Nutrition Commons^™

Outclimbing Cognitive Decline: Age, Western Diet, Resistance Exercise, And The Brain., Leila Dzinic

Electronic Thesis and Dissertation Repository

Increased age and obesity diminish motivation, perseverance, and spatial memory function. Aerobic exercise interventions have successfully rescued some of these processes. However, in older and heavier populations aerobic exercise is not as sustainable due to high risk of injury. Resistance exercise consists of physical activity where maximum oxygen consumption is not increased and has been proposed as a safe and effective intervention for this population. Here, we used touchscreen-based cognitive testing to elucidate the influence of resistance exercise on motivation and spatial memory in aged, diet-induced obese mice, using a water restriction procedure I develop in Chapter 2. Mice underwent …

Smartphones For Smart Eating: Evaluating The Effectiveness Of Smartphone Applications On Improving Adolescent Food Knowledge, Heather A. Jantzi

Electronic Thesis and Dissertation Repository

Many Canadian adolescents have unhealthy eating habits which are risk factors for developing chronic diseases later in life. Food literacy plays a role in healthy eating habits but teens in Ontario currently lack sufficient nutrition education learning opportunities in home and school environments. Across health research, smartphones have been utilized as a novel medium to promote learning and alter behaviour. This thesis seeks to understand the effectiveness of smartphone applications at improving food knowledge in adolescents through (i) a systematic review of published interventions, and (ii) by investigating the efficacy of a novel location-based smartphone application. Findings from this thesis …

Sarcopenia In Head And Neck Cancer: A Prognostic Analysis, Nedeljko Jovanovic

Electronic Thesis and Dissertation Repository

Introduction: In head and neck cancer (HNC), loss of skeletal muscle mass (SMM), or sarcopenia, is a strong prognostic factor for outcomes. However, inconsistencies in its assessment limit our understanding of the relationship between sarcopenia and nutrition-related outcomes. This project evaluated the significance of sarcopenia as described in the literature and as demonstrated in a cohort of HNC patients.

Methods: A scoping review was first conducted followed by a retrospective cohort study with data collected from 194 oropharyngeal carcinoma patients treated with definitive radiation/chemoradiation. Sarcopenia was assessed from computed tomography (CT) imaging at the third cervical vertebra (C3) and the …

Examining The Correlates Of Adolescent Food And Nutrition Knowledge In London, Ontario, Rachel Ann Brown

Electronic Thesis and Dissertation Repository

Food literacy is a set of skills and knowledge that are integral to diet. It is common among teenagers to not have basic food literacy skills needed to consume a healthy diet. This exploratory study examined: (1) the current state of food and nutrition knowledge among adolescents in grades 9-12 in the London-Middlesex region of Ontario; and (2) predictors of food knowledge among adolescents. Data for this study were drawn from baseline youth and parent survey data collected for the SmartAPPetite project, a smartphone application-based intervention study which aims to improve food and nutrition knowledge and dietary habits of adolescents. …

Evaluating The Implementation Of The Centrally Procured School Food Program (Cpsfp) In Southwestern Ontario Elementary Schools, Mariam R. Ismail

Electronic Thesis and Dissertation Repository

School food programs can improve children’s health and well-being, while also creating economic opportunities for local food systems. Program evaluations of such interventions have always been done, but from the perspectives of their effectiveness. Yet, few have thoroughly examined the process or implementation practices of these interventions. The aim of this dissertation was to evaluate the implementation of the Centrally Procured School Food Program (CPSFP), a procurement and delivery-based school food program in Southwestern Ontario, that aims to improve elementary school-aged children’s intake of fruit and vegetables (FVs). Canada remains one of the few industrialized nations without a national school …

Investigating Elementary School Food Programs: Impacts On Child Knowledge And Dietary Behaviours, Paige Colley

Electronic Thesis and Dissertation Repository

Good nutrition is an important part of maintaining a healthy lifestyle. A balanced diet can promote positive health outcomes, protecting against health problems caused by nutritional deficiencies. Canada has reported poor diet quality and high rates of overweight and obesity among children. Obesity has been linked to several non-communicable diseases including type 2 diabetes, heart disease, and some forms of cancer. Efforts to improve lifelong, healthy eating behaviours must be implemented.

