fouladkhah

Agricultural and Environmental Sciences Faculty Research

Although vital for maintaining health when consumed in moderation, various epidemiological studies in recent years have shown a strong association between excess dietary sodium with an array of health complications. These associations are robust and clinically significant for development of hypertension and prehypertension, two of the leading causes of preventable mortality worldwide, in adults with a high-sodium diet. Data from developed nations and transition economies show worldwide sodium intake of higher than recommended amounts in various nations. While natural foods typically contain a moderate amount of sodium, manufactured food products are the main contributor to dietary sodium intake, up to …

Smoking, Depression, And Hospital Costs Of Respiratory Cancers: Examining Race And Sex Variation, Baqar A. Husaini, Robert S. Levine, Phillip Lammers, Pam Hull, Meggan Novotny, Majaz Moonis

Center for Prevention Research Publications

Objective To investigate the effect of smoking and depression on hospital costs for lung cancer (LC).

Methods We extracted data on depression, smoking history, demographics, and hospital charges for patients with respiratory cancers (ICD-9 codes 161–163, 165) from the 2008 Tennessee Hospital Discharge Data System. The sample (n=6665) was mostly white (86%) and male (57%). Age-adjusted rates were developed in accordance with Centers for Disease Control and Prevention methods, and hospital costs were compared for patients with LC with versus without depression and a smoking history.

Results Three findings (P<0.001) emerged: (1) the LC rate was higher among blacks than among whites, and higher among men than among women; (2) while 66% of LC patients smoked (more men than women without racial variation), 24% had depression (more females and whites were depressed); (3) the LC hospital cost was 54% higher than the non-LC hospital cost, and this cost doubled for patients with LC with depression and smoking versus those without such characteristics.

Conclusion While LC is more prevalent among …

A Community-Driven Intervention For Improving Biospecimen Donation In African American Communities, Kushal Patel, Wendelyn Inman, Jemal Gishe, Owen Johnson, Elizabeth Brown, Mohamed Kanu, Rosemary Theriot, Maureen Sanderson, Pamela Hull, Margaret Hargreaves

Public Health, Health Administration, and Health Sciences Faculty Research

Introduction

Human biospecimens are an invaluable resource for addressing cancers and other chronic diseases. The purpose of this study was to assess the impact of an educational intervention on biospecimen knowledge and attitudes.

Methods

The participants consisted of 112 African Americans, 18 years and older, and who had not provided biospecimens for any health-related research in the past. A total of 55 participants received the educational brochure, and 57 received the educational video. The main outcomes of the study were knowledge and attitudes for biospecimen donation. This information was collected pre- and post-intervention.

Results

The average knowledge scores increased ( …

Time From Screening Mammography To Biopsy And From Biopsy To Breast Cancer Treatment Among Black And White, Women Medicare Beneficiaries Not Participating In A Health Maintenance Organization, Rebecca Selove, Barbara Kilbourne, Mary Kay Fadden, Maureen Sanderson, Maya Foster, Regina Offodile, Baqar Husaini, Charles Mouton, Robert S. Levine

Sociology Faculty Research

Purpose

There is a breast cancer mortality gap adversely affecting Black women in the United States. This study assessed the relationship between number of days between abnormal mammogram, biopsy, and treatment among Medicare (Part B) beneficiaries ages 65 to 74 and 75 to 84 years, accounting for race and comorbidity.

Methods

A cohort of non-Hispanic Black and non-Hispanic White women residing in the continental United States and receiving no services from a health maintenance organization was randomly selected from the Center for Medicare and Medicaid Services denominator file. The cohort was followed from 2005 to 2008 using Center …

An Empirical Investigation Of Funding Trends In Global Health, Marie H. Martin, Megan E. Streams

Public Administration Faculty Research

Background Since 2005, funding for global health has increased, not only from donor OECD nations, but also from within low-income and middle-income countries via their own governmental health spending. However, there has been little analysis of budgetary trends in global health from a public finance angle. This study provides a quantitative analysis of the distribution of annual changes in country-level government expenditures for domestic health (1995–2012) using the theoretical lens of budgetary punctuated equilibrium theory (PET).

Methods We used health financing data from the Institute for Health Metrics and Evaluation to calculate country-level annual changes in government spending on domestic …

The Public Health Exposome: A Population-Based, Exposure Science Approach To Health Disparities Research, Paul D. Juarez, Patricia Matthews-Juarez, Darryl B. Hood, Wansoo Im, Robert S. Levine, Barbara J. Kilbourne, Michael A. Langston, Mohammad Z. Al-Hamdan, William L. Crosson, Maurice G. Estes, Sue M. Estes, Vincent K. Agboto, Paul Robinson, Sacoby Wilson, Maureen Y. Lichtveld

Sociology Faculty Research

The lack of progress in reducing health disparities suggests that new approaches are needed if we are to achieve meaningful, equitable, and lasting reductions. Current scientific paradigms do not adequately capture the complexity of the relationships between environment, personal health and population level disparities. The public health exposome is presented as a universal exposure tracking framework for integrating complex relationships between exogenous and endogenous exposures across the lifespan from conception to death. It uses a social-ecological framework that builds on the exposome paradigm for conceptualizing how exogenous exposures “get under the skin”. The public health exposome approach has led our …

