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Higher Unsaturated Fatty Acid Intake And Aerobic Training Are Related With Lower Intramyocellular Lipid In Older Adults, Hillary D. McLean 2016 University of Kentucky

Higher Unsaturated Fatty Acid Intake And Aerobic Training Are Related With Lower Intramyocellular Lipid In Older Adults, Hillary D. Mclean

Posters-at-the-Capitol

Title: Higher Unsaturated Fatty Acid Intake and Aerobic Training are Related to Lower Intramyocellular Lipid in Older Adults

1Hillary McLean, 2Maja Redzic, and 3D. Travis Thomas

Department: 1Department of Agriculture, 2Department of Pharmacology and Nutritional Sciences, and 3Department of Clinical Sciences

Funding: R21AG046762-01A1, UL1TR000117, T32DK007778-16

Word Count: 298/300

Intramyocellular lipid (IMCL) is associated with metabolic dysfunction in aging. Exercise is known to influence IMCL accumulation and was recently observed to have a direct association with vitamin D status (25(OH)D) in our lab. In addition, we observed an inverse association between IMCL ...


Development Of An Online Food Safety Training For Employees Of University Farms And School Gardens, Angela M. Shaw, Catherine Strohbehn, Linda L. Naeve 2016 Iowa State University

Development Of An Online Food Safety Training For Employees Of University Farms And School Gardens, Angela M. Shaw, Catherine Strohbehn, Linda L. Naeve

Angela M. Shaw

With a rise in the number of publicly accessed fruit and vegetable growing venues, there is a need for food safety training for staff of these schools and research facilities. This project created a variety of media options to educate workers about proper ways to handle fruit and vegetables to ensure food safety.


On-Farm Food Safety: Cleaning And Sanitizing Guide, Catherine Strohbehn, Aubrey Mendonca, Lester Wilson, Paul Domoto, Margaret Smith, Byron Brehm-Stecher, Angela M. Shaw 2016 Iowa State University

On-Farm Food Safety: Cleaning And Sanitizing Guide, Catherine Strohbehn, Aubrey Mendonca, Lester Wilson, Paul Domoto, Margaret Smith, Byron Brehm-Stecher, Angela M. Shaw

Angela M. Shaw

Using good sanitation practices during production, harvesting, and packaging can help reduce the risk of microbial contamination of fresh produce. Soil, fertilizers, harvesting equipment, water, workers, or animals such as livestock, pets, and pests can be sources of harm- ful microorganisms that cause foodborne illness. Surfaces that come in contact with produce must be washed, rinsed, and sanitized regularly. Employees need to understand and use appropriate food handling practices.


Tissue-Specific Alterations Of Methyl Group Metabolism With Dna Hypermethylation In The Zucker (Type 2) Diabetic Fatty Rat., Kelly T. Williams, Kevin Schalinske 2016 Iowa State University

Tissue-Specific Alterations Of Methyl Group Metabolism With Dna Hypermethylation In The Zucker (Type 2) Diabetic Fatty Rat., Kelly T. Williams, Kevin Schalinske

Kevin Schalinske

BackgroundAltered methyl group and homocysteine metabolism were tissue-specific, persistent, and preceded hepatic DNA hypomethylation in type 1 diabetic rats. Similar metabolic perturbations have been shown in the Zucker (type 2) diabetic fatty (ZDF) rat in the pre-diabetic and early diabetic stages, but tissue specificity and potential impact on epigenetic marks are unknown, particularly during pathogenesis.

Methods ZDF (fa/fa) and lean (+/?) control rats were killed at 12 and 21 weeks of age, representing early and advanced diabetic conditions. Blood and tissues were analysed with respect to methyl group and homocysteine metabolism, including DNA methylation.

Results At 12 weeks, hepatic ...


