Medicine and Health Sciences Commons^™

Enhancing Post-Injury Rehabilitation: A Focus On Prehabilitation For Athletes, Kariya Jennings, Kyanne Crockarell, Rishi Gulati, Mallory Rae, Dakota Hill, Deborah Edmondson

Physical Therapy Student Research

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No abstract provided.

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Public Health Importance Of Preventive Measures For Salmonella Tennessee And Salmonella Typhimurium Strain Lt2 Biofilms, Simen Asefaw, Sadiye Aras, Md Niamul Kabir, Sabrina Wadood, Shahid Chowdhury, Aliyar Cyrus Fouladkhah

Biology Faculty Research

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Various serovars of Salmonella had been the subject of research for over 150 years; nonetheless, the bacterium has remained an important pathogen of public health concern to date. The tremendous ability of Salmonella to form biofilms on biotic and abiotic surfaces is an important underlying reason for the prevalence of this opportunistic pathogen in healthcare, manufacturing, and the food chain. The current study illustrates that using very common industrial antimicrobial treatments at the highest concentrations suggested by the manufacturers is only efficacious against planktonic and one-day mature biofilms of the pathogen while exhibiting a lack of efficacy for complete removal …

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Using Community-Based Participatory Research To Assess The Needs Of Hiv-Related Services For Infected Individuals In Rural Communities, Elizabeth Brown, Charles Brown, Owen Johnson, Wendelyn Inman, Revlon Briggs, Wanda Burrell, Rosemary Theriot, Elizabeth Williams, Alexis Heaston

Public Health, Health Administration, and Health Sciences Faculty Research

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HIV/AIDS remains a significant health concern in rural communities, which may also experience many disparate issues including reduced access to health services (Department of Health and Human Services, 2015). Community efforts should be increased to improve services to people living with HIV/AIDS (PLWHA), especially in rural communities. In the state of Tennessee, using a community-based participatory research (CBPR) approach, a needs assessment was conducted to identify gaps, barriers, and strategies for improving HIV-related comprehensive care services for people diagnosed with HIV/AIDS in 26 rural counties. The paper describes the CBPR partnership and the needs assessment project that was conducted and …

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Longitudinal Education And Career Outcomes Of A Cancer Research Training Program For Underrepresented Students: The Meharry-Vanderbilt-Tennessee State University Cancer Partnership, Meredith L. Meadows, Sarah V. Suiter, Linda J. Sealy, Dana R. Marshall, Margaret M. Whalen, Samuel E. Adunyah

Chemistry Faculty Research

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This study examined longitudinal education and career outcomes of the Meharry-Vanderbilt-Tennessee State University Cancer Partnership, the longest-running National Cancer Institute (NCI) Comprehensive Partnerships in Advancing Cancer Health Equity (CPACHE) program site in the United States. Degree completion rates were calculated and progression along the entire postsecondary “pipeline” was quantified for 204 participants recruited between 2011 and 2020. For participants who had entered the workforce, career outcomes were also analyzed. Relative to comparison data, participants completed degrees and progressed through the higher education “pipeline” to earn advanced degrees at remarkably high rates; the majority entered careers in which they support or …

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Assessing The Contribution Of Immigrants To Canada's Nursing And Health Care Support Occupations: A Multi-Scalar Analysis, Rafael Harun, Margaret Walton-Roberts

Social Work and Urban Studies Faculty Research

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Background

The World Health Organization adopted the Global Strategy on Human Resources for Health Workforce 2030 in May 2016. It sets specific milestones for improving health workforce planning in member countries, such as developing a health workforce registry by 2020 and ensuring workforce self-sufficiency by halving dependency on foreign-trained health professionals. Canada falls short in achieving these milestones due to the absence of such a registry and a poor understanding of immigrants in the health workforce, particularly nursing and healthcare support occupations. This paper provides a multiscale (Canada, Ontario, and Ontario’s Local Health Integration Networks) overview of immigrant participation in …