Exploration Of Preterm Birth Rates Using The Public Health Exposome Database And Computational Analysis Methods, Anne D. Kershenbaum, Michael A. Langston, Robert S. Levine, Arnold M. Saxton, Tonny J. Oyana, Barbara J. Kilbourne, Gary L. Rogers, Lisaann S. Gittner, Suzanne H. Baktash, Patricia Matthews-Juarez, Paul D. Juarez

Sociology Faculty Research

Recent advances in informatics technology has made it possible to integrate, manipulate, and analyze variables from a wide range of scientific disciplines allowing for the examination of complex social problems such as health disparities. This study used 589 county-level variables to identify and compare geographical variation of high and low preterm birth rates. Data were collected from a number of publically available sources, bringing together natality outcomes with attributes of the natural, built, social, and policy environments. Singleton early premature county birth rate, in counties with population size over 100,000 persons provided the dependent variable. Graph theoretical techniques were used …

Social Determinants And The Classification Of Disease: Descriptive Epidemiology Of Selected Socially Mediated Disease Constellations, Robert S. Levine, Barbara A. Kilbourne, George S. Rust, Michael A. Langston, Baqar A. Husaini, Lisaann S. Gittner, Maureen Sanderson, Charles H. Hennekens

Sociology Faculty Research

Background

Most major diseases have important social determinants. In this context, classification of disease based on etiologic or anatomic criteria may be neither mutually exclusive nor optimal.

Methods and Findings

Scalable Combinatorial Tools For Health Disparities Research, Michael A. Langston, Robert S. Levine, Barbara J. Kilbourne, Gary L. Rogers Jr., Anne D. Kershenbaum, Suzanne H. Baktash, Steven S. Coughlin, Arnold M. Saxton, Vincent K. Agboto, Darryl B. Hood, Maureen Y. Litchveld, Tonny J. Oyana, Patricia Matthews-Juarez, Paul D. Juarez

Sociology Faculty Research

Despite staggering investments made in unraveling the human genome, current estimates suggest that as much as 90% of the variance in cancer and chronic diseases can be attributed to factors outside an individual’s genetic endowment, particularly to environmental exposures experienced across his or her life course. New analytical approaches are clearly required as investigators turn to complicated systems theory and ecological, place-based and life-history perspectives in order to understand more clearly the relationships between social determinants, environmental exposures and health disparities. While traditional data analysis techniques remain foundational to health disparities research, they are easily overwhelmed by the ever-increasing size …

Mammography Use Among Women With And Without Diabetes: Results From The Southern Community Cohort Study, Maureen Sanderson, Loren Lipworth, Xijing Han, Alicia Beeghly-Fadiel, David Shen-Miller, Kushal A. Patel, William J. Blot, Margaret K. Hargreaves

Public Health, Health Administration, and Health Sciences Faculty Research

Studies have shown an increased risk of breast cancer associated with diabetes which may be due to differences in mammography use among women who have diabetes compared with women who do not have diabetes. Baseline data was used from the Southern Community Cohort Study – a prospective cohort study conducted primarily among low-income persons in the southeastern United States – to examine the association between diabetes and mammography use. In-person interviews collected information on diabetes and mammography use from 14,665 white and 30,846 black women aged 40–79 years between 2002 and 2009. After adjustment for potential confounding, white women with …

Factors Influencing Breast Cancer Screening In Low-Income African Americans In Tennessee, Kushal Patel, Mohamed Kanu, Jianguo Liu, Brea Bond, Elizabeth Brown, Elizabeth Williams, Rosemary Theriot, Stephanie Bailey, Maureen Sanderson, Margaret Hargreaves

Public Health, Health Administration, and Health Sciences Faculty Research

This study examined demographic and lifestyle factors that influenced decisions and obstacles to being screened for breast cancer in low-income African Americans in three urban Tennessee cities. As part of the Meharry Community Networks Program (CNP) needs assessment, a 123-item community survey was administered to assess demographic characteristics, health care access and utilization, and screening practices for various cancers in low-income African Americans. For this study, only African American women 40 years and older (n = 334) were selected from the Meharry CNP community survey database. There were several predictors of breast cancer screening such as marital status and having …

Hpv Vaccine Use Among African American Girls: Qualitative Formative Research Using A Participatory Social Marketing Approach, Pamela C. Hull, Elizabeth A. Williams, Dineo Khabele, Candace Dean, Brea Bond, Maureen Sanderson

Public Health, Health Administration, and Health Sciences Faculty Research

Objective

To generate recommendations for framing messages to promote HPV vaccination, specifically for African American adolescents and their parents who have not yet made a decision about the vaccine (the “Undecided” market segment).

Methods

Focus groups and interviews were conducted with African American girls ages 11–18 (N = 34) and their mothers (N = 31), broken into market segments based on daughter's vaccination status and mother's intent to vaccinate.