This dissertation investigated the impacts of school food programming on child nutrition. A Centrally Procured School Food Program (CPSFP) was implemented at 30 elementary schools in Southwestern Ontario, Canada. …

Effects Of A Pregnancy Lifestyle Intervention On Emotion Regulation In Infants Responding To A Toy Removal Task At One-Year Of Age, Mollie Manley

Electronic Thesis and Dissertation Repository

Poor infant emotion regulation (ER) has been linked with increased psychopathological risk in infancy and childhood. The Developmental Origins of Health and Disease Hypothesis suggests the prenatal period as the earliest point of intervention, where fetal exposure to healthy lifestyle changes can promote optimal ER in infancy. Infant electroencephalography (EEG; n=13) and heart rate variability (HRV; n=18) were measured at rest and in response to a toy removal task, to determine the ER of infants whose mothers participated in a nutrition and exercise intervention during pregnancy. Results demonstrated positive left frontal alpha asymmetry at rest (0.08± 0.66) and in response …

The Difference In A1c Of Children And Adolescents With Type 1 Diabetes Mellitus Using Carbohydrate Counting Compared To Those Using A Structured Meal Plan, Alia El Kubbe

Electronic Thesis and Dissertation Repository

Carbohydrate counting (CHO) is a nutrition education tool used by patients with type 1 diabetes mellitus (T1DM). The primary objective was to assess glycated hemoglobin (A1C) in participants with T1DM using CHO counting vs. those using a structured meal plan (SMP). The secondary objectives were to determine if BMI-for-age, parental income, parental involvement, and mothers’ educational level were associated with their children’s glycemic control. A cross sectional study was conducted, where participants aged 4-18 years, or their parents completed a survey. Total sample size was 88 participants (77 in the CHO counting group and 11 in the SMP group). There …

Impact Of Feeding Tube Status On Health Outcomes For Individuals With Oropharyngeal Cancer, Nedeljko Jovanovic

Electronic Thesis and Dissertation Repository

Abstract

This study investigated differences in outcomes related to health, swallowing, and quality of life (QoL) for individuals with oropharyngeal squamous cell carcinoma (OPSCC) receiving either radiotherapy (RT) alone, or concomitant chemoradiotherapy (CRT). Differences were assessed based on whether patients received a feeding tube (FT group) or not (NFT group). Measures including the Functional Oral Intake Scale (FOIS), Performance Status Scale for Head and Neck Cancer (PSS-HN), M.D. Anderson Dysphagia Inventory (MDADI), and weight were collected for 126 individuals at baseline, and at 3, 6, and 12 months post-treatment. Data were analyzed to identify potential prognostic differences between the groups, …

Analysis Of Added Sugar Intake Of Canadian Children And Adolescents: Findings From The Canadian Community Health Survey On Nutrition, Ulaina Tariq

Electronic Thesis and Dissertation Repository

Background: The added sugar intake of children and adolescents in Canada warrants more research due to its contribution to obesity, diabetes, and other chronic and mental health issues.

Objective: To assess the trends and correlates of added sugar intake in Canadians aged 6 to 17.

Methods: Data were provided by the Canadian Community Health Survey-Nutrition 2004 and 2015. Statistical analysis included multivariable regression and t-tests.

