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Full-Text Articles in Pharmacology
Association Between Abcb1 Polymorphism And Response To Sodium Valproate Treatment In Malaysian Epilepsy Patients, Zahurin Mohamed
Association Between Abcb1 Polymorphism And Response To Sodium Valproate Treatment In Malaysian Epilepsy Patients, Zahurin Mohamed
Zahurin Mohamed
Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30% of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy patients. Genotypeswere assessed in 249 drug-resistant and 256 drug-responsive Malaysian patients for C1236T, G2677T/A, and C 5T polymorphisms in the ABCB1 gene. No genotypes, alleles, or haplotypes were associated with the response to VPA in either the overall group or Chinese, Indian, and Malay subgroups. Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene …
Association Of Brain-Derived Neurotrophic Factor (Val66met) Genetic Polymorphism With Methamphetamine Dependence In A Malaysian Population, Zahurin Mohamed
Association Of Brain-Derived Neurotrophic Factor (Val66met) Genetic Polymorphism With Methamphetamine Dependence In A Malaysian Population, Zahurin Mohamed
Zahurin Mohamed
Methamphetamine is a highly addictive psychostimulant that has surged in popularity worldwide in the last decade. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is widely expressed in the adult mammalian brain and plays an important role in the long-term survival, differentiation, and outgrowth of neurons. Previous studies suggested that the BDNF gene may be involved in the mechanisms underlying substance dependence. This study investigated the association of the BDNF gene Val66Met polymorphism with methamphetamine dependence and with psychosis in a Malaysian population with different ethnicities. The BDNF Val66Met polymorphism was genotyped by PCR-RFLP in 186 male …
Evidence Of An Interaction Between Nifedipine And Nafcillin In Humans, Zahurin Mohamed
Evidence Of An Interaction Between Nifedipine And Nafcillin In Humans, Zahurin Mohamed
Zahurin Mohamed
Aims Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4. Methods Nine healthy normotensive subjects participated in this randomized placebo-controlled two-way crossover study examining the effects of 5 days' pretreatment of nafcillin 500 mg or placebo four times daily on the pharmacokinetics of an oral dose of nifedipine 10 mg. Plasma nifedipine concentrations were measured by gas chromatography-mass spectro. Results The area …