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Articles 1 - 30 of 152

Full-Text Articles in Developmental Neuroscience

Micrornas Are Necessary For Bmp-7-Induced Dendritic Growth In Cultured Rat Sympathetic Neurons, Vidya Chandrasekaran Sep 2019

Micrornas Are Necessary For Bmp-7-Induced Dendritic Growth In Cultured Rat Sympathetic Neurons, Vidya Chandrasekaran

Vidya Chandrasekaran

Neuronal connectivity is dependent on size and shape of the dendritic arbor. However, mechanisms controlling dendritic arborization, especially in the peripheral nervous system, are not completely understood. Previous studies have shown that bone morphogenetic proteins (BMPs) are important initiators of dendritic growth in peripheral neurons. In this study, we examined the hypothesis that post-transcriptional regulation mediated by microRNAs (miRNAs) is necessary for BMP-7-induced dendritic growth in these neurons. To examine the role of miRNAs in BMP-7-induced dendritic growth, microarray analyses was used to profile miRNA expression in cultured sympathetic neurons from the superior cervical ganglia of embryonic day 21 rat pups at 6 and 24 h after treatment with BMP-7 (50 ng/mL). Our data showed that BMP-7 significantly …

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Relationship Of Maternal And Infant Cortisol Matrices With Later Infant Behavior And Temperament, Anastasia Perris Jun 2019

Relationship Of Maternal And Infant Cortisol Matrices With Later Infant Behavior And Temperament, Anastasia Perris

Anastasia Perris

 Prenatal stress has been correlated with adverse developmental outcomes affecting infant cognition and behavior. Previous studies have shown that prenatal stress can lead to increased susceptibility to adult disease but few studies have looked at the physiological stress response system by measuring the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Cortisol, the output of the HPA axis can be secreted in many different matrices (saliva, blood, urine, feces and hair). Most studies that do, only look at one measure of hormone production instead of examining multiple matrices. Additionally these studies do not look at the relationship between matrices. Hair provides a …

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Are Different Actions Mediated By Distinct Systems Of Knowledge In Infancy?, Peter Vishton Oct 2018

Are Different Actions Mediated By Distinct Systems Of Knowledge In Infancy?, Peter Vishton

Peter Vishton

This chapter considers why studies of infant looking and reaching often suggest different patterns of cognitive and perceptual development. In some cases, convergent results have emerged from studies of infant looking and reaching, but differences are common. The most typical results suggest less adult-like perception and cognition in studies of reaching than in studies of looking. Several reaching studies, however, do not fit this pattern, suggesting that reaching actions may be mediated by distinct systems of knowledge and information processing. Comparisons of research on other behaviors, such as crawling and walking, also suggest that infant knowledge systems vary across actions. …

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Mapping Molecular Datasets Back To The Brain Regions They Are Extracted From: Remembering The Native Countries Of Hypothalamic Expatriates And Refugees, Arshad M. Khan, Alice H. Grant, Anais Martinez, Gully Apc Burns, Brendan S. Thatcher, Vishwanath T. Anekonda, Benjamin W. Thompson, Zachary S. Roberts, Daniel H. Moralejo, James E. Blevins Jun 2018

Mapping Molecular Datasets Back To The Brain Regions They Are Extracted From: Remembering The Native Countries Of Hypothalamic Expatriates And Refugees, Arshad M. Khan, Alice H. Grant, Anais Martinez, Gully Apc Burns, Brendan S. Thatcher, Vishwanath T. Anekonda, Benjamin W. Thompson, Zachary S. Roberts, Daniel H. Moralejo, James E. Blevins

Arshad M. Khan, Ph.D.

