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Full-Text Articles in Molecular Biology
Evaluation Of Wild Yam (Dioscorea Villosa) As A Demethylating Agent And Its Anti Metastatic Activity In Human Breast Cancer Cells, Pranapda Aumsuwan
Evaluation Of Wild Yam (Dioscorea Villosa) As A Demethylating Agent And Its Anti Metastatic Activity In Human Breast Cancer Cells, Pranapda Aumsuwan
Electronic Theses and Dissertations
No abstract provided.
Notch Regulation Of Human Breat Cancer Progression: Contrasting Roles For Notch Signaling, Christine F. O'Neill
Notch Regulation Of Human Breat Cancer Progression: Contrasting Roles For Notch Signaling, Christine F. O'Neill
Electronic Theses and Dissertations
Notch signaling is associated with activation of either oncogenic or tumor suppressor activities. The human mammary adenocarcinoma cell line, MDA-MB-231, was characterized in vitro and in xenografts in vivo to test the hypothesis that activation of Notch signaling regulates mammary tumor phenotype. Notch 1, Notch2, and Notch4 signaling was compared by stable expression of their constitutively active intracellular domains (ICD). Notch4 activation led to enhanced tumorigenicity, in addition to increased cell proliferation and survival in vitro, whereas the activation of Notch 1 or Notch2 decreased cell proliferation and survival, in which Notch2 increased apoptosis. Stably transfected cell lines were …