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Laboratory and Basic Science Research Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Bioethics and Medical Ethics (32)
- Medicine and Health Sciences (32)
- Research Methods in Life Sciences (22)
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- Animal Studies (5)
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Articles 31 - 35 of 35
Full-Text Articles in Laboratory and Basic Science Research
Ethics, Welfare, And Laboratory Animal Management, David J. Allan, Judith K. Blackshaw
Ethics, Welfare, And Laboratory Animal Management, David J. Allan, Judith K. Blackshaw
Experimentation Collection
Animals have been used in medical research from as far back as 129-199 A.D. when Galen, a Greek medical scientist, used a pig for his experiments. In the sixteenth and seventeenth centuries, anatomical dissections were carried out on animals; Galvani used frogs in 1791 for his experiments and the Russian physiologist, Pavlov, carried out his famous dog experiments in the early 1900s. Since this time, large numbers of animals have been used in biomedical and other research. In 1963 the first edition of "The Guide for the Care and Use of Laboratory Animals" was published, and the United States Public …
Alternatives To Aversive Procedures With Animals In The Psychology Teaching Setting, Jeffrey A. Kelly
Alternatives To Aversive Procedures With Animals In The Psychology Teaching Setting, Jeffrey A. Kelly
Experimentation Collection
In this paper, we will consider the treatment of laboratory animals in psychology instruction and will focus on practical alternatives to traditional practices that cause pain and distress to animals. While the discussion will draw on psychology for examples, many of the issues apply equally to the instruction of students in other courses of study, including medicine, veterinary medicine, biology, and physiology.
The Imbalance Between Experiment And Theory In Biology: The Need For Theory-Directed Modeling, M. L. Fidelman, D. C. Mikulecky
The Imbalance Between Experiment And Theory In Biology: The Need For Theory-Directed Modeling, M. L. Fidelman, D. C. Mikulecky
Experimentation Collection
In biological and biomedical research, the vast majority of resources are focused on conducting experiments. Most of these experiments utilize animals. Only a tiny amount of resources is spent on theory and modeling. It is our contention and the basic theme of this paper that the imbalance between theory and experiment in biology produces very poor science. The implications of which are that many of the experiments conducted have little real scientific meaning or value and, therefore, go hand-in-hand with unnecessary animal use and suffering. Given the finite resources available for research, the redirection of significant resources from an almost …
Alternatives To Animal Experimentation, Steven M. Niemi
Alternatives To Animal Experimentation, Steven M. Niemi
Experimentation Collection
Alternatives to animal experimentation are highly touted today by animal welfare advocates. Their campaign for adoption of alternatives has caused much discussion and debate within and outside of the biomedical community. The purpose of this paper was to examine the controversy and assess the more common alternatives, including the bacterial mutagenicity assay or Ames test, cell culture, and mathematical models for toxicity prediction. Safety testing of chemicals is the most promising of the fields for alternatives where laboratory animals are used, and incorporation of alternatives with live-animal assays is increasing. However, due to limitations of alternatives in use currently, there …
Protection Of Animals And Animal Experimentation: A Survey Of Scientific Experts, Norbert Lagoni, Joachim Fiebelkorn, Hans-Joachim Wormuth
Protection Of Animals And Animal Experimentation: A Survey Of Scientific Experts, Norbert Lagoni, Joachim Fiebelkorn, Hans-Joachim Wormuth
Experimentation Collection
This article summarizes information from a survey of biomedical scientists, specifically pharmacologists and toxicologists, on the use of laboratory animals and the potential for replacing their use with alternative methods for the development and evaluation of pharmaceutical substances. The majority of those surveyed felt that the alternatives could supplement or complement animal tests, but not replace the tests altogether. However, most favored the use of nonsentient material in safety tests.