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University of Arkansas, Fayetteville

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Full-Text Articles in Human and Clinical Nutrition

Assessment Of Novel Protein Ingredient Arthrospira Platensis (Microalgae) And Soybean Genotype Amino Acid And Oil Selection Improvements On Broiler Performance, Savannah Wells Crafton Dec 2022

Assessment Of Novel Protein Ingredient Arthrospira Platensis (Microalgae) And Soybean Genotype Amino Acid And Oil Selection Improvements On Broiler Performance, Savannah Wells Crafton

Graduate Theses and Dissertations

Two experiments were conducted to assess the efficiency of including novel protein ingredient Arthrospira platensis or improved soybean meal in a broiler diet. The first experiment aimed to determine the feeding value of soybean meal produced from varieties of soybeans bred for increased amino acid content (SBAA) improved oil content (SBO) compared to a conventional soybean variety in an ANOVA design fed to Cobb 500 female broilers for 28-42d of age. The SBAA and SBO soybeans contained overall higher amino acid content and lower oligosaccharide content compared to the conventional soybean variety in addition to improved oil quality. The second …


Enhancing Amino Acid Utilization For Broiler Chickens Under Different Scenarios Of Dietary Protein Reduction And Subclinical Coccidiosis, Derrell Trevor Lee Dec 2022

Enhancing Amino Acid Utilization For Broiler Chickens Under Different Scenarios Of Dietary Protein Reduction And Subclinical Coccidiosis, Derrell Trevor Lee

Graduate Theses and Dissertations

Five experiments were conducted to evaluate responses of broiler chickens fed diets with different dietary amino acid (AA) levels when fed normal and reduced dietary crude protein (RCP) diets and reared under different coccidiosis control programs. In the studies with the use of RCP diets, the relationship between dietary Gly + Ser and the Met:Cys ratio was investigated. Experiment 1 evaluated broilers in 2 coccidiosis control programs (live vaccine or in-feed zoalene) and fed increased dietary AA derived from soybean meal or unbound sources from 0-40 d. Vaccination impaired young (0-26 d) broiler body weight gain (BWG) and feed conversion …


Examining The Effects Of Oral Contraceptive Use On Thermoregulation, Whitley C. Atkins May 2022

Examining The Effects Of Oral Contraceptive Use On Thermoregulation, Whitley C. Atkins

Graduate Theses and Dissertations

Purpose: The purpose of this investigation was to evaluate the effects of combined (estradiol and progestin) monophasic oral contraceptive pill (OCP) use on thermoregulation. Further, we sought to evaluate OCP use on acute rehydration post-exercise in the heat using recommended rehydration guidelines. Methods: Twelve healthy, aerobically trained (VO2peak = 47.8 ± 4.7 mL/kg/min), long term female oral contraceptive users completed a familiarization trial and two experimental days separated by ≥ 7 days. The two experimental trials were identical except for the hormone dosing phase. One trial was completed during the third week of active pill dosing (ACT) and one during …


The Impact Of Dietary Protein Supplementation As Part Of A Time Restricted Feeding Eating Pattern On Sleep, Mood, And Body Composition In Adults With Overweight Or Obesity, Rebecca L. Bowie May 2022

The Impact Of Dietary Protein Supplementation As Part Of A Time Restricted Feeding Eating Pattern On Sleep, Mood, And Body Composition In Adults With Overweight Or Obesity, Rebecca L. Bowie

Graduate Theses and Dissertations

Obesity in the United States continues to increase, and effective, long-term weight loss strategies are limited. Time restricted feeding (TRF) is a dietary intervention that has potential to serve as an effective long-term weight loss strategy, however more data is needed to establish the effectiveness of a TRF eating pattern on obesity and its related health outcomes. To our knowledge, manipulation of macronutrient composition during TRF intervention and the effect of TRF on sleep and mood have not been studied. Therefore, the objective of this study was to determine the effect of protein supplementation during TRF on mood, sleep, and …


