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Pathogenic Microbiology Commons

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Candida albicans

Dissertations and Theses in Biological Sciences

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The Roles Of Biotin In Candida Albicans Physiology, Nur Ras Aini Ahmad Hussin Nov 2016

The Roles Of Biotin In Candida Albicans Physiology, Nur Ras Aini Ahmad Hussin

Dissertations and Theses in Biological Sciences

Due to the increased number of immunocompromised patients, infections by Candida albicans have significantly increased in recent years. C. albicans transition from yeast to germ tubes is an essential factor for virulence. In this study we noted that Lee's medium, commonly used to induce filamentation, contained 500-fold more biotin than needed for growth. Thus, we investigated the effects of excess biotin on growth rate and filamentation by C. albicans in different media. At 37 °C, excess biotin (4 µM) enhanced germ tube formation (GTF) ca. 10-fold in both Lee's medium and a defined glucose proline medium, and ca ...


Farnesol Signaling In Candida Albicans, Melanie L. Langford Apr 2010

Farnesol Signaling In Candida Albicans, Melanie L. Langford

Dissertations and Theses in Biological Sciences

Candida albicans is a polymorphic fungus that causes a range of disease in humans, from mucosal infections to systemic disease. Its ability to cause disease is linked to conversion between yeast and filamentous forms of growth, and the first quorum-sensing molecule discovered in an eukaryote, farnesol, blocks this transition. In C. albicans, farnesol also kills mating-competent opaque cells, inhibits biofilm formation, protects the cells from oxidative stress, and can be a virulence factor or protective agent in disseminated and mucosal mouse models of infection, respectively. While much emphasis has been placed on determining its effect on C. albicans morphology, the ...