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Full-Text Articles in Medicine and Health Sciences

The Public Health Exposome: A Population-Based, Exposure Science Approach To Health Disparities Research, Paul D. Juarez, Patricia Matthews-Juarez, Darryl B. Hood, Wansoo Im, Robert S. Levine, Barbara J. Kilbourne, Michael A. Langston, Mohammad Z. Al-Hamdan, William L. Crosson, Maurice G. Estes, Sue M. Estes, Vincent K. Agboto, Paul Robinson, Sacoby Wilson, Maureen Y. Lichtveld Dec 2014

The Public Health Exposome: A Population-Based, Exposure Science Approach To Health Disparities Research, Paul D. Juarez, Patricia Matthews-Juarez, Darryl B. Hood, Wansoo Im, Robert S. Levine, Barbara J. Kilbourne, Michael A. Langston, Mohammad Z. Al-Hamdan, William L. Crosson, Maurice G. Estes, Sue M. Estes, Vincent K. Agboto, Paul Robinson, Sacoby Wilson, Maureen Y. Lichtveld

Sociology Faculty Research

The lack of progress in reducing health disparities suggests that new approaches are needed if we are to achieve meaningful, equitable, and lasting reductions. Current scientific paradigms do not adequately capture the complexity of the relationships between environment, personal health and population level disparities. The public health exposome is presented as a universal exposure tracking framework for integrating complex relationships between exogenous and endogenous exposures across the lifespan from conception to death. It uses a social-ecological framework that builds on the exposome paradigm for conceptualizing how exogenous exposures “get under the skin”. The public health exposome approach has led our …


Exploration Of Preterm Birth Rates Using The Public Health Exposome Database And Computational Analysis Methods, Anne D. Kershenbaum, Michael A. Langston, Robert S. Levine, Arnold M. Saxton, Tonny J. Oyana, Barbara J. Kilbourne, Gary L. Rogers, Lisaann S. Gittner, Suzanne H. Baktash, Patricia Matthews-Juarez, Paul D. Juarez Nov 2014

Exploration Of Preterm Birth Rates Using The Public Health Exposome Database And Computational Analysis Methods, Anne D. Kershenbaum, Michael A. Langston, Robert S. Levine, Arnold M. Saxton, Tonny J. Oyana, Barbara J. Kilbourne, Gary L. Rogers, Lisaann S. Gittner, Suzanne H. Baktash, Patricia Matthews-Juarez, Paul D. Juarez

Sociology Faculty Research

Recent advances in informatics technology has made it possible to integrate, manipulate, and analyze variables from a wide range of scientific disciplines allowing for the examination of complex social problems such as health disparities. This study used 589 county-level variables to identify and compare geographical variation of high and low preterm birth rates. Data were collected from a number of publically available sources, bringing together natality outcomes with attributes of the natural, built, social, and policy environments. Singleton early premature county birth rate, in counties with population size over 100,000 persons provided the dependent variable. Graph theoretical techniques were used …


Social Determinants And The Classification Of Disease: Descriptive Epidemiology Of Selected Socially Mediated Disease Constellations, Robert S. Levine, Barbara A. Kilbourne, George S. Rust, Michael A. Langston, Baqar A. Husaini, Lisaann S. Gittner, Maureen Sanderson, Charles H. Hennekens Nov 2014

Social Determinants And The Classification Of Disease: Descriptive Epidemiology Of Selected Socially Mediated Disease Constellations, Robert S. Levine, Barbara A. Kilbourne, George S. Rust, Michael A. Langston, Baqar A. Husaini, Lisaann S. Gittner, Maureen Sanderson, Charles H. Hennekens

Sociology Faculty Research

Background

Most major diseases have important social determinants. In this context, classification of disease based on etiologic or anatomic criteria may be neither mutually exclusive nor optimal.

Methods and Findings

Units of analysis comprised large metropolitan central and fringe metropolitan counties with reliable mortality rates – (n = 416). Participants included infants and adults ages 25 to 64 years with selected causes of death (1999 to 2006). Exposures included that residential segregation and race-specific social deprivation variables. Main outcome measures were obtained via principal components analyses with an orthogonal rotation to identify a common factor. To discern whether the common …


Scalable Combinatorial Tools For Health Disparities Research, Michael A. Langston, Robert S. Levine, Barbara J. Kilbourne, Gary L. Rogers Jr., Anne D. Kershenbaum, Suzanne H. Baktash, Steven S. Coughlin, Arnold M. Saxton, Vincent K. Agboto, Darryl B. Hood, Maureen Y. Litchveld, Tonny J. Oyana, Patricia Matthews-Juarez, Paul D. Juarez Oct 2014

Scalable Combinatorial Tools For Health Disparities Research, Michael A. Langston, Robert S. Levine, Barbara J. Kilbourne, Gary L. Rogers Jr., Anne D. Kershenbaum, Suzanne H. Baktash, Steven S. Coughlin, Arnold M. Saxton, Vincent K. Agboto, Darryl B. Hood, Maureen Y. Litchveld, Tonny J. Oyana, Patricia Matthews-Juarez, Paul D. Juarez