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The Black Church And Public Health: A Key Partnership For Theory Driven Covid-19 Recovery Efforts, Natasha R. Brown, Candice L. Alick, Alexis G. Heaston, Shanada Monestime, Nicolette Powe

Public Health, Health Administration, and Health Sciences Faculty Research

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The COVID-19 epidemic has negatively impacted the Black community in the United States. Despite current disease mitigation efforts, work is still needed to ensure that Black individuals living in the United States understand their risks regarding COVID-19 infection whether vaccinated or unvaccinated. Thus, the current article posits that the Black church, in concert with public health practitioners, is a venue through which theoretically based health messages should be designed and disseminated regarding COVID-19 recovery efforts. The Health Belief Model and the Harm Reduction approach are posed as theoretical frameworks to facilitate the design of such messages.

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Is The Use Of Oral Contraceptive Beneficial To Female Athletes In The Prevention Of Anterior Cruciat Ligament Injury?, Mia Faragalli, Kara Taylor, Abi Welch, Edilberto Raynes

Student Research

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No abstract provided.

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Clinician Perception Of Treatment For Schizophrenia: Sensory-Based Therapy Or Medication, Sydney Hill, Alexa Almond, Kelsie Moosmann, Sara Boggs

Student Research

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Purpose

The purpose of this study is to evaluate clinicians' perception of treatment and lived experience of occupational therapists treating clients diagnosed with Schizophrenia. The two identified treatment variables will be medication and sensory-based therapy and their relation to emotional regulation.

Methods

This study uses a mixed method, correlational design and data will be collected using an online Google Forms platform. Participants include licensed and registered occupational therapists who are currently treating individuals diagnosed with Schizophrenia. The survey was written to branch to relevant questions based on participants' answers. This branching method allows us to collect perception of treatment and …

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Magnetic Nanoparticles Enhanced Surface Plasmon Resonance Biosensor For Rapid Detection Of Salmonella Typhimurium In Romaine Lettuce, Devendra Bhandari, Fur-Chi Chen, Roger C. Bridgman

Human Sciences Faculty Research

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Salmonella is one of the major foodborne pathogens responsible for many cases of illnesses, hospitalizations and deaths worldwide. Although different methods are available to timely detect Salmonella in foods, surface plasmon resonance (SPR) has the benefit of real-time detection with a high sensitivity and specificity. The purpose of this study was to develop an SPR method in conjunction with magnetic nanoparticles (MNPs) for the rapid detection of Salmonella Typhimurium. The assay utilizes a pair of well-characterized, flagellin-specific monoclonal antibodies; one is immobilized on the sensor surface and the other is coupled to the MNPs. Samples of romaine lettuce contaminated with …

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Immunometabolic Dysregulation At The Intersection Of Obesity And Covid-19, Collins N. Khwatenge, Marquette Pate, Laura C. Miller, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

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Obesity prevails worldwide to an increasing effect. For example, up to 42% of American adults are considered obese. Obese individuals are prone to a variety of complications of metabolic disorders including diabetes mellitus, hypertension, cardiovascular disease, and chronic kidney disease. Recent meta-analyses of clinical studies in patient cohorts in the ongoing coronavirus-disease 2019 (COVID-19) pandemic indicate that the presence of obesity and relevant disorders is linked to a more severe prognosis of COVID-19. Given the significance of obesity in COVID-19 progression, we provide a review of host metabolic and immune responses in the immunometabolic dysregulation exaggerated by obesity and the …

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Jordan's Public Policy Response To Covid-19 Pandemic: Insight And Policy Analysis, Wa’Ed Alshoubaki, Michael Harris

Public Administration Faculty Research

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The aim of this study was to gain an understanding of how the Jordanian government has responded and continues to respond to the COVID-19 pandemic. It utilizes the interpretive policy analysis approach through document analysis. The analysis showed that Jordan created social protection policies to assist people who lost their jobs or whose work was suspended due to the coronavirus. The economic policies build solidarity and facilitate the private sector’s recovery. The health care measures firmly applied included lockdown, wearing masks, and restrictions on gatherings and public events. Jordan uses hard power and imposes sanctions on any violation that threatens …

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Association Of Oral Microbiota With Lung Cancer Risk In A Low-Income Population In The Southeastern Usa, Jiajun Shi, Yaohua Yang, Hua Xie, Xiaofei Wang, Jie Wu, Jirong Long, Regina Courtney, Xiao-Ou Shu, Wei Zheng, William J. Blot, Qiuyin Cai

Biology Faculty Research

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Purpose

Oral microbiome plays an important role in oral health and systemic diseases, including cancer. We aimed to prospectively investigate the association of oral microbiome with lung cancer risk.

