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Full-Text Articles in Pharmacology
Association Between Abcb1 Polymorphism And Response To Sodium Valproate Treatment In Malaysian Epilepsy Patients, Zahurin Mohamed
Association Between Abcb1 Polymorphism And Response To Sodium Valproate Treatment In Malaysian Epilepsy Patients, Zahurin Mohamed
Zahurin Mohamed
Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30% of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy patients. Genotypeswere assessed in 249 drug-resistant and 256 drug-responsive Malaysian patients for C1236T, G2677T/A, and C 5T polymorphisms in the ABCB1 gene. No genotypes, alleles, or haplotypes were associated with the response to VPA in either the overall group or Chinese, Indian, and Malay subgroups. Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene …
Evidence Of An Interaction Between Nifedipine And Nafcillin In Humans, Zahurin Mohamed
Evidence Of An Interaction Between Nifedipine And Nafcillin In Humans, Zahurin Mohamed
Zahurin Mohamed
Aims Nafcillin (Wyeth Laboratories, Philadelphia, PA, USA) has been reported to induce the metabolism of cyclosporin and warfarin, which are known substrates of cytochrome P-450 (CYP). However, there has not been any report to date on its possible interaction with nifedipine, an index substrate of the enzyme, CYP3A4. Methods Nine healthy normotensive subjects participated in this randomized placebo-controlled two-way crossover study examining the effects of 5 days' pretreatment of nafcillin 500 mg or placebo four times daily on the pharmacokinetics of an oral dose of nifedipine 10 mg. Plasma nifedipine concentrations were measured by gas chromatography-mass spectro. Results The area …