Pharmacology, Toxicology and Environmental Health Commons^™

Trace Metal Concentrations Across Trophic Levels In Cotton Fields Of Xinjiang Province, China, Jessica Quinn

All Student Theses

Trace metals become concentrated in urban and peri-urban soils with the use of agricultural practices and industrial emissions. Fertilizers, liming, sewage sludge, and irrigation water contain metals which accumulate in agricultural fields and pose a risk to humans and wildlife. Coal plants and brickyards release metals into the atmosphere which are deposited on soil and plant surfaces. This research quantifies the concentrations of nine trace metals in three different soil types. A total of 116 rodents were sampled in cotton fields and a desert. Cotton plants and triplicate soil samples were collected with each rodent capture. Soil samples were analyzed …

Analysis Of Anthropogenic Effects On Topsoil Throughout The California Polytechnic State University Campus In San Luis Obispo, Brooke L. Hamilton

Earth and Soil Sciences

Soils reflect the health of a landscape, and in many cases carry the burden of anthropogenic activity, continually changing in characteristics such as pH, soil texture, soil structure, carbon:nitrogen ratios (C:N), and chemical composition. In a study sampling six different soils on the California Polytechnic State University campus in San Luis Obispo, these five soil characteristics were tested for and the results were determined. Soil samples consist of the top 5-10 cm of soil profiles, with sample sites varying according to degree of human contact; the locations the samples were taken from are as follows: (1) Walters Creek Ranch pasture, …

Poisonous Rangeland Plants In San Luis Obispo County, Sara Litten, Amanda Ou

Animal Science

Poisonous Rangeland Plants in San Luis Obispo County is a comprehensive educational guide to rangeland plants that are toxic to domestic livestock. This guide begins with an exploration of how the biological systems are affected by the poisonous plant toxins. The biochemistry behind these toxins is included in the discussion. Next, reference material for fourteen plants that inhabit San Luis Obispo County is provided. This information includes specific toxins found in poisonous plants, affected animals, symptoms of poisoning, stages of growth, lethal dose, and distribution of the plant in California. This section of the guide is filled with helpful photos …

Quantifying Legacy Effects Of Managed Disturbance On Sagebrush Steppe Resilience And Diversity, Julie Ripplinger

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Land-use legacies can affect landscapes for decades to millennia. A long history of shrub management exists in the sagebrush steppe of the Intermountain West where shrub-removal treatments, a type of managed disturbance, have been implemented for over 50 years to reduce sagebrush cover. The assumption behind managed disturbances is that they will increase forage for domestic livestock and improve wildlife habitat. However, the long-term effects of managed disturbance on plant community composition and diversity are not well understood. We investigated the legacy effects of three common types of managed disturbance (chemical, fire, and mechanical treatments) on plant community diversity and …

Adaptivearc And The Future Of The Energy Industry, Trevor Chase

Earth and Soil Sciences

No abstract provided.

A Gis Analysis Of The Environmental Variables Related To Rift Valley Fever Outbreaks, Jacqueline Florette Jackson

Health Services Research Dissertations

Rift Valley fever is a mosquito-borne disease that causes widespread febrile illness and mortality in domestic animals as well as humans (Gaff, 2007). Rift Valley fever virus was first isolated in 1931 (Daubney, 1931), and since then, outbreaks have occurred in sub-Saharan Africa, southern Africa, Egypt, Saudi Arabia, Yemen and Madagascar, proving it to be a virus able to invade ecologically diverse regions (Gaff, 2007). The potential introduction of Rift Valley fever into the United States suggests the potential for human infection and major economic disruption. It is important to understand the role environmental variables have played in historical outbreaks …

Retrieval Of Atmospheric Elemental Carbon Records Using Lake Sediments : Implications In Radiative Forcing, Tanveer Ahmed

Legacy Theses & Dissertations (2009 - 2024)

Elemental or black carbon (EC or BC) aerosols produced during incomplete combustion strongly absorb solar radiation and contribute to global warming, and cause cardiopulmonary disease. Long-term atmospheric EC measurements, [EC]_atm, are needed to validate global climate models to estimate the impact of EC on earth's temperature. Such data is sparse.