Resistant Starch: Promise For Improving Human Health, Diane F. Birt, Terri D. Boylston, Suzanne Hendrich, Jay-Lin Jane, James Hollis, Li Li, John F. McClelland, Samuel Moore, Gregory J. Phillips, Matthew James Rowling, Kevin Schalinske, Marvin Paul Scott, Elizabeth M. Whitley 2016 Iowa State University

Resistant Starch: Promise For Improving Human Health, Diane F. Birt, Terri D. Boylston, Suzanne Hendrich, Jay-Lin Jane, James Hollis, Li Li, John F. Mcclelland, Samuel Moore, Gregory J. Phillips, Matthew James Rowling, Kevin Schalinske, Marvin Paul Scott, Elizabeth M. Whitley

Kevin Schalinske

Ongoing research to develop digestion-resistant starch for human health promotion integrates the disciplines of starch chemistry, agronomy, analytical chemistry, food science, nutrition, pathology, and microbiology. The objectives of this research include identifying components of starch structure that confer digestion resistance, developing novel plants and starches, and modifying foods to incorporate these starches. Furthermore, recent and ongoing studies address the impact of digestion-resistant starches on the prevention and control of chronic human diseases, including diabetes, colon cancer, and obesity. This review provides a transdisciplinary overview of this field, including a description of types of resistant starches; factors in plants that affect ...


Mapping Of Iron And Zinc Quantitative Trait Loci In Soybean For Association To Iron Deficiency Chlorosis Resistance, Keith E. King, Gregory A. Peiffer, Manju B. Reddy, Nick Lauter, Shun Fu Lin, Silvia R. Cianzio, Randy C. Shoemaker 2016 Iowa State University

Mapping Of Iron And Zinc Quantitative Trait Loci In Soybean For Association To Iron Deficiency Chlorosis Resistance, Keith E. King, Gregory A. Peiffer, Manju B. Reddy, Nick Lauter, Shun Fu Lin, Silvia R. Cianzio, Randy C. Shoemaker

Manju B. Reddy

Iron deficiency chlorosis (IDC) in soybean results in yield losses or in extreme cases death. Breeding for resistance has shown limited success with no cultivar having complete resistance. Mineral content of the soybean could be an indicator of the ability of the plant to withstand the effects of IDC. Iron (Fe) and zinc (Zn) concentration was examined in soybean seed and leaves. SSR, RFLP, and BARCSOYSSR markers were used to construct a linkage map used for mapping of Fe and Zn concentrations. The QTL analysis for the combined data identified one major QTL for seed Fe accumulation on chromosome 20 ...


Inhibition Of Non-Haem Iron Absorption In Man By Polyphenolic-Containing Beverages, Richard F. Hurrell, Manju B. Reddy, James D. Cook 2016 Swiss Federal Institute of Technology, Zurich

Inhibition Of Non-Haem Iron Absorption In Man By Polyphenolic-Containing Beverages, Richard F. Hurrell, Manju B. Reddy, James D. Cook

Manju B. Reddy

The effects of different polyphenol-containing beverages on Fe absorption from a bread meal were estimated in adult human subjects from the erythrocyte incorporation of radio-Fe. The test beverages contained different polyphenol structures and were rich in either phenolic acids (chlorogenic acid in coffee), monomeric flavonoids (herb teas, camomile (Matricaria recutita L.)), vervain (Verbena officinalis L.), lime flower (Tilia cordata Mill.), pennyroyal (Mentha pulegium L.) and peppermint (Mentha piperita L.), or complex polyphenol polymerization products (black tea and cocoa). All beverages were potent inhibitors of Fe absorption and reduced absorption in a dose-dependent fashion depending on the content of total polyphenols ...


Negative Effect Of Camu-Camu (Myrciaria Dubia) Despite High Vitamin C Content On Iron Bioavailability, Using A Caco-2 Cell Model, Yael Nemirovsky, Nelly Zavaleta, Maria E. Villanueva, Seth M. Armah, Sixto A. Iman, Manju B. Reddy 2016 Universidad Nacional Agraria La Molina

Negative Effect Of Camu-Camu (Myrciaria Dubia) Despite High Vitamin C Content On Iron Bioavailability, Using A Caco-2 Cell Model, Yael Nemirovsky, Nelly Zavaleta, Maria E. Villanueva, Seth M. Armah, Sixto A. Iman, Manju B. Reddy

Manju B. Reddy

It is well known that vitamin C is an important enhancer of nonheme iron bioavailability due to its high reducing capacity. Camu-camu, a fruit that grows in the jungle of Peru, contains high amount of vitamin C (2,780 mg per 100 g). In this study, we investigated the effect of camu-camu on nonheme iron bioavailability from two different meals (rice with lentils and wheat flour porridge) using an in vitro Caco-2 cell model. These two meals were treated with three different camu-camu juice concentrations (C0 = 0 g, C1 = typical consumption, and C2 = 3X typical consumption). The results showed that ...