Methods

We analyzed 156 incident lung cancer cases (73 European Americans and 83 African Americans) and 156 individually matched controls nested within the Southern Community Cohort Study. Oral microbiota were assessed using 16S rRNA gene sequencing in pre-diagnostic mouth rinse samples. Paired t test and the permutational multivariate analysis of variance test were used to evaluate lung cancer risk association with alpha diversity or beta diversity, respectively. Conditional logistic regression models …

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Current And Future Implications Of Covid-19 Among Youth Wheelchair Users: 24-Hour Activity Behavior, Ryan T. Conners, Lauren C. Bates, Patricia Pagan Lassalle, Gabriel Zieff, Paul N. Whitehead, Sandra Stevens, Lauren Killen, Robert Cochrum, Kathryn L. Rodebaugh, Mark Faghy, Lee Stoner

Human Performance and Sport Sciences faculty Research

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Preventative measures taken worldwide to decrease the transmission of COVID-19 have had a tremendous impact on youth. Following social restrictions, youth with and without physical disabilities are engaging in less physical activity, more increased sedentary behavior, and poor sleep habits. Specifically, youth wheelchair users (YWU) are likely disproportionately affected by COVID- 19 and have a higher risk of contraction due to underlying comorbidities. While we cannot control all of the negative long-term implications of COVID-19 for YWU, participation in positive 24-h activity behaviors can decrease chronic disease risk and the likelihood of long-term complications resulting from infection. This commentary is …

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Virus-Targeted Transcriptomic Analyses Implicate Ranaviral Interaction With Host Interferon Response In Frog Virus 3-Infected Frog Tissues, Yun Tian, Francisco De Jesús Andino, Collins N. Khwatenge, Jiuyi Li, Jacques Robert, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

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Ranaviruses (Iridoviridae), including Frog Virus 3 (FV3), are large dsDNA viruses that cause devastating infections globally in amphibians, fish, and reptiles, and contribute to catastrophic amphibian declines. FV3’s large genome (~105 kb) contains at least 98 putative open reading frames (ORFs) as annotated in its reference genome. Previous studies have classified these coding genes into temporal classes as immediate early, delayed early, and late viral transcripts based on their sequential expression during FV3 infection. To establish a high-throughput characterization of ranaviral gene expression at the genome scale, we performed a whole transcriptomic analysis (RNA-Seq) using total RNA samples containing both …

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Targeted Transcriptomics Of Frog Virus 3 In Infected Frog Tissues Reveal Non-Coding Regulatory Elements And Micrornas In The Ranaviral Genome And Their Potential Interaction With Host Immune Response, Yun Tian, Collins N. Khwatenge, Jiuyi Li, Francisco De Jesús Andino, Jacques Robert, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

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Background: Frog Virus 3 (FV3) is a large dsDNA virus belonging to Ranaviruses of family Iridoviridae. Ranaviruses infect cold-blood vertebrates including amphibians, fish and reptiles, and contribute to catastrophic amphibian declines. FV3 has a genome at ~105 kb that contains nearly 100 coding genes and 50 intergenic regions as annotated in its reference genome. Previous studies have mainly focused on coding genes and rarely addressed potential non-coding regulatory role of intergenic regions.

