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Full-Text Articles in Developmental Neuroscience
Astroglial Boundary Formation And Epha4 Signaling In Neuroblast Migration, Nicholas B. Gallo
Astroglial Boundary Formation And Epha4 Signaling In Neuroblast Migration, Nicholas B. Gallo
University Scholar Projects
Adult neurogenesis, the process of generating new neurons from neural precursors, is a highly complex process that is limited to two specific areas of the brain, the dentate gyrus of the hippocampus and the subventricular zone (SVZ). Despite continued research investigating neurogenesis in these two regions, we still lack a fundamental understanding of the molecular mechanisms of neural cell division, migration, differentiation, and integration in the postnatal brain. In particular, the rostral migratory stream (RMS), which is a cellular migratory route for newly generated neuronal precursors that travel from the SVZ to the olfactory bulb, will provide a useful model …
Characterization Of The Ependymal Barrier Due To Human Aging And Injury In Murine Models, Ye Sun
Characterization Of The Ependymal Barrier Due To Human Aging And Injury In Murine Models, Ye Sun
University Scholar Projects
Ventriclulomegaly, or the expansion of the ventricles in the brain, is a phenomenon associated with age and injury to the brain. The ependymal layer that encases the ventricles displays certain degrees of plasticity and regenerative ability due to its associated stem cell niche, the subventricular zone (SVZ). Previous research in the Conover Lab has shown that in the mouse, which maintains an actively proliferating SVZ into adulthood, there is an intact ependymal monolayer throughout normal aging, with maintained lateral ventricle size with some degree of stretching. In contrast, the human SVZ declines in proliferative capacity after infancy, and age-related changes …