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Articles 61 - 61 of 61
Full-Text Articles in Cell Biology
Investigating The Affects Of Cucurbitacin-I On Cellular Motility, Rebecca Lafleur
Investigating The Affects Of Cucurbitacin-I On Cellular Motility, Rebecca Lafleur
Honors Scholar Theses
Cellular migration is an integral component of many biological processes including immune function, wound healing and cancer cell metastasis. A complete model illustrating the mechanism by which cells accomplish movement is still lacking. Exploring the affects of various drugs on cell motility may be instrumental in discovering new proteins which mediate cell movement. This project aims ultimately to characterize the molecular target of the drug Cucurbitacin-I, a natural plant product. This drug has been shown to inhibit migration of epithelial sheets and may have anti-tumor activity.
In this paper, we show that Cucurbitacin-I inhibits the migration of MDCK and B16F1 …