Results: In 2015, 35.66% of Canadians aged 6 to 17 met sugar intake guidelines. Compared to 2004, in 2015 intake of fruit and vegetables was higher, while sugar and caloric intake was lower. Sedentary activity, …

Behaviour Change Intervention Strategies To Prevent Excessive Gestational Weight Gain In Pregnant Women Using A Nutrition And Exercise Lifestyle Intervention Program (Nelip), Karishma Hosein

Electronic Thesis and Dissertation Repository

Maternal obesity and excessive gestational weight gain (EGWG) are associated with adverse maternal and fetal outcomes. To evaluate the effectiveness of different behaviour change intervention strategies, it was hypothesized that the introduction of a single behaviour change, followed by a second, would be more effective at preventing early and total EGWG in pregnant women compared to the early simultaneous introduction of both behaviour changes. Eighteen pregnant women were block randomized into one of 3 Nutrition and Exercise Lifestyle Intervention Program (NELIP) strategies (full NELIP, Nutrition followed by Exercise N+E, Exercise followed by Nutrition E+N) and were followed at weekly face-to-face …

The Effect Of Diet On Midgut And Resulting Changes In Infectiousness Of Acmnpv Baculovirus In Trichoplusia Ni, Elizabeth Chen

Electronic Thesis and Dissertation Repository

The cabbage looper, Trichoplusia ni, a global generalist lepidopteran pest, has developed resistance to many synthetic and biological insecticides, requiring effective and environmentally acceptable alternatives. One possibility is the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV). This baculovirus is highly infectious for T. ni, with potential as a biocontrol agent, however, its effectiveness is strongly influenced by dietary context. In this study, microscopy and transcriptomics were used to examine how the efficacy of this virus was affected when T. ni larvae were raised on different diets. Larvae raised on potato host plants had lower chitinase and chitin deacetylase transcript levels …

The Application Of Self-Administered Nutrition Screening Tools And Evaluations Of The Impact Of Malnutrition On Quality Of Life In Individuals With Head And Neck Cancer, Mark J. P. Lynch

Electronic Thesis and Dissertation Repository

Abstract

Background: Individuals with head and neck cancer (HNCa) are at an increased risk of malnutrition. Therefore, self-administered nutrition screens which attempt to address their nutritional concerns may yield benefits for treatment outcomes and quality of life (QOL).

Methods: 34 participants (26 men, 8 women) completed one demographic and two QOL surveys, two nutrition self-screening tools, a nutrition assessment and an ease-of-use questionnaire. Results of the screens were compared to those of the assessment, and relationships between QOL, nutrition status, and demographics were examined.

Results: 32.3% of participants were identified as nutritionally compromised. The sensitivity and specificity for the PG-SGA …

Nutrition Screening In The Adult Stroke Population Using The Canadian Nutrition Screening Tool In Comparison With The Subjective Global Assessment, Tess Coutu

Electronic Thesis and Dissertation Repository

Although the Canadian Best Practice Recommendations for Stroke Care recommend all acute stroke patients be screened for malnutrition within 48 hours of admission to hospital using a valid screening tool, none have been validated for use in adult acute stroke patients. The Canadian Nutrition Screening Tool (CNST) tool has been validated within medicine and surgery patients. The purpose of this study is to estimate the level of agreement between the CNST and the Subjective Global Assessment (SGA), a nutrition assessment tool, in a cohort of 58 acute adult stroke patients at the Southwestern Ontario Regional Stroke Centre in London. In …

The Long Haul: Migratory Flight Preparation And Performance In Songbirds, Morag F. Dick

Electronic Thesis and Dissertation Repository

Migration requires birds to sustain high intensity endurance exercise for periods lasting from hours to days. Similar to athletes, preparation and nutrition is key to success. Birds seasonally prepare for migration, which includes increasing the capacity to oxidize fat in the flight muscles. Beyond fuelling migration, n-3 long-chain polyunsaturated fatty acids (PUFA) are hypothesized to be natural doping agents and increase endurance and fatty acid oxidative capacity. I examined how birds prepare for and sustain migratory flight and directly tested the role of n-3 PUFA. Using yellow-rumped warblers (Setophaga coronata) as a model species, I first examined the …

