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Articles 1 - 3 of 3
Full-Text Articles in Molecular Biology
Enabling Sum Frequency Spectroscopy And Fluorescence Correlation Spectroscopy Of Model Cellular Membranes, Sarah M. Sterling
Enabling Sum Frequency Spectroscopy And Fluorescence Correlation Spectroscopy Of Model Cellular Membranes, Sarah M. Sterling
Electronic Theses and Dissertations
The majority of proteins secreted from cells contain a signal peptide sequence that is required for secretion mediated by the endoplasmic reticulum and Golgi apparatus. However, many proteins lack the essential signal peptide sequence, yet still undergo secretion. Such proteins are known to regulate cell proliferation, differentiation, and migration. Fibroblast growth factor 1 (FGF-1) is one protein which undergoes non-classical protein transport. The role of its interactions with the cellular membrane during non-classical protein transport is not fully understood, although FGF-1 has shown preferential destabilizing effects on artificial membranes composed of acidic phospholipids. In the present work, physiologically relevant model …
Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter
Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter
Honors College
The innate immune system is highly conserved amongst all multicellular organisms. Yet a constant battle exists between host cells and pathogens due to the rapid evolution of immune system components. Functional genomics and in silico methods can be employed to elucidate the evolutionary patterns of vertebrate immunity to pathogenic fungi such as Candida albicans, an opportunistic fungal pathogen that can cause lethal candidiasis in the immunocompromised. Mammals such as humans and mice possess conserved C-type lectin receptors that recognize the C. albicans cell wall. However, these receptors have not been identified in fish. Here I describe how we identified potential …
Reverse Genetic Analysis Of A Cysteine Protease-Encoding Gene (Rd19a) Of Arabidopsis Thaliana In Relation To The Mechanism Of Resistance To The Piercing/Sucking Insect Myzus Persicae, Siobhan A. Cusack
Honors College
A recent study in Solanum bulbocastanum (a wild relative of the cultivated potato) aiming to identify potential genes involved in aphid and pathogen resistance mechanisms found that a homolog of the Arabidopsis thaliana cysteine protease gene RD19a is upregulated during aphid infestation. RD19a is upregulated in response to abiotic stresses such as drought and high salinity, and rd19a mutants show increased susceptibility to bacterial infection. In this study, Arabidopsis rd19a mutants and wild-type plants were subjected to aphid feeding to observe and compare the molecular, physiological and phenotypic responses. The aim was to further establish the proof of concept regarding …