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Full-Text Articles in Cell Biology
Ets-2 Is A Target For An Akt (Protein Kinase B)/Jun N-Terminal Kinase Signaling Pathway In Macrophages Of Motheaten-Viable Mutant Mice, Alicia E. Schaffner, James L. Smith, Joseph K. Hofmeister, Matthew Hartman, Guo Wei, David Forsthoefel, David A. Hume, Michael C. Ostrowski
Ets-2 Is A Target For An Akt (Protein Kinase B)/Jun N-Terminal Kinase Signaling Pathway In Macrophages Of Motheaten-Viable Mutant Mice, Alicia E. Schaffner, James L. Smith, Joseph K. Hofmeister, Matthew Hartman, Guo Wei, David Forsthoefel, David A. Hume, Michael C. Ostrowski
Science and Mathematics Faculty Publications
The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice. The CSF-1 and ets-2 target genes coding for Bcl-x, urokinase plasminogen activator, and scavenger receptor were also expressed at high levels independent of CSF-1 addition to me-v cells. Akt (protein kinase B) was constitutively active in me-v macrophages, and an Akt immunoprecipitate catalyzed phosphorylation of ets-2 at threonine 72. The p54 isoform of c-jun N-terminal kinase–stress-activated kinase (JNK- SAPK) coimmunoprecipitated with Akt from me-v macrophages, and treatment ofme-v cells …