Arsenic Speciation Analysis Of Biological Fluids : A Study Of Liquid Chromatography Coupled To Analytical Atomic Spectrometric Instrumentation, Kanna Ito

Legacy Theses & Dissertations (2009 - 2024)

Arsenic exists as many different chemical forms including inorganic, methylated and dietary species. The toxicity of these species varies: some are highly toxic and can cause adverse health effects in many parts of the body; others are considered relatively non-toxic. Monitoring arsenic exposure is usually accomplished by its direct measurement in biological fluids. Urine is the specimen of choice for assessing arsenic exposure, because of its short biological half-life in blood. There have been very few studies of arsenic species in blood, yet such research can provide valuable information on arsenic distribution and its metabolism in the body.

Preparation And Application Of Transgenic And Knockout Mouse Models For Studies On Cytochrome P450 Functions, Yuan Wei

Legacy Theses & Dissertations (2009 - 2024)

The overall objective of this dissertation is to study the in vivo function of microsomal cytochrome P450 monooxygenases (P450s), which metabolize numerous drugs, chemical carcinogens, environmental pollutants, as well as endogenous signaling molecules such as steroid hormones and eicosanoids. The major research tool of this study involves the development of transgenic and knockout mouse models. The specific aims are 1) to study the in vivo function of NADPH-cytochrome P450 reductase (CPR) and CPR-dependent enzymes using a mouse model with a reversible hypomorphic Cpr gene; 2) to study the in vivo function of CYP2A13 with a CYP2A13- transgenic model; and 3) …

The Malawi Project: From Conventional To Holistic Decision Making, Grace Wetmore

Animal Science

How the Cal Poly Malawi Appropriate Technologies Team, and other development groups, can use Holistic Management to aid developing countries in an effort towards a sustainable future.

Impact Of Ambient Air Pollution On Survival Of Renal Transplant Recipients, Rhonda Kristine Hwang

Loma Linda University Electronic Theses, Dissertations & Projects

There is increasing evidence that ambient air pollution is associated with coronary heart disease morbidity and mortality. This research has focused on the general public and less so on possible sensitive subgroups even though these may have even greater susceptibility to adverse effects of ambient air pollution. With highly prevalent traditional as well as nontraditional risk factors, renal transplant recipients may potentially be a sensitive subgroup. The purpose of this study was to evaluate the possible effect of between long-term exposure to air pollution on the risk of CHD mortality among renal transplant recipients. This cohort study includes 32,239 adult, …

Water Quality Changes In A Constructed Wetland At The Springs Preserve In Las Vegas, Nevada, Aaron Mathis Miller

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Springs Preserve near downtown Las Vegas, Nevada contains a seven-acre constructed wetland. Springs Preserve managers are planning to use water from the constructed wetland to irrigate creeks immediately north of the wetland. These creeks will be used by a variety ofaquatic wildlife, including endangered amphibians sensitive to harmful metalloids, such as selenium, lead, and arsenic.

In an attempt to answer toxicological questions about contaminant concentrations in the constructed wetland, three metals and metalloids (selenium, arsenic, and lead), two nutrients (nitrogen and phosphorus), and the major ionic species were analyzed at four sampling locations for aqueous concentrations, in two separate …

Group Feeding For The Lactating Cow, Anthony Joseph Martin

Dairy Science

Feeding individualized rations for lactating dairy cattle in the commercial herd based on dietary needs is a popular issue. This has been a debating topic since evolution of the Total Mixed Ration (TMR). Since dairymen were able to mix grain in a feed wagon and mix a specific dietary ration to meet the demand for an organized group, there has been an issue in which protocol cow pen grouping should take. Dairymen have always feed cattle based on if lactating or late in their gestation, nonlactating. With the evolution of the TMR dairymen are then allowed to go into more …

Evaluating Acute Toxicity Of Cadmium To Chironomid Using Hemoglobin As A Molecular Biomarker, Jun Taek Oh