Oxalate And Phytate Of Soy Foods, Ismail A. Al-Wahsh, Harry T. Horner, Reid G. Palmer, Manju B. Reddy, Linda K. Massey 2016 Washington State University

Oxalate And Phytate Of Soy Foods, Ismail A. Al-Wahsh, Harry T. Horner, Reid G. Palmer, Manju B. Reddy, Linda K. Massey

Manju B. Reddy

The consumption of foods made from soybeans is increasing because of their desirable nutritional value. However, some soy foods contain high concentrations of oxalate and/or phytate. Oxalate is a component of calcium oxalate kidney stones, whereas phytate is an inhibitor of calcium kidney stone formation. Thirty tested commercial soy foods exhibited ranges of 0.02−2.06 mg oxalate/g and 0.80−18.79 mg phytate/g. Commercial soy foods contained 2−58 mg of total oxalate per serving and 76−528 mg phytate per serving. Eighteen of 19 tofu brands and two soymilk brands contained less than ...


An Evaluation Of Edta Compounds For Iron Fortification Of Cereal-Based Foods, Richard F. Hurrell, Manju B. Reddy, Joseph Burri, James D. Cook 2016 Nestlé Research Centre

An Evaluation Of Edta Compounds For Iron Fortification Of Cereal-Based Foods, Richard F. Hurrell, Manju B. Reddy, Joseph Burri, James D. Cook

Manju B. Reddy

Fe absorption was measured in adult human subjects consuming different cereal foods fortified with radiolabelled FeSO4, ferrous fumarate or NaFeEDTA, or with radiolabelled FeSO4 or ferric pyrophosphate in combination with different concentrations of Na2EDTA. Mean Fe absorption from wheat, wheat–soyabean and quinoa (Chenopodium quinoa) infant cereals fortified with FeSO4 or ferrous fumarate ranged from 0·6 to 2·2 %. For each infant cereal, mean Fe absorption from ferrous fumarate was similar to that from FeSO4 (absorption ratio 0·91–1·28). Mean Fe absorption from FeSO4-fortified bread rolls was 1·0 ...


Genetic Modification Of Low Phytic Acid 1-1 Maize To Enhance Iron Content And Bioavailability, Maneesha R. Aluru, Steve R. Rodermel, Manju B. Reddy 2016 Iowa State University

Genetic Modification Of Low Phytic Acid 1-1 Maize To Enhance Iron Content And Bioavailability, Maneesha R. Aluru, Steve R. Rodermel, Manju B. Reddy

Manju B. Reddy

High phytate content in staple food crops is a major barrier to successful iron biofortification. We have exploited the low phytic acid 1-1 (lpa1-1) mutant of maize to generate transgenic plants with up-to 70 μg/g seed iron through the endosperm-specific overexpression of soybean ferritin, resulting in more than 2-fold improvement in iron bioavailability. The levels of bioavailable seed iron achieved in this study greatly exceed any achieved thus far and closely approach values estimated to have a nutritional impact on target populations. Gene expression studies reveal a large induction of the YS1 transporter in leaves and severe repression of ...


Iron Bioavailability Of Hemoglobin From Soy Root Nodules Using A Caco-2 Cell Culture Model, Amy K. Proulx, Manju B. Reddy 2016 Iowa State University

Iron Bioavailability Of Hemoglobin From Soy Root Nodules Using A Caco-2 Cell Culture Model, Amy K. Proulx, Manju B. Reddy

Manju B. Reddy

Heme iron has been identified in many plant sourcesmost commonly in the root nodules of leguminous plants, such as soy. Our objective was to test the effectiveness of soy root nodule (SRN) and purified soy hemoglobin (LHb) in improving iron bioavailability using an in vitro Caco-2 cell model, with ferritin response as the bioavailability index. We assessed bioavailability of iron from LHb (either partially purified (LHbA) or purified (LHbD)) with and without food matrix and compared it with that from bovine hemoglobin (BHb), ferrous sulfate (FeSO4), or SRN. Bioavailability of each treatment was normalized to 100% of the FeSO4 treatment ...