This article, which includes novel unpublished data along with commentary and analysis,
focuses on approaches to link transcriptomic, proteomic, and peptidomic datasets mined from
brain tissue to the original locations within the brain that they are derived from using digital atlas
mapping techniques. We use, as an example, the transcriptomic, proteomic and peptidomic
analyses conducted in the mammalian hypothalamus. Following a brief historical overview, we
highlight studies that have mined biochemical and molecular information from the hypothalamus
and then lay out a strategy for how these data can be linked spatially to the mapped locations in a
canonical brain atlas …

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Jennifer Maurer Phd Thesis.Pdf, Jennifer Maurer Nov 2017

Jennifer Maurer Phd Thesis.Pdf, Jennifer Maurer

Jennifer Maurer


Signaling cascades, such as the extracellular signal-regulated kinase (ERK) pathway, play vital roles in early vertebrate development. Signals through these pathways are initiated by a growth factor or hormone, are transduced through a kinase cascade, and result in the expression of specific downstream genes that promote cellular proliferation, growth, or differentiation.Tight regulation of these signals is provided by positive or negative modulators at varying levels in the pathway, and is required for proper development and function. Two members of the dual-specificity phosphatase (Dusp) family, dusp6 and dusp2, are believed to be negative regulators of the ERK pathway and are …

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Developmental Decline In Neuronal Regeneration By The Progressive Change Of Two Intrinsic Timers, Yan Zou, Hui Chiu, Anna Zinovyeva, Victor Ambros, Chiou-Fen Chuang, Chieh Chang Oct 2015

Developmental Decline In Neuronal Regeneration By The Progressive Change Of Two Intrinsic Timers, Yan Zou, Hui Chiu, Anna Zinovyeva, Victor Ambros, Chiou-Fen Chuang, Chieh Chang

Victor R. Ambros

Like mammalian neurons, Caenorhabditis elegans neurons lose axon regeneration ability as they age, but it is not known why. Here, we report that let-7 contributes to a developmental decline in anterior ventral microtubule (AVM) axon regeneration. In older AVM axons, let-7 inhibits regeneration by down-regulating LIN-41, an important AVM axon regeneration-promoting factor. Whereas let-7 inhibits lin-41 expression in older neurons through the lin-41 3' untranslated region, lin-41 inhibits let-7 expression in younger neurons through Argonaute ALG-1. This reciprocal inhibition ensures that axon regeneration is inhibited only in older neurons. These findings show that a let-7-lin-41 regulatory circuit, which was previously …

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Reward Enhances Tic Suppression In Children Within Months Of Tic Disorder Onset, Deanna J. Greene, Jonathan M. Koller, Amy Robichaux-Viehoever, Emily C. Bihun, Bradley L. Schlaggar, Kevin J. Black Jan 2015

Reward Enhances Tic Suppression In Children Within Months Of Tic Disorder Onset, Deanna J. Greene, Jonathan M. Koller, Amy Robichaux-Viehoever, Emily C. Bihun, Bradley L. Schlaggar, Kevin J. Black

Kevin J. Black, MD

Tic disorders are childhood onset neuropsychiatric disorders characterized by motor and/or vocal tics. Research has demonstrated that children with chronic tics (including Tourette syndrome and Chronic Tic Disorder: TS/CTD) can suppress tics, particularly when an immediate, contingent reward is given for successful tic suppression. As a diagnosis of TS/CTD requires tics to be present for at least one year, children in these tic suppression studies had been living with tics for quite some time. Thus, it is unclear whether the ability to inhibit tics is learned over time or present at tic onset. Resolving that issue would inform theories of …

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Effects Of Polychlorinated Biphenyl (Pcb) On Response Perseveration And Ultrasonic Vocalization Emission In Rat During Development, Howard Cromwell Dec 2013

Effects Of Polychlorinated Biphenyl (Pcb) On Response Perseveration And Ultrasonic Vocalization Emission In Rat During Development, Howard Cromwell

Howard Casey Cromwell

The 3 major symptoms of autistic spectrum disorders include 1) social behavioral alterations, 2) problems in communication and 3) higher-order motoric deficits of perseveration and stereotyped movements. Previous work has shown that early developmental exposure to polychlorinated biphenyls (PCBs) alters rat pup social motivation and juvenile rat social recognition/investigation. The present work extends this previous research by examining how perinatal PCB exposure alters motoric functions and communication abilities at different stages of development. Action perseveration was examined using performance measures from a T-maze environment. Communication abilities were evaluated by monitoring ultrasound emission in rat pups during a brief isolation from …

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Behavioral, Biochemical, And Molecular Indices Of Stress Are Enhanced In Female Versus Male Rats Experiencing Nicotine Withdrawal, Laura O'Dell Apr 2013

