Neuroscience and Neurobiology Commons^™

Destined Failure, Chengjun Pan

Masters Theses

I attempt to examine the complex structure of human communication, explaining why it is bound to fail. By reproducing experienceable phenomena, I demonstrate how they can expose communication structure and reveal the limitations of our perception and symbolization.I divide the process of communication into six stages: input, detection, symbolization, dictionary, interpretation, and output. In this thesis, I examine the flaws and challenges that arise in the first five stages. I argue that reception acts as a filter and that understanding relies on a symbolic system that is full of redundancies. Therefore, every interpretation is destined to be a deviation.

Analysis Of Electrophysiological Markers And Correlated Components Of Neural Responses To Discourse Coherence, Kurt M. Masiello

Dissertations, Theses, and Capstone Projects

Constructing meaning from spoken language is invaluable for learning, social interaction, and communication. In clinical populations with developmental disorders of speech comprehension, the severity of disruption can persist and vary from limiting occupational opportunities to lower performance outcomes. Previous research has reported an event-related potential (ERP) neural positivity over right hemisphere lateral anterior sites in response to semantic and discourse processing. Although useful as a marker for clinical populations of autism spectrum disorder (ASD) and developmental language disorder (DLD), little is understood about the dynamics and neural sources of this biological marker. In addition to traditional methods of ERP analysis, …

Multilingualism And Memory: Investigating Possible Differences In The Abilities Of Monolingual And Multilingual College Students, Clara E. Barned

Honors Projects

This study investigated whether there is a difference in the memories of monolingual and multilingual undergraduate students using simple memorization tasks. There were 46 participants, 30 of which were monolingual (only knew one language) and 16 of which were multilingual (knew two or more languages). There was found to be no significant difference between the performance of the two groups, with the data generating a p-value of 0.557. This study further suggests related avenues of research and ways in which the study could be improved in the future.

Translation Al Mercato Del Pesce: The Importance Of Human Input For Machine Translation, Emma Y. Schechter , '23

Senior Theses, Projects, and Awards

This thesis investigates translation of Italian idioms and metaphors into English, and the difficulties encountered by Machine Translation in this process. I use a framework of foreign concepts to explain many of the difficulties, as well as interviews with native Italian and English speakers to provide further context for the cultural knowledge encoded in figurative language. I conclude that in Machine Translation a consistent human input interface as well as a continuous training in language corpora is crucial to improve the accuracy of translated metaphors and idioms, using Italian to English translation as a case study.

The Biological Influence Of Stories & The Importance Of Reading Fiction, Elise N. Good, Katharine Schaab

The Kennesaw Journal of Undergraduate Research

Fictional narratives and stories have persisted throughout human history. However, perhaps due to a bias that stories offered nothing more than entertainment for the reader or perhaps that they are not useful outside of the realm of academia, the research within science academia has been lacking in literature on why these narratives have endured. Unfortunately, due to the lack of conversation across disciplines, particularly those of science and literature, this subject has not been thoroughly investigated through an interdisciplinary lens. Within this paper, the goal is to analyze the benefits of fictional narratives through biological, evolutionary, and neuropsychological perspectives. Research …

The Role Of Word Knowledge In Error Detection: A Challenge To The Broken-Error-Monitor Account Of Dyslexia, Lindsay N. Harris, Benjamin Creed, Charles A. Perfetti, Benjamin Rickles

Faculty Peer-Reviewed Publications

Dyslexic children often fail to correct errors while reading aloud, and dyslexic adolescents and adults exhibit lower amplitudes of the error-related negativity (ERN)—the neural response to errors—than typical readers during silent reading. Past researchers therefore suggested that dyslexia may arise from a faulty error-detection mechanism that interferes with orthographic learning and text comprehension. An alternative possibility is that comprehension difficulty in dyslexics is primarily a downstream effect of low-quality lexical representations—that is, poor word knowledge. On this view the attenuated ERN in dyslexics is a byproduct, rather than a source, of underdeveloped orthographic knowledge. Because the second view implies a …

The Electrophysiological Correlates Of Text Integration And Direct Vs. Indirect Articles: A Centralized And Lateralized Examination, Deanna C. Hall

Theses and Dissertations (Comprehensive)

As we read, we develop mental models of the discourse content called situation models. Situation models are integral to how we keep track of information, and to do so in an ongoing event incoming information needs to be integrated into the model or discarded. The type of information being presented, and its relation to prior data, impacts how that new information is processed. The current research examined discourse passages containing concepts that were either previously mentioned (match), mentioned with a general term (general category), unmentioned in lieu of another concept (mismatch), or completely unmentioned previously (indeterminate), and examined how these …

Linguistic Variation From Cognitive Variability: The Case Of English 'Have', Muye Zhang

Linguistics Graduate Dissertations

In this dissertation, I seek to construct a model of meaning variation built upon variability in linguistic structure, conceptual structure, and cognitive makeup, and in doing so, exemplify an approach to studying meaning that is both linguistically principled and neuropsychologically grounded. As my test case, I make use of the English lexical item ‘have' by proposing a novel analysis of its meaning based on its well-described variability in English and its embed- ding into crosslinguistically consistent patterns of variation and change.