Results: Using a whole transcriptomic analysis of total RNA samples containing both the viral and cellular transcripts from FV3-infected frog tissues, we detected virus-specific reads mapping in …

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Phycobilins As Potent Food Bioactive Broad-Spectrum Inhibitors Against Proteases Of Sars-Cov-2 And Other Coronaviruses: A Preliminary Study, Brahmaiah Pendyala, Ankit Patras, Chandravanu Dash

Agricultural and Environmental Sciences Faculty Research

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In the 21st century, we have witnessed three coronavirus outbreaks: SARS in 2003, MERS in 2012, and the ongoing pandemic coronavirus disease 2019 (COVID-19). The search for efficient vaccines and development and repurposing of therapeutic drugs are the major approaches in the COVID-19 pandemic research area. There are concerns about the evolution of mutant strains (e.g., VUI – 202012/01, a mutant coronavirus in the United Kingdom), which can potentially reduce the impact of the current vaccine and therapeutic drug development trials. One promising approach to counter the mutant strains is the “development of effective broad-spectrum antiviral drugs” against coronaviruses. This …

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Sex Differences In Weight Perception And Weight Gain Among Black College Students In The Usa, Jounghee Lee, Jaesin Sa, Jean-Philippe Chaput, James Heimdal, Beatrice Nelson, Beom-Young Cho, Elizabeth Kwon

Human Performance and Sport Sciences faculty Research

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Objectives

The aims of this study were to examine the prevalence of overweight/obesity and to explore sex differences in body weight perceptions and correlates of weight gain among Black students at 2 historically Black colleges and universities (HBCUs) in the USA.

Methods

Participants completed a paper-based survey, and their height and weight were measured (67% completion rate).

Results

The overweight and obesity rates were 33.8% and 26.9%, respectively. More females than males accurately assessed their weight (p<0.05). Body weight underestimation was associated with male sex, excellent/very good perceived overall health, and not being informed by a doctor of having overweight or obesity (p<0.01). Higher odds of ≥5% weight gain were related to female sex, living on campus, and not being informed by a doctor of having overweight or obesity (p<0.05).

Conclusion

Given the high overweight and obesity rates among Black students, HBCUs in the USA should develop intervention strategies for …

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Combined Luteolin And Indole-3-Carbinol Synergistically Constrains Erα-Positive Breast Cancer By Dual Inhibiting Estrogen Receptor Alpha And Cyclin-Dependent Kinase 4/6 Pathway In Cultured Cells And Xenograft Mice, Xiaoyong Wang, Lijuan Zhang, Qi Dai, Hongzong Si, Longyun Zhang, Sakina E. Eltom, Hongwei Si

Human Sciences Faculty Research

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The high concentrations of individual phytochemicals in vitro studies cannot be physiologically achieved in humans. Our solution for this concentration gap between in vitro and human studies is to combine two or more phytochemicals. We screened 12 phytochemicals by pairwise combining two compounds at a low level to select combinations exerting the synergistic inhibitory effect of breast cancer cell proliferation. A novel combination of luteolin at 30 μM (LUT30) and indole-3-carbinol 40 μM (I3C40) identified that this combination (L30I40) synergistically constrains ERα⁺ breast cancer cell (MCF7 and T47D) proliferation only, but not triple-negative breast cancer cells. At the same …

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Dietary Anti-Aging Polyphenols And Potential Mechanisms, Jing Luo, Hongwei Si, Zhenquan Jia, Dongmin Liu

Human Sciences Faculty Research

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For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, and decreasing morbidities. With the assistance of basic research investigating the potential mechanisms, it has become clear that the beneficial effects of plant-based foods are mainly due to the large amount of bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies in humans have supported that the supplementation of polyphenols have various health-promoting effects, especially in the elderly population. In vitro examinations on the anti-aging mechanisms of polyphenols have been widely performed, using different types of natural and synthetic phenolic compounds. The …

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Evaluation Of Triclosan Exposures On Secretion Of Pro-Inflammatory Cytokines From Human Immune Cells, Wendy J. Wilburn, Sara Jamal, Farah Ismail, Dylan Brooks, Margaret Whalen