Indicator Amino Acid Derived Estimates Of Dietary Protein Requirement In Exercise-Trained Individuals, Arash Bandegan

Electronic Thesis and Dissertation Repository

Despite a number of nitrogen balance (NB) studies indicating increased dietary protein needs in Endurance (ET) and strength (ST) trained athletes, the Institute of Medicine (2005) has concluded, based largely on methodological concerns, that “no additional dietary protein is suggested for healthy adults undertaking resistance or endurance exercise”. Indicator amino acid oxidation method (IAAO) has been recently used for determination of protein requirement in humans. This method is based on the concept that when one indispensable amino acid (AA) is deficient for protein synthesis, then all other AA, including the indicator, will be considered excess and oxidized. With increasing intakes …

Evaluating The Role Of Intestinal Transporters In Fruit Juice-Drug Interactions, Mandy Mj Li

Electronic Thesis and Dissertation Repository

Fruit juice-drug interactions (FJDIs) involving non-metabolized oral medications result in decreased drug exposure that may lead to reduced therapeutic efficacy. The effect is thought to be mediated by inhibition of the intestinal drug transporters organic anion transporting polypeptide 1A2 and 2B1 (OATP1A2 and OATP2B1) by fruit juice constituents, however the exact mechanisms remain controversial. We tested the hypothesis that fruit juices limit the absorption of fexofenadine through interactions with specific intestinal transporters. In vitro transport and fruit juice inhibition studies using fexofenadine, a medication involved in FJDIs, revealed that in addition to previously implicated transporters, organic cation transporter 1 (OCT1) …

Exploring Cross-Sectional Associations Between Unhealthy Food Outlet Exposure And Bmi Z-Score In Elementary School Children In London, Canada, Krista Cook

Electronic Thesis and Dissertation Repository

The food environment has been implicated in the continuing epidemic of childhood obesity in Canada. The purpose of this thesis is to examine associations between the food environment, childhood weight, and unhealthy diets using data collected by the Spatial Temporal Environmental and Activity Monitoring (STEAM) project conducted among children (N=852) aged 9 to 14 years in Southwestern Ontario between 2010 and 2013. Global Positioning System (GPS) monitors and Geographic Information Systems (GIS) were used to determine the time children spent within 100m of an unhealthy food outlet on weekdays. Structural equation modeling was used to assess the effect of exposure …

Molecular Mechanisms Linking Amino Acid (Leucine) Deprivation To Igfbp-1 Hyperphosphorylation In Fetal Growth Restriction, Niyati M. Malkani

Electronic Thesis and Dissertation Repository

In this study, we explore the molecular mechanisms linking amino acid (leucine) deprivation to IGFBP-1 hyperphosphorylation in vitro. During pregnancy, a maladaptive fetal response to in utero amino acid deprivation leads to Fetal Growth Restriction (FGR). FGR infants display elevated phosphorylated IGFBP-1, which is associated with decreased IGF-I bioavailability. Leucine deprivation inhibits mechanistic target of rapamycin (mTOR) signaling and stimulates the amino acid response (AAR). Using HepG2 cells, a model for fetal hepatocytes, we demonstrate that in leucine deprivation, the AAR modulates total and phosphorylated IGFBP-1 while mTOR mediates total IGFBP-1 secretion only. We also reveal that protein kinases …

Nicotinamide Riboside Delivery Generates Nad+ Reserves To Protect Vascular Cells Against Oxidative Damage, Krista M. Hawrylyshyn

Electronic Thesis and Dissertation Repository

The ability of vascular cells to withstand oxidative insults is critical to vascular health. NAD⁺, which drives poly (ADP-ribose) polymerase (PARP) and sirtuin (SIRT) reactions, can be compromised and strategies for overcoming this limitation in the vasculature do not exist. This study determines if nicotinamide riboside (NR) delivery can augment NAD⁺ stores and fuel resistance to oxidative stress. I established that oxidative-stress insult on vascular cells decreased NAD⁺ levels, accompanied by a striking increase in nuclear PAR-chain accumulation. PARP inhibition abolished PAR-chain formation and preserved NAD⁺ levels, establishing PARP in NAD⁺ consumption in this …