Results

Findings suggested that the HPV vaccine should be presented to “Undecided” mothers and adolescents as a routine vaccine (just like other vaccines) that helps prevent cancer. Within the “Undecided” segment, …

Plasma Selenium Biomarkers In Low Income Black And White Americans From The Southeastern United States, Margaret K. Hargreaves, Jianguo Liu, Maciej S. Buchowski, Kushal A. Patel, Celia O. Larson, David G. Schlundt, Donna M. Kenerson, Kristina E. Hill, Raymond F. Burk, William J. Blot

Public Health, Health Administration, and Health Sciences Faculty Research

Biomarkers of selenium are necessary for assessing selenium status in humans, since soil variation hinders estimation of selenium intake from foods. In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interindividual differences in 383 low-income blacks and whites selected from a stratified random sample of adults aged 40–79 years, who were participating in a long-term cohort study in the southeastern United States (US). We assessed the utility of these biomarkers to determine differences in selenium status and their association with demographic, socio-economic, dietary, and other indicators. Dietary selenium intake …

A Community-Driven Intervention For Prostate Cancer Screening In African Americans, Kushal Patel, Flora Ukoli, Jianguo Liu, Derrick Beech, Katina Beard, Byron Brown, Maureen Sanderson, Donna Kenerson, Leslie Cooper, Marie Canto, Bill Blot, Margaret Hargreaves

Public Health, Health Administration, and Health Sciences Faculty Research

The purpose of the study was to assess the impact of an educational intervention on prostate cancer screening behavior and knowledge. Participants were 104 African American men, 45 years and older, who had not been screened for prostate cancer with a prostate-specific antigen and/or digital rectal exam within the past year. All participants received an intervention delivered by trained lay community educators using a prostate cancer educational brochure developed in collaboration with the community, with structured interviews preintervention and 3 months postintervention. The main study outcomes included prostate-specific antigen screening rates during the 3-month interval and knowledge, barriers to screenings, …

Firearms, Youth Homicide, And Public Health, Robert S. Levine, Irwin Goldzweig, Barbara Kilbourne, Paul Juarez

Sociology Faculty Research

Homicide is seven times as common among U.S. non-Hispanic Black as among non-Hispanic White youth ages 15 to 24 years. In 83% of these youth homicides, the murder weapon is a firearm. Yet, for more than a decade, the national public health position on youth violence has been largely silent about the role of firearms, and tools used by public health professionals to reduce harm from other potential hazards have been unusable where guns are concerned. This deprives already underserved populations from the full benefits public health agencies might be able to deliver. In part, political prohibitions against research about …

Diabetes And Co-Morbid Depression Among Racially Diverse, Low-Income Adults, Chandra Y. Osborn, Kushal A. Patel, Jianguo Liu, Hollister W. Trott, Maciej S. Buchowski, Margaret K. Hargreaves, William J. Blot, Sarah S. Cohen, David G. Schlundt

Public Health, Health Administration, and Health Sciences Faculty Research

Background

Research suggests individuals with diabetes are twice as likely as those without diabetes to be clinically depressed. Still unknown is the relationship between diabetes and depression in socioeconomically disadvantaged populations. Purpose

We examined the relationship between diabetes and depressive symptoms in a large, racially diverse, low-income cohort in the southeastern USA. Methods

A total of 69,068 adults were recruited from community health centers in 12 southeastern states. A fully adjusted polytomous logistic regression model tested the relationship between demographics, lifestyle behaviors, antidepressant use, body mass index, diabetes diagnosis, diabetes duration, diabetes medication compliance, and depressive symptoms using the Centers …

Using A Participatory Research Process To Address Disproportionate Hispanic Cancer Burden, Pamela C. Hull, Juan R. Canedo, Michelle C. Reece, Irma Lira, Francisco Reyes, Erandi Garcia, Paul Juarez, Elizabeth Williams, Baqar A. Husaini

Public Health, Health Administration, and Health Sciences Faculty Research

Community-based participatory research (CBPR) offers great potential for increasing the impact of research on reducing cancer health disparities. This article reports how the Community Outreach Core (COC) of the Meharry–Vanderbilt–Tennessee State University (TSU) Cancer Partnership has collaborated with community partners to develop and implement CBPR. The COC, Progreso Community Center, and Nashville Latino Health Coalition jointly developed and conducted the 2007 Hispanic Health in Nashville Survey as a participatory needs assessment to guide planning for subsequent CBPR projects and community health initiatives. Trained community and student interviewers surveyed 500 Hispanic adults in the Nashville area, using a convenience sampling method. …

Chronic Illness And Smoking Cessation, Kushal Patel, David Schlundt, Celia Larson, Hong Wang, Anne Brown, Margaret Hargreaves

Public Health, Health Administration, and Health Sciences Faculty Research

Introduction

Smoking is among the leading causes of premature mortality and preventable death in the United States. Although smoking contributes to the probability of developing chronic illness, little is known about the relationship between quitting smoking and the presence of chronic illness. The present study investigated the association between diagnoses of one or more chronic diseases (diabetes, hypertension, or high cholesterol) and smoking status (former or current smoker). Methods

The data analyzed were a subset of questions from a 155-item telephone-administered community survey that assessed smoking status, demographic characteristics, and presence of chronic disease. The study sample consisted of 3,802 …