Chemistry Faculty Research

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Triclosan (TCS) is widely used in personal hygiene products, such as mouthwash and toothpaste, and is found in human tissues. Interleukin (IL)-1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNFα), and interferon gamma (IFNγ) are pro-inflammatory cytokines and inappropriately elevated levels of each have been associated with pathologies including rheumatoid arthritis and certain cancers. Here we examine effects of TCS on the secretion of the pro-inflammatory cytokines from human immune cell preparations. TCS at concentrations between 0.05–5 μM consistently increased the secretion of IL-1β, IL-6, and TNFα within 24 h of exposure and the increases often maintained out to 6 …

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A Data Analytics Study For Adverse Reactions Of Blood Donors By Age, Gender, And Donation Type, Muhammed Miah, Shah J. Miah

Business Information Systems Faculty Research

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The blood donation process is usually very safe, and blood donors are comfortable during the blood donation procedure; however, blood donors occasionally experience various types of adverse reactions during or at the end of blood donation. Some of these reactions are very minor while blood donors sometimes experience serious reactions as well. This study aims to analyze the various types of adverse reactions experienced by the blood donors. The study conducts detailed analysis on a significant amount of real data collected through a blood organization in the southern part of the United States and provides the results regarding the frequency …

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A Systematic Review Of The Effects Of Blood Flow Restriction Training On Quadriceps Muscle Atrophy And Circumference Post Acl Reconstruction, Derek Charles, Ryan White, Caleb Reyes, Drew Palmer

Physical Therapy Faculty Research

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Background:

ACL reconstruction often results in an extended period of muscle atrophy and weakness. Blood flow restriction (BFR) training is a technique that has been shown to decrease muscle atrophy in a variety of populations.

Purpose:

The purpose of this systematic review was to analyze the research presented on the effect of blood flow restriction training on quadriceps muscle atrophy and circumference post ACL reconstruction.

Study Design:

Systematic Review

Methods:

Articles were reviewed using the databases Google Scholar, PubMed, and EBSCO. Keywords included blood flow restriction training, ACL reconstruction, and quadriceps.

Inclusion criteria included:

English language, peer-reviewed journals; randomized control …

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Use Of Implementation Science In Tobacco Control Intervention Studies In The Usa Between 2000 And 2020: A Scoping Review Protocol, Rebecca Selove, Sarah Neil-Sztramko, Jennifer Leng, Philip D. Walker, Ramzi George Salloum, Tamar Ginossar, Carolyn Heckman, Taneisha S. Scheuermann, Todd Combs, Raquel Qualls-Hampton, Rebecca Armstrong, Shellie Ellis

Center for Prevention Research Publications

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Introduction Despite continuing efforts to reduce tobacco use in the USA, decline in smoking rates have stalled and smoking remains a major contributor to preventable death. Implementation science could potentially improve uptake and impact of evidence-based tobacco control interventions; however, no previous studies have systematically examined how implementation science has been used in this field. Our scoping review will describe the use of implementation science in tobacco control in the USA, identify relevant gaps in research and suggest future directions for implementation science application to tobacco control.

Methods and analysis Our team, including a medical research librarian, will conduct a …

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Heartland Virus In Lone Star Ticks, Alabama, Usa, Brent C. Newman, William B. Sutton, Abelardo C. Moncayo, Holly R. Hughes, Ali Taheri, Thomas C. Moore, Callie J. Schweitzer, Yong Wang

Agricultural and Environmental Sciences Faculty Research

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We detected Heartland virus (HRTV) in lone star nymphs collected in 2018 in northern Alabama, USA. Real-time reverse transcription PCR selective for the small segment of the HRTV genome and confirmatory sequencing of positive samples showed high identity with HRTV strains sequenced from Tennessee and Missouri.