The Relationship Between Dairy Product Consumption And Cognitive Performance In A Group Of Community-Dwelling Healthy Older Adults, Mariam R. Ismail

Electronic Thesis and Dissertation Repository

Dietary intake is one of the modifiable factors that may affect older adults’ cognitive function in their later years. Very little research has considered the potential role of dairy products on cognitive function. The aim of the present study was twofold: first, to investigate whether there is a difference in cognitive performance between older adults who consumed the recommended amount of dairy products (3 servings per day) and individuals who consumed less than the recommended amount (1 or 2 servings per day); second, to examine whether there is an association between the nutrients contained in the dairy products and cognitive …

Biosteel High Performance Sports Drink Improves Exercise Performance Following A Simulated Hockey Game, Kolten C. Abbott

Electronic Thesis and Dissertation Repository

INTRODUCTION: BioSteel High Performance Sports Drink (BioSteel) is one of the most popular sports supplements consumed by professional and amateur athletes. BioSteel Inc^® claims that consumption of BioSteel before and during exercise will result in “enhanced energy while delaying the onset of muscular and mental fatigue”. PURPOSE: Assess the efficacy of BioSteel supplementation on anaerobic and aerobic exercise performance as well as sport-specific cognition throughout exercise. METHODS: Eleven exercise-trained men completed a simulated hockey game on a cycle ergometer under two experimental conditions: BioSteel and isoenergetic placebo. Measures of exercise performance and cognition were assessed before, throughout and after …

Behavioral Feeding Problems Of Normally Developing Children Under 4 Years Of Age, Julia Stanislavskaia

Electronic Thesis and Dissertation Repository

Objectives: The objectives were to identify common problematic behaviours in cases of normally-developing children under four years of age and determine whether there were associations between responsiveness to treatment and number of behaviours and visits to the clinic, as well as low body weight. Rationale: The motive for this study was to address the gaps in literature by characterizing the population, acquiring data to help establish consistent nomenclature and categorization as well as information to help design a screening tool in the future. Methods: Secondary data was collected retrospectively from 106 medical charts that fit the inclusion criteria. The data …

The Effect Of Nutrition On The Microbiome In Pregnant Women And The Use Of Micronutrient Supplemented Probiotic Yogurt To Improve Outcomes, Megan Kathleen Enos

Electronic Thesis and Dissertation Repository

The aims of this study were to characterize the gut, oral, and vaginal microbiotas of pregnant women with varying nutritional status and to determine if daily supplementation with probiotic yogurt containing Lactobacillus rhamnosus GR-1 and ground Moringa leaves, would ‘normalize’ the microbiota and improve pregnancy outcomes. For the latter, a clinical study was performed in Mwanza, Tanzania, in which consumption of yogurt for 88 ± 31 days, starting from the second trimester, did not result in excess weight gain, altered pregnancy outcomes or increased blood nutrient levels compared to an under-nourished group not taking the yogurt. Ingestion of the probiotic …

Molecular Mechanisms Underlying The Early Life Programming Of The Liver, Gurjeev Sohi

Electronic Thesis and Dissertation Repository

Clinical studies have demonstrated that intrauterine growth restriction (IUGR) offspring, faced with a nutritional mismatch postpartum, have an increased risk of developing the metabolic syndrome. The maternal protein restriction (MPR) rat model has been extensively studied to investigate the adverse effects of a nutritional mismatch in postnatal life of IUGR offspring. Previous studies have demonstrated that MPR leads to impaired function of the liver, an important metabolic organ. However the underlying mechanisms which predispose these offspring to the metabolic syndrome remain elusive. In the following studies, low protein diet during pregnancy and lactation led to IUGR offspring with decreased liver …