Androidal Fat Dominates In Predicting Cardiometabolic Risk In Postmenopausalwomen, O. A. Matvienko, D. L. Alekel, S. N. Bhupathiraju, Heike Hofmann, L. M. Ritland, M. B. Reddy, M. D. Van Loan, C. D. Perry 2016 University of Northern Iowa

Androidal Fat Dominates In Predicting Cardiometabolic Risk In Postmenopausalwomen, O. A. Matvienko, D. L. Alekel, S. N. Bhupathiraju, Heike Hofmann, L. M. Ritland, M. B. Reddy, M. D. Van Loan, C. D. Perry

Manju B. Reddy

We hypothesized that soy isoflavones would attenuate the anticipated increase in androidal fat mass in postmenopausal women during the 36-month treatment, and thereby favorably modify the circulating cardiometabolic risk factors: triacylglycerol, LDLC, HDL-C, glucose, insulin, uric acid, C-reactive protein, fibrinogen, and homocysteine. We collected data on 224 healthy postmenopausal women at risk for osteoporosis (45.8–65 y, median BMI 24.5) who consumed placebo or soy isoflavones (80 or 120 mg/d) for 36 months and used longitudinal analysis to examine the contribution of isoflavone treatment, androidal fat mass, other biologic factors, and dietary quality to cardiometabolic outcomes. Except ...


Echinacea Sanguinea And Echinacea Pallida Extracts Stimulate Glucuronidation And Basolateral Transfer Of Bauer Alkamides 8 And 10 And Ketone 24 And Inhibit P-Glycoprotein Transporter In Caco-2 Cells, Zhiyi Qiang, Catharine Hauck, Joe-Ann McCoy, Mark P. Widrlechner, Manju B. Reddy, Patricia A. Murphy, Suzanne Hendrich 2016 Iowa State University

Echinacea Sanguinea And Echinacea Pallida Extracts Stimulate Glucuronidation And Basolateral Transfer Of Bauer Alkamides 8 And 10 And Ketone 24 And Inhibit P-Glycoprotein Transporter In Caco-2 Cells, Zhiyi Qiang, Catharine Hauck, Joe-Ann Mccoy, Mark P. Widrlechner, Manju B. Reddy, Patricia A. Murphy, Suzanne Hendrich

Manju B. Reddy

The use of Echinacea as a medicinal herb is prominent in the United States, and many studies have assessed the effectiveness of Echinacea as an immunomodulator. We hypothesized that Bauer alkamides 8, 10, and 11 and ketone 24 were absorbed similarly either as pure compounds or from Echinacea sanguinea and Echinacea pallida ethanol extracts, and that these Echinacea extracts could inhibit the P-glycoprotein transporter in Caco-2 human intestinal epithelial cells. Using HPLC analysis, the permeation rate of Bauer alkamides by passive diffusion across Caco-2 cells corresponded with compound hydrophilicity (alkamide 8 > 10 > 11), independent of the plant extract matrix. Both ...


Fermentation And Lactic Acid Addition Enhance Iron Bioavailability Of Maize, Amy K. Proulx, Manju B. Reddy 2016 Iowa State University

Fermentation And Lactic Acid Addition Enhance Iron Bioavailability Of Maize, Amy K. Proulx, Manju B. Reddy

Manju B. Reddy

Maize is one of the most important cereal crops for human consumption, yet it is of concern due to its low iron bioavailability. The objective of this study was to determine the effects of processing on iron bioavailability in common maize products and elucidate better processing techniques for enhancing iron bioavailability. Maize products were processed to represent different processing techniques: heating (porridge), fermentation (ogi), nixtamalization (tortillas), and decortication (arepas). Iron and phytate contents were evaluated. Iron bioavailability was assessed using the Caco-2 cell model. Phytate content of maize products was significantly reduced by decortication (25.6%, p ) 0.003) and ...


Soup Consumption Is Associated With A Reduced Risk Of Overweight And Obesity But Not Metabolic Syndrome In Us Adults: Nhanes 2003-2006, Yong Zhu, James H. Hollis 2016 University of Iowa

Soup Consumption Is Associated With A Reduced Risk Of Overweight And Obesity But Not Metabolic Syndrome In Us Adults: Nhanes 2003-2006, Yong Zhu, James H. Hollis

James Hollis

A limited number of studies have found that soup consumption is related to a lower risk of overweight and obesity in Asian and European populations, however, these studies do not provide a consistent picture regarding the association between soup consumption and markers of metabolic syndrome. To date, no study examining the relationship between soup and body weight or metabolic syndrome have been conducted in the US population. The present study used a sample of 4158 adults aged 19–64 who participated in the National Health and Nutrition Examination Survey between 2003 and 2006. The frequency of soup consumption was determined ...