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How Does Ginsenoside Rh2 Mitigate Adipogenesis In Cultured Cells And Obese Mice?, Longyun Zhang, Carlos Virgous, Hongwei Si

Human Sciences Faculty Research

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Ginsenoside Rh2, an intermediate metabolite of ginseng, but not naturally occurring, has recently drawn attention because of its anticancer effect. However, it is not clear if and how Rh2 inhibits preadipocytes differentiation. In the present study, we hypothesized that ginsenoside Rh2 attenuates adipogenesis through regulating the peroxisome proliferator-activated receptor gamma (PPAR-γ) pathway both in cells and obese mice. Different concentrations of Rh2 were applied both in 3T3-L1 cells and human primary preadipocytes to determine if Rh2 inhibits cell differentiation. Dietary Rh2 was administered to obese mice to determine if Rh2 prevents obesity in vivo. The mRNA and protein expression of …

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The Threat Of Antibiotic Resistance In Changing Climate, Aliyar Cyrus Fouladkhah, Brian Thompson, Janey Smith Camp

Agricultural and Environmental Sciences Faculty Research

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As the earliest form of life, microorganisms have elaborate mechanisms for adapting to changes in environmental conditions.

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A Literature Review And Clinical Commentary On The Development Of Iliotibial Band Syndrome In Runners, Derek Charles, Clay Rodgers

Physical Therapy Faculty Research

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Background and Purpose:

Iliotibial Band Syndrome (ITBS) is the second leading cause of pain in runners and there are a number of theories related to its etiology. Multiple theories exist for the etiology of ITBS related symptoms including anterior-posterior friction of the IT band on the lateral femoral condyle during knee flexion and extension activities, compression of a layer of fat near the IT band distal attachment, and inflammation of the IT band bursa. The purpose of this literature review and clinical commentary was to explore the potential factors that contribute to ITBS development in runners.

Description of Topic with …

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Information Mining For Covid-19 Research From A Large Volume Of Scientific Literature, Sabber Ahamed, Manar D. Samad

Computer Science Faculty Research

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The year 2020 has seen an unprecedented COVID-19 pandemic due to the outbreak of a novel strain of coronavirus in 180 countries. In a desperate effort to discover new drugs and vaccines for COVID-19, many scientists are working around the clock. Their valuable time and effort may benefit from computer-based mining of a large volume of health science literature that is a treasure trove of information. In this paper, we have developed a graph-based model using abstracts of 10,683 scientific articles to find key information on three topics: transmission, drug types, and genome research related to coronavirus. A subgraph is …

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Fate And Biofilm Formation Of Wild-Type And Pressure-Stressed Pathogens Of Public Health Concern In Surface Water And On Abiotic Surfaces, Md Niamul Kabir, Sadiye Aras, Sabrina Wadood, Shahid Chowdhury, Aliyar Cyrus Fouladkhah

Agricultural and Environmental Sciences Faculty Research

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Since the historic outbreak near Broad Street in London, which serves as cornerstone of modern epidemiology, infectious diseases spread in surface and sub-surface water has been a persisting public health challenge. The current study investigated persistence of wild-type and pressure-stressed Listeria monocytogenes, Escherichia coli O157:H7, and non-typhoidal Salmonella enterica serovars in surface water stored aerobically for up to 28 days at 5, 25, and 37 °C. Additionally, biofilm formation of wild-type and pressure-stressed non-typhoidal Salmonella serovars were monitored on surface of stainless steel and rubber coupons for 28 days at 25 and 37 °C. While L. monocytogenes exhibited a lower …

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Improving Community Advisory Board Engagement In Precision Medicine Research To Reduce Health Disparities, Erin Connors, Rebecca Selove, Juan Canedo, Maureen Sanderson, Pamela Hull, Marilyn Adams, Ila Mcdermott, Calvin Barlow, Denice Johns-Porter, Caree Mcafee, Karen Gilliam, Oscar Miller, Nora Cox, Mary Kay Fadden, Stephen King, Hilary Tindle

Sociology Faculty Research

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Community Advisory Boards (CABs) are used in efforts to reduce health disparities; however, there is little documentation in the literature regarding their use in precision medicine research. In this case study, an academic-CAB partnership developed a questionnaire and patient educational materials for two precision smoking cessation interventions that involved use of genetic information. The community-engaged research (CEnR) literature provided a framework for enhancing benefits to CAB members involved in developing research documents for use with a low-income, ethnically diverse population of smokers. The academic partners integrated three CEnR strategies: 1) in-meeting statements acknowledging their desire to learn from community partners, …

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