Evaluating The Impact Of Two Different Methods Of Diabetes Self-Management Education On Knowledge, Attitude, And Behaviours Of Patients With Type 2 Diabetes Mellitus, Laura B. Briden

Electronic Thesis and Dissertation Repository

This study compared the effectiveness of diabetes self-management education (DSME) methods by examining changes in knowledge, attitude, and behaviour (KAB) after receiving education. Participants from a convenience sample were randomized into two groups, one receiving education through conversation maps and the other through traditional group education. Participants’ knowledge and attitude changes were measured by using a repeated measures pre-test/post-test design and changes in Hb A1c were observed. Focus groups were conducted after education was received to obtain perceptions and self-reported behaviour changes. Significant knowledge and attitude score changes were observed in the conversation map group after education. When comparing the …

The Effects Of A Six Month Nutrition Intervention On Diet Quality In Persons With Or At Risk For The Metabolic Syndrome, Rebecca Horne

Electronic Thesis and Dissertation Repository

One quarter of the world’s population is thought to have the metabolic syndrome, and first line treatments include dietary strategies for weight loss. Restrictive diet interventions commonly used in research appear to lack long-term sustainability; therefore, other approaches are warranted. The Canadian Healthy Eating Index (CHEI) was used as a framework and outcome measure for a 6-month ad-libitum diet quality intervention that assessed diet quality and key risk factors of the syndrome. Participants (n=23) were randomized to the nutrition program (n=16) or usual care (control) (n=7). Post intervention, CHEI scores increased by 9.1 and 3.4 points intervention and control, respectively …

Residents Living In A Retirement Community Are At Risk For Numerous Nutrient Inadequacies, Ohood M. Alharbi

Electronic Thesis and Dissertation Repository

Purpose: To determine the nutrient adequacy of the diet of older adults living in a retirement community (RC). Methods: Residents were surveyed using a 21-item Health Questionnaire and Three Day Food Records were used to estimate the adequacy of their diets. Food records were analyzed using ESHA Food Processor®; all data were tabulated and analyzed using SPSS version 19 software. Results: Response rate, 28.7%; mean age, 86 ± 8.1 years; mean BMI, 25.6 ± 4.6 kg/m²; polypharmacy, 75%; health conditions (most nutrition-related), 75%; 60% performed between 30-150 min of physical activity/week. Participants met the EER and AMDRs for …

Does A Group Lifestyle Behaviour Change Program (Prepare) Have An Impact On The Nutritional And Health Characteristics In Adults With Prediabetes?, Jennifer Broxterman

Electronic Thesis and Dissertation Repository

Objective: Lifestyle interventions that target diet and physical activity have been shown to reduce the development of Type 2 diabetes (T2DM) in individuals at risk; however, accessible and effective community-based prevention programs remain lacking. The purpose of this study was to assess the impact of PREPARE, a group lifestyle behaviour change program in adults with prediabetes.

Methods: Adults diagnosed with prediabetes could self-select PREPARE (n=48, intervention arm), consisting of six monthly group nutrition and physical activity education sessions, or, a one-time group education session (n=15, controls), both aimed to prevent Type 2 Diabetes Mellitus (T2DM). Primary outcome measures included dietary, …

Planning, Implementation, And Formative Evaluation Of A Food Literacy Program, Heather M. Thomas

Electronic Thesis and Dissertation Repository

The overall purpose of this dissertation was to examine the planning, implementation, and formative evaluation of a community-based food literacy program for youth. Article 1 provided a summary of the community-based cooking program for at-risk youth. Objectives included the provision of applied food literacy and cooking skills education augmented with fieldtrips to local farms. Eight at-risk youth (five girls and three boys, mean age = 14.6) completed the intervention. Post intervention, five of eight participants completed in-depth interviews about their experiences.

Article 2 was a formative evaluation of the cooking program focused on gaining an understanding of participants’ (i.e., at-risk …