I support this analysis by investigating its real-time comprehension patterns through behavioral, electropsychophysiological, and hemodynamic brain data, thereby incorporating …

Monolingual And Bilingual Language Networks In Healthy Subjects Using Functional Mri And Graph Theory, Qiongge Li, Luca Pasquini, Gino Del Ferraro, Madeleine Gene, Kyung K. Peck, Hernán A. Makse, Andrei I. Holodny

Publications and Research

Bilingualism requires control of multiple language systems, and may lead to architectural differences in language networks obtained from clinical fMRI tasks. Emerging connectivity metrics such as k-core may capture these differences, highlighting crucial network components based on resiliency. We investigated the influence of bilingualism on clinical fMRI language tasks and characterized bilingual networks using connectivity metrics to provide a patient care benchmark. Sixteen right-handed subjects (mean age 42-years; nine males) without neurological history were included: eight native English-speaking monolinguals and eight native Spanish-speaking (L1) bilinguals with acquired English (L2). All subjects underwent fMRI with gold-standard clinical language tasks. Starting from …

Systematic Review Of Race/Ethnicity In Parkinson's Disease, Amia Fisher

Honors Theses

The goal of this study was to examine race/ethnicity with an emphasis on African Ancestry in Parkinson’s Disease (PD) through a systematic review. Out of 448 scholarly articles that were originally extracted from the search, 445 were excluded due to their irrelevance regarding race/ethnicity and African ancestry in PD. Three scholarly articles were obtained through a PubMed/MEDLINE search for the review. Amongst the three sources that were chosen, there were more than 450,000 participants with PD that ranged in ages 40-65+; each case of PD within these studies were reported from 1993-2005. The varying races/ethnicities of White/non-Hispanic White, Black/African American, …

The Inevitability Of Collision: Creating Empathy Through Fiction, Danielle Beckman

Regis University Student Publications (comprehensive collection)

While the stigma for mental illnesses has greatly declined in the last decade, there is still a disconnect between individuals without neurological illnesses and those with neurological illnesses, especially those that cause individuals to lose contact with reality. The goal of this interdisciplinary paper is to create empathy for these individuals, specifically people with schizophrenia, Alzheimer disease, and post-traumatic amnesia. Through a collection of four stories told from the perspective of these unreliable narrators, I used fiction writing techniques from the field of cognitive literary studies such as gapping and defamiliarization to create more empathy in the reader. In reading …

Marrying Science And Experience: An Exploration Of How Multilinguals Interact With And Between Languages And Cultures, Allie Heeg Polzin

MA TESOL Collection

This paper will begin exploring bi- and multilingualism at an individual level. The author will explore previous research written on how the brain processes several languages, how languages might affect individuals emotionally, and how one switches between languages as well as the effects of this, if any. Beyond this, the experience of navigating languages between discourse communities and balancing two or more cultures will be considered. As the title suggests, the science of multilingualism will be married with the diverse individual experience while considering both intrapersonal and interpersonal relations. The author will look at her own experience as well as …

Neural Indices Of Vowel Discrimination In Monolingual And Bilingual Infants And Children, Yan H. Yu, Carol Tessel, Henry Han, Luca Campanelli, Nancy Vidal, Jennifer Gerometta, Karen Garrido-Nag, Hia Datta, Valerie L. Shafer

Publications and Research

Objectives: To examine maturation of neural discriminative responses to an English vowel contrast from infancy to 4 years of age and to determine how biological factors (age and sex) and an experiential factor (amount of Spanish versus English input) modulate neural discrimination of speech.

Design: Event-related potential (ERP) mismatch responses (MMRs) were used as indices of discrimination of the American English vowels [ε] versus [I] in infants and children between 3 months and 47 months of age. A total of 168 longitudinal and cross-sectional data sets were collected from 98 children (Bilingual Spanish–English: 47 male and 31 female …

Examining Delayed Onset Of Dementia In The Bilingual Geriatric Population, Erica Brown, Elizabeth Hartman

Grace Peterson Nursing Research Colloquium

Background: Dementia is the largest cause of dependency and disability in older adults, affecting nearly 50 million people worldwide with about 10 million new cases every year. Presently, there are no cures for dementia. Consequently, a growing body of evidence suggests that bilingualism may delay the onset of clinical dementia symptoms by several years.