Behavioral, Biochemical, And Molecular Indices Of Stress Are Enhanced In Female Versus Male Rats Experiencing Nicotine Withdrawal, Laura O'Dell

Laura Elena O'Dell

Stress is a major factor that promotes tobacco use and relapse during withdrawal. Although women are more vulnerable to tobacco use than men, the manner in which stress contributes to tobacco use in women versus men is unclear.Thus, the goal of this study was to compare behavioral and biological indices of stress in male and female rats during nicotine withdrawal. Since the effects of nicotine withdrawal are age-dependent, this study also included adolescent rats. An initial study was conducted to provide comparable nicotine doses across age and sex during nicotine exposure and withdrawal. Rats received sham surgery or an osmotic …

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Pleiotropic And Isoform-Specific Functions For Pitx2 In Superior Colliculus And Hypothalamic Neuronal Development, Mindy Waite Dec 2012

Pleiotropic And Isoform-Specific Functions For Pitx2 In Superior Colliculus And Hypothalamic Neuronal Development, Mindy Waite

Mindy Waite

Transcriptional regulation of gene expression during development is critical for proper neuronal differentiation and migration. Alternative splicing and differential isoform expression have been demonstrated for most mammalian genes, but their specific contributions to gene function are not well understood. In mice, the transcription factor gene Pitx2 is expressed as three different isoforms (PITX2A, PITX2B, and PITX2C) which have unique amino termini and common DNA binding homeodomains and carboxyl termini. The specific roles of these isoforms in neuronal development are not known. Here we report the onset of Pitx2ab and Pitx2c isoform-specific expression by E9.5 in the developing mouse brain. Using …

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Retinal Ganglion Cell Differentiation And Transplantation, Jonathan Hertz Dec 2012

Retinal Ganglion Cell Differentiation And Transplantation, Jonathan Hertz

Jonathan Hertz

Adult central nervous system (CNS) neurons fail to regenerate following injury, and there is no repair or replacement of cells lost after injury or in neurodegenerative diseases. There is much interest in transplanting stem cell-derived neurons into the injured nervous system and enhancing the differentiation of donor cells into mature, integrated and functional neurons. Little is known, however, about what signals control the differentiation and integration of neurons, either during development or in the adult. Generating appropriate types of donor neurons from stem cells has been challenging because the signals that regulate neural subtype-specific fates are largely unknown. Therefore, it …

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Brain Function Differences In Language Processing In Children And Adults With Autism, Diane L. Williams, Vladimir L. Cherkassky, Robert A. Mason, Timothy A. Keller, Nancy J. Minshew, Marcel Adam Just Dec 2012

Brain Function Differences In Language Processing In Children And Adults With Autism, Diane L. Williams, Vladimir L. Cherkassky, Robert A. Mason, Timothy A. Keller, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.

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Brain Activity Of Normal And Low Iq Children: The Neural Efficiency Hypothesi, Fabio T. Rocha, Armando F. Rocha, Sueli Angeloti Dec 2012

Brain Activity Of Normal And Low Iq Children: The Neural Efficiency Hypothesi, Fabio T. Rocha, Armando F. Rocha, Sueli Angeloti

Armando F Rocha

The neural efficiency hypothesis (NEH) of intelligence claims that subjects performing a complex task may well use a limited number of brain circuits and/or fewer neurons while poor performers use more circuits and/or neurons, some of which are inessential or detrimental to task performance. The present paper studies the EEG activity associated with reading and arithmetic calculation by normal and mental retarded children. Correlation analysis of the electrical activity recorded by 10/20 electrode system was used to calculate the amount of information allocated by individuals to solve these tasks. Multiple regression analyses showed that IQ linearly correlates with the amount …

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Substituting The Senses, Mirko Farina, Julian Kiverstein, Andy Clark Dec 2012

Substituting The Senses, Mirko Farina, Julian Kiverstein, Andy Clark

Mirko Farina

Sensory substitution devices are a type of sensory prosthesis that (typically) convert visual stimuli transduced by a camera into tactile or auditory stimulation. They are designed to be used by people with impaired vision so that they can recover some of the functions normally subserved by vision. In this chapter we will consider what philosophers might learn about the nature of the senses from the neuroscience of sensory substitution. We will show how sensory substitution devices work by exploiting the cross-modal plasticity of sensory cortex: the ability of sensory cortex to pick up some types of information about the external …

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Effect Of Nicotine On Body Composition, Laura O'Dell May 2012

Effect Of Nicotine On Body Composition, Laura O'Dell

Laura Elena O'Dell

No abstract provided.