Seton Hall University Dissertations and Theses (ETDs)

Effects of cadmium (Cd), a heavy metal contaminant, on hemoglobin were investigated in aquatic midge fly larvae of the Family, Chironomidae. In this study, chironomid populations from one polluted site, Kearny Marsh, New Jersey, two reference sites, North East Creek, and Bass Harbor, ME, and a laboratory population were taxonomically identified and tested for their sensitivity to Cd. Heavy metals in tissue, water and sediment were analyzed using Atomic Absorption Spectroscopy. Water quality at each site was assessed by measuring pH, dissolved oxygen (DO), oxidation-reduction potential ( eH), salinity and temperature. Hemoglobin proteins in individual larvae were easily detected using …

Biomonitoring Of Perfluorochemicals In Human Blood, Breast Milk, Saliva, And Urine, Lin Tao

Legacy Theses & Dissertations (2009 - 2024)

Perfluorochemicals (PFCs) have been used as surfactants and surface protectors in a large number of consumer products. PFCs have been reported to elicit adverse health effects in laboratory animals and humans, and have been detected in foodstuffs and in human bodies. In this dissertation, analytical methods were developed for the determination of trace levels of PFCs in human blood, dried blood spot, breast milk, saliva, and urine. An assessment of human exposure to PFCs was performed by analyzing human specimens collected from the United States and several Asian countries. Blood, breast milk, and dried blood spots were found to be …

Multiple Antibiotic Resistant Staphylococcus Spp. In Environmental Settings, Stephen Shost

Legacy Theses & Dissertations (2009 - 2024)

Ninety staphylococci carrying the mecA gene, including 17 strains of methicillin-resistant Staphylococcus aureus (MRSA), were isolated from environmental settings within New York State. Waterborne staphylococci harboring mecA were isolated from multiple sources: the Hudson River near a combined sewage overflow; urban streams; freshwater and marine beaches; a swimming pool; swimming pool decks; combined sewage; as well as wastewater treatment plant (WWTP) primary sewage influent, mixed liquor, aeration water, and final (unchlorinated) effluent. Environmental MRSA strains were isolated from beach water (n=3); swimming pool deck water (n=1); Hudson River water (n=2); combined sewage (n=3); as well as wastewater treatment plant mixed …

Factors That Influence The Distribution Of Antibiotic Resistant Bacteria In The Mud River, Wv, Timothy Shaun Dotson

Theses, Dissertations and Capstones

Background: Prior studies of the Ohio and Mud Rivers have shown that fecal contamination alone does not explain the distribution of antibiotic resistant bacteria (ARB) in surface waters. The objectives of this study were to determine effects on the distribution of ARB in the Mud.

Methods: Water samples and physical parameters were collected twice per season in spring through fall at 12 sites on the Mud River. Aliquots were plated on R2A agar and R2A agar plus individual antibiotics for the enumeration of total cultivable bacteria, and cultivable bacteria resistant to ciprofloxacin, virginiamycin, or tetracycline respectively. The IDEXX Quanti-Tray/2000™ method …

Smoking, Anemia, And Risk Of Oral Clefts In Utah, Melinda Michelle Moss

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cigarette smoke contains sufficient carbon monoxide to induce maternal and fetal hypoxia. Hypoxia is a known teratogen, and consequently maternal smoking has been the focus of many studies on adverse birth outcomes, including cleft lip and palate. Current literature of epidemiological studies on smoking and clefts suggests a modest but statistically significant increase in risk of clefting associated with maternal smoking. A biological condition that may also contribute to hypoxia is anemia. Data from the Utah Child and Family Health Study was used to assess the effects of hypoxia-inducing conditions, maternal smoking, anemia, and their interaction, on the risk of …

Antibiotic Resistant And Coliform Bacteria In The Ohio River; 2002 To 2004, Lisa Marie Smith

