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Developmental Neuroscience Commons

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2008

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Articles 1 - 16 of 16

Full-Text Articles in Developmental Neuroscience

Effects Of Pre-Pubertal Social Experiences On The Responsiveness Of Juvenile Rats To Predator Odors, Stephen M. Siviy Sep 2008

Effects Of Pre-Pubertal Social Experiences On The Responsiveness Of Juvenile Rats To Predator Odors, Stephen M. Siviy

Psychology Faculty Publications

The extent to which social variables may modulate the fear associated with a predator cue was assessed in juvenile rats. Cat odor reduced play to a comparable extent in both socially housed and isolate-housed rats, although socially housed rats exhibited more risk assessment during extinction. Rats that had played previously in the context used for assessing fear hid slightly less when exposed to cat odor than those rats that had not played previously in the testing context. However, no other differences were found between these two groups suggesting that prior social experience with the testing context has minimal effects on …


Maternal Cocaine Administration In Mice Alters Dna Methylation And Gene Expression In Hippocampal Neurons Of Neonatal And Prepubertal Offspring, Svetlana I. Novikova, Fang He, Jie Bai, Nicholas J. Cutrufello, Michael S. Lidow, Ashiwel S. Undieh Apr 2008

Maternal Cocaine Administration In Mice Alters Dna Methylation And Gene Expression In Hippocampal Neurons Of Neonatal And Prepubertal Offspring, Svetlana I. Novikova, Fang He, Jie Bai, Nicholas J. Cutrufello, Michael S. Lidow, Ashiwel S. Undieh

Publications and Research

Previous studies documented significant behavioral changes in the offspring of cocaine-exposed mothers. We now explore the hypothesis that maternal cocaine exposure could alter the fetal epigenetic machinery sufficiently to cause lasting neurochemical and functional changes in the offspring. Pregnant CD1 mice were administered either saline or 20 mg/kg cocaine twice daily on gestational days 8–19. Male pups from each of ten litters of the cocaine and control groups were analyzed at 3 (P3) or 30 (P30) days postnatum. Global DNA methylation, methylated DNA immunoprecipitation followed by CGI2 microarray profiling and bisulfite sequencing, as well as quantitative real-time RT-PCR gene expression …


Effects Of Neonatal Handling On Play Behavior And Fear Towards A Predator Odor In Juvenile Rats, Stephen M. Siviy Feb 2008

Effects Of Neonatal Handling On Play Behavior And Fear Towards A Predator Odor In Juvenile Rats, Stephen M. Siviy

Psychology Faculty Publications

The effects of brief daily separation, also known as "handling," during the first 2 weeks of life on play behavior and fearfulness toward a predatory odor were assessed in juvenile rats. Handled rats were more playful than nonhandled control rats, and while handling had no effect on the direct response of these rats toward a predatory odor, handled rats did not exhibit a conditioned suppression of play when tested later in the same context where they had been exposed to the predatory odor. Handled rats were still wary of the environment in that they continued to show a heightened level …


Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell Jan 2008

Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell

Laura Elena O'Dell

No abstract provided.


Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell Jan 2008

Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell

Laura Elena O'Dell

No abstract provided.


Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell Jan 2008

Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell

Laura Elena O'Dell

No abstract provided.


Brain Bases Of Individual Differences In Cognition, Chantel Prat, Marcel Just Dec 2007

Brain Bases Of Individual Differences In Cognition, Chantel Prat, Marcel Just

Marcel Adam Just

No abstract provided.


A Decrease In Brain Activation Associated With Driving When Listening To Someone Speak, Marcel Just, Timothy Keller, Jacquelyn Cynkar Dec 2007

A Decrease In Brain Activation Associated With Driving When Listening To Someone Speak, Marcel Just, Timothy Keller, Jacquelyn Cynkar

Marcel Adam Just

No abstract provided.