Objectives: The purpose of this review is to summarize and analyze current evidence from studies that examined how bilingualism delays the onset of dementia. Evidence is reviewed suggesting that bilingualism may delay the dementia symptoms due to an increase in cognitive reserve, which refers to an …

The Critical Need For Mental Health Education To Be Mandated In New Mexico's Public Schools, Bonnie L. Murphy

Shared Knowledge Conference

Based on a review of research and best practices in mental health awareness and skills, this inquiry project argues for state legislative policies that would require mental health awareness and skills in the K-12 curriculum. Mental health affects individual accomplishments in every stage of people’s lives beginning in early childhood and throughout the life cycle. Prevention and treatment of mental illness plays a key role in the ability of an individual to cope with loss and develop resiliency and perseverance in challenging times and to make better decisions that improve the individual’s life and the lives of those around them. …

Language Experience With A Native-Language Phoneme Sequence Modulates The Effects Of Attention On Cortical Sensory Processing, Valerie L. Shafer, Monica Wagner, Jungmee Lee, Francesca Mingino, Colleen O'Brien, Adam Constantine, Mitchell Steinschneider

Publications and Research

Auditory evoked potentials (AEP) reflect spectro-temporal feature changes within the spoken word and are sufficiently reliable to probe deficits in auditory processing. The current research assessed whether attentional modulation would alter the morphology of these AEPs and whether native-language experience with phoneme sequences would influence the effects of attention. Native-English and native-Polish adults listened to nonsense word pairs that contained the phoneme sequence onsets /st/, /sət/, /pət/ that occur in both the Polish and English languages and the phoneme sequence onset /pt/ that occurs in the Polish language, but not the English language. Participants listened to word pairs within two …

Cognitive And Neurobiological Degeneration Of The Mental Lexicon In Primary Progressive Aphasia, Jet M. J. Vonk

Dissertations, Theses, and Capstone Projects

The ease with which we use the thousands of words in our vocabulary stands in stark contrast to our difficulty establishing how they are organized in our mind and brain. The breakdown of language due to cortical atrophy in primary progressive aphasia (PPA) creates conditions to study this organization at a cognitive and neurobiological level in that the three variants of this disease, namely non-fluent, logopenic, and semantic PPA, each bear their own signature of language-specific decline and cortical atrophy. As the impaired regions in each variant are linked to different lexical and semantic attributes of words, lexical decision performance …

The Power Of Prayer, Victoria Dawn Thompson

Capstone Collection

If words are arbitrary, how does prayer have power?” is the question of inquiry in this paper. An unobtrusive Content Analysis inquiry methodology was used to answer this question. The answer lies in the finding that words and thoughts are not the same thing, and our thoughts expand beyond the audible and visible. The implication for professional practice these findings present is that a deeper awareness of “Self” is needed to understand people’s miraculous way of resolving conflict via prayer.

Neurophysiological And Behavioral Responses Of Mandarin Lexical Tone Processing, Yan H. Yu, Valerie L. Shafer, Elyse S. Sussman

Publications and Research

Language experience enhances discrimination of speech contrasts at a behavioral- perceptual level, as well as at a pre-attentive level, as indexed by event-related potential (ERP) mismatch negativity (MMN) responses. The enhanced sensitivity could be the result of changes in acoustic resolution and/or long-term memory representations of the relevant information in the auditory cortex. To examine these possibilities, we used a short (ca. 600 ms) vs. long (ca. 2,600 ms) interstimulus interval (ISI) in a passive, oddball discrimination task while obtaining ERPs. These ISI differences were used to test whether cross-linguistic differences in processing Mandarin lexical tone are a function of …

On The Screen, In The Mind: An Erp Investigation Into The Interaction Between Visuo-Spatial Information And Spatial Language During On-Line Processing, Emily Zane

Dissertations, Theses, and Capstone Projects

This project used Event-Related Potentials (ERPs) to explore neurophysiological brain responses to prepositional phrases involving concrete and abstract reference nouns (e.g., "plate" and "moment", respectively) after the presentation of objects with varying spatial features. Prepositional phrases were headed by in or on and were either matching (e.g., "in the plate/moment") or mismatching (e.g., "on the plate/moment"). Conjunction phrase matches and fillers were also presented. Before half of the concrete-phrase items, a photographic depiction of the reference noun was presented. In these photographs, objects were displayed in a way that was either more appropriate for in or for on. Similarly, before …

Hpcnmf: A High-Performance Toolbox For Non-Negative Matrix Factorization, Karthik Devarajan, Guoli Wang