Food Allergy Education In The Hospitality Industry, Hayley Stull May 2022

Food Allergy Education In The Hospitality Industry, Hayley Stull

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Food allergies affect thousands of people, because hospitality foodservice workers come into contact with the public, it is necessary that they need to be fully trained to ensure the safety of the public. This is especially important for those who possess food allergies. Previous research has shown major gaps in knowledge amongst these workers, which can lead to the potential to harm individuals with a food allergy. There is a lack in the consistency of training specifically concerning food allergies for food service workers across all states in the U.S. There are previous forms of educational tools concerning food allergies …


Camp: Children’S Acceptance Of Muffins With Different Proteins, Amber Knoernschild May 2022

Camp: Children’S Acceptance Of Muffins With Different Proteins, Amber Knoernschild

Human Nutrition and Hospitality Management Undergraduate Honors Theses

In 2019, around 40% of school-aged children in Arkansas were classified as overweight (~17%) and obese (~23%), according to BMI data collected. Children with obesity have an increased risk of developing type 2 diabetes, hypertension, and dyslipidemia. Unhealthy eating habits, such as skipping breakfast, have been strongly associated with overeating, weight gain and obesity. Breakfast is a key component of a healthy diet and can positively impact children’s health and well-being. However, there has been a steady decline in breakfast consumption in US children over the past 40 years. Specifically, breakfast consumption declined among 8–10-yearold children by 9% and adolescents …


The Effects Of Time Restricted Feeding On Markers Of Type 2 Diabetes, Brooke Martin May 2022

The Effects Of Time Restricted Feeding On Markers Of Type 2 Diabetes, Brooke Martin

Biological Sciences Undergraduate Honors Theses

Type 2 diabetes is one of the fastest growing chronic diseases in the country, comprising 10% of the American population. Obesity rates are at an all-time high and greatly increase risk factors for developing diabetes. Insulin resistance is the main feature of type 2 diabetes and causes management of the disease to be extremely difficult. Currently there are different possible treatments for type 2 diabetes including medication and dieting. However, diets involving fasting, though high in popularity, do not have a lot of evidence regarding their ability to prevent the development of type 2 diabetes.

Time restricted feeding (TRF) is …


Efficacy Of Multivitamin-Mineral Supplementation On Measures Of Anxiety, Depression, Self-Esteem, Dysregulation, And Perceived Stress In Young Adults, Courtney Gorden May 2022

Efficacy Of Multivitamin-Mineral Supplementation On Measures Of Anxiety, Depression, Self-Esteem, Dysregulation, And Perceived Stress In Young Adults, Courtney Gorden

Graduate Theses and Dissertations

Mental health in the United States is at an all-time low with 21% of adults 18+ suffering from depression or anxiety. When compared with other categories, emerging adults (18-25 years old) have the highest prevalence of mental health disorders at 30%. Young adults face an inordinate amount of stress given the COVID-19 pandemic, being in a unique developmental stage, experiencing new relationships, and transitioning from high school to their professional lives. Vitamins and minerals have roles in neurobiochemistry and have been investigated for effects on mental health with mixed results. Few studies factor in the unique emerging adult developmental stage …


Recipe Modification For Cardiovascular Health, Meg Tolbert May 2022

Recipe Modification For Cardiovascular Health, Meg Tolbert

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Cardiovascular disease (CVD) is the leading cause of death globally. CVDs affect the heart and blood vessels. The most prominent CVDs are coronary artery disease, cerebrovascular disease, rheumatic heart disease, and other conditions. More than four out of five CVD deaths are due to heart attacks and strokes.

The most important behavioral risk factors of heart disease and stroke are unhealthy diet and physical inactivity, but also include harmful abuse of tobacco and alcohol. These lifestyle factors display themselves as phenotypes like high blood pressure, high blood glucose and blood lipids, diabetes, and obesity. These risk factors, outside of genotype …


Dissonance Between Christian Beliefs And Eating Habits In The South, Karli Dianne Stringer Dec 2021

Dissonance Between Christian Beliefs And Eating Habits In The South, Karli Dianne Stringer

Graduate Theses and Dissertations

The purpose of this qualitative study was to initiate understanding of how obesity in the South is still so prevalent even though the majority of inhabitants subscribe to a faith that discourages unhealthy lifestyles. Furthermore, the information presented in this research sought to fill the knowledge gap for communicators and educators concerning the dissonance between Christianity in the South and the unhealthy eating habits of Southerners. Grounded in the Cognitive Dissonance Theory, this study comprised of a semi-structured interview route in which Protestant evangelical Christians in the South (N = 11) participated in a descriptive study conducted by a committee …