Theses, Dissertations and Capstones

During 2002 and 2003 samples, collected every five miles along the Ohio River, were analyzed for total cultivable bacteria, ciprofloxacin resistant bacteria, erythromycin resistant bacteria, tetracycline resistant bacteria, and fecal coliforms. During 2004 samples were analyzed for total cultivable bacteria, ciprofloxacin resistant bacteria, sulfamethizole resistant bacteria, tetracycline resistant bacteria, Virginiamycin resistant bacteria, total coliforms, and Escherichia coli. The objectives of this study were to systematically collect data on fecal coliforms, E. coli, and antibiotic resistant bacteria in the Ohio River and its major tributaries; to determine if antibiotic resistance populations are correlated to each other or to coliforms; and …

Validation Of Passive Air Sampling Monitors Onboard United States Navy Submarines, Larry A. Mcfarland

Community & Environmental Health Theses & Dissertations

An operating submarine creates a unique air quality mixture of compounds that result from a combination of human metabolism, construction materials, materials brought onboard and compounds created through the interaction of ship systems. A comprehensive study of submarine atmospheres is ongoing during deployments of U.S. Navy nuclear submarines. As part of the overall effort, a paired air sampling comparison field validation was conducted to compare the air sampling effectiveness of passive diffusive monitors compared to more traditional active air sampling methods when sampling for acrolein, formaldehyde and ozone in the enclosed submarine atmosphere. Acrolein monitors containing 2-hydroxymethylpiperidine (HMP) impregnated glass …

Chromate Dissociation From Primer Paint In Simulated Lung Fluid, Tiffany J. R. Morgan

Theses and Dissertations

OSHA has proposed a new strontium chromate exposure standard that would potentially cause Air Force paint facilities to be in violation of the proposed standard if adopted. This proposed reduction make the continued use of chromate containing primer paints very difficult. There is currently no acceptable replacements for chromate containing primer paints on AF aircraft. This study suggests that paint particles with chromate bound in primer paint may be unavailable for bodily absorption if inhaled and a reduced standard for painting applications may be unnecessary. Primer paint overspray was collected into simulated lung fluid (SLF) and allowed 6 hr, 24 …

The Accuracy Of Nitrous Oxide Passive Dosimeters As Compared With An Infra-Red Spectrographic Reference Method, Susan Allen

Community & Environmental Health Theses & Dissertations

Nitrous oxide is a gas often used in dental, surgical and veterinary operations as an anesthetic agent. Employees stationed in proximity of fugitive gas emissions may potentially suffer adverse health effects from chronic exposure to this agent. Passive dosimeters can be worn in the breathing zone of potentially affected personnel during exposure periods, then later analyzed to quantify nitrous oxide exposure. This study sought to establish the accuracy of several commercially available passive monitoring devices for nitrous oxide by comparison against an infra-red spectrophotometric reference method.

The Relationship Between Ohio River Bass Tournament Success Rates, Forage Fish Abundance And Environmental Conditions, Jeffrey V. Ginger

Theses, Dissertations and Capstones

Due to increasing pressure from Ohio River bass anglers with regard to decreasing catch rates in 1981,1990, and 1997, the West Virginia Division of Natural Resources (WVDNR) initiated a study of black bass populations. The Ohio River Valley Water Sanitation Commission (ORSANCO), in conjunction with state and Federal agencies, has collected population data on Ohio River fishes at lock chambers and has measured various water quality parameters since 1957. That data coupled with Ohio River bass tournament data collected by the DNR since 1975 and other fishery data sets provided a historic look into the variability of angler success. These …

Heavy Metal Toxicity In Bioremediation: Microbial Cultures And Microscopy, Jason B. Goodbody

Theses and Dissertations

This research employed a variety of microscopy and spread plating techniques to observe the effects of heavy metal treatments on a toluene-selected bacterial population. Microbial colonies were cultured on spread plates and the resulting numbers were compared to respiration data. The mechanisms of reproduction were demonstrated to be more sensitive to metal treatments than were the mechanisms of respiration. Phase contrast, Gram stain, fluorescent microscopy, were used to compare and document a wide variety of bacteria resulting from different metal treatments as well as from environmental changes within the source bioreactor. The removal of sensitive bacteria and the selection of …

