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Articles 61 - 65 of 65
Full-Text Articles in Physiology
Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis
Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis
Wayne State University Dissertations
MECHANISMS OF TRANSLATION ARREST FOLLOWING FOCAL BRAIN
ISCHEMIA
by
MONIQUE K. LEWIS
August 2011
Advisor: Dr. Donald DeGracia
Major: Physiology
Degree: Doctor of Philosophy
The loss of blood flow to the brain is termed ischemia and the subsequent resumption of blood flow is termed reperfusion. Brain ischemia and reperfusion (I/R) occurs primarily following resuscitation from cardiac arrest and stroke and presents one of the most significant clinical challenges. At present, there are no clinically effective pharmacologic interventions to halt brain damage following I/R. The major Aim of this dissertation will be to investigate possible mechanisms involved in neuron death following …
The Potential Role Of Innate Immunity In The Pathogenesis Of Post-Operative Adhesions, Jennell White
The Potential Role Of Innate Immunity In The Pathogenesis Of Post-Operative Adhesions, Jennell White
Wayne State University Dissertations
Post-operative adhesion development occurs in the vast majority of patients following abdominal surgery and is a natural occurrence of peritoneal-wound healing. These fibrous bands may form within the first 5-7 days post-surgery and have the ability to cause a distortion in the normal anatomical positioning of abdominal organs. Consequently, adhesions are major contributors to small bowel obstruction, infertility, and severe pelvic and abdominal pain. Physiological processes responsible for adhesion formation remain obscure though it is believed to involve cell migration, proliferation, and differentiation of several cell types including mesothelial cells, fibroblasts, and inflammatory and immune cells. Substances released from these …
Mechanisms Of Persistent Translation Arrest Following Global Brain Ischemia And Reperfusion, Jill Theresa Jamison
Mechanisms Of Persistent Translation Arrest Following Global Brain Ischemia And Reperfusion, Jill Theresa Jamison
Wayne State University Dissertations
ABSTRACT
MECHANISMS OF PERSISTENT TRANSLATION ARREST FOLLOWING GLOBAL BRAIN ISCHEMIA and REPERFUSION
by
JILL T. JAMISON
December 2011
Advisor: Donald J. DeGracia, Ph.D.
Major: Physiology
Degree: Doctor of Philosophy
The information presented here studies the mechanisms that underlie persistent translation arrest (TA) following global brain ischemia and reperfusion (I/R). To summarize the main findings I have discovered a new mechanism for prolonged post-ischemic TA that correlated exactly with in vivo translation rates and correlated precisely with cell outcome. Through the extensive colocalization studies, my results indicate that the mRNA granules are ribonomic structures involved with mRNA regulation. This finding is …
Neural And Humoral Control Of Regional Vascular Beds Via A1 Adenosine Receptors Located In The Nucleus Of The Solitary Tract, Joseph Martin Mcclure
Neural And Humoral Control Of Regional Vascular Beds Via A1 Adenosine Receptors Located In The Nucleus Of The Solitary Tract, Joseph Martin Mcclure
Wayne State University Dissertations
Previous studies from our laboratory showed that activation of NTS A1 adenosine
receptors yields variable hemodynamic responses with prevailing pressor and iliac
vasoconstrictor responses. These responses are accompanied with differential
activation of regional sympathetic activity (adrenal>>renal≥lumbar) and inhibition of
baroreflex mechanisms at the level of the NTS. The variability of the hemodynamic
responses was a result of simultaneous Β-adrenergic vasodilation counteracted with
sympathetic and unknown humoral vasoconstriction. Among many potential
vasoconstrictors vasopressin, angiotensin II and circulating norepinephrine were
considered. Therefore, blood pressure and iliac vascular responses evoked by
selective stimulation of NTS A1 adenosine receptors (CPA 330 …
The Impact Of Mitochondria On Preimplantation Development In The Rhesus Macaque, Tiffini Charieace Gibson
The Impact Of Mitochondria On Preimplantation Development In The Rhesus Macaque, Tiffini Charieace Gibson
Wayne State University Dissertations
Assisted Reproduction Technologies (ART) have been used to treat infertility since 1790. In the centuries following, dramatic advances have been made in the field of infertility research through the employment of a variety of species. Despite these advances, determination of oocyte and embryo quality remains largely subjective. Ascertainment of methods to measure oocyte and embryo quality to improve selection in ART clinics and increase pregnancy success rates is imperative. These methods are only possible with a more comprehensive understanding of the cellular and molecular properties of oocytes and preimplantation embryos. A key component of all cells, including oocytes and embryos, …