Divergent Selection For Water Conversion Ratio In Broiler Populations, Joseph Hiltz Dec 2021

Divergent Selection For Water Conversion Ratio In Broiler Populations, Joseph Hiltz

Graduate Theses and Dissertations

Water scarcity is a global reality and with the anticipated population growth, freshwater resources will be further strained to meet both human needs and agriculture applications. To ensure a water sustainable and food secure future, all aspects of agriculture must become more efficient. Two strategies were explored. The potential of improving water efficiency in broilers was examined. The first strategy was to develop a more efficient and accurate method for measuring water consumption/inputs in agriculture. To date, water measuring technology has lacked the necessary sophistication to assure accuracy and repeatability of low flow water usage.

After establishing a low flow …


The Effect Of Whey Protein Supplementation At Breakfast On Tryptophan Levels, Food Intake, And Mood In Postmenopausal Women In A 16-Week Randomized Controlled Trial, Danielle Warren May 2021

The Effect Of Whey Protein Supplementation At Breakfast On Tryptophan Levels, Food Intake, And Mood In Postmenopausal Women In A 16-Week Randomized Controlled Trial, Danielle Warren

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Whey protein isolate supplementation has been recognized as having potential for regulating appetite, thereby potentially improving mood and food intake.

The objectives of this project were to 1) analyze the effects of high-quality whey protein intake on overall diet, and 2) identify and examine a correlation between tryptophan levels and mood regulation.

This research was conducted using a randomized experimental design. A total of 13 post-menopausal women (12+ months after last reported menstrual cycle) were recruited and allocated to one of two dietary intervention (DI) groups: 1) control (maintain current lifestyle; CON; n = 6), and 2) whey protein isolate …


Impact Of Different Plant-Based Foods Consumption On The Composition And Diversity Of Gut Microbiota, Ayoub Al Othaim May 2021

Impact Of Different Plant-Based Foods Consumption On The Composition And Diversity Of Gut Microbiota, Ayoub Al Othaim

Graduate Theses and Dissertations

Plant-based diets are primarily derived from plant sources, including fruits and vegetables. Such patterns are associated with health benefits by promoting general health and preventing many diseases and metabolic disorders. Fruits and vegetables are key sources of high-quality nutrients such as dietary fibers and polyphenols. Since they are rich in dietary fibers and polyphenols, whole fruits and vegetables represent unique and somewhat understudied modulators of the gut microbiota and its associated functions. This study aims to (i) investigate the impact of varying dilutions of cherry juices concentrate on the composition of the murine gut microbiota, (ii) investigate the impact of …


Dietary Regulation Of Successful Aging, Aubree L. Hawley Dec 2020

Dietary Regulation Of Successful Aging, Aubree L. Hawley

Graduate Theses and Dissertations

The current growth of the older population is unprecedented in U.S. history. Chronic disease and functional limitation commonly develop prior to old age, leading to prolonged physical disability and decreased well-being. The development of chronic disease and loss of independence is associated with lean body mass (LBM) loss and fat mass gain beginning in middle age. Therefore, it is important to identify modifiable factors to mitigate deleterious shifts in body composition to promote successful aging (SA). The concept of SA is associated with longevity, the absence of disease and disability, and subjective components of well-being, however, an operational definition has …


Effects Of Broccoli And Carrots On Fecal Microrna Expression In Infants: A Short-Term Feeding Study, Kaleigh E. Beane Jul 2020

Effects Of Broccoli And Carrots On Fecal Microrna Expression In Infants: A Short-Term Feeding Study, Kaleigh E. Beane

Graduate Theses and Dissertations

Diets, through multiple mechanisms, cause significant impact on human health and disease etiology; proposed modes of action include modulation of non-coding RNAs and influences on the gut microbiome. Specifically, phytochemicals change human miRNA expression thereby impacting gut microbiome and/or increasing host immune functions. Apiaceous and cruciferous vegetables have been linked to decreased chronic inflammation, which is closely related with the host immune system, yet it is not investigated how these two classes of vegetables influence the colonic miRNA profile. In this study, therefore we aimed to determine the effects of short-term feeding of broccoli and carrot to infants on fecal …


