Open Access. Powered by Scholars. Published by Universities.®
![Digital Commons Network](http://assets.bepress.com/20200205/img/dcn/DCsunburst.png)
Pharmacology, Toxicology and Environmental Health Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- Selected Works (4)
- Himmelfarb Health Sciences Library, The George Washington University (2)
- Louisiana Tech University (2)
- Old Dominion University (2)
- University of Arkansas, Fayetteville (2)
-
- University of Kentucky (2)
- University of Mississippi (2)
- University of Tennessee, Knoxville (2)
- Augustana College (1)
- Brigham Young University (1)
- Cleveland State University (1)
- Duquesne University (1)
- Florida International University (1)
- Fordham University (1)
- Louisiana State University (1)
- Maurer School of Law: Indiana University (1)
- Missouri University of Science and Technology (1)
- Purdue University (1)
- Rowan University (1)
- Tennessee State University (1)
- Universitas Indonesia (1)
- University of Georgia School of Law (1)
- University of Louisville (1)
- University of Nebraska - Lincoln (1)
- University of South Alabama (1)
- Utah State University (1)
- Virginia Commonwealth University (1)
- Washington University in St. Louis (1)
- Western Michigan University (1)
- Keyword
-
- Drug delivery (3)
- Genetic engineering (3)
- Alginate (2)
- Applied sciences (2)
- Ass'n for Molecular Pathology (2)
-
- BRCA 1 (2)
- BRCA 2 (2)
- Controlled release (2)
- Diamond v. Chakrabarty (2)
- Drug release (2)
- Erlotinib (2)
- FDA (2)
- Federal Circuit (2)
- Flow Cytometry (2)
- IVCDD (2)
- IVD (2)
- Mayo Collaborative Services (2)
- Myriad Genetics (2)
- Myriad I (2)
- Myriad II (2)
- Nanoparticle (2)
- Prometheus Laboratories (2)
- 17β-estradiol; Estrone; GAC adsorption; Biologically active carbon (1)
- AIDS (1)
- Absurdity (1)
- Acetaminophen (1)
- Actinomadura hibisca (1)
- Aging (1)
- Alzheimer’s disease (1)
- Automation (1)
- Publication Year
- Publication
-
- Doctoral Dissertations (4)
- Bioelectrics Publications (2)
- Electronic Theses and Dissertations (2)
- Graduate Theses and Dissertations (2)
- Honors Theses (2)
-
- Masters Theses (2)
- Pharmacology and Physiology Faculty Publications (2)
- Theses and Dissertations (2)
- Z Li (2)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (1)
- BioImaging and BioSystems Research (1)
- Biology: Student Scholarship & Creative Works (1)
- Chemical & Biomedical Engineering Faculty Publications (1)
- Department of Chemical and Biomolecular Engineering: Faculty Publications (1)
- FIU Electronic Theses and Dissertations (1)
- IP Theory (1)
- Jonathan R. K. Stroud (1)
- Joseph P Robinson (1)
- Journal of Intellectual Property Law (1)
- Journal of Nonprofit Innovation (1)
- LSU Doctoral Dissertations (1)
- Makara Journal of Science (1)
- McKelvey School of Engineering Theses & Dissertations (1)
- Pharmacology and Nutritional Sciences Faculty Publications (1)
- Student Theses 2015-Present (1)
- TIGER Institute Faculty Research (1)
- The Summer Undergraduate Research Fellowship (SURF) Symposium (1)
- Theses and Dissertations--Neuroscience (1)
- Publication Type
- File Type
Articles 31 - 39 of 39
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
A Thousand Tiny Pieces: The Federal Circuit’S Fractured Myriad Ruling, Lessons To Be Learned, And The Way Forward, Jonathan R. K. Stroud
A Thousand Tiny Pieces: The Federal Circuit’S Fractured Myriad Ruling, Lessons To Be Learned, And The Way Forward, Jonathan R. K. Stroud
Jonathan R. K. Stroud
No abstract provided.
High-Throughput Secondary Screening At The Single-Cell Level, Joseph Robinson
High-Throughput Secondary Screening At The Single-Cell Level, Joseph Robinson
Joseph P Robinson
No abstract provided.