Autism-Like Behavioral Phenotypes In Btbr Ttf/J Mice. Genes, Hewlet Mcfarlane Dec 2007

Autism-Like Behavioral Phenotypes In Btbr Ttf/J Mice. Genes, Hewlet Mcfarlane

Hewlet McFarlane

No abstract provided.


Fmri Investigation Of Working Memory For Faces In Autism: Visual Coding And Underconnectivity With Frontal Areas, Hideya Koshino, Rajesh Kana, Timothy Keller, Vladimir Cherkassky, Nancy Minshew, Marcel Just Dec 2007

Fmri Investigation Of Working Memory For Faces In Autism: Visual Coding And Underconnectivity With Frontal Areas, Hideya Koshino, Rajesh Kana, Timothy Keller, Vladimir Cherkassky, Nancy Minshew, Marcel Just

Marcel Adam Just

No abstract provided.


The Effects Of Prenatal Stress On Motivation In The Rat Pup, Howard Cromwell Dec 2007

The Effects Of Prenatal Stress On Motivation In The Rat Pup, Howard Cromwell

Howard Casey Cromwell

Exposure to prenatal stress (PNS) has been shown to induce a set of psychological and behavioral changes in developing offspring. We used the rodent model to investigate whether PNS produces changes in the ability of the pup to express social motivation.We used a set of behavioral tasks including monitoring ultrasonic vocalizations after isolation, a conditioned place preference, and a novel and familiar odor approach test. Pregnant Long–Evans rats were exposed to an unpredictable, variable stressor twice daily during the third week of gestation. Isolation vocalizations were assessed on postnatal day (PND) 10. Pup affinity for the dam was evaluated on …


Using Fmri Brain Activation To Identify Cognitive States Associated With Perception Of Tools And Dwellings, Svetlana V. Shinkareva, Robert A. Mason, Vicente L. Malave, Wei Wang, Tom M. Mitchell, Marcel Adam Just Dec 2007

Using Fmri Brain Activation To Identify Cognitive States Associated With Perception Of Tools And Dwellings, Svetlana V. Shinkareva, Robert A. Mason, Vicente L. Malave, Wei Wang, Tom M. Mitchell, Marcel Adam Just

Marcel Adam Just

No abstract provided.


Modifying The Brain Activation Of Poor Readers During Sentence Comprehension With Extended Remedial Instruction: A Longitudinal Study Of Neuroplasticity, Ann Meyler, Timothy A. Keller, Vladimir L. Cherkassky, John D. E. Gabrieli, Marcel Adam Just Dec 2007

Modifying The Brain Activation Of Poor Readers During Sentence Comprehension With Extended Remedial Instruction: A Longitudinal Study Of Neuroplasticity, Ann Meyler, Timothy A. Keller, Vladimir L. Cherkassky, John D. E. Gabrieli, Marcel Adam Just

Marcel Adam Just

No abstract provided.


What Brain Imaging Can Tell Us About Embodied Meaning, Marcel Adam Just Dec 2007

What Brain Imaging Can Tell Us About Embodied Meaning, Marcel Adam Just

Marcel Adam Just

No abstract provided.


Theory Of Mind Disruption And Recruitment Of The Right Hemisphere During Narrative Comprehension In Autism, Robert A. Mason, Diane L. Williams, Rajesh K. Kana, Nancy J. Minshew, Marcel Adam Just Dec 2007

Theory Of Mind Disruption And Recruitment Of The Right Hemisphere During Narrative Comprehension In Autism, Robert A. Mason, Diane L. Williams, Rajesh K. Kana, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.


Predicting Human Brain Activity Associated With The Meanings Of Nouns, Tom M. Mitchell, Svetlana V. Shinkareva, Andrew Carlson, Kai-Min Chang, Vicente L. Malave, Robert A. Mason, Marcel Adam Just Dec 2007

Predicting Human Brain Activity Associated With The Meanings Of Nouns, Tom M. Mitchell, Svetlana V. Shinkareva, Andrew Carlson, Kai-Min Chang, Vicente L. Malave, Robert A. Mason, Marcel Adam Just

Marcel Adam Just

No abstract provided.