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Articles 1 - 8 of 8
Full-Text Articles in Behavioral Neurobiology
Active Encoding Of Space Through Time, Michele Rucci, Jonathan D. Victor
Active Encoding Of Space Through Time, Michele Rucci, Jonathan D. Victor
MODVIS Workshop
No abstract provided.
Impact Of Adolescent Social Isolation On Adult, Binge-Like Ethanol Consumption And Plasma Corticosterone In High-Alcohol-Preferring Mice, Eva Cullins
The Journal of Purdue Undergraduate Research
Adolescent stress exposure increases the likelihood of alcohol misuse and alcohol use disorder (AUD) in adulthood; however, it is not clear how genetic and environmental factors interact to increase risk. This study examined how adolescent social isolation affects adult binge-like ethanol drinking and levels of the stress hormone corticosterone in male and female mice with a genetic predisposition toward high alcohol preference (HAP). Twenty-eight HAP mice were separated into group-housed (GH) and socially isolated (SI) conditions (n = 13, 13). Binge drinking was assessed using a drinking in the dark (DID) procedure. Blood samples were taken before DID and after …
The Effects Of Adolescent Chronic Mild Stress: In Female Wistar-Kyoto Rats, Anna Hallowell
The Effects Of Adolescent Chronic Mild Stress: In Female Wistar-Kyoto Rats, Anna Hallowell
The Journal of Purdue Undergraduate Research
Despite years of research to understand under-lying mechanisms and develop more effective treatment approaches for mood disorders, numerous challenges exist. Many chronic stress models are used to study mood disorders, how-ever the majority have been established with adult males. This is problematic considering that affective disorders are more common in women, and generally develop during late adolescence. Studies have indicated fundamental behavioral, physiological, and neural differences between males and females in response to the same external stressors, furthering a need to develop sex-specific paradigms to accurately model the etiology of mood disorders in females. The Wistar-Kyoto (WKY) rat strain is …
A Touchscreen Assay To Probe The Role Of The Serotonergic System In Learning And Visual Information Processing, Jeffrey M. Dorsch, Alexandr Pak, Alexander A. Chubykin
A Touchscreen Assay To Probe The Role Of The Serotonergic System In Learning And Visual Information Processing, Jeffrey M. Dorsch, Alexandr Pak, Alexander A. Chubykin
The Summer Undergraduate Research Fellowship (SURF) Symposium
The neurotransmitter serotonin is involved in numerous processes in the brain such as behavior, learning, memory, mood, and neurodevelopment. Serotonin signaling is regulated by the serotonin transporter protein (SERT), which maintains normal serotonin levels. Mutations in the SERT gene are known to correlate with cognitive and behavioral deficits seen in psychiatric disorders, such as anxiety disorders, depression, and autism spectrum disorder. Researchers study these deficits using SERT knockout (KO) mice, a model that lacks functional SERT and displays changes in anxiety, learning, and motivation. We are interested in how the absence of SERT affects visual processing and learning. A popular …
Central And Peripheral Difference In Perceptual Bias In Ambiguous Perception Using Dichoptic Stimuli --- Implications For The Analysis-By-Synthesis Process In Visual Recognition, Li Zhaoping Prof
MODVIS Workshop
No abstract provided.
Comparing Diverse V1 Models On The Same Platform: Virtual V1sion, Cheryl Olman
Comparing Diverse V1 Models On The Same Platform: Virtual V1sion, Cheryl Olman
MODVIS Workshop
No abstract provided.
Behavioral Outputs Of Fragile-X Autistic Mice Exposed To Open-Field, Randomized, Short-Term Visual Stimuli, Nicholas M. Dicola, Alexander A. Chubykin
Behavioral Outputs Of Fragile-X Autistic Mice Exposed To Open-Field, Randomized, Short-Term Visual Stimuli, Nicholas M. Dicola, Alexander A. Chubykin
The Summer Undergraduate Research Fellowship (SURF) Symposium
Animal models of different neurological disorders are required for studying the pathophysiology of these diseases, and for potential development of pharmacological and behavioral treatments. The scientific community often uses mouse models for behavior studies due to their powerful genetic tools and low cost. However, subjective measurement techniques are often used when analyzing mice for behavioral traits which often results in discrepancies in results. An automated tracking software would aim to eliminate these discrepancies and subjective analysis. This lab has developed a software program which offered an ability to automatically collect open-field behavioral data with simultaneous on-line analysis. Python, an open …
Elucidation Of Pharmacologically Manipulated Responding In The Delay Discounting Task In High Alcohol Preferring Mice, Meredith Halcomb
Elucidation Of Pharmacologically Manipulated Responding In The Delay Discounting Task In High Alcohol Preferring Mice, Meredith Halcomb
Open Access Dissertations
Impulsive behavior is the hallmark of many psychopathologies. Uncovering the neurobiological mechanisms driving impulsivity is paramount in the development of through the delay discounting (DD) task in both human and animal models. The present study is an examination of the predictive validity of the two primary types of DD procedures in animals, the Adjusting Amounts (AA) and within session Increasing Delays (ID) tasks. Methods:Subjects were administered either1.25 mg/kg d-amphetamine (AMP), 1.5 g/kg ethanol (EtOH) or saline and tested in either the AA or ID method for 15 days to evaluate drug effects on impulsive behavior. Results: Stimulant administration resulted …