COBRA Preprint Series

Non-negative matrix factorization (NMF) is a widely used machine learning algorithm for dimension reduction of large-scale data. It has found successful applications in a variety of fields such as computational biology, neuroscience, natural language processing, information retrieval, image processing and speech recognition. In bioinformatics, for example, it has been used to extract patterns and profiles from genomic and text-mining data as well as in protein sequence and structure analysis. While the scientific performance of NMF is very promising in dealing with high dimensional data sets and complex data structures, its computational cost is high and sometimes could be critical for …

Parkinson’S Disease Disrupts Both Automatic And Controlled Processing Of Action Verbs, L. Fernandino, L. Conant, J. Binder, K. Blindauer, B. Hiner, K. Spangler, Rutvik Desai

Rutvik Desai

No abstract provided.

Anatomy Is Strategy: Skilled Reading Differences Associated With Structural Connectivity Differences In The Reading Network, W. Graves, J. Binder, Rutvik Desai, C. Humphries, B. Stengel, M. Seidenberg

Rutvik Desai

No abstract provided.

Where Is The Semantic System? A Critical Review And Meta-Analysis Of 120 Functional Neuroimaging Studies, J. Binder, Rutvik Desai, W. Graves, L. Conant

Rutvik Desai

No abstract provided.

Presence-At-Hand, Eric Lyle Schultz

Graduate School of Art Theses

Abstract

The writing that follows is intended to provide a theoretical framework for the motives behind my practice. The primary concerns addressed are the reception, transmission, and physical shape of knowledge. I will discuss a human condition that exists as a byproduct of both the legacy of representation as well as the innate biology of the brain. I will argue that as a society we are governed by the residue of an extreme logic, and that this condition places severe margins on our potential for creative solutions. I will propose that our ability to create meaning is stifled by the …

Effects Of Meaningfulness In Left Angular Gyrus And Right Insula, Anna Nowaczyk

Georgia State Undergraduate Research Conference

No abstract provided.

Lexical Mechanics: Partitions, Mixtures, And Context, Jake Ryland Williams

Graduate College Dissertations and Theses

Highly structured for efficient communication, natural languages are complex systems. Unlike in their computational cousins, functions and meanings in natural languages are relative, frequently prescribed to symbols through unexpected social processes. Despite grammar and definition, the presence of metaphor can leave unwitting language users "in the dark," so to speak. This is not problematic, but rather an important operational feature of languages, since the lifting of meaning onto higher-order structures allows individuals to compress descriptions of regularly-conveyed information. This compressed terminology, often only appropriate when taken locally (in context), is beneficial in an enormous world of novel experience. However, what …

The New Normal: Goodness Judgments Of Non-Invariant Speech, Julia R. Drouin

Honors Scholar Theses

Previous research has found that perceptual learning, or normalizing the idiosyncratic phonemes of speech, causes a shift in speech sound category boundaries. The present study examined if perceptual learning was limited to the boundary or if also caused a shift in internal category structure. Seventeen individuals participated in three behavioral tasks to explicate this question. In the Lexical Decision task, participants were trained in either /s/-biasing or /ʃ/- biasing context. In the Goodness Judgment task, participants rated a continuum of sounds on perceived /s/ goodness using a designated scale. Finally, in the Phoneme Identification task, participants listened to the same …

Examining The Intersection Of The Cognitive Advantages And Disadvantages Of The Bilingual Brain, Irina Rabkina

Scripps Senior Theses

Two conflicting findings characterize cognitive processing accompanying bilingualism. The “bilingual advantage” refers to improved cognitive performance for bilingual compared to monolingual participants. Most bilingual advantages fall under the umbrella of cognitive control mechanisms, most frequently demonstrated using the Stroop task and the Simon task (e.g., Bialystok, 2008; Coderre, Van Heuven, & Conklin, 2013). The “bilingual disadvantage,” on the other hand, refers to bilinguals’ diminished performance on tasks that require word retrieval or switching between languages. This study examined the intersection of the bilingual advantage and the bilingual disadvantage to investigate whether they stem from a single cognitive control process. The …

Time, Perspectives, Verbs, And Imagining Events, Jeffrey P. Hong

Theses and Dissertations (Comprehensive)

During the processing of verbs, readers form internal representations of the events described by those verbs. Two key elements in the construction of event representations are temporal information, given by the verbs that describe the represented events, and the visual perspective from which the events are represented. The current study is composed of two experiments aimed at examining the roles these two factors play in event representation. Specifically, the study aimed to determine how temporal information and visual perspective are represented during event imagination.

Experiment 1 investigated the role of temporal information associated with verbs, given by grammatical aspect (GA) …