The Effect Of Breakfast Macronutrient Composition In Children Ages 7-17 Years Old As A Potential Method To Combat Childhood Obesity, Angela M. Tacinelli May 2020

The Effect Of Breakfast Macronutrient Composition In Children Ages 7-17 Years Old As A Potential Method To Combat Childhood Obesity, Angela M. Tacinelli

Graduate Theses and Dissertations

The prevalence of childhood overweight and obesity is an ongoing concern. Currently, approximately 20% of children in the United States are obese. While obesity was once regarded merely as excessive adiposity within the body, it is has emerged as a major risk factor for chronic diseases such as metabolic syndrome, type 2 diabetes, and cardiovascular disease. Obesity is multifactorial in nature. Weight gain can result from an energy imbalance in the body due to excess energy intake (calories in) and decreased energy expenditure (calories out). Identifying methods to combat obesity is essential. Nutritional intervention may be a strategy to help …


Association Of Micronutrient Inadequacy And Body Mass Index In Young Adults, Taylor Peabody May 2020

Association Of Micronutrient Inadequacy And Body Mass Index In Young Adults, Taylor Peabody

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Background

Micronutrient inadequacy has been found at higher levels in overweight and obese individuals in a broad range of ages relative to healthy weight. Insufficient micronutrient levels can have a negative impact on physical and mental health along with excess weight.

Objective

Due to health consequences related to inadequate micronutrient intake and the understanding that the general population not only fails to meet the majority of micronutrient recommendations, but is also overweight or obese, the objective of this study is to first, determine if young adults in the Northwest Arkansas Region are consuming adequate levels of micronutrients and second, if …


Efficacy Of Multivitaim-Mineral Supplementation On Health-Related Quality Of Life And Physical Activity In Young Adults, Sarah Pendergraft May 2020

Efficacy Of Multivitaim-Mineral Supplementation On Health-Related Quality Of Life And Physical Activity In Young Adults, Sarah Pendergraft

Graduate Theses and Dissertations

Micronutrients are essential for both physical and mental health. There is a correlation between poor health and mood and micronutrient deficiencies. Young adults age 18-24 are an at-risk, understudied population likely to benefit from multivitamin mineral supplementation. Multivitamin mineral supplementation is a potential way to bridge gaps in micronutrient levels, thus influencing health-related outcomes. Here, we provide the first attempt at influencing health-related quality of life and physical activity with a multivitamin mineral supplement in young adults. Using a supplement formulated without herbal extracts and caffeine, this double-blind study examined the efficacy of a daily multivitamin mineral supplement for 30 …


The Effect Of Protein And Omega-3 Fatty Acid Supplementation On Regulation Of Sleep And Mood In Postmenopausal Women, Caroline Baughn May 2020

The Effect Of Protein And Omega-3 Fatty Acid Supplementation On Regulation Of Sleep And Mood In Postmenopausal Women, Caroline Baughn

Biological Sciences Undergraduate Honors Theses

The older population of the United States is in a period of rapid growth [1]. population of those in the United States aged 65 or older will double to about 72 million in the next 25 year [1]. This population is at increased risk for obesity, chronic diseases, decreased quality of life, and premature death. Therefore, guidelines for healthy aging are desperately needed. In 2015 alone, 67.7% of adults in the United States aged 65 or older reported having two or more chronic conditions [2]. Treatment for those in the older population afflicted by multiple chronic conditions alone accounts for …


The Role Of Higher Protein Diets In The Regulation Of Mood And Sleep In Patients With Metabolic Syndrome, Mckenzie Fellinger May 2020

The Role Of Higher Protein Diets In The Regulation Of Mood And Sleep In Patients With Metabolic Syndrome, Mckenzie Fellinger

Biological Sciences Undergraduate Honors Theses

Metabolic Syndrome is becoming a more prevalent health issue within the United States, currently affecting 22% of adults (Capuron et al., 2008). Several factors contribute to the diagnosis of Metabolic Syndrome, including obesity, high levels of triglycerides, elevated blood pressure, and low high-density lipoprotein cholesterol. Metabolic Syndrome puts those who have it at an increased risk for numerous diseases, such as type 2 diabetes, cardiovascular disease, and cancer (Jennings et al., 2007). Several studies have shown that Metabolic Syndrome plays a negative role in sleep and mood of those with the disease. Individuals with Metabolic Syndrome often have poor sleep …


