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Articles 1 - 8 of 8
Full-Text Articles in Developmental Neuroscience
Astroglial Boundary Formation And Epha4 Signaling In Neuroblast Migration, Nicholas B. Gallo
Astroglial Boundary Formation And Epha4 Signaling In Neuroblast Migration, Nicholas B. Gallo
University Scholar Projects
Adult neurogenesis, the process of generating new neurons from neural precursors, is a highly complex process that is limited to two specific areas of the brain, the dentate gyrus of the hippocampus and the subventricular zone (SVZ). Despite continued research investigating neurogenesis in these two regions, we still lack a fundamental understanding of the molecular mechanisms of neural cell division, migration, differentiation, and integration in the postnatal brain. In particular, the rostral migratory stream (RMS), which is a cellular migratory route for newly generated neuronal precursors that travel from the SVZ to the olfactory bulb, will provide a useful model …
Astroglial Boundary Formation And Epha4 Signaling In Neuroblast Migration, Nicholas B. Gallo
Astroglial Boundary Formation And Epha4 Signaling In Neuroblast Migration, Nicholas B. Gallo
Honors Scholar Theses
Adult neurogenesis, the process of generating new neurons from neural precursors, is a highly complex process that is limited to two specific areas of the brain, the dentate gyrus of the hippocampus and the subventricular zone (SVZ). Despite continued research investigating neurogenesis in these two regions, we still lack a fundamental understanding of the molecular mechanisms of neural cell division, migration, differentiation, and integration in the postnatal brain. In particular, the rostral migratory stream (RMS), which is a cellular migratory route for newly generated neuronal precursors that travel from the SVZ to the olfactory bulb, will provide a useful model …
Characterization Of The Ependymal Barrier Due To Human Aging And Injury In Murine Models, Ye Sun
Characterization Of The Ependymal Barrier Due To Human Aging And Injury In Murine Models, Ye Sun
University Scholar Projects
Ventriclulomegaly, or the expansion of the ventricles in the brain, is a phenomenon associated with age and injury to the brain. The ependymal layer that encases the ventricles displays certain degrees of plasticity and regenerative ability due to its associated stem cell niche, the subventricular zone (SVZ). Previous research in the Conover Lab has shown that in the mouse, which maintains an actively proliferating SVZ into adulthood, there is an intact ependymal monolayer throughout normal aging, with maintained lateral ventricle size with some degree of stretching. In contrast, the human SVZ declines in proliferative capacity after infancy, and age-related changes …
Fiber Pathways For Language In The Developing Brain: A Diffusion Tensor Imaging (Dti) Study, Iris J. Broce
Fiber Pathways For Language In The Developing Brain: A Diffusion Tensor Imaging (Dti) Study, Iris J. Broce
FIU Electronic Theses and Dissertations
The present study characterized two fiber pathways important for language, the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) and the frontal aslant tract (FAT), and related these tracts to speech, language, and literacy skill in children five to eight years old. We used Diffusion Tensor Imaging (DTI) to characterize the fiber pathways and administered several language assessments. The FAT was identified for the first time in children. Results showed no age-related change in integrity of the FAT, but did show age-related change in the left (but not right) SLF/AF. Moreover, only the integrity of the right FAT was related to phonology but …
The Mammalian Neocortex New Pyramidal Neuron: A New Conception, Miguel Marín-Padilla
The Mammalian Neocortex New Pyramidal Neuron: A New Conception, Miguel Marín-Padilla
Dartmouth Scholarship
The new cerebral cortex (neocortex) and the new type of pyramidal neuron are mammalian innovations that have evolved for operating their increasing motor capabilities while essentially using analogous anatomical and neural makeups. The human neocortex starts to develop in 6-week-old embryos with the establishment of a primordial cortical organization, which resembles the primitive cortices of amphibian and reptiles. From the 8th to the 15th week of age, new pyramidal neurons, of ependymal origin, are progressively incorporated within this primordial cortex forming a cellular plate that divides its components into those above it (neocortex first layer) and those below it (neocortex …
Nel Positively Regulates The Genesis Of Retinal Ganglion Cells By Promoting Their Differentiation And Survival During Development, Chizu Nakamoto, Soh-Leh Kuan, Amy Findlay, Elaine Durward, Zhufeng Ouyang, Masaru Nakamoto, Ewa Zakrewska, Takuma Endo
Nel Positively Regulates The Genesis Of Retinal Ganglion Cells By Promoting Their Differentiation And Survival During Development, Chizu Nakamoto, Soh-Leh Kuan, Amy Findlay, Elaine Durward, Zhufeng Ouyang, Masaru Nakamoto, Ewa Zakrewska, Takuma Endo
Biology Faculty Publications
For correct functioning of the nervous system, the appropriate number and complement of neuronal cell types must be produced during development. However, the molecular mechanisms that regulate the production of individual classes of neurons are poorly understood. In this study, we investigate the function of the thrombospondin-1–like glycoprotein, Nel (neural epidermal growth factor [EGF]-like), in the generation of retinal ganglion cells (RGCs) in chicks. During eye development, Nel is strongly expressed in the presumptive retinal pigment epithelium and RGCs. Nel overexpression in the developing retina by in ovo electroporation increases the number of RGCs, whereas the number of displaced amacrine …
Effects Of Early Experience And Plasticity On Neuronal Morphology Within The Prefrontal Cortex In A Rodent Model Of Hypoxia-Ischemia, Zarah M. Melendez
Effects Of Early Experience And Plasticity On Neuronal Morphology Within The Prefrontal Cortex In A Rodent Model Of Hypoxia-Ischemia, Zarah M. Melendez
Honors Projects
Hypoxia-ischemia (HI) is low oxygenation to the brain paired with low blood supply that can disrupt normal patterns of brain development. HI injury is characterized by many long-term cognitive and behavioral deficits including working memory. Neuronal plasticity due to early sensory or learning experience has been suggested to facilitate recovery of function after neonatal brain injury. Plasticity is the ability for the nervous system, more specifically neurons, and their synapses to modify their function and morphology due to experiences, which in turn correlate with changes in behavior. The objective of the present study was to investigate the effects of neonatal …
The Benefits Of Breastfeeding, Avery Kordus
The Benefits Of Breastfeeding, Avery Kordus
Senior Honors Theses
Breastfeeding research is plentiful, and the majority of the literature shows that breast milk is the superior form of infant nutrition except in the rare circumstances of infant metabolic disorders, maternal drug use, or positive HIV status. In comparison to formula, breast milk provides improved cognition, development, behavior, bonding, nutrition, digestion, immunity, and long-term health with fewer diseases and conditions in infants. Mothers are benefited by breastfeeding through bonding, faster weight loss, and reduction in certain cancers and conditions. Breast milk contains the proper amount of carbohydrates, fats, proteins, vitamins, and minerals, and is also specialized for each infant and …