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The Evolved Apprentice. How Evolution Made Humans Unique, Mirko Farina Jan 2012

The Evolved Apprentice. How Evolution Made Humans Unique, Mirko Farina

Mirko Farina

No abstract provided.

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Perception, Action, And Consciousness: Sensorimotor Dynamics And Two Visual Systems, Mirko Farina Jan 2012

Perception, Action, And Consciousness: Sensorimotor Dynamics And Two Visual Systems, Mirko Farina

Mirko Farina

No abstract provided.

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Do Ssds Extend The Conscious Mind?, Mirko Farina, Julian Kiverstein Jan 2012

Do Ssds Extend The Conscious Mind?, Mirko Farina, Julian Kiverstein

Mirko Farina

Is the brain the biological substrate of consciousness? Most naturalistic philosophers of mind have supposed that the answer must obviously be «yes » to this question. However, a growing number of philosophers working in 4e (embodied, embedded, extended, enactive) cognitive science have begun to challenge this assumption, arguing instead that consciousness supervenes on the whole embodied animal in dynamic interaction with the environment. We call views that share this claim dynamic sensorimotor theories of consciousness (DSM). Clark (2009), a founder and leading proponent of the hypothesis of the extended mind, demurs, arguing that as matter of fact the biology of …

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Distinctive Neural Processes During Learning In Autism, Sarah Schipul, Diane Williams, Timothy Keller, Nancy Minshew, Marcel Just Dec 2011

Distinctive Neural Processes During Learning In Autism, Sarah Schipul, Diane Williams, Timothy Keller, Nancy Minshew, Marcel Just

Marcel Adam Just

No abstract provided.

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Brain Activation For Language Dual-Tasking: Listening To Two People Speak At The Same Time And A Change In Network Timing, Augusto Buchweitz, Timothy Keller, Ann Meyler, Marcel Just Dec 2011

Brain Activation For Language Dual-Tasking: Listening To Two People Speak At The Same Time And A Change In Network Timing, Augusto Buchweitz, Timothy Keller, Ann Meyler, Marcel Just

Marcel Adam Just

No abstract provided.

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Autism As A Neural Systems Disorder: A Theory Of Frontal-Posterior Underconnectivity, Marcel Just, Timothy Keller, Vicente Malave, Rajesh Kana, Sashank Varma Dec 2011

Autism As A Neural Systems Disorder: A Theory Of Frontal-Posterior Underconnectivity, Marcel Just, Timothy Keller, Vicente Malave, Rajesh Kana, Sashank Varma

Marcel Adam Just

No abstract provided.

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An Fmri Investigation Of Analogical Mapping In Metaphor Comprehension: The Influence Of Context And Individual Cognitive Capacities On Processing Demands., Chantel Prat, Robert Mason, Marcel Just Dec 2011

An Fmri Investigation Of Analogical Mapping In Metaphor Comprehension: The Influence Of Context And Individual Cognitive Capacities On Processing Demands., Chantel Prat, Robert Mason, Marcel Just

Marcel Adam Just

No abstract provided.

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A Novel Taulacz Allele Reveals A Requirement For Pitx2 In Formation Of The Mammillothalamic Tract, Mindy Waite Dec 2011

A Novel Taulacz Allele Reveals A Requirement For Pitx2 In Formation Of The Mammillothalamic Tract, Mindy Waite

Mindy Waite

The hypothalamic mammillary region is critical for spatial memory and vestibular processing. Pitx2 encodes a paired-like transcription factor that is highly expressed in the developing mammillary region and is required for subthalamic nucleus formation. Here we analyzed a loss of function Pitx2-TaulacZ knock-in allele to study the effects of Pitx2 deficiency on neuronal projections in the embryonic mammillary region. Pitx2-expressing neurons contribute axons to principal mammillary, mammillotegmental and mammillotectal tracts. Embryos with Pitx2 deficiency exhibit axonal fibers in the principal mammillary tract that are improperly bundled and disorganized, yet project caudally toward the tectum and tegmentum. Embryos …

