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Full-Text Articles in Virology
Loss Of Cell Surface Agal During Catarrhine Evolution: Possible Implications For The Evolution Of Resistance To Viral Infections And For Oligocene Lineage Divergence, Idalia Aracely Rodriguez
Loss Of Cell Surface Agal During Catarrhine Evolution: Possible Implications For The Evolution Of Resistance To Viral Infections And For Oligocene Lineage Divergence, Idalia Aracely Rodriguez
Doctoral Dissertations
The divergence of the two superfamilies belonging to the Infraorder Catarrhini –Cercopithecoidea (Old World monkeys) and Hominoidea (apes, including humans) – is generally assumed to have occurred during the Oligocene, between 38 and 20 million years ago. Genetic studies indicate that this time period was one of active genetic evolution under strong purifying selection for catarrhine primates. This includes selective pressures on the glycoprotein galactosyltransferase 1 (GGTA1) gene and subsequent inactivation “clocked” at approximately 28 ma, possibly prior to the Cercopithecoidea/Hominoidea split. The GGTA1 gene codes for an a1,3 galactosyltransferase (GT) enzyme that synthesizes a terminal disaccharide, …