Sociology Faculty Research

Despite staggering investments made in unraveling the human genome, current estimates suggest that as much as 90% of the variance in cancer and chronic diseases can be attributed to factors outside an individual’s genetic endowment, particularly to environmental exposures experienced across his or her life course. New analytical approaches are clearly required as investigators turn to complicated systems theory and ecological, place-based and life-history perspectives in order to understand more clearly the relationships between social determinants, environmental exposures and health disparities. While traditional data analysis techniques remain foundational to health disparities research, they are easily overwhelmed by the ever-increasing size …


Mammography Use Among Women With And Without Diabetes: Results From The Southern Community Cohort Study, Maureen Sanderson, Loren Lipworth, Xijing Han, Alicia Beeghly-Fadiel, David Shen-Miller, Kushal A. Patel, William J. Blot, Margaret K. Hargreaves Apr 2014

Mammography Use Among Women With And Without Diabetes: Results From The Southern Community Cohort Study, Maureen Sanderson, Loren Lipworth, Xijing Han, Alicia Beeghly-Fadiel, David Shen-Miller, Kushal A. Patel, William J. Blot, Margaret K. Hargreaves

Public Health, Health Administration, and Health Sciences Faculty Research

Studies have shown an increased risk of breast cancer associated with diabetes which may be due to differences in mammography use among women who have diabetes compared with women who do not have diabetes. Baseline data was used from the Southern Community Cohort Study – a prospective cohort study conducted primarily among low-income persons in the southeastern United States – to examine the association between diabetes and mammography use. In-person interviews collected information on diabetes and mammography use from 14,665 white and 30,846 black women aged 40–79 years between 2002 and 2009. After adjustment for potential confounding, white women with …


Factors Influencing Breast Cancer Screening In Low-Income African Americans In Tennessee, Kushal Patel, Mohamed Kanu, Jianguo Liu, Brea Bond, Elizabeth Brown, Elizabeth Williams, Rosemary Theriot, Stephanie Bailey, Maureen Sanderson, Margaret Hargreaves Feb 2014

Factors Influencing Breast Cancer Screening In Low-Income African Americans In Tennessee, Kushal Patel, Mohamed Kanu, Jianguo Liu, Brea Bond, Elizabeth Brown, Elizabeth Williams, Rosemary Theriot, Stephanie Bailey, Maureen Sanderson, Margaret Hargreaves

Public Health, Health Administration, and Health Sciences Faculty Research

This study examined demographic and lifestyle factors that influenced decisions and obstacles to being screened for breast cancer in low-income African Americans in three urban Tennessee cities. As part of the Meharry Community Networks Program (CNP) needs assessment, a 123-item community survey was administered to assess demographic characteristics, health care access and utilization, and screening practices for various cancers in low-income African Americans. For this study, only African American women 40 years and older (n = 334) were selected from the Meharry CNP community survey database. There were several predictors of breast cancer screening such as marital status and having …


Hpv Vaccine Use Among African American Girls: Qualitative Formative Research Using A Participatory Social Marketing Approach, Pamela C. Hull, Elizabeth A. Williams, Dineo Khabele, Candace Dean, Brea Bond, Maureen Sanderson Jan 2014

Hpv Vaccine Use Among African American Girls: Qualitative Formative Research Using A Participatory Social Marketing Approach, Pamela C. Hull, Elizabeth A. Williams, Dineo Khabele, Candace Dean, Brea Bond, Maureen Sanderson

Public Health, Health Administration, and Health Sciences Faculty Research

Objective

To generate recommendations for framing messages to promote HPV vaccination, specifically for African American adolescents and their parents who have not yet made a decision about the vaccine (the “Undecided” market segment).

Methods

Focus groups and interviews were conducted with African American girls ages 11–18 (N = 34) and their mothers (N = 31), broken into market segments based on daughter's vaccination status and mother's intent to vaccinate.

Results

Findings suggested that the HPV vaccine should be presented to “Undecided” mothers and adolescents as a routine vaccine (just like other vaccines) that helps prevent cancer. Within the “Undecided” segment, …


Plasma Selenium Biomarkers In Low Income Black And White Americans From The Southeastern United States, Margaret K. Hargreaves, Jianguo Liu, Maciej S. Buchowski, Kushal A. Patel, Celia O. Larson, David G. Schlundt, Donna M. Kenerson, Kristina E. Hill, Raymond F. Burk, William J. Blot Jan 2014

Plasma Selenium Biomarkers In Low Income Black And White Americans From The Southeastern United States, Margaret K. Hargreaves, Jianguo Liu, Maciej S. Buchowski, Kushal A. Patel, Celia O. Larson, David G. Schlundt, Donna M. Kenerson, Kristina E. Hill, Raymond F. Burk, William J. Blot

Public Health, Health Administration, and Health Sciences Faculty Research

Biomarkers of selenium are necessary for assessing selenium status in humans, since soil variation hinders estimation of selenium intake from foods. In this study, we measured the concentration of plasma selenium, selenoprotein P (SEPP1), and glutathione peroxidase (GPX3) activity and their interindividual differences in 383 low-income blacks and whites selected from a stratified random sample of adults aged 40–79 years, who were participating in a long-term cohort study in the southeastern United States (US). We assessed the utility of these biomarkers to determine differences in selenium status and their association with demographic, socio-economic, dietary, and other indicators. Dietary selenium intake …