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Distinct Populations Of Gabaergic Neurons In Mouse Rhombomere 1 Express But Do Not Require The Homeodomain Transcription Factor Pitx2, Mindy Waite Dec 2011

Distinct Populations Of Gabaergic Neurons In Mouse Rhombomere 1 Express But Do Not Require The Homeodomain Transcription Factor Pitx2, Mindy Waite

Mindy Waite

Hindbrain rhombomere 1 (r1) is located caudal to the isthmus, a critical organizer region, and rostral to rhombomere 2 in the developing mouse brain. Dorsal r1 gives rise to the cerebellum, locus coeruleus, and several brainstem nuclei, whereas cells from ventral r1 contribute to the trochlear and trigeminal nuclei as well as serotonergic and GABAergic neurons of the dorsal raphe. Recent studies have identified several molecular events controlling dorsal r1 development. In contrast, very little is known about ventral r1 gene expression and the genetic mechanisms regulating its formation. Neurons with distinct neurotransmitter phenotypes have been identified in ventral r1 …

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Exploring Commonalities Across Participants In The Neural Representation Of Objects, Svetlana V. Shinkareva, Vicente L. Malave, Marcel Adam Just, Tom M. Mitchell Dec 2011

Exploring Commonalities Across Participants In The Neural Representation Of Objects, Svetlana V. Shinkareva, Vicente L. Malave, Marcel Adam Just, Tom M. Mitchell

Marcel Adam Just

No abstract provided.

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Identifying Bilingual Semantic Neural Representations Across Languages, Augusto Buchweitz, Svetlana V. Shinkareva, Robert A. Mason, Tom M. Mitchell, Marcel Adam Just Dec 2011

Identifying Bilingual Semantic Neural Representations Across Languages, Augusto Buchweitz, Svetlana V. Shinkareva, Robert A. Mason, Tom M. Mitchell, Marcel Adam Just

Marcel Adam Just

No abstract provided.

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Embraining Culture: Leaky Minds And Spongy Brains, Julian Kiverstein, Mirko Farina May 2011

Embraining Culture: Leaky Minds And Spongy Brains, Julian Kiverstein, Mirko Farina

Mirko Farina

We offer an argument for the extended mind based on considerations from brain development. We argue that our brains develop to function in partnership with cognitive resources located in our external environments. Through our cultural upbringing we are trained to use artefacts in problem solving that become factored into the cognitive routines our brains support. Our brains literally grow to work in close partnership with resources we regularly and reliably interact with. We take this argument to be in line with complementarity or “second-wave” defences of the extended mind that stress the functional differences between biological elements and external, environmental …

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Gabaergic And Glutamatergic Identities Of Developing Midbrain Pitx2 Neurons, Mindy Waite Jan 2011

Gabaergic And Glutamatergic Identities Of Developing Midbrain Pitx2 Neurons, Mindy Waite

Mindy Waite

Pitx2, a paired-like homeodomain transcription factor, is expressed in post-mitotic neurons within highly restricted domains of the embryonic mouse brain. Previous reports identified critical roles for PITX2 in histogenesis of the hypothalamus and midbrain, but the cellular identities of PITX2-positive neurons in these regions were not fully explored. This study characterizes Pitx2 expression with respect to midbrain transcription factor and neurotransmitter phenotypes in mid-to-late mouse gestation. In the dorsal midbrain, we identified Pitx2-positive neurons in the stratum griseum intermedium (SGI) as GABAergic and observed a requirement for PITX2 in GABAergic differentiation. We also identified two Pitx2-positive neuronal populations in the …

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Cognitive Systems And The Extended Mind, Mirko Farina Jan 2011

Cognitive Systems And The Extended Mind, Mirko Farina

Mirko Farina

No abstract provided.

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Differentiable Cortical Networks For Inferences Concerning People’S Intentions Versus Physical Causality, Robert Mason, Marcel Just Dec 2010

Differentiable Cortical Networks For Inferences Concerning People’S Intentions Versus Physical Causality, Robert Mason, Marcel Just

Marcel Adam Just

No abstract provided.

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