Dietary Oil Composition Differentially Modulates Intestinal Endotoxin Transport And Postprandial Endotoxemia, Venkatesh Mani, James H. Hollis, Nicholas K. Gabler 2016 Iowa State University

Dietary Oil Composition Differentially Modulates Intestinal Endotoxin Transport And Postprandial Endotoxemia, Venkatesh Mani, James H. Hollis, Nicholas K. Gabler

James Hollis

Background: Intestinal derived endotoxin and the subsequent endotoxemia can be considered major predisposing factors for diseases such as atherosclerosis, sepsis, obesity and diabetes. Dietary fat has been shown to increase postprandial endotoxemia. Therefore, the aim of this study was to assess the effects of different dietary oils on intestinal endotoxin transport and postprandial endotoxemia using swine as a model. We hypothesized that oils rich in saturated fatty acids (SFA) would augment, while oils rich in n-3 polyunsaturated fatty acids (PUFA) would attenuate intestinal endotoxin transport and circulating concentrations. Methods: Postprandial endotoxemia was measured in twenty four pigs following a porridge ...


Short-Term Exposure To Heat Stress Attenuates Appetite And Intestinal Integrity In Growing Pigs 1, S. C. Pearce, M. V. Sanz-Fernandez, James Hollis, Lance H. Baumgard, Nicholas K. Gabler 2016 Iowa State University

Short-Term Exposure To Heat Stress Attenuates Appetite And Intestinal Integrity In Growing Pigs 1, S. C. Pearce, M. V. Sanz-Fernandez, James Hollis, Lance H. Baumgard, Nicholas K. Gabler

James Hollis

Acute heat stress (HS) and heat stroke can be detrimental to the health, well-being, and performance of mammals such as swine. Therefore, our objective was to chronologically characterize how a growing pig perceives and initially copes with a severe heat load. Crossbred gilts (n=32; 63.8±2.9 kg) were subjected to HS conditions (37°C and 40% humidity) with ad libitum intake for 0, 2, 4, or 6 h (n=8/time point). Rectal temperature (Tr), respiration rates (RR), and feed intake were determined every 2 h. Pigs were euthanized at each time point and fresh ileum and ...


Soup Consumption Is Associated With A Lower Dietary Energy Density And A Better Diet Quality In Us Adults, Yong Zhu, James Hollis 2016 University of Iowa

Soup Consumption Is Associated With A Lower Dietary Energy Density And A Better Diet Quality In Us Adults, Yong Zhu, James Hollis

James Hollis

Epidemiological studies have revealed that soup consumption is associated with a lower risk of obesity. Moreover, intervention studies have reported that soup consumption aids in body-weight management. However, little is known about mechanisms that can explain these findings. The objective of the present study was to investigate associations between soup consumption and daily energy intake, dietary energy density (ED), nutrient intake and diet quality. Adults aged 19–64 years who participated in the National Health and Nutrition Examination Surveys during 2003–8 were included in the study. Soup consumers were identified from the first dietary recall using the United States ...


Resistant Starch: Promise For Improving Human Health, Diane F. Birt, Terri D. Boylston, Suzanne Hendrich, Jay-Lin Jane, James Hollis, Li Li, John F. McClelland, Samuel Moore, Gregory J. Phillips, Matthew James Rowling, Kevin Schalinske, Marvin Paul Scott, Elizabeth M. Whitley 2016 Iowa State University

Resistant Starch: Promise For Improving Human Health, Diane F. Birt, Terri D. Boylston, Suzanne Hendrich, Jay-Lin Jane, James Hollis, Li Li, John F. Mcclelland, Samuel Moore, Gregory J. Phillips, Matthew James Rowling, Kevin Schalinske, Marvin Paul Scott, Elizabeth M. Whitley

Suzanne Hendrich

Ongoing research to develop digestion-resistant starch for human health promotion integrates the disciplines of starch chemistry, agronomy, analytical chemistry, food science, nutrition, pathology, and microbiology. The objectives of this research include identifying components of starch structure that confer digestion resistance, developing novel plants and starches, and modifying foods to incorporate these starches. Furthermore, recent and ongoing studies address the impact of digestion-resistant starches on the prevention and control of chronic human diseases, including diabetes, colon cancer, and obesity. This review provides a transdisciplinary overview of this field, including a description of types of resistant starches; factors in plants that affect ...


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