Does Macronutrient Consumption Affect Aerobic Capacity?, Jordan Bush-Means Dec 2019

Does Macronutrient Consumption Affect Aerobic Capacity?, Jordan Bush-Means

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Fitness in the United States is declining as the prevalence of obesity rises. It is known generally that exercise and diet both play a part in becoming fit, therefore veering away from being obese and/or overweight. Although people are aware they need to eat healthy foods and participate in physical activity, the role that dietary behaviors have on exercise, particularly aerobic capacity, remains unresolved. Purpose: The purpose of this study was to analyze dietary behaviors and to examine associations with maximal aerobic capacity. We hypothesize that those who consume each food group will have a higher volume …


Influences Of Autism Spectrum Disorder On Sensory And Emotional Responses To Smell And Taste Cues, Asmita Singh Aug 2019

Influences Of Autism Spectrum Disorder On Sensory And Emotional Responses To Smell And Taste Cues, Asmita Singh

Graduate Theses and Dissertations

Autism spectrum disorder (ASD) is a developmental disability that causes social, communication, behavioral and sensory challenges. The prevalence has been on a rise, with the latest reports stating 1 in 59 children is diagnosed with ASD. These challenges play a significant role in feeding behavior, leading to reduced nutrition among individuals. Much research in this field has been attributed to children, however, this study was focused on the adult population, in an attempt to improve their quality of life. Building on previous findings and knowledge gaps, the objectives of this thesis were two-fold: To better understand the sensory experiences of …


Alcohol Use, Dietary, And Exercise Behaviors: A Latent Profile Analysis Of Young Adult Lifestyle Behaviors, Ryan Wesley Grant May 2019

Alcohol Use, Dietary, And Exercise Behaviors: A Latent Profile Analysis Of Young Adult Lifestyle Behaviors, Ryan Wesley Grant

Graduate Theses and Dissertations

As individuals enter adulthood, their lifestyles and lifestyle behaviors begin to change drastically. These lifestyle behavior changes in emerging adulthood provide a foundation for future health behaviors that often persist through all of adulthood. The aim of this study was to use Latent profile analyses (LPA) to discover distinct profiles of homogenous groups of young adults based on alcohol, diet, and exercise behaviors. Overall, five distinct profiles for both males and females were identified: Moderates, Unhealthy Eaters, Medium Drinkers, Healthier Eaters and Exercisers, and Heavy Drinkers. Heavy Drinkers and Unhealthy Eaters were the highest risk groups and reported the highest …


Assessment Of Factors That Impact Hydration Status Of Professional And Collegiate Mascots, Caroline Atwell May 2019

Assessment Of Factors That Impact Hydration Status Of Professional And Collegiate Mascots, Caroline Atwell

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Mascots have unique physical demands and nutrition needs. They exert themselves tremendously on a variety of game days and at practices throughout the week. Hydration is as significant for mascots as it is for any other athlete, yet there is little to no known research available to help this population achieve a good hydration status. Studying similar populations such as cheerleaders, band members, football players, and firefighters provided a better understanding of mascot hydration. The purpose of this study was to examine the level of hydration knowledge in mascots performing at the collegiate and professional levels and determine the different …


The Association Between Fruit And Vegetable Consumption And Mental Health Among Young Adults, Natalie Miller May 2019

The Association Between Fruit And Vegetable Consumption And Mental Health Among Young Adults, Natalie Miller

Human Nutrition and Hospitality Management Undergraduate Honors Theses

While the majority of the American population is aware that fruits and vegetables can improve physical health, research also suggests that mental health may benefits as well. With depression and anxiety rates increasing and fruit and vegetable consumption decreasing across the country there is potential that the two are related. It has been found that majority of American adults do not meet fruit and vegetable recommendations, while 16 million adults face depression and anxiety. Young adults reported the lowest amount of fruit and vegetable consumption, as well as some of the highest rates of depression and anxiety. The purpose of …