Proteomic Analysis Of 17Β-Estradiol Degradation By Stenotrophomonas Maltophilia, Zhongtian Li
Proteomic Analysis Of 17Β-Estradiol Degradation By Stenotrophomonas Maltophilia, Zhongtian Li
Z Li
Microbial degradation plays a critical role in determining the environmental fate of steroid hormones, such as 17β-estradiol (E2). The molecular mechanisms governing the microbial transformation of E2 and its primary degradation intermediate, estrone (E1), are largely unknown. The objective of this study was to identify metabolism pathways that might be involved in microbial estrogen degradation. To achieve the objective, Stenotrophomonas maltophilia strain ZL1 was used as a model estrogen degrading bacterium and its protein expression level during E2/E1 degradation was studied using quantitative proteomics. During an E2 degradation experiment, strain ZL1 first converted E2 to E1 stoichiometrically. At 16 h …
Removing 17Β-Estradiol From Drinking Water In A Biologically Active Carbon (Bac) Reactor Modified From A Granular Activated Carbon (Gac) Reactor, Zhongtian Li
Z Li
Estrogenic compounds in drinking water sources pose potential threats to human health. Treatment technologies are needed to effectively remove these compounds for the production of safe drinking water. In this study, GAC adsorption was first tested for its ability to remove a model estrogenic compound, 17β-estradiol (E2). Although GAC showed a relatively high adsorption capacity for E2 in isotherm experiments, it appeared to have a long mass transfer zone in a GAC column reactor, causing an early leakage of E2 in the effluent. With an influent E2 concentration of 20 μg/L, the GAC reactor was able to bring down effluent …
A Thousand Tiny Pieces: The Federal Circuit’S Fractured Myriad Ruling, Lessons To Be Learned, And The Way Forward, Jonathan R. K. Stroud
A Thousand Tiny Pieces: The Federal Circuit’S Fractured Myriad Ruling, Lessons To Be Learned, And The Way Forward, Jonathan R. K. Stroud
IP Theory
No abstract provided.
Electro-Gene Transfer To Skin Using A Noninvasive Multielectrode Array, Siqi Guo, Amy Donate, Gaurav Basu, Cathryn Lundberg, Loree Heller, Richard Heller
Electro-Gene Transfer To Skin Using A Noninvasive Multielectrode Array, Siqi Guo, Amy Donate, Gaurav Basu, Cathryn Lundberg, Loree Heller, Richard Heller
Bioelectrics Publications
Because of its large surface area and easy access for both delivery and monitoring, the skin is an attractive target for gene therapy for cutaneous diseases, vaccinations and several metabolic disorders. The critical factors for DNA delivery to the skin by electroporation (EP) are effective expression levels and minimal or no tissue damage. Here, we evaluated the non-invasive multielectrode array (MEA) for gene electrotransfer. For these studies we utilized a guinea pig model, which has been shown to have a similar thickness and structure to human skin. Our results demonstrate significantly increased gene expression 2 to 3 logs above injection …
Nanoengineered Templates For Controlled Delivery Of Bioactive Compounds, Nalinkanth Ghone Veerabadran
Nanoengineered Templates For Controlled Delivery Of Bioactive Compounds, Nalinkanth Ghone Veerabadran
Doctoral Dissertations
The significance of any drugs, therapeutic proteins, or any bioactive compounds, is based not only on their effects on diseases but also on how specifically, how readily, how controllable and how prolonged their effects on the disease without having any side effects. Thus the techniques involved in the drug encapsulation and its controlled release for a longer duration of time form one of the important processes of drug reformulation. In recent years nanoparticles have created overwhelming attention for delivering drugs by nanoencapsulation. The smaller size of nanoparticles has longer circulation time and higher cellular uptake when compared with larger size …
Drug Loading And Release From Polypeptide Multilayer Nanofilms, Yang Zhong
Drug Loading And Release From Polypeptide Multilayer Nanofilms, Yang Zhong
Doctoral Dissertations
Polypeptides, linear macromolecules, are formed from amino acid residues by linkage of peptide bonds. Proteins are polypeptides too, with more complex conformations contributing to specific functionalities. Disulfide bonds are very important to maintain the structure and functions of proteins, which will form between two cysteine (Cys) residues under oxidizing circumstance.
Cys containing polypeptides are designed and synthesized by F-moc (9-Fluorenylmethyloxycarbonyl) chemistry. The number and position of Cys residues can be controlled by amino acid sequences design and following peptide synthesis, which is important to gain insights on the nature of polyelectrolyte multilayer film assembly and stability.
Both commercial and designed …
1-Nitronaphthalene Causes Ultrastructural Changes Primarily In Nonciliated Bronchiolar Epithelium Followed By Ciliated Epithelium In The Rat, John-Michael Sauer
1-Nitronaphthalene Causes Ultrastructural Changes Primarily In Nonciliated Bronchiolar Epithelium Followed By Ciliated Epithelium In The Rat, John-Michael Sauer
Masters Theses
This study describes morphological changes in the lung at several time intervals following a single injection of 1-Nitronaphthalene (100 mg/kg intraperitoneal) in male Sprague-Dawley rats using transmission and scanning electron microscopy. Dilation of the smooth endoplasmic reticulum and mitochondrial distension in the nonciliated bronchiolar (Clara) cells was apparent as early as 1 hour after injection, while adjacent ciliated cell showed minimal changes. At 6 hours, when respiratory distress was apparent in the animals, Clara and ciliated cells exhibited chromatin clumping, loss of mitochondrial cristae and cytoplasmic vacuolization. Also at 6 hours, the interstitial area around the terminal bronchioles was infiltrated …