Human Immunodeficiency Virus (Hiv)/Hepatitis B Virus (Hbv) Risk Perception Related To Needlestick Injuries At A Medical School In Norfolk, Virginia, Ronald B. Hartman

Community & Environmental Health Theses & Dissertations

A limited number of studies have been conducted to assess the perceptions of risk of medical students and residents for acquiring Human Immunodeficiency Virus (HIV) or Hepatitis B Virus (HBV) via percutaneous (needlestick) injuries while performing clinical training. The purpose of this study is to investigate these perceptions of risk, and to determine whether there is an association between a high perception of risk and a low incidence of needlestick injury. The method of investigation was a four-page survey questionnaire. The instrument was investigated for reliability by use of a pilot study with a small group of medical students and …

A Test Of An Alternate Calibration Matrix For Niosh Method 7300, Robert T. Vitek

Community & Environmental Health Theses & Dissertations

The purpose of this study was to determine if the analytical results (when determining cadmium, lead, and zinc concentrations) for air sample filters prepared and analyzed according to N:OSH Method 7300, differ significantly, from those obtained when the instrument is calibrated using EPA Method 200.7 acid matrix standards. The null hypothesis was that no statistically significant difference, measured at the 95% confidence level, would exist between results obtained from the two calibration standards. Careful standard and sample preparation, the use of an internal standard, and the application of working standard and working internal standard correction factors served to isolate the …

An Analysis Of 1994 Air Force Toxic Release Inventory Reporting, Brian A. Pollock

Theses and Dissertations

The purpose of this research is to analyze the Air Force's 1994 Toxic Release Inventory data. Statistical tests were used to meet the following research objectives: (1) review the CY 94 data to determine which chemicals were most often reported and which bases and major commands had the most releases in terms of the number of chemicals reported and the amount of chemicals reported and (2) investigate factors which could influence the reporting status of a facility. An analysis of the TRI data showed that dichloromethane was the chemical released in the largest amount while methyl ethyl ketone was the …

Modified Model For Transient Response Of Mrna Synthesis To Magnetic Field Exposure, Timothy W. Crosnoe

Theses and Dissertations

It is a well-known fact that high frequency, or radio frequency, radiation can be directly harmful to biological tissue. The radiation frequencies to which humans are most exposed, however, are the extremely low frequencies, or ELFs. To date there has been no definitive measure for predicting the ability of low frequency electromagnetic radiation to cause adverse biological effects. Two specific measures, average magnetic field and kinetic index, have been used in studies to determine if they are useful predictors of adverse effects, specifically leukemia. Unfortunately, both have shown only marginal results. This thesis analyzed and improved the kinetic index measure …

Development Of A Comprehensive Base-Level Environmental Training Program For Total Environmental Compliance, William M. Barrett Jr

Theses and Dissertations

The leadership of the Air Force has established a goal of total environmental compliance because it is the right and necessary thing to do. Commitment to this goal can be accomplished through strong leadership, however, achieving this goal can only be accomplished through effective training. The lack of consistent guidance for developing and executing comprehensive base- level environmental training programs has forced bases to develop these training programs by whatever means available to them. This has resulted in a broad variation in the thoroughness of base-level training programs throughout the Air Force. This research effort investigates the relationship between the …

Development Of Field Guidance For Assessing Feasibility Of Intrinsic Bioremediation To Restore Petroleum-Contaminated Soils, John T. Enyeart

Theses and Dissertations

This research evaluated the process of intrinsic bioremediation, also called natural attenuation, and the parameters that affected it. The goal of this study was to use these intrinsic bioremediation parameters to develop a valid prediction of the cleanup duration using this restoration technology. This analysis was limited to a JP-4 release and focused on the remediation of the BTEX constituents to a cleanup level of 10 ppm total BTEX. The review of intrinsic bioremediation found that the BTEX hydrocarbons can aerobically and anaerobically biodegrade. Of the many factors that affect intrinsic bioremediation, those that most influenced its occurrence were the …