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Articles 1 - 3 of 3
Full-Text Articles in Behavioral Neurobiology
The Ush2a Gene: An Analysis Of Ultrasonic Vocalizations In A Mouse Model Of Usher Syndrome Type 2, Kiana R. Akhundzadeh
The Ush2a Gene: An Analysis Of Ultrasonic Vocalizations In A Mouse Model Of Usher Syndrome Type 2, Kiana R. Akhundzadeh
Honors Scholar Theses
Usher syndrome type 2 is a complex autosomal recessive genetic disorder that is characterized by moderate to severe congenital sensorineural hearing loss, the onset of retinitis pigmentosa in the second decade of life, and in some cases, vestibular dysfunction. Mutations in the USH2A gene account for 85% of cases of type 2. The USH2A gene is responsible for encoding the protein usherin, which has an important role in the development and function of inner ear hair cells and retinal photoreceptors. Until recently, it has been believed that carriers of the USH2A mutation were phenotype free. However, recent data has suggested …
A Touchscreen Assay To Probe The Role Of The Serotonergic System In Learning And Visual Information Processing, Jeffrey M. Dorsch, Alexandr Pak, Alexander A. Chubykin
A Touchscreen Assay To Probe The Role Of The Serotonergic System In Learning And Visual Information Processing, Jeffrey M. Dorsch, Alexandr Pak, Alexander A. Chubykin
The Summer Undergraduate Research Fellowship (SURF) Symposium
The neurotransmitter serotonin is involved in numerous processes in the brain such as behavior, learning, memory, mood, and neurodevelopment. Serotonin signaling is regulated by the serotonin transporter protein (SERT), which maintains normal serotonin levels. Mutations in the SERT gene are known to correlate with cognitive and behavioral deficits seen in psychiatric disorders, such as anxiety disorders, depression, and autism spectrum disorder. Researchers study these deficits using SERT knockout (KO) mice, a model that lacks functional SERT and displays changes in anxiety, learning, and motivation. We are interested in how the absence of SERT affects visual processing and learning. A popular …
Sleep Alterations In Mouse Genetic Models Of Human Disease, Mansi Sethi
Sleep Alterations In Mouse Genetic Models Of Human Disease, Mansi Sethi
Theses and Dissertations--Biology
Sleep is a process essential for the well-being of an animal and in humans as much as one-third of our life is spent in sleep. Yet, the biological need for sleep still remains a conundrum. Our knowledge of the genes influencing sleep and the mechanisms regulating the process can be advanced with the utilization of genetic and genomic approaches which, in turn, may inform us about the functions of sleep as well. With this goal, I have investigated and examined sleep-wake phenotypes for a variety of transgenic and knock out animals.
For the first part of my research (Chapter 3), …