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Articles 1 - 7 of 7
Full-Text Articles in Behavioral Neurobiology
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Electronic Thesis and Dissertation Repository
Nicotine dependence is causally linked to increased risk of mood/anxiety disorders in later life. Females are reported to experience a higher prevalence of anxiety/depressive disorders and challenges in smoking cessation therapies, suggesting a potential sex-specific response to nicotine exposure and mood/anxiety disorder risk. However, pre-clinical evidence of sex-specific responses to adolescent nicotine exposure is unclear. Thus, to determine any sex differences in anxiety/depressive-related outcomes, adolescent male and female Sprague Dawley rats received nicotine (0.4 mg/kg; 3x daily) or saline injections for 10 consecutive days, followed by behavioural testing, in-vivo electrophysiology and Western Blot analyses. Our results revealed that adolescent nicotine …
Estrogen Modulation Of Vta Dopamine Neuron Physiology And Behavioral Responsivity To Variable Social Stressors, Mary R. Shanley
Estrogen Modulation Of Vta Dopamine Neuron Physiology And Behavioral Responsivity To Variable Social Stressors, Mary R. Shanley
Dissertations, Theses, and Capstone Projects
The behavioral output of different animals, or even the same animal in different contexts, is remarkably variable in response to the same external stimulus. This behavioral diversity is due to the complex integration of external and internal stimuli, through both neuronal and hormonal signals that selects the best behavioral response. By their nature as long-distance signaling molecules, hormones play a critical role in communicating information about internal states across the organism. Many hormones produced in the periphery target the central nervous system to modulate animal behavior, selecting for behaviors that are appropriate over behaviors that are maladaptive in that specific …
Estrogen Disruption Of Hypothalamic Neural Activity, Princess Dickson
Estrogen Disruption Of Hypothalamic Neural Activity, Princess Dickson
Cal Poly Humboldt theses and projects
The brain is highly dependent on the endocrine system for proper neurodevelopment, as it plays a key role in many biological processes. Bisphenol A is a chemical found in plastics that has the potential to mimic the effects of Estrogen in the body, at least weakly. People interact with plastic that contains BPA regularly, and people are at risk for exposure even before being born. The abundance of BPA, along with other exogenous estrogens, makes examining the relationship between early exposure and changes in brain activity imperative. The current study aims to establish a relationship between disrupted estrogen function and …
Test Of Bpa's Estrogenic Effects On Brain Aromatase Expression, Neural Activity, And Locomotive Behavior In Zebrafish Larvae, Ryan J. Mcauley
Test Of Bpa's Estrogenic Effects On Brain Aromatase Expression, Neural Activity, And Locomotive Behavior In Zebrafish Larvae, Ryan J. Mcauley
Cal Poly Humboldt theses and projects
Bisphenol A (BPA) is a well-known endocrine disrupting chemical that mimics the effects of estrogens. Aromatase B (Cyp19a1b) is a brain-specific enzyme that converts testosterone to estrogen and is highly upregulated in response to estrogen receptor activation localized to radial glial cells. During embryonic zebrafish development, there is a small window of time denoted by an increase in neurogenesis and estrogen receptor activity. Previous studies have demonstrated that a low dose BPA exposure (0.1µM) during this window causes hyperlocomotion in larval zebrafish, yet no further explanation for this behavior change has been described. The purpose of this study was to …
The Cellular Context Of Estradiol Regulation In The Zebra Finch Auditory Forebrain, Maaya Ikeda
The Cellular Context Of Estradiol Regulation In The Zebra Finch Auditory Forebrain, Maaya Ikeda
Doctoral Dissertations
Estradiol, traditionally known as a hormone that communicates with distant cells in the body, is also synthesized locally in the brain to act as a neuromodulator. Neuromodulators differ from neurotransmitters in that they simultaneously affect a population of neurons and their actions are not limited to the synapse. One of the many effects of estradiol signaling is rapid modulation of auditory processing in response to external stimuli. The enzyme required for estradiol synthesis, aromatase, is highly expressed in the regions that are involved in higher-order processing of sounds in humans and songbirds. Since zebra finches, a type of songbird, are …
Increased Body Weight In Adulthood Following A Peripubertal Stressor And Proposed Mechanism For Effects Of Increased Adiposity On Estrogen-Dependent Behaviors, Christina F. Gagliardi
Increased Body Weight In Adulthood Following A Peripubertal Stressor And Proposed Mechanism For Effects Of Increased Adiposity On Estrogen-Dependent Behaviors, Christina F. Gagliardi
Masters Theses
Exposure to certain stressors during a sensitive period around puberty can lead to enduring effects on an animal’s response to estradiol. In estradiol-influenced behaviors, such as sexual receptivity, hippocampal-dependent learning and memory, depression-like behavior, and anxiety-like behaviors, exposure to a peripubertal stressor such as shipping stress or an injection of lipopolysaccharide (LPS) can eliminate or even reverse the normal response to estradiol. In addition to regulating these behaviors, estradiol play a role in the regulation of body weight. While some of the previous studies touched on short-term effects on body weight, no systemic long-term study of the effects of a …
Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, Howard Cromwell
Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, Howard Cromwell
Howard Casey Cromwell
Abstract. Perinatal exposure to PCB has been reported to cause a variety of health effects including endocrine disruption, and immunologic, reproductive, neurologic, and behavioral deficits. In the present study, a mixture of two PCB congeners, one non-coplanar (PCB 47) and one coplanar (PCB 77), were administered to young female Sprague-Dawley rats by route of maternal dietary consumption (either 12.5 ppm or 25.0 ppm, w/w). Impact on learning and memory were examined by radial arm maze on postnatal day 24-27. After behavioral tests were completed, the rats were transcardially perfused, and brains were excised. Immunohistochemistry for ER- β was carried out …