The Acute Effects Of Citrulline Malate And Bonded Arginine Silicate Supplementation On Vasodilation Of Young Adults, Jeffrey Rogers May 2019

The Acute Effects Of Citrulline Malate And Bonded Arginine Silicate Supplementation On Vasodilation Of Young Adults, Jeffrey Rogers

Health, Human Performance and Recreation Undergraduate Honors Theses

Abstract

Background

Clinicians, professional athletes, and recreational athletes are interested in supplementation that up-regulates nitric oxide (NO) production in blood vessel endothelium, increasing arterial vasodilation. Benefits from these supplements include improvements in blood pressure, muscle hyperemia, and exercise performance. Citrulline Malate (CM) is a pre-workout ingredient, popular for its ability to increase exercise performance and blood serum concentrations of L-arginine, resulting in NO production. Recently, Inositol-Stabilized Arginine Silicate (ASI, Nitrosigine) has been added to many of the most popular pre-workout blends, following a group of studies showing ASI increases serum arginine and reduces post-workout muscle damage. Research has yet to …


Effects Of An Educational Intervention On Nutrition And Healthy Eating Habits In Minority Group Parents And Children Living In Arkansas, Peri Clay May 2019

Effects Of An Educational Intervention On Nutrition And Healthy Eating Habits In Minority Group Parents And Children Living In Arkansas, Peri Clay

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: The Hispanic population is the largest growing minority ethnic group in the United States today. Minority groups have an added struggle with obesity and have higher rates of obesity in this country than the caucasian counterparts. While minority group parents want more for their children they face many cultural and language barriers related to proper nutrition and hydration. This prevents these families from gaining adequate nutrition.

Objective: The purpose was to evaluate the impact of nutrition education on obesity rates through implementation of a year long educational intervention for minority group mothers and their children through and …


Effects Of An Educational Intervention On Exclusive Breastfeeding Rates In Marshallese Mothers Residing In The U.S., Connor K. Otto Dec 2018

Effects Of An Educational Intervention On Exclusive Breastfeeding Rates In Marshallese Mothers Residing In The U.S., Connor K. Otto

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: The largest population of Marshallese immigrants in the Contiguous U.S. resides in Northwest Arkansas. Despite adequate access to healthcare, the Marshallese face many health disparities, perhaps partly due to the language barrier they face in healthcare settings and education. Regarding breastfeeding rates, women in the Marshall Islands have a significantly higher rate of exclusive breastfeeding than in Marshallese women residing in the U.S. who face cultural barriers. Breastfeeding is positively correlated to many benefits for infants and is recommended exclusively for at least 6 months by pediatric policy organizations.

Objective: The purpose of this research is to examine breastfeeding …


Effect Of Grain Sorghum Polyphenols On Fecal Fermentation, Danielle Marie Ashley Aug 2018

Effect Of Grain Sorghum Polyphenols On Fecal Fermentation, Danielle Marie Ashley

Graduate Theses and Dissertations

Obesity is an increasing epidemic which during 2015-2016 afflicted 39.8% of adults and 18.5% of youth in the United States. Not only can obesity affect quality of life, but it can lead to life-threatening diseases such as type 2 diabetes, heart disease, stroke, and some cancers. Animal and human research have demonstrated a pattern of gut microbiota perturbation in overweight and obesity, characterized by a reduction of beneficial bacterial species and increase in harmful species. Diet has been established as a contributing factor in gut ecology, and foods including fiber, resistant starch, and polyphenols have been found to both enhance …


Bioavailability Of Bioactive Compounds, Wing Shun Lam Aug 2018

Bioavailability Of Bioactive Compounds, Wing Shun Lam

Graduate Theses and Dissertations

Arachidin-1 (Ara-1) and arachidin-3 (Ara-3) are stilbenoids found in hairy peanut roots, which have been shown to possess similar, if not higher, efficacy in biological activities when compared to nonprenylated analogs such as piceatannol and resveratrol. Blackberry essences are concentrated volatiles, which are characterized by low molecular weight, lipophilic properties, and have also been demonstrated to have health benefits. As interest in dietary bioactive compounds functional ingredients increase, more emphasis has been placed on identifying which compounds have high efficacy as well as bioavailability. The ability of a compound to exert its health promoting